metricas
covid
Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Concurrent lymphoid and Philadelphia chromosome-negative myeloproliferative neop...
Journal Information

Statistics

Follow this link to access the full text of the article

Scientific letter
Concurrent lymphoid and Philadelphia chromosome-negative myeloproliferative neoplasms
Neoplasias mieloproliferativas crónicas con cromosoma Filadelfia negativo y neoplasias linfoides concurrentes
Jose Miguel Torregrosa, Gloria Soler, Shirley Cancio, Francisca Ferrer-Marin
Corresponding author
fferrermarin@gmail.com

Corresponding author.
Unidad de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Instituto Murciano de Investigación Biosanitaria, Murcia, Spain
Read
3
Times
was read the article
0
Total PDF
3
Total HTML
Share statistics
 array:24 [
  "pii" => "S2387020616000954"
  "issn" => "23870206"
  "doi" => "10.1016/j.medcle.2016.02.030"
  "estado" => "S300"
  "fechaPublicacion" => "2015-10-05"
  "aid" => "3177"
  "copyright" => "Elsevier España, S.L.U.. All rights reserved"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Med Clin. 2015;145:318-9"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 3
    "HTML" => 3
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0025775314008288"
      "issn" => "00257753"
      "doi" => "10.1016/j.medcli.2014.11.012"
      "estado" => "S300"
      "fechaPublicacion" => "2015-10-05"
      "aid" => "3177"
      "copyright" => "Elsevier España, S.L.U."
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Med Clin. 2015;145:318-9"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 26
        "formatos" => array:2 [
          "HTML" => 20
          "PDF" => 6
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fica</span>"
        "titulo" => "Neoplasias mieloproliferativas cr&#243;nicas con cromosoma Filadelfia negativo y neoplasias linfoides concurrentes"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "318"
            "paginaFinal" => "319"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Concurrent lymphoid and Philadelphia chromosome-negative myeloproliferative neoplasms"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jose Miguel Torregrosa, Gloria Soler, Shirley Cancio, Francisca Ferrer-Marin"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Jose Miguel"
                "apellidos" => "Torregrosa"
              ]
              1 => array:2 [
                "nombre" => "Gloria"
                "apellidos" => "Soler"
              ]
              2 => array:2 [
                "nombre" => "Shirley"
                "apellidos" => "Cancio"
              ]
              3 => array:2 [
                "nombre" => "Francisca"
                "apellidos" => "Ferrer-Marin"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2387020616000954"
          "doi" => "10.1016/j.medcle.2016.02.030"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616000954?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775314008288?idApp=UINPBA00004N"
      "url" => "/00257753/0000014500000007/v1_201509120059/S0025775314008288/v1_201509120059/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2387020616001054"
    "issn" => "23870206"
    "doi" => "10.1016/j.medcle.2016.02.040"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-05"
    "aid" => "3281"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46;"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Med Clin. 2015;145:319-20"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 5
      "HTML" => 5
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
      "titulo" => "Serum tumour markers in asymptomatic patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "319"
          "paginaFinal" => "320"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Marcadores tumorales s&#233;ricos en pacientes asintom&#225;ticos"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Joaquim Torn&#233; Cachot, Jos&#233; Manuel Baucells Azcona, Jes&#250;s Blanch Falp, David Blancas Altabella"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Joaquim"
              "apellidos" => "Torn&#233; Cachot"
            ]
            1 => array:2 [
              "nombre" => "Jos&#233; Manuel"
              "apellidos" => "Baucells Azcona"
            ]
            2 => array:2 [
              "nombre" => "Jes&#250;s"
              "apellidos" => "Blanch Falp"
            ]
            3 => array:2 [
              "nombre" => "David"
              "apellidos" => "Blancas Altabella"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0025775315001876"
        "doi" => "10.1016/j.medcli.2015.03.008"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775315001876?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616001054?idApp=UINPBA00004N"
    "url" => "/23870206/0000014500000007/v2_201604010141/S2387020616001054/v2_201604010141/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2387020616000917"
    "issn" => "23870206"
    "doi" => "10.1016/j.medcle.2016.02.026"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-05"
    "aid" => "3261"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46;"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Med Clin. 2015;145:317-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 5
      "HTML" => 5
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
