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Both ferritin and hepcidin increase in inflammatory processes, associating anaemia and finding a correlation between the two values in such a situation.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> High levels of ferritin, when associated with an increase of hepcidin, show inflammation and anaemia caused by decreased intestinal iron absorption and deposition in macrophages, while low levels of hepcidin, also with high ferritin levels, demonstrate iron overload caused by enhanced intestinal iron absorption and its release from macrophages.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Hepcidin is a hormone that synthesizes the liver and regulates iron metabolism through control of its intestinal absorption and deposit mobilization for an effective erythropoiesis.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> Cytokines are generated in all infectious/inflammatory processes, these, in turn, are responsible for the increase of acute phase reactants, including ferritin. Some of the inflammatory cytokines released, especially interleukin 6, can induce hepcidin synthesis. This involves iron immobilization in the intestinal mucosa and in the deposits, with bone marrow supply shortage.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Ferritin is an iron storage protein, but also an acute phase reactant, therefore, elevated levels of ferritin may involve an iron or an acute phase reactant overload; in the first case, it is associated with hemochromatosis, while the second is mainly linked with inflammatory diseases.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">2,3</span></a> When ferritin levels reach higher levels, over 10,000<span class="elsevierStyleHsp" style=""></span>μg/ml, the hyperferritinemic syndrome is defined, among which Still's disease is included.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Commercial <span class="elsevierStyleItalic">kits</span> for hepcidin determination are currently available. These can be used to make the differential diagnosis for hyperferritinemia and distinguish between iron overload or inflammatory anemia.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> In addition, several drugs are under research and development, both hepcidin agonists and antagonists, which will allow us to deal with these processes in a more specific way.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Therefore, we consider it useful to determine the levels of hepcidin in inflammatory processes that occur with hyperferritinemia and anaemia of chronic disorder because it can help with both the pathogenesis and the diagnosis, and, in the not-so-distant future, with the possibility to perform a specific treatment with new drugs.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: López-Aparicio A, del Castillo-Rueda A. Hepcidina y ferritina en la enfermedad de Still. Med Clin (Barc). 2017;148:e13.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enfermedad de Still del adulto" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Castañeda" 1 => "E.F. Vicente" 2 => "M.A. González-Gay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2016" "volumen" => "147" "paginaInicial" => "217" "paginaFinal" => "222" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hepcidin in the diagnosis of iron disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Girelli" 1 => "E. Nemeth" 2 => "D.W. Swinkels" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1182/blood-2015-12-639112" "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2016" "volumen" => "127" "paginaInicial" => "2809" "paginaFinal" => "2813" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27044621" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sistemática diagnóstica en la hiperferritinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Altés" 1 => "M.J. Pérez-Lucena" 2 => "M. Bruguera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2013" "volumen" => "142" "paginaInicial" => "412" "paginaFinal" => "417" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The hyperferritinemic syndrome: macrophage activation syndrome, Still's disease, septic shock and catastrophic antiphospholipid syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Rosario" 1 => "G. Zandman-Goddard" 2 => "E.G. Meyron-Holtz" 3 => "D.P. D’Cruz" 4 => "Y. Shoenfeld" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1741-7015-11-185" "Revista" => array:5 [ "tituloSerie" => "BMC Med" "fecha" => "2013" "volumen" => "11" "paginaInicial" => "185" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23968282" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum hepcidin levels in hospitalized patients. A pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Del Castillo-Rueda" 1 => "N. Mastkiv" 2 => "M.I. Moreno-Carralero" 3 => "M.J. Morán-Jiménez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Am J Hematol" "fecha" => "2013" "volumen" => "88" "paginaInicial" => "E226" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000014800000003/v1_201703130933/S2387020617300931/v1_201703130933/en/main.assets" "Apartado" => array:4 [ "identificador" => "43309" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000014800000003/v1_201703130933/S2387020617300931/v1_201703130933/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020617300931?idApp=UINPBA00004N" ]
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Letter to the Editor
Hepcidin and ferritin levels in Still's disease
Hepcidina y ferritina en la enfermedad de Still
Ana López-Aparicio, Alejandro del Castillo-Rueda
Corresponding author
Unidad de Ferropatología y Radicalosis, Servicio de Medicina Interna, Hospital General Universitario Gregorio Marañón, Madrid, Spain