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"documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2021;156:361-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Neurotoxicity secondary to valacyclovir" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "361" "paginaFinal" => "362" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Neurotoxicidad por valaciclovir" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Antonio Rosales-Castillo, Juan de Dios López-González Gila, Elena Clavero García" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Antonio" "apellidos" => "Rosales-Castillo" ] 1 => array:2 [ "nombre" => "Juan de Dios" "apellidos" => "López-González Gila" ] 2 => array:2 [ "nombre" => "Elena" "apellidos" => "Clavero García" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775320300853" "doi" => "10.1016/j.medcli.2019.12.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775320300853?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621000917?idApp=UINPBA00004N" "url" => "/23870206/0000015600000007/v1_202104020834/S2387020621000917/v1_202104020834/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2387020621001108" "issn" => "23870206" "doi" => "10.1016/j.medcle.2020.06.035" "estado" => "S300" "fechaPublicacion" => "2021-04-09" "aid" => "5356" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2021;156:360" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Indication of glucocorticoid pulses for patients with SARS-CoV-2 infection" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "360" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Indicación de los pulsos de glucocorticoides en pacientes con infección por SARS-COV-2" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Felipe Blasco Patiño, Ana Elena Guillamón Sánchez" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Felipe" "apellidos" => "Blasco Patiño" ] 1 => array:2 [ "nombre" => "Ana Elena" "apellidos" => "Guillamón Sánchez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775320305236" "doi" => "10.1016/j.medcli.2020.06.041" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775320305236?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621001108?idApp=UINPBA00004N" "url" => "/23870206/0000015600000007/v1_202104020834/S2387020621001108/v1_202104020834/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Reply" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "361" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jose Luis Callejas, Norberto Ortego Centeno" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Jose Luis" "apellidos" => "Callejas" "email" => array:1 [ 0 => "jlcalleja@telefonica.net" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Norberto" "apellidos" => "Ortego Centeno" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Unidad de Enfermedades Sistémicas, Hospital San Cecilio, Granada, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Respuesta" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">First of all, I would like to thank Dr. Blasco and Dr. Guillamón for their comments on our paper and offer some thoughts and considerations. In our opinion, and in that of many other authors, there is no doubt about the existence of a hyperinflammatory response in a subgroup of patients, and that ferritin has been a basic laboratory test for the diagnosis of this complication.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3</span></a> This storm is remarkably similar to that which occurs in hemophagocytic syndrome or in macrophage activation syndrome associated with systemic autoimmune diseases, and in the former case, despite the association in most adult patients with an infectious aetiology, the mainstay of treatment is glucocorticoids.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The results of the RECOVERY<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> study, which we are sure the authors did not have access to at the time of writing their letter when they took a position against the use of glucocorticoids, are absolutely conclusive about their benefit on mortality in these patients.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Callejas JL, Ortego Centeno N. Respuesta. Med Clin (Barc). 2021;156:361–361.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "On the alert for cytokine storm: immunopathology in COVID-19" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.A. Henderson" 1 => "S.W. Canna" 2 => "G.S. Schulert" 3 => "S. Volpi" 4 => "P.Y. Lee" 5 => "K.F. Kernan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.41285" "Revista" => array:7 [ "tituloSerie" => "Arthritis Rheumatol" "fecha" => "2020" "volumen" => "72" "paginaInicial" => "1059" "paginaFinal" => "1063" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32293098" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0022534711032733" "estado" => "S300" "issn" => "00225347" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Soy" 1 => "G. Keser" 2 => "P. Atagündüz" 3 => "F. Tabak" 4 => "I. Atagündüz" 5 => "S. Kayhan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10067-020-05190-5" "Revista" => array:7 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2020" "volumen" => "39" "paginaInicial" => "2085" "paginaFinal" => "2094" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32474885" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0015028200017441" "estado" => "S300" "issn" => "00150282" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COVID-19 gone bad: a new character in the spectrum of the hyperferritinemic syndrome?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Colafrancesco" 1 => "C. Alessandri" 2 => "F. Conti" 3 => "R. Priori" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.autrev.2020.102573" "Revista" => array:5 [ "tituloSerie" => "Autoimmun Rev" "fecha" => "2020" "volumen" => "19" "paginaInicial" => "102573" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32387470" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hemophagocytic lymphohistiocytosis in adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Campo" 1 => "N. Berliner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.hoc.2015.06.009" "Revista" => array:6 [ "tituloSerie" => "Hematol Oncol Clin North Am" "fecha" => "2015" "volumen" => "29" "paginaInicial" => "915" "paginaFinal" => "925" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26461151" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "RECOVERY Collaborative Group. Dexamethasone in hospitalized patients with Covid-19 - preliminary report" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:2 [ 0 => "P. Horby" 1 => "W.S. Lim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa2021436" "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "2020" "numero" => "Jul 17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32222134" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0022534712049609" "estado" => "S300" "issn" => "00225347" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000015600000007/v1_202104020834/S238702062100111X/v1_202104020834/en/main.assets" "Apartado" => array:4 [ "identificador" => "43309" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000015600000007/v1_202104020834/S238702062100111X/v1_202104020834/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S238702062100111X?idApp=UINPBA00004N" ]
