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Nicolau syndrome after glatiramer acetate injection
Síndrome de Nicolau tras inyección de acetato de glatirámero
Alejandro Lobato-Berezo
, Marcela Martínez-Pérez, Adrián Imbernón-Moya, Miguel Ángel Gallego-Valdés
Corresponding author
Departamento de Dermatología, Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain
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We report the case of a 32 year old woman with relapsing-remitting multiple sclerosis treated with intramuscular injections of glatiramer acetate who, after the last injection in abdomen, showed an ill-defined large plate in right hypochondriac region and flank of the mesogastrio, purplish color and infiltrated when touching (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Skin biopsy revealed epidermal changes and leukocytoclastic vasculitis with eosinophil isolated, indicative of toxicoderma plus lobular panniculitis with fat necrosis.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Lobato-Berezo A, Martínez-Pérez M, Imbernón-Moya A, Gallego-Valdés MÁ. Síndrome de Nicolau tras inyección de acetato de glatirámero. 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