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array:23 [ "pii" => "S2387020623000220" "issn" => "23870206" "doi" => "10.1016/j.medcle.2022.09.014" "estado" => "S300" "fechaPublicacion" => "2023-02-10" "aid" => "6108" "copyright" => "Elsevier España, S.L.U.. All rights reserved" "copyrightAnyo" => "2022" "documento" => "article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Med Clin. 2023;160:133-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S2387020623000232" "issn" => "23870206" "doi" => "10.1016/j.medcle.2022.10.007" "estado" => "S300" "fechaPublicacion" => "2023-02-10" "aid" => "6110" "documento" => "article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Med Clin. 2023;160:135-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>" "titulo" => "Prevalence of acute pulmonary thromboembolism in patients with COVID-19 related pulmonary involvement: A study of 240 lung perfusion scans" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "135" "paginaFinal" => "136" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Prevalencia de tromboembolia pulmonar aguda en pacientes con compromiso pulmonar relacionado con COVID-19: un estudio de 240 gammagrafías de perfusión pulmonar" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mohsen Bakhshi-Kashi, Saeed Farzanefar, Mehrshad Abbasi" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Mohsen" "apellidos" => "Bakhshi-Kashi" ] 1 => array:2 [ "nombre" => "Saeed" "apellidos" => "Farzanefar" ] 2 => array:2 [ "nombre" => "Mehrshad" "apellidos" => "Abbasi" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020623000232?idApp=UINPBA00004N" "url" => "/23870206/0000016000000003/v1_202302051543/S2387020623000232/v1_202302051543/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2387020623000037" "issn" => "23870206" "doi" => "10.1016/j.medcle.2023.01.001" "estado" => "S300" "fechaPublicacion" => "2023-02-10" "aid" => "6088" "copyright" => "Elsevier España, S.L.U." "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Clin. 2023;160:129-32" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Special article</span>" "titulo" => "Medical generalism. Past, present and future" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "129" "paginaFinal" => "132" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "El generalismo médico. Pasado, presente y futuro" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ramon Pujol Farriols, Marina Geli Fabrega" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Ramon" "apellidos" => "Pujol Farriols" ] 1 => array:2 [ "nombre" => "Marina" "apellidos" => "Geli Fabrega" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775322004596" "doi" => "10.1016/j.medcli.2022.09.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775322004596?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020623000037?idApp=UINPBA00004N" "url" => "/23870206/0000016000000003/v1_202302051543/S2387020623000037/v1_202302051543/en/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>" "titulo" => "Impact of the COVID 19 pandemic on new diagnoses of HIV infection" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "133" "paginaFinal" => "134" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Pilar Galicia, José Sanz Moreno, José-Manuel Ramos-Rincón" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Pilar" "apellidos" => "Galicia" "email" => array:1 [ 0 => "pilarteresa.galicia@salud.madrid.org" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "José" "apellidos" => "Sanz Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "José-Manuel" "apellidos" => "Ramos-Rincón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Microbiología Clínica, Hospital Universitario Príncipe de Asturias, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Medicina Interna, Hospital Universitario Príncipe de Asturias, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Medicina Clínica, Universidad Miguel Hernández, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Impacto de la pandemia COVID-19 en los nuevos diagnósticos de la infección por VIH" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2521 "Ancho" => 1676 "Tamanyo" => 243511 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a) Survival function: time from diagnosis to negativization of the viral load. (b) Survival function: time from ART treatment to negativization of the viral load.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The SARS-CoV2 pandemic has posed a real challenge to health systems, and has led to significant changes in their capacity to respond to other diseases, including the HIV infection,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> although we don’t know the impact on HIV patients.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Our interest was to assess if the pandemic has altered the response times of the health care system to HIV infection.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> With this objective we analyzed whether the SARS-CoV2 pandemic has led to a delay in the time to reach negative viral load and a change in the clinical characteristics of patients with primary HIV diagnosis in the area of a tertiary hospital in Madrid.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Retrospective longitudinal study of cases diagnosed with primary HIV infection in the health area of the Hospital Universitario Príncipe de Asturias in a period of 18 months before (October 2018–March 2020) and after the pandemic (March 2020–October 2021). We collected variables related to primary endpoint (time from first diagnosis of HIV infection to seronegativity); sociodemographic data; HIV-related and primary care variables. Survival analysis from the diagnosis data to negativization of viral load was performed using the Kaplan–Meier method. Differences between pandemic periods were assessed by the Mantel–Haenszel statistic (log-rank test). <span class="elsevierStyleItalic">p</span> values<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05 were considered statistically significant.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The study was carried out in accordance with the principles of the latest revision of the Declaration of Helsinki and approved by the Hospital Universitario Príncipe de Asturias's Ethics Committee (Protocol number: IE ETS).</p><p id="par0025" class="elsevierStylePara elsevierViewall">The sample was constituted by 31 HIV patients, 15 corresponding to pre-pandemic period and 16 to post-pandemic period. Clinical situation of the post-pandemic patients was worse than those of the pre-pandemic period with longer times to first visit (median: 27 days vs 14), and to ART beginning (25 days vs 13). In addition, they had lower number of CD4 lymphocytes (194 vs 381) and lower viral load at diagnosis (47,871 vs 109,470). The percentage of patients with negative viral load during follow-up, was higher in the pre-pandemic period than in the post-pandemic period (86.7% vs 37.5%; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.009).</p><p id="par0030" class="elsevierStylePara elsevierViewall">The primo diagnosis was mainly performed in hospital setting (70%). The median of CD4 lymphocytes was significantly lower in hospital diagnoses than in primary care (138 vs 381; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.046). The event of HIV primo diagnosis was recorded in PC clinical records in 67.9% of the cases.