Share
array:24 [ "pii" => "S2387020616307999" "issn" => "23870206" "doi" => "10.1016/j.medcle.2016.12.049" "estado" => "S300" "fechaPublicacion" => "2016-12-16" "aid" => "3795" "copyright" => "Elsevier España, S.L.U.. All rights reserved" "copyrightAnyo" => "2016" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2016;147:568" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0025775316304985" "issn" => "00257753" "doi" => "10.1016/j.medcli.2016.09.038" "estado" => "S300" "fechaPublicacion" => "2016-12-16" "aid" => "3795" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2016;147:568" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 24 "formatos" => array:2 [ "HTML" => 19 "PDF" => 5 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>" "titulo" => "Crisis comicial por la interacción sertralina-metilfenidato" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "568" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Epileptic seizure due to drug interaction between sertraline and methylphenidate" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Patricia Peña Guerrero, Carolina Magro Fernández, Eduardo Durán Ferreras" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Patricia" "apellidos" => "Peña Guerrero" ] 1 => array:2 [ "nombre" => "Carolina" "apellidos" => "Magro Fernández" ] 2 => array:2 [ "nombre" => "Eduardo" "apellidos" => "Durán Ferreras" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2387020616307999" "doi" => "10.1016/j.medcle.2016.12.049" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616307999?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775316304985?idApp=UINPBA00004N" "url" => "/00257753/0000014700000012/v1_201612100119/S0025775316304985/v1_201612100119/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2387020616307963" "issn" => "23870206" "doi" => "10.1016/j.medcle.2016.12.046" "estado" => "S300" "fechaPublicacion" => "2016-12-16" "aid" => "3788" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2016;147:569" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Dilatation of inferior vena cava in patients with anorexia nervosa" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "569" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Dilatación de la vena cava inferior en pacientes con anorexia nerviosa" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ariadna Ayerza Casas, Cecilia García Lasheras, Laura Escartín Madurga" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Ariadna" "apellidos" => "Ayerza Casas" ] 1 => array:2 [ "nombre" => "Cecilia" "apellidos" => "García Lasheras" ] 2 => array:2 [ "nombre" => "Laura" "apellidos" => "Escartín Madurga" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S002577531630447X" "doi" => "10.1016/j.medcli.2016.09.033" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S002577531630447X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616307963?idApp=UINPBA00004N" "url" => "/23870206/0000014700000012/v1_201702040025/S2387020616307963/v1_201702040025/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2387020616308002" "issn" => "23870206" "doi" => "10.1016/j.medcle.2016.12.050" "estado" => "S300" "fechaPublicacion" => "2016-12-16" "aid" => "3796" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2016;147:567-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Cutaneous <span class="elsevierStyleItalic">larva migrans</span> acquired in Asturias, Spain" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "567" "paginaFinal" => "568" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "<span class="elsevierStyleItalic">Larva migrans</span> cutánea adquirida en Asturias" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Yolanda Hidalgo García, Cristina Fernández Sánchez, Diana Rodríguez Villar" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Yolanda" "apellidos" => "Hidalgo García" ] 1 => array:2 [ "nombre" => "Cristina" "apellidos" => "Fernández Sánchez" ] 2 => array:2 [ "nombre" => "Diana" "apellidos" => "Rodríguez Villar" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775316304997" "doi" => "10.1016/j.medcli.2016.09.039" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775316304997?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616308002?idApp=UINPBA00004N" "url" => "/23870206/0000014700000012/v1_201702040025/S2387020616308002/v1_201702040025/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Epileptic seizure due to drug interaction between sertraline and methylphenidate" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "568" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Patricia Peña Guerrero, Carolina Magro Fernández, Eduardo Durán Ferreras" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Patricia" "apellidos" => "Peña Guerrero" "email" => array:1 [ 0 => "patricia.pena.guerrero@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Carolina" "apellidos" => "Magro Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Eduardo" "apellidos" => "Durán Ferreras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Medicina Familiar y Comunitaria, Zona Básica de Salud de Camas, Camas, Sevilla, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Interna, Complejo Hospitalario Universitario de Huelva, Huelva, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Neurología, Complejo Hospitalario Universitario de Huelva, Huelva, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Crisis comicial por la interacción sertralina-metilfenidato" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Depression and epilepsy are entities that increase neuronal excitability.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Although the exact pathophysiology is unknown, the depressive disorder involves several neurotransmitters, so that when imbalances occur in these, the risk of seizures in susceptible patients increases. There are drugs, such as the antidepressants, which may favour the onset of epileptic episodes as the seizure threshold is lowered.</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 14-year-old male, with no history of interest except for attention deficit-hyperactivity disorder under treatment for some years with methylphenidate (MPH) 54<span class="elsevierStyleHsp" style=""></span>mg/day, and, just during the last 15 days, receiving sertraline (SRT) solution 10<span class="elsevierStyleHsp" style=""></span>mg/day for depressive symptoms. The patient was admitted for a generalised tonic–clonic seizure without tongue biting, followed by drowsiness and postepileptic amnesia. It was the first seizure with these characteristics. The examination was normal, as well as a complete lab test, X-ray, electrocardiogram, electroencephalogram (EEG) and cranial CT scan. Suspecting that the SRT was the cause of the seizure, its administration was suspended since that moment.