      "titulo" => "Ocular thelaziosis&#44; an emergent zoonosis in Spain"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "317"
          "paginaFinal" => "318"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Thelaziosis ocular&#44; una zoonosis emergente en Espa&#241;a"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1735
              "Ancho" => 1625
              "Tamanyo" => 247003
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Specimen of <span class="elsevierStyleItalic">Thelazia callipaeda</span> collected from the conjunctival sac of the patient&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ramiro L&#243;pez Medrano, Gloria Guerra Calleja, Carolina D&#237;ez Morrondo, Rosario Panadero Font&#225;n"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Ramiro"
              "apellidos" => "L&#243;pez Medrano"
            ]
            1 => array:2 [
              "nombre" => "Gloria"
              "apellidos" => "Guerra Calleja"
            ]
            2 => array:2 [
              "nombre" => "Carolina"
              "apellidos" => "D&#237;ez Morrondo"
            ]
            3 => array:2 [
              "nombre" => "Rosario"
              "apellidos" => "Panadero Font&#225;n"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0025775315001323"
        "doi" => "10.1016/j.medcli.2015.02.014"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775315001323?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616000917?idApp=UINPBA00004N"
    "url" => "/23870206/0000014500000007/v2_201604010141/S2387020616000917/v2_201604010141/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
    "titulo" => "Concurrent lymphoid and Philadelphia chromosome-negative myeloproliferative neoplasms"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">Dear Editor</span>&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "318"
        "paginaFinal" => "319"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Jose Miguel Torregrosa, Gloria Soler, Shirley Cancio, Francisca Ferrer-Marin"
        "autores" => array:4 [
          0 => array:2 [
            "nombre" => "Jose Miguel"
            "apellidos" => "Torregrosa"
          ]
          1 => array:2 [
            "nombre" => "Gloria"
            "apellidos" => "Soler"
          ]
          2 => array:2 [
            "nombre" => "Shirley"
            "apellidos" => "Cancio"
          ]
          3 => array:4 [
            "nombre" => "Francisca"
            "apellidos" => "Ferrer-Marin"
            "email" => array:1 [
              0 => "fferrermarin&#64;gmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Unidad de Hematolog&#237;a y Oncolog&#237;a M&#233;dica&#44; Hospital Universitario Morales Meseguer&#44; Centro Regional de Hemodonaci&#243;n&#44; Instituto Murciano de Investigaci&#243;n Biosanitaria&#44; Murcia&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Neoplasias mieloproliferativas cr&#243;nicas con cromosoma Filadelfia negativo y neoplasias linfoides concurrentes"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Three studies have shown that patients with chronic myeloproliferative neoplasms &#40;cMPN&#41; have 2&#46;8&#8211;3&#46;4 times higher risk of developing a lymphoproliferative neoplasim &#40;LPN&#41; compared to general population&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;3</span></a> In most cases&#44; the diagnosis of LPN is subsequent to cMPN&#44; and in less than 10&#37; cases it is synchronous or prior to the development of myeloid disease&#44; possibly by the increased aggressiveness of lymphoid neoplasms&#46; Therefore&#44; these patients would die before developing a cMPN&#46; The molecular basis underlying this association is not well understood&#46; In recent years&#44; in addition to <span class="elsevierStyleItalic">JAK2</span><span class="elsevierStyleSup">V617F</span>&#44; in cMPN patients&#44; an increasing number of mutations have been identified in other genes&#44; such as&#58; <span class="elsevierStyleItalic">DNMT3A</span>&#44; <span class="elsevierStyleItalic">TET2</span>&#44; <span class="elsevierStyleItalic">ASXL1</span>&#44; <span class="elsevierStyleItalic">NRAS&#47;KRAS</span>&#44; <span class="elsevierStyleItalic">TP53</span>&#44; <span class="elsevierStyleItalic">AML1&#47;RUNX1</span>&#44; <span class="elsevierStyleItalic">CBL</span>&#44; <span class="elsevierStyleItalic">CALR</span>&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;5</span></a> Defects in some of these genes have also been identified in patients with lymphoid neoplasms&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;6&#44;7</span></a> In fact&#44; recent studies have shown that epigenetic changes might have a role in lymphogenesis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In this study&#44; the prevalence and timing of LPN was assessed in patients diagnosed with cMPN &#40;according to the World Health Organization criteria at the time of reporting data<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a>&#41; recorded in our database from 2000 to 2013&#46; In patients with both diseases it was studied whether mutations in genes related to myeloid condition lead to this association&#46; In genomic DNA obtained from whole blood after venipuncture at diagnosis&#44; the presence of the JAK2<span class="elsevierStyleSup">V617F</span> mutation