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Inicio Medicina Clínica (English Edition) Effect of antiresorptive and bone forming treatments in bone erosions in rheumat...
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Vol. 154. Issue 9.
Pages 358-365 (May 2020)
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Vol. 154. Issue 9.
Pages 358-365 (May 2020)
Review
Effect of antiresorptive and bone forming treatments in bone erosions in rheumatoid arthritis
Efecto del tratamiento antirresortivo y osteoformador en las erosiones óseas en la artritis reumatoide
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3
Ana Belén Azuaga-Piñangoa,
Corresponding author
abazuaga@clinic.cat

Corresponding author.
, Pilar Perisa,b
a Servicio de Reumatología, Hospital Clínic, Universidad de Barcelona, Barcelona, Spain
b CIBERehd, Barcelona, Spain
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Table 1. Characteristics of clinical studies on the effect of denosumab on bone erosions.
Table 2. Characteristics of clinical studies on the effect of bisphosphonates on bone erosions.
Table 3. Characteristics of clinical studies on the effect of teriparatide on bone erosions.
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Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease that can cause joint destruction and marked disability. Early treatment with disease-modifying drugs, including biological therapy, is the principal treatment to prevent the structural damage associated with this entity. Some studies have indicated that concomitant treatment with antiresorptives, such as bisphosphonates or denosumab, could prevent erosive lesions in this process, and it has even been suggested that treatment with a bone forming agent, such as teriparatide, could revert previously established erosive lesions. In this article we review the evidence available on the efficacy of treatment with antiresorptives and bone forming agents in the prevention and/or treatment of bone erosions associated with RA.

Keywords:
Rheumatoid arthritis
Bone erosion
Denosumab
Bisphosphonate
Teriparatide
Osteoporosis
Zoledronic acid
Resumen

La artritis reumatoide (AR) es una enfermedad inflamatoria crónica que puede ocasionar destrucción articular y marcada discapacidad. El tratamiento precoz con fármacos modificadores de la enfermedad, incluyendo la terapia biológica, constituye el principal tratamiento para prevenir el daño estructural asociado a esta entidad. Algunos estudios han indicado que el tratamiento concomitante con antirresortivos, como los bisfosfonatos o el denosumab, podría prevenir el desarrollo de lesiones erosivas en este proceso, e incluso se ha sugerido que el tratamiento con un osteoformador, como la teriparatida, podría revertir las lesiones erosivas previamente establecidas. En este artículo se revisa la evidencia disponible sobre la eficacia del tratamiento antirresortivo y osteoformador en la prevención o tratamiento de las erosiones óseas asociadas a la AR.

Palabras clave:
Artritis reumatoide
Erosiones óseas
Denosumab
Bisfosfonatos
Teriparatida
Osteoporosis
Zoledronato

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