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Inicio Medicina Clínica (English Edition) Liraglutide for the treatment of obesity among patients with hidradenitis suppur...
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Vol. 162. Issue 3.
Pages 118-122 (February 2024)
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Vol. 162. Issue 3.
Pages 118-122 (February 2024)
Brief report
Liraglutide for the treatment of obesity among patients with hidradenitis suppurativa
Liraglutida en el tratamiento de la obesidad en pacientes con hidradenitis supurativa
Joana Nicolaua,
Corresponding author
jnicolauramis@gmail.com

Corresponding author.
, Antoni Nadalb, Pilar Sanchísa, Antelm Pujola, Lluís Masmiquela, Cristina Nadalb
a Endocrinology and Nutrition Department, Hospital Universitario Son Llàtzer, Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Baleares, Spain
b Dermatology Department, Hospital Universitario Son Llàtzer, Palma de Mallorca, Baleares, Spain
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Figures (1)
Tables (2)
Table 1. Changes in anthropometric, dermatological, and psychological variables after three months of treatment with liraglutide 3mg.
Table 2. Comparison of metabolic and inflammatory parameters among patients with HS and obesity after three months of treatment with liraglutide 3mg.
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Abstract
Background and aims

Hidradenitis suppurativa (HS) is associated with obesity. Weight loss is frequently reflected in an amelioration in the severity of the lesions. Case reports have suggested that liraglutide might improve not only weight but also skin. We aimed to study the effects of liraglutide 3mg in patients with obesity and HS on metabolic and dermatological parameters.

Methods

14 patients started treatment with liraglutide for 3 months. Severity of the lesions was evaluated using the Hurley Staging System and quality of life with the DLQI (Dermatology Quality Index).

Results

There was a significant reduction in BMI (39.3±6.2 vs 35.6±5.8; p=0.002), waist circumference (121.3±19.2 vs 110.6±18.1cm; p=0.01), CRP (4.5±2.2 vs 3±2.1mg/L; p=0.04), homocysteine (16.2±2.9 vs 13.3±3μmol/L; p=0.005) and plasma cortisol (15.9±4.8 vs 12.6±4.5μg/dL; p=0.007). Hurley (2.6±0.5 vs 1.1±0.3; p=0.002) and DLQI (12.3±2.8 vs 9.7±6.9; p=0.04) improved significantly. In multiple regression analysis, weight loss did not correlate with any inflammatory parameter or Hurley.

Conclusions

Liraglutide 3mg is effective and safe among patients with HS and obesity. Long-term studies are mandatory to assess the effects of liraglutide on skin lesions and inflammatory markers among subjects with HS beyond weight loss.

Keywords:
Hidradenitis suppurativa
Obesity
Metabolic syndrome
Liraglutide
Inflammatory markers
Resumen
Antecedentes y objetivos

La hidradenitis supurativa (HS) se asocia a la obesidad. La pérdida de peso frecuentemente comporta una mejora en la gravedad de las lesiones. Casos aislados han sugerido que la liraglutida podría mejorar no solo el peso sino también la piel. Nuestro objetivo fue estudiar los efectos de liraglutida 3mg en pacientes con obesidad y HS sobre los parámetros metabólicos y dermatológicos.

Métodos

Catorce pacientes iniciaron tratamiento con liraglutida durante 3meses. La gravedad de las lesiones se evaluó mediante la Escala de Hurley y la calidad de vida con el Dermatology Quality Index (DLQI).

Resultados

Hubo una reducción significativa en el IMC (39,3±6,2 vs 35,6±5,8; p=0,002), la circunferencia de cintura (121,3±19,2 vs 110,6±18,1cm; p=0,01), la PCR (4,5±2,2 vs 3±2,1mg/l; p=0,04), la homocisteína (16,2±2,9 vs 13,3±3μmol/l; p=0,005) y el cortisol plasmático (15,9±4,8 vs 12,6±4,5μg/dl; p=0,007). El Hurley (2,6±0,5 vs 1,1±0,3; p=0,002) y la DLQI (12,3±2,8 vs 9,7±6,9; p=0,04) mejoraron significativamente. En el análisis de regresión múltiple, la pérdida de peso no se correlacionó con ningún parámetro inflamatorio ni con el Hurley.

Conclusiones

Liraglutida 3mg es eficaz y segura en pacientes con HS y obesidad. Serán necesarios estudios a largo plazo para evaluar los efectos de la liraglutida sobre las lesiones cutáneas y los marcadores inflamatorios en la HS más allá de la pérdida de peso.

Palabras clave:
Hidradenitis supurativa
Obesidad
Síndrome metabólico
Liraglutida
Marcadores inflamatorios

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