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Letter to the Editor
Secondary hypertransaminasemia to macro-aspartate aminotransferase
Hipertransaminasemia secundaria a macroaspartato aminotransferasa
Vanesa Crujeiras Martínez
Corresponding author
, Rebeca Saborido Fiaño, Nazareth Martinón Torres, Rosaura Leis Trabazo
Unidad de Gastroenterología, Hepatología y Nutrición Pediátrica, Complexo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Hypertransaminasemia or isolated elevated aminotransferases&#44; is a relatively common finding in asymptomatic patients&#44; being a sensitive indicator&#44; but nonspecific&#44; of hepatocellular damage&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a girl aged 5 years and 5 months with casual analytical finding of increased GOT &#40;562<span class="elsevierStyleHsp" style=""></span>UI&#47;l&#41;&#44; which persisted in subsequent tests&#46; The patient was referred to Gastroenterology and Pediatric Hepatology for hypertransaminasemia study completion&#46; The girl was asymptomatic&#44; did not report abdominal pain&#44; asthenia or muscle weakness&#46; She had normal bowel habits and from an anthropometric point of view she had a height to weight ratio within &#8722;0&#46;5<span class="elsevierStyleHsp" style=""></span>DE for her age&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination showed good general condition&#44; she was well hydrated&#44; with adequate skin and mucous membrane color&#46; Cardiac auscultation showed rhythmic heartbeats&#44; with no relevant murmurs&#46; Pulmonary auscultation was normal&#46; The abdomen was soft&#44; depressible&#44; painless&#59; there were no palpable masses&#44; hepatomegaly or splenomegaly&#46; From a neurological point of view there were no focal neurological signs&#44; with preserved and symmetrical sensitivity and strength&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The CBC showed figures within the limits of normal hemoglobin&#44; platelet and leukocyte levels&#46; Serum biochemistry showed persistent increased GOT &#40;447 and 510<span class="elsevierStyleHsp" style=""></span>UI&#47;l&#41; in the various analytical controls carried out for 14 months&#44; with normal levels of GPT&#44; GGT&#44; bilirubin&#44; albumin&#44; amylase&#44; lipase and alkaline phosphatase&#46; Renal function and coagulation showed no abnormalities&#46; The determination of immunoglobulins&#44; plasma copper&#44; ceruloplasmin&#44; iron metabolism and alpha-1-antitrypsin was within normal levels&#46; Celiac disease antibodies and determination of ANA&#44; AML&#44; anti-LKM and anti-SLA autoantibodies&#44; as well as the hepatotropic virus serology&#44; were negative&#46; She underwent an abdominal ultrasound&#44; which showed a normal liver structure and echogenicity&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Other extrahepatic causes of high aspartate aminotransferase &#40;AST&#41; were excluded&#44; including hemolysis&#44; myopalthy&#44; thyroid disease and extreme exercise as she had normal levels of CK&#44; LDH and aldolase B at rest as well as normal levels of thyroid hormones&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">To study the presence of macro-AST macroenzyme&#44; AST activity was assessed in the supernatant after precipitation with polyethylene glycol&#46; AST activity decreased to 8&#37;&#44; confirming the suspected diagnosis&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Macroenzymes are complexes formed by binding of enzymes such as amylase&#44; creatine kinase&#44; alkaline phosphatase and AST to plasma proteins such as immunoglobulins G&#44; A or beta-lipoproteins&#44; forming soluble macromolecular complexes&#44; with a high molecular weight and a longer half-life compared to the unbound enzymes&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3&#44;4</span></a> The formation of these immune-enzyme complexes is not associated with any specific disease&#46; However&#44; their presence may lead to increased serum levels of the enzyme isolated and persistent&#44; leading to misdiagnosis and unnecessary tests&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Macro-AST should be suspected in case of hypertransaminasemia with persistent increased AST in a patient with no further abnormalities in liver function&#44; with normal serum levels of ALP&#44; GGT&#44; alkaline phosphatase and muscle enzymes&#46; Diagnosis requires demonstration of complex macro-AST in serum by direct methods for separating serum proteins depending on their molecular weight&#46; It has been determined in the laboratory by polyethylene glycol precipitation methods&#44; thermal stability of IgG-AST&#44; immunoelectrophoresis or gel filtration chromatography&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> Macrocomplex precipitation with polyethylene glycol and the subsequent AST activity determination in the supernatant is a simple method&#44; often used in diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Macro-AST detection is not a transitory phenomenon&#44; existing references in the medical literature that reflect the persistence of this finding in patients over 10 years&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> The absence of disease over a long monitoring period in these patients calls for the benign nature of this phenomenon&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Therefore&#44; since the macro-AST is a rare biochemical abnormality and is a benign process not requiring treatment&#44; diagnosis interest lies in distinguishing it from other causes of hypertransaminasemia&#44; in order to avoid unnecessary additional diagnostic tests&#46;</p></span>"
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                          "autores" => array:2 [
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                          "autores" => array:2 [
                            0 => "G&#46; Aragon"
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                        "fecha" => "2010"
                        "volumen" => "77"
                        "paginaInicial" => "195"
                        "paginaFinal" => "204"
                        "link" => array:1 [
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                          "autores" => array:6 [
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                    0 => array:1 [
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                        "tituloSerie" => "J Pediatr"
                        "fecha" => "1998"
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                        "paginaInicial" => "286"
                        "paginaFinal" => "289"
                        "link" => array:1 [
                          0 => array:2 [
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Onuigbo"
                            1 => "R&#46; Yin"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.4065/75.11.1223-b"
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                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "2000"
                        "volumen" => "75"
                        "paginaInicial" => "1223"
                        "paginaFinal" => "1224"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11075758"
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                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Macroenzyme detection by polyethylene glycol precipitation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;F&#46; Davidson"
                            1 => "D&#46;J&#46; Watson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1258/000456303322326425"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Clin Biochem"
                        "fecha" => "2003"
                        "volumen" => "40"
                        "paginaInicial" => "514"
                        "paginaFinal" => "520"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14503988"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Prevalence and long-term course of macro-aspartate aminotransferase in children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Caropreso"
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                            2 => "S&#46; Lenta"
                            3 => "D&#46; Palmieri"
                            4 => "M&#46; Esposito"
                            5 => "D&#46;F&#46; Vitale"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.jpeds.2008.11.010"
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                        "tituloSerie" => "J Pediatr"
                        "fecha" => "2009"
                        "volumen" => "154"
                        "paginaInicial" => "744"
                        "paginaFinal" => "748"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19111320"
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                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
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              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Macro-aspartate aminotransferase &#40;macro-AST&#41;&#46; A 12-year follow-up study in a young female"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Orlando"
                            1 => "A&#46; Carbone"
                            2 => "F&#46; Lirussi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.meg.0000085482.12407.4c"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Gastroenterol Hepatol"
                        "fecha" => "2003"
                        "volumen" => "15"
                        "paginaInicial" => "1371"
                        "paginaFinal" => "1373"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14624163"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
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Original language: English
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