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Letter to the Editor
Dementia solved with surgery: Report of a case
Demencia curada con cirugía: a propósito de un caso
Cristina Tejera Péreza,
Corresponding author
, José Ángel Flores Garcíab
a Servicio de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain
b Servicio de Cirugía Hepatobiliar y Pancreática, Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Insulinoma is the most frequent pancreatic neuroendocrine tumour&#44; characterised by insulin secretion&#44; and its key symptom is hypoglycaemia&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> with an incidence of 1&#8211;4 cases per million inhabitants&#46; The typical presentation of insulinoma is Whipple&#39;s triad&#58; validated plasma blood sugar levels &#60;50<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; symptoms consistent with hypoglycaemia and their resolution after glucose administration&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Upon revision of the medical literature available in PubMed using the key words &#8220;dementia&#8221;&#44; &#8220;insulinoma&#8221; and &#8220;Alzheimer&#39;s disease&#8221;&#44; we present the first case of cognitive impairment secondary to insulinoma in Europe and its resolution after surgical treatment&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The subject is a 61 year-old female brought to the Emergency Department due to hypoglycaemia of 20<span class="elsevierStyleHsp" style=""></span>mg&#47;dl with impairment of the consciousness level and recovery after intravenous infusion of glucose at 50&#37;&#46; Acute disease was ruled out at that moment and after blood sugar levels stabilisation&#46; The Endocrinology department was informed&#46; She had high blood pressure treated with enalapril 5<span class="elsevierStyleHsp" style=""></span>mg&#44; incipient Alzheimer type dementia &#40;GDS 4&#44; CDR 1&#41; treated with galantamine 24<span class="elsevierStyleHsp" style=""></span>mg and hysterectomy for uterine fibroids&#46; During the 2 previous years&#44; she had experienced feeling of objects spinning&#44; general discomfort and pallor after walking 30<span class="elsevierStyleHsp" style=""></span>min&#46; She was assessed by the Cardiology Department&#44; where the presence of a heart condition was ruled out&#46; 15 months before her admission&#44; she was assessed by the Neurology department due to failure to perform instrumental activities&#46; A complete examination was carried out and she was diagnosed with Alzheimer type dementia&#46; Treatment was initiated with 5<span class="elsevierStyleHsp" style=""></span>mg of donepezil&#44; but after 4 months&#44; it was discontinued due to night terrors and episodes of visual hallucinations&#44; and changed to galantamine 24<span class="elsevierStyleHsp" style=""></span>mg&#46; She reported episodes consistent with hypoglycaemia&#44; for which she had never been examined before&#44; predominantly during the morning&#44; which resolved with fruits or sweets&#46; For the last 2 years approximately&#44; the symptoms appeared when the subject was resting or performing activities that required effort&#46; She had gained 12<span class="elsevierStyleHsp" style=""></span>kg of weight in that time&#46; She denied taking unprescribed medication&#44; having insulin or hypoglycaemic drugs available&#44; consuming toxic agents&#44; having dietary transgressions&#44; fasting and doing exhausting exercise&#46; The examination showed only class II obesity&#46; A fasting test was performed&#44; and the results were consistent with endogenous hyperinsulinism&#46; Sulfonylurea detection was negative&#46; Chromogranin A and neuron-specific enolase were normal&#46; The abdominal CT scan and NMRI&#44; the scintigram with somatostatin analogues and the PET&#8211;CT showed no evidence of injuries consistent with insulinoma&#46; The pancreatic protocol CT scan in the ventral area of the body showed a hypervascularised image of 1&#46;5<span class="elsevierStyleHsp" style=""></span>cm diameter and density alteration consistent with neuroendocrine tumour&#46; The patient was assessed by hepato-biliary and pancreatic surgery&#44; selecting elective surgery as the best option&#46; The intraoperative ultrasound scan showed a hypoechoic image of 2<span class="elsevierStyleHsp" style=""></span>cm diameter&#44; separated from the duct of Wirsung&#44; in the pancreatic body&#46; Tumour enucleation was performed&#46; The intraoperative biopsy was consistent with insulinoma-like neuroendocrine tumour&#44; confirmed in the definitive biopsy&#44; with no data of malignancy in the piece&#46; The study was completed to disregard diseases associated with the insulinoma&#44; and it turned out to be negative&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Our patient had a benign insulinoma that appeared initially as cognitive deterioration consistent with Alzheimer type dementia&#46; Weight gain occurs in 18&#37; of the patients&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Diagnosis delay is not unusual as the symptoms are frequently attributed to psychiatric&#44; cardiac or neurological disease&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> The biochemical diagnosis of the insulinoma is carried out with the fasting test&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Once it is done&#44; the location diagnosis must be performed&#44; as it is essential to differentiate between insulinoma and adult nesidioblastosis&#46; It can be performed through non-invasive &#40;ultrasound scan&#44; CT scan&#44; NMRI&#44; PET&#8211;CT and scintigram&#41; or invasive &#40;endoscopic ultrasound scan&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> arteriogram and selective venous catheterization<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a>&#41; tests&#46; Most of them are intrapancreatic&#44; unique and smaller than 2<span class="elsevierStyleHsp" style=""></span>cm&#46; The preferred treatment for this condition is surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> The selection of the procedure depends on the tumour mass&#44; location&#44; relation with neighbouring structures and pancreatic involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> In patients at high surgical risk&#44; other less invasive treatments are preferred&#44; such as drugs &#40;analogues of somatostatin&#44; diazoxide&#41;&#44; ablative treatment of the injury with alcohol&#44; radiofrequency ablation or embolization&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Regular reviews shall be carried out to rule out associated diseases or polyglandular syndrome&#46; The patient was reassessed by the Neurology department 3 months after surgery and no data of cognitive impairment or failure were observed in the ordered tests&#46; Nowadays&#44; she&#39;s subject to regular reviews and she continues asymptomatic&#46;</p></span>"
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