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Inicio Medicina Clínica (English Edition) Burden of COVID-19 variant omicron in immunocompromised patients in Spain: Syste...
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Available online 26 September 2024
Burden of COVID-19 variant omicron in immunocompromised patients in Spain: Systematic review
Carga de la COVID-19 variante ómicron en pacientes inmunocomprometidos en España: revisión sistemática
Raúl Ortiz-de-Lejarazua,
Corresponding author
lejarazu@gmail.com

Corresponding author.
, Borja Quiroga Gilib, Alberto López Garcíac
a Centro Nacional de Gripe, Hospital Clínico Universitario y Facultad de Medicina de Valladolid, Valladolid, Spain
b IIS-La Princesa, Servicio de Nefrología, Hospital Universitario de la Princesa, Madrid, Spain
c Servicio de Hematología y Hemoterapia, Fundación Jiménez Díaz, Madrid, Spain
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Table 1. Population data in Spain during the study period (01/04/2022 to 31/03/2023).
Table 2. Characteristics of the included studies and their populations. Description of the immunocompromised population.
Table 3. Risk factors and health outcomes in the immunocompromised population with COVID-19.
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Abstract

After the COVID-19 pandemic, the Omicron variant of the SARS-CoV-2 virus became the dominant lineage in Spain in 2022. Although it possesses a milder pathogenicity than previous variants, it still poses a high risk of causing severe COVID-19 for immunocompromised populations.

A systematic review was conducted to assess the burden of COVID-19 in Spain among immunocompromised patients during the Omicron predominance (1/04/2022–1/04/2023), using PubMed, Cochrane Library, and EPICOVIDEHA between May and July 2023.

The search retrieved 217 articles, of which a total of 5 were included. Upon analysis, it was observed that immunocompromised patients during the Omicron lineage predominance continue to exhibit higher rates of hospitalizations, ICU admissions, and mortality compared to the general population affected by COVID-19. Although the pandemic has ended, the risk persists for immunocompromised individuals.

Keywords:
COVID-19 omicron
Burden of disease
Spain
Immunocompromised
Resumen

Tras la pandemia de la COVID-19, la variante Ómicron del virus SARS-CoV-2 se convirtió en el linaje dominante en España en 2022. Aunque posee una patogenicidad más leve que las anteriores variantes, sigue suponiendo un riesgo elevado de ocasionar una forma de COVID-19 grave para la población inmunodeprimida.

Se realizó una revisión sistemática para evaluar la carga de la COVID-19 en España en pacientes inmunocomprometidos durante la predominancia de Ómicron (1/04/2022- 1/04/2023), en PubMed, Cochrane Library y EPICOVIDEHA entre mayo y julio de 2023.

La búsqueda recuperó 217 artículos, incluyéndose un total de 5. Tras su análisis, se observó que los pacientes inmunocomprometidos durante el predominio del linaje Ómicron siguen presentando una mayor tasa de hospitalizaciones, ingresos en la UCI y mortalidad que la población general afectada por COVID-19. Aunque la pandemia ha terminado, para los inmunodeprimidos continua el riesgo.

Palabras clave:
COVID-19 ómicron
Carga de la enfermedad
España
Inmunocomprometido

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