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"apellidos" => "Milisenda" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0025775322000045" "doi" => "10.1016/j.medcli.2022.01.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775322000045?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020622002558?idApp=UINPBA00004N" "url" => "/23870206/0000015800000011/v1_202206190623/S2387020622002558/v1_202206190623/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2387020622002236" "issn" => "23870206" "doi" => "10.1016/j.medcle.2021.10.015" "estado" => "S300" "fechaPublicacion" => "2022-06-10" "aid" => "5861" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2022;158:e8-e9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Panniculitis in patients treated with BRAF/MEK inhibitors: Presentation of 4 new cases" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "e8" "paginaFinal" => "e9" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Paniculitis en pacientes tratados con iBRAF/iMEK: presentación de 4 nuevos casos" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1763 "Ancho" => 2007 "Tamanyo" => 478153 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical and histopathological characteristics of panniculitis lesions. A and B) Clinical characteristics of 2 of the cases: erythematous-violaceous nodular lesions (→) on the legs (A) and arms (B). C) Septal panniculitis: predominantly septal lymphohistiocytic infiltrate (*). D) Lobular panniculitis: lymphohistiocytic fat lobule infiltrate (→).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Patricia Cordeiro González, Ana Taibo Martínez, Carmen Peña Penabad" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Patricia" "apellidos" => "Cordeiro González" ] 1 => array:2 [ "nombre" => "Ana" "apellidos" => "Taibo Martínez" ] 2 => array:2 [ "nombre" => "Carmen" "apellidos" => "Peña Penabad" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775321006710" "doi" => "10.1016/j.medcli.2021.10.017" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775321006710?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020622002236?idApp=UINPBA00004N" "url" => "/23870206/0000015800000011/v1_202206190623/S2387020622002236/v1_202206190623/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image in medicine</span>" "titulo" => "Eczema herpeticum in atopic dermatitis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "566" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Emilio de Dios Berna-Rico, Maria Belen de Nicolas-Ruanes, Emilio Garcia-Mouronte, Patricia Burgos-Blasco" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Emilio de Dios" "apellidos" => "Berna-Rico" "email" => array:1 [ 0 => "emilioberna2a@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Maria Belen" "apellidos" => "de Nicolas-Ruanes" ] 2 => array:2 [ "nombre" => "Emilio" "apellidos" => "Garcia-Mouronte" ] 3 => array:2 [ "nombre" => "Patricia" "apellidos" => "Burgos-Blasco" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Dermatology Department, Ramon y Cajal University Hospital, IRYCIS, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eccema herpeticum en dermatitis atópica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 763 "Ancho" => 904 "Tamanyo" => 188535 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Descriptive legend</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 23-year-old man presented to the emergency department with a one-week history of painful facial rash, without fever or associated systemic symptoms. His past medical history included moderate-to-severe atopic dermatitis (AD). Physical examination revealed multiple non-grouped umbilicated vesicles and crusted hemorrhagic erosions located symmetrically on his face, with no mucosal involvement (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>). Eczema herpeticum (EH) was suspected and immediate therapy with oral valacyclovir was initiated. Rash resolved in ten days. A polymerase chain reaction from a vesicle swab resulted positive for Herpes simplex virus 1 (HSV-1) infection, confirming our diagnosis.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">EH represents a generalized HSV skin infection that appears more frequently in patients with AD. The skin barrier dysfunction, the Th2 immune-polarization and the IFN-pathway malfunction commonly seen in these patients could lead to a more unrestrained viral spread. Its differential diagnosis encompasses eczema coxsackium, eczema vaccinatum, impetigo, scabies and primary varicella infection. Severe AD with intense excoriated papules should also be considered. Life-threatening complications, such as hepatitis or encephalitis, may occur in severe forms. Therefore, treatment should be started based upon clinical suspicion, being visual recognition of the entity of paramount importance. Guanosine analogues, such as acyclovir or valacyclovir, constitute the treatment of choice.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Data availability statement</span><p id="par0015" class="elsevierStylePara elsevierViewall">The data that support the findings of this study are available from the corresponding author upon reasonable request. The data are not publicly available due to privacy or ethical restrictions.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Informed consent</span><p id="par0030" class="elsevierStylePara elsevierViewall">The patient in this manuscript has given written informed consent to publication of his case details.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Funding</span><p id="par0020" class="elsevierStylePara elsevierViewall">The article has no funding source.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflict of interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Descriptive legend" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Data availability statement" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Informed consent" ] 3 => array:2 [ "identificador" => "sec0015" "titulo" => "Funding" ] 4 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflict of interest" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 815 "Ancho" => 904 "Tamanyo" => 172725 ] ] ] 1 => array:6 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 763 "Ancho" => 904 "Tamanyo" => 188535 ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000015800000011/v1_202206190623/S2387020622001462/v1_202206190623/en/main.assets" "Apartado" => array:4 [ "identificador" => "51820" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in medicine" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000015800000011/v1_202206190623/S2387020622001462/v1_202206190623/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020622001462?idApp=UINPBA00004N" ]