was analyzed in all patients&#59; c-KIT<span class="elsevierStyleSup">D816V</span> in patients with suspected systemic mastocytosis &#40;SM&#41; &#40;both by polymerase chain reaction &#91;PCR&#93;&#44; quantitative in real-time&#41;&#59; CALR in JAK2<span class="elsevierStyleSup">V617F</span>-negative patients &#40;by analysis of PCR fragments&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> and in patients with both neoplasms &#40;cMPN and LPN&#41;&#44; a selected panel of genes &#40;CBL &#91;exons 8 and 9&#93;&#44; ASXL1 &#91;exon 12&#93;&#44; NRAS&#47;KRAS &#91;exons 1 and 2&#93;&#44; IDH1&#47;2 &#91;exon 4&#93; and the complete coding region of TET2 and RUNX1&#41; by Sanger-type sequencing&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The overall study included 216 patients &#40;122 cases of essential thrombocythemia &#91;ET&#93;&#44; 50 of polycythemia vera &#91;PV&#93;&#44; 38 of myelofibrosis and 6 SM&#41;&#44; with a median age at diagnosis of 49 years &#40;IQR 22&#8211;92&#41; and a median follow-up of 82 months &#40;IQR 42&#8211;132&#41;&#46; Of the 216 cMPN patients included&#44; 4 &#40;1&#46;85&#37;&#41; had a concurrent LPN&#46; Clinical and biological characteristics of these 4 patients are reported in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; The lymphoid neoplasms identified were two chronic lymphatic leukemia &#40;CLL&#44; cases 1 and 2&#41;&#44; 1 Primary cutaneous centrofollicular non-Hodgkin lymphoma &#40;case 3&#41; and a T-cell large granular lymphocyte leukemia&#40;T-LGL&#41; &#40;case 4&#41;&#46; Unlike other studies&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a> in ours&#44; LPN diagnosis was prior to &#40;case 3&#41;&#44; or synchronous to the cMPN &#40;remaining cases&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; One patient &#40;case 3&#41; required specific treatment for lymphoid neoplasm &#40;R-CHOP chemotherapy plus local radiation therapy&#41;&#44; while the rest remain in therapeutic abstention regarding this disease&#46; Regarding the mutational status of the 3 cMPN patients with negative Philadelphia chromosome &#40;1 PV and 2 ET&#41; JAK2 was mutated in 2 of them&#46; In the third patient&#44; negative for JAK2<span class="elsevierStyleSup">V617F</span>&#44; mutations in CALR &#40;case 1&#41; were not found either&#46; The SM patient presented mutation in c-KIT<span class="elsevierStyleSup">D816V</span>&#46; However&#44; none of the 4 patients with concurrent cMPN and LPN showed mutations in the panel of selected genes &#40;KRAS&#44; NRAS&#44; CBL&#44; ASXL1&#44; IDH1&#47;2&#44; TP53&#44; RUNX1 and TET2&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Association between cMPN and LPN is a rare event&#58; &#8764;1&#8211;1&#46;34&#37; incidence&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;3</span></a> According to the medical literature&#44;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a> in our study&#44; the incidence of this association is higher in men&#44; and CLL is the LPN most frequently associated&#46; We describe the second case ever reported on the association between a cMPN and T-LGL<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> and the first in which the association is with a primary cutaneous lymphoma&#46; The latter patient also developed&#44; while under cytoreductive therapy with hydroxyurea&#44; a prostate neoplasm and a colon neoplasm&#46; Although it has been suggested that hydroxyurea can induce mutations in TP53&#44;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> one of the genes most frequently mutated in human cancers&#44; no mutations were reported in this gene&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Also it is interesting in our study the association between SM with a B-CLL&#46; The SM associated to clonal hematological disease of line other than mast cell&#44; account for 30&#37; of SM&#44; but are frequently associated with myeloid neoplasms&#44; mainly chronic myelomonocytic leukemia&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> The association with lymphoid neoplasm&#44; as in our case&#44; is unusual&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In summary&#44; previous studies have attempted to address the question of whether there is a genetic predisposition to both hematological diseases &#40;cMPN-LPN&#41;&#44; with poor results&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a> In our study&#44; we have not detected additional mutations other than c-KIT<span class="elsevierStyleSup">D816V</span> and JAK2<span class="elsevierStyleSup">V617F</span>&#44; previously known&#46; The small size of our sample&#44; along with the low frequency of these mutations in cMPN&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> is the main limitation of this study&#46; Despite these results&#44; we cannot rule out that genes other than the selected genes &#40;such as DNMT3A&#44; SF3B1&#44; NOTCH&#41;&#44; or even not discovered yet&#44; might promote genetic predisposition to both hematological neoplasms&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Torregrosa JM&#44; Soler G&#44; Cancio S&#44; Ferrer-Marin F&#46; Neoplasias mieloproliferativas cr&#243;nicas con cromosoma Filadelfia negativo y neoplasias linfoides concurrentes&#46; Med Clin &#40;Barc&#41;&#46; 2015&#59;145&#58;318&#8211;319&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">CLL&#44; chronic lymphocytic leukemia&#59; NHL&#44; non-Hodgkin lymphoma&#59; SM&#44; systemic mastocytosis&#59; LPN&#44; lymphoproliferative neoplasm&#59; CMPN&#44; chronic myeloproliferative neoplasia&#59; PV&#44; polycythemia vera&#59; RT&#44; radiotherapy&#59; M&#44; male&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">cMPN&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Age at diagnosis</th><th class="td" title="table-head  " align="left" valign="top" scope="col">LPN&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Mutation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Cytogenetics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Accompanying solid tumors &#40;stage&#44; treatment&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">cMPN&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">LPN&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B-CLL &#40;Rai-Binet 0-A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">JAK2</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">V617F</span></span> non mutated&#46; <span class="elsevierStyleItalic">CALR</span> non mutated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">SM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B-CLL &#40;Rai-Binet 0-A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">c-<span class="elsevierStyleItalic">KIT</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">D816V</span></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Trisomy 12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Primary cutaneous follicular NHL &#40;stage 3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">JAK2</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">V617F</span></span> mutated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Prostate neoplasm &#40;in situ&#44; local RT&#41; Rectal adenocarcinoma &#40;B Coller&#44; surgery&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T-cell large granular lymphocyte leukemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">JAK2</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">V617F</span></span> mutated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Not available&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1024707.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Characteristics of patients diagnosed with chronic myeloproliferative neoplasm and lymphoproliferative neoplasm&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased risk of lymphoid neoplasms in patients with Philadelphia chromosome-negative myeloproliferative neoplasms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Vannucchi"
                            1 => "G&#46; Masala"
                            2 => "E&#46; Antonioli"
                            3 => "M&#46; Chiara Susini"
                            4 => "P&#46; Guglielmelli"
                            5 => "L&#46; Pieri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1055-9965.EPI-09-0353"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Epidemiol&#46; Biomarkers Prev"
                        "fecha" => "2009"
                        "volumen" => "18"
                        "paginaInicial" => "2068"
                        "paginaFinal" => "2073"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19531676"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased risk of lymphoid neoplasm in patients with myeloproliferative neoplasm&#58; a study of 1&#44;915 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Rumi"
                            1 => "F&#46; Passamonti"
                            2 => "C&#46; Elena"
                            3 => "D&#46; Pietra"
                            4 => "L&#46; Arcaini"
                            5 => "C&#46; Astori"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3324/haematol.2010.033779"
                      "Revista" => array:6 [
                        "tituloSerie" => "Haematologica"
                        "fecha" => "2011"
                        "volumen" => "96"
                        "paginaInicial" => "454"
                        "paginaFinal" => "458"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21109692"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Simultaneous and sequential concurrent myeloproliferative and lymphoproliferative neoplasms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Hauck"
                            1 => "D&#46; Jonigk"
                            2 => "H&#46; Kreipe"
                            3 => "K&#46; Hussein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000342484"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Haematol"
                        "fecha" => "2013"
                        "volumen" => "129"
                        "paginaInicial" => "187"
                        "paginaFinal" => "196"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23257916"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New mutations and pathogenesis of myeloproliferative neoplasms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46; Vainchenker"
                            1 => "F&#46; Delhommeau"
                            2 => "S&#46;N&#46; Constantinescu"
