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Letter to the Editor
Pseudotumoral neuro-behçet in a patient treated with anti-tumor necrosis factor alpha
Síndrome neurológico seudotumoral de la enfermedad de Behçet en un paciente tratado con antagonistas del factor de necrosis tumoral
Lina Martínez-Estupiñán
Corresponding author
linamarti@gmail.com

Corresponding author.
, Francisco Javier López-Longo, Indalecio Monteagudo, Luis Carreño Pérez
Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Magnetic resonance axial brain image&#58; there is an area at the supratentorial compartment where signal disturbance pertaining the white substance adjacent to the left-side inferior horn is observed&#46; There is another area in the posterior cavity with signal disturbance showing mass effect affecting right-sided cerebellar hemisphere&#46; These lesions are T2-hyperintense with some internal heterogeneous areas&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">One of the main causes of morbimortality is the central nervous system condition caused by Beh&#231;et&#39;s disease&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> It is classified in 2 main categories&#58; nonparenchymal&#44; causing vascular deterioration&#44; and parenchymal&#44; which develops like an aseptic meningoencephalitis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> In some cases&#44; there might be extensive brain lesions known as pseudotumoral neuro-Beh&#231;et&#39;s disease&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> In 2012&#44; Noel et al&#46; published a compilation of 23 cases reported in medical literature&#44; and they estimated that this presentation had a 1&#46;8&#37; prevalence among neurological manifestations&#46; The most common histopathological finding was inflammatory perivasculitis&#46; The typical image seen on magnetic resonance imaging &#40;MRI&#41; was a space-occupying lesion with mass effect&#44; T1-hypointense enhanced by contrast&#44; and T2-hyperintense&#59; lesions were mostly located at the capsulolenticular&#44; thalamus&#44; brain stem&#44; basal ganglia and cerebral cortex areas&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> We present the case of a patient who developed a severe&#44; treatment-refractory&#44; pseudotumoral syndrome&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Clinical case</span>&#58; 23-year old male diagnosed with Beh&#231;et&#39;s disease in 2008&#44; initially treated with prednisone 20&#8211;30<span class="elsevierStyleHsp" style=""></span>mg&#47;day and colchicine&#44; with partial response&#46; In February 2011&#44; he was given a treatment based on infliximab &#40;IFX&#41;&#59; 4 months later the patient had an adverse reaction&#44; and the drug was changed for adalimumab &#40;ADA&#41;&#46; In October 2011&#44; the patient started experiencing gait alterations&#44; dizziness and vomiting&#44; and had to be admitted&#46; The MRI showed a pseudotumoral lesion at the right hemicerebellum&#44; and less extensive injuries in the white substance at the right-sided inner capsule anterior arm&#44; and in the area near mesial arm temporal structures &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In addition to ADA&#44; the patient was administered oral azathioprine &#40;1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#41; and methylprednisolone &#40;MP&#41; by intravenous pulses &#40;IV&#41; &#40;500<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#47;5 days&#41;&#44; with disease remission&#46; A month later the patient was readmitted with fever&#44; behavioural disturbances&#44; hallucinations and short-term memory loss&#46; The cerebrospinal fluid analysis evidenced aseptic meningitis without monoclonal expansion&#46; The patient received new pulses of MP &#40;500<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#47;5 days&#41;&#44; showing a good response&#59; he was started on a treatment with tocilizumab &#40;TCZ&#41;&#44; and when corticosteroids were orally administered&#44; symptoms reappeared&#46; The brain MRI showed an inflammatory extensive lesion at the limbic system structures&#44; more accentuated on the left side&#46; A new MP cycle &#40;500<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#47;5 day&#41; including IV cyclophosphamide IV &#40;500<span class="elsevierStyleHsp" style=""></span>mg&#47;month&#41; was administered&#46; After a month&#44; the patient developed right-sided hemiparesis and suffered deterioration of his supratentorial and infratentorial lesions&#44; as shown by the MRI&#46; A new MP cycle &#40;1<span class="elsevierStyleHsp" style=""></span>g&#47;day&#47;5 days&#41; including rituximab was administered&#44; and the patient received 5 sessions of plasmapheresis&#46; Due to the negative response to the treatment&#44; a brain biopsy was performed&#44; causing a 5<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>cm intraparenchymal bruise above left-sided basal ganglia&#46; The histological study showed reagent-like changes&#59; there were no signs of encephalitis or atypical lymphoid elements&#46; Two days after completing the brain biopsy&#44; the patient had an epileptic seizure with a prolonged post-critical period&#44; having to be admitted to the intensive care unit&#46; After 5 months of undergoing an immunosuppressant treatment&#44; the patient passed away due to an intraparechymal haemorrhage&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Discussion</span>&#58; no medical strategy to treat neuro-Beh&#231;et&#39;s disease has been ratified in controlled clinic trials<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> to date&#46; Most patients with pseudotumoral lesions received a treatment with high doses of steroids along with immunosuppressants&#44; and in 2011&#44; the case of a patient who obtained clinical remission<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">3&#8211;5</span></a> after being treated with biological therapies &#40;daclizumab&#44; IFX and TCZ&#41; was reported&#46; The neurological symptoms experienced by our patient had first appeared during the treatment with <span class="elsevierStyleItalic">tumour necrosis factor</span> &#40;TNF&#41; blockers&#44; a drug that has been associated with the development of demyelinating lesions that&#44; typically&#44; improve when the treatment is suspended&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> The brain lesions sustained by our patient were extensive and persisted after suspending the anti-TNF treatment&#59; the corticosteroids and immunosuppressants administered proved to be inefficient&#46; In the series compiling 23 cases&#44; 2 patients passed away &#40;8&#46;7&#37;&#41; and 7 &#40;30&#46;5&#37;&#41; had some sort of sequelae&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> confirming that pseudotumoral neuro-Beh&#231;et is one of the presentations of the Beh&#231;et&#39;s disease&#44; increasing the risk of suffering severe sequelae and threatening life&#46;</p></span>"
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ISSN: 23870206
Original language: English
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