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The use of antidepressants may trigger the onset of epileptic seizures, particularly in patients with a history of epilepsy, the elderly, those taking high doses of antidepressants or those with neurological injuries, among others.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">SRT is a selective serotonin reuptake inhibitor, a first-choice drug in the treatment of various disorders (depression, dysthymic and obsessive-compulsive disorder), as it presents the best evidence and the best risk/benefit balance, and is considered an antidepressant with a low epileptogenic risk. Others, such as duloxetine, bupropion or venlafaxine, have a medium or medium–high risk.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Even SRT could help control seizures by inhibiting (reducing the permeability of the presynaptic sodium channels) secretion of proinflammatory cytokines (IL-1β and TNF-α), which increase in both epilepsy and depression. Even though it reduces brain excitability,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> at high doses, by co-activation of serotonergic brain receptors, it can induce an increase in seizure frequency in epileptic patients.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1,3</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Besides, 3 cases of epileptic seizures have also been published in which, like in the case of our patient, SRT was combined with MPH. They were analysed in 2008.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> MPH is a mild stimulant of the central nervous system, as it blocks the presynaptic reuptake of norepinephrine and dopamine, with its consequent release into the extraneuronal space. It may lower the seizure threshold in epileptic patients and even in those without previous history of epileptic seizures or EEG abnormalities, as in the case of our patient. The cases found in the literature review conducted on the epileptogenic synergistic effect of MPH and SRT have been very rare. McGlohn and Bostwick were the first to report, in 1995, the appearance of seizures after administration of MPH in a 61-year-old man already receiving treatment with SRT. Two years later, Feeney and Klykyl described the onset of seizures after the introduction of SRT in a 13-year-old already under treatment with MPH for years; and finally, in 2008, Schertz and Steinberg<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> described another case in a 12-year-old adolescent. Neither our patient nor any of the other patients had another epileptic seizure after the withdrawal of SRT.</p><p id="par0030" class="elsevierStylePara elsevierViewall">According to the Drug Interaction Probability Scale of Horn et al.,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> which uses different questions about potential interactions and pharmacological properties, there would be a probable interaction. Therefore, we believe that taking MPH with SRT contributed decisively to our patient experiencing the seizure, even though the antidepressant dose was not high, and, therefore, we submitted the corresponding notification of suspected adverse reaction to the Andalusian Center of Pharmacovigilance. By way of conclusion, we can say that SRT has two different interactions regarding epilepsy; although it is considered a safe drug in patients with this condition, there is a risk (even though low) of triggering the onset of seizures, especially if it is administered in conjunction with other drugs such as MPH. Therefore, it must be used at the lowest possible dose, and if a patient taking SRT has an epileptic seizure, this drug should be considered as responsible, even when administered at usual doses.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Peña Guerrero P, Magro Fernández C, Durán Ferreras E. Crisis comicial por la interacción sertralina-metilfenidato. Med Clin (Barc). 2016;147:568.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antidepresivos en epilepsia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. Castaño-Monsalve" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Neurol" "fecha" => "2013" "volumen" => "57" "paginaInicial" => "117" "paginaFinal" => "122" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23881616" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sertraline reduces IL-1β and TNF-α mRNA expression and overcomes their rise induced by seizures in the rat hippocampus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Sitges" 1 => "C. Gómez" 2 => "B. Aldana" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0111665" "Revista" => array:5 [ "tituloSerie" => "PLoS One" "fecha" => "2014" "volumen" => "9" "paginaInicial" => "e111665" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25364907" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Seizure with sertraline: is there a risk?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Sarkar" 1 => "S. Gangadhar" 2 => "E. Subramaniam" 3 => "S.K. Praharaj" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Neuropsychiatry Clin Neurosci" "fecha" => "2014" "volumen" => "26" "paginaInicial" => "27" "paginaFinal" => "32" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Seizures induced by the combination treatment of methylphenidate and sertraline" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Schertz" 1 => "T. Steinberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/cap.2007.0141" "Revista" => array:6 [ "tituloSerie" => "J Child Adolesc Psychopharmacol" "fecha" => "2008" "volumen" => "18" "paginaInicial" => "301" "paginaFinal" => "303" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18582188" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proposal for a new tool to evaluate drug interaction cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.R. Horn" 1 => "P.D. Hansten" 2 => "L.N. Chan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1345/aph.1H423" "Revista" => array:6 [ "tituloSerie" => "Ann Pharmacother" "fecha" => "2007" "volumen" => "41" "paginaInicial" => "674" "paginaFinal" => "680" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17389673" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000014700000012/v1_201702040025/S2387020616307999/v1_201702040025/en/main.assets" "Apartado" => array:4 [ "identificador" => "46463" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000014700000012/v1_201702040025/S2387020616307999/v1_201702040025/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616307999?idApp=UINPBA00004N" ]