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Globally, the probability to achieve a viral load negative was of 50% at 9.22 months of follow-up. By pandemic period the median time to achieve negative VL since primo diagnosis was of 5.8 and 12.2 months for prepandemic and postpandemic periods, respectively (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.372 by log-rank tests) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>a). On the other hand, 18 (64.3%) patients achieve the negativization of viral load since the beginning of ART treatment during a follow-up period of 163.83 patient-months with a maximum of 32.66 months. In this period, the median time to achieve VL negativization from the beginning of ART was of 3.80 months for the global sample. By pandemic period the median survival was of 2.18 and 10.90 for pre and postpandemic periods, respectively (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.407 by log rank test) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>b).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Our study analyzes the first diagnosis of HIV infection in the 18 months before and after the start of the SARS-CoV2 pandemic, showing clearly worse clinical results in those patients diagnosed after the pandemic.</p><p id="par0045" class="elsevierStylePara elsevierViewall">It is worth noting that despite the multiple campaigns implemented in PC on HIV screening,<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3,4</span></a> the diagnosis of these patients continues to be eminently hospital-based. In this regard, we also recorded previous consultations in primary care for diseases with a higher risk of prevalence and frequency of HIV, with a strikingly lower number of consultations in the post-pandemic period than in the pre-pandemic (73.3% pre-pandemic vs 35.7% post-pandemic), probably due to the impact of the pandemic on the primary care model in our health care area.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The main strength of our study is that gaps in population-based HIV screening have been detected, especially after the COVID pandemic. It is obvious that early detection of HIV clearly affects the survival of our patients. Therefore, it is very important to carry out campaigns that allow a better screening of the infection and to achieve the WHO objectives of 95% of patients diagnosed.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors’ contributions</span><p id="par0055" class="elsevierStylePara elsevierViewall">PG and ML were the responsible of the design of the study and the analysis of the data. All authors contributed to the draft of the manuscript, critically revised subsequent versions, and agreed upon the final version of this manuscript prior to submission. The authors read and approved the final manuscript.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Ethics approval and consent to participate</span><p id="par0060" class="elsevierStylePara elsevierViewall">The study was carried out in accordance with the principles of the latest revision of the Declaration of Helsinki. International standards for the conduct of epidemiological studies, which are contained in the International Guidelines for the Ethical Review of Epidemiological Studies were likewise followed. The study was approved by the Hospital Universitario Príncipe de Asturias's Ethics Committee (Protocol number: IE ETS).</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Consent for publication</span><p id="par0065" class="elsevierStylePara elsevierViewall">Not applicable.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Availability of data and materials</span><p id="par0070" class="elsevierStylePara elsevierViewall">The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Funding</span><p id="par0075" class="elsevierStylePara elsevierViewall">The Fundación Investigación Hospital Universitario Principe de Asturias partially supported this project.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors declare no potential conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Authors’ contributions" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Ethics approval and consent to participate" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Consent for publication" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Availability of data and materials" ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Funding" ] 5 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflicts of interest" ] 6 => array:2 [ "identificador" => "xack650572" "titulo" => "Acknowledgements" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2521 "Ancho" => 1676 "Tamanyo" => 243511 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(a) Survival function: time from diagnosis to negativization of the viral load. (b) Survival function: time from ART treatment to negativization of the viral load.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "HIV/AIDS. UJUNPo. Prevailing against pandemics by putting people at the centre. World Aids Day Report. 2020." ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HIV testing in Spain: are we doing our job?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Martínez Sanz" 1 => "M.J. Pérez Elías" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Enfermedades Infecciosas y Microbiologia Clinica (Engl Ed)" "fecha" => "2021" "volumen" => "39" "paginaInicial" => "1" "paginaFinal" => "2" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improving the evidence for indicator condition guided HIV testing in Europe: results from the HIDES II Study – 2012–2015" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Raben" 1 => "A.K. Sullivan" 2 => "A. Mocroft" 3 => "G. Kutsyna" 4 => "V. Hadžiosmanović" 5 => "A. Vassilenko" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0220108" "Revista" => array:5 [ "tituloSerie" => "PLOS ONE" "fecha" => "2019" "volumen" => "14" "paginaInicial" => "e0220108" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31408476" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Indicator condition guided human immunodeficiency virus requesting in primary health care: results of a collaboration" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Cayuelas-Redondo" 1 => "I. Menacho-Pascual" 2 => "P. Noguera-Sánchez" 3 => "C. Goicoa-Gago" 4 => "G. Pollio-Peña" 5 => "R. Blanco-Delgado" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eimc.2015.01.020" "Revista" => array:6 [ "tituloSerie" => "Enfermedades Infecciosas y Microbiologia Clinica" "fecha" => "2015" "volumen" => "33" "paginaInicial" => "656" "paginaFinal" => "662" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25769383" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modified scoping review of the enablers and barriers to implementing primary health care in the COVID-19 context" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Edelman" 1 => "R. Marten" 2 => "H. Montenegro" 3 => "K. Sheikh" 4 => "S. Barkley" 5 => "A. Ghaffar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/heapol/czab075" "Revista" => array:6 [ "tituloSerie" => "Health Policy Plan" "fecha" => "2021" "volumen" => "36" "paginaInicial" => "1163" "paginaFinal" => "1186" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34185844" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack650572" "titulo" => "Acknowledgements" "texto" => "<p id="par0085" class="elsevierStylePara elsevierViewall">We would like to thank to Dr. Manuel Linares and Dra. Belén Beteré for her contribution to this study and to all Microbiology Department staff.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000016000000003/v1_202302051543/S2387020623000220/v1_202302051543/en/main.assets" "Apartado" => array:4 [ "identificador" => "43311" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000016000000003/v1_202302051543/S2387020623000220/v1_202302051543/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020623000220?idApp=UINPBA00004N" ]