                            3 => "O&#46;A&#46; Bernard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2011-02-292102"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2011"
                        "volumen" => "118"
                        "paginaInicial" => "1723"
                        "paginaFinal" => "1735"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21653328"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Somatic mutations of calreticulin in myeloproliferative neoplasms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Klampfl"
                            1 => "H&#46; Gisslinger"
                            2 => "A&#46;S&#46; Harutyunyan"
                            3 => "H&#46; Nivarthi"
                            4 => "E&#46; Rumi"
                            5 => "J&#46;D&#46; Milosevic"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa1311347"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2013"
                        "volumen" => "369"
                        "paginaInicial" => "2379"
                        "paginaFinal" => "2390"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24325356"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TET2 and DNMT3A mutations in human T-cell lymphoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Couronn&#233;"
                            1 => "C&#46; Bastard"
                            2 => "O&#46;A&#46; Bernard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMc1111708"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2012"
                        "volumen" => "366"
                        "paginaInicial" => "95"
                        "paginaFinal" => "96"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22216861"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Z&#46;Y&#46; Xu-Monette"
                            1 => "L&#46;J&#46; Medeiros"
                            2 => "Y&#46; Li"
                            3 => "R&#46;Z&#46; Orlowski"
                            4 => "M&#46; Andreeff"
                            5 => "C&#46;E&#46; Bueso-Ramos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1182/blood-2011-11-366062"
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "2012"
                        "volumen" => "119"
                        "paginaInicial" => "3668"
                        "paginaFinal" => "3683"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22275381"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "WHO classification of tumours of haematopoietic and lymphoid tissues"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;H&#46; Swerdlow"
                            1 => "E&#46; Campo"
                            2 => "N&#46;L&#46; Harris"
                            3 => "E&#46;S&#46; Jaffe"
                            4 => "S&#46;A&#46; Pileri"
                            5 => "H&#46; Stein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2008"
                        "editorial" => "International Agency for Research on Cancer &#40;IARC&#41;"
                        "editorialLocalizacion" => "Lyon&#44; France"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bone marrow failure due to T-cell large granular lymphocytic leukemia in a patient with essential thrombocythemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;R&#46; Selvan"
                            1 => "P&#46;F&#46; Sheehy"
                            2 => "F&#46;S&#46; Heinemann"
                            3 => "S&#46; Anbuganapathi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.leukres.2010.09.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Leuk Res"
                        "fecha" => "2011"
                        "volumen" => "35"
                        "paginaInicial" => "278"
                        "paginaFinal" => "282"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20934219"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute myeloid leukemia and myelodysplastic syndromes following essential thrombocythemia treated with hydroxyurea&#58; high proportion of cases with 17p deletion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Sterkers"
                            1 => "C&#46; Preudhomme"
                            2 => "J&#46;L&#46; Lai"
                            3 => "J&#46;L&#46; Demory"
                            4 => "M&#46;T&#46; Caulier"
                            5 => "E&#46; Wattel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Blood"
                        "fecha" => "1998"
                        "volumen" => "91"
                        "paginaInicial" => "616"
                        "paginaFinal" => "622"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9427717"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/23870206/0000014500000007/v2_201604010141/S2387020616000954/v2_201604010141/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "43311"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Scientific letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/23870206/0000014500000007/v2_201604010141/S2387020616000954/v2_201604010141/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616000954?idApp=UINPBA00004N"
]
Article information
ISSN: 23870206
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2017 October 2 0 2
2017 September 1 0 1

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos