metricas
covid
Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Vogt-Koyanagi-Harada disease
Journal Information

Statistics

Follow this link to access the full text of the article

Letter to the Editor
Vogt-Koyanagi-Harada disease
Enfermedad de Vogt-Koyanagi-Harada
Jorge Ortiz Balbuenaa,
Corresponding author
jmob1982@gmail.com

Corresponding author.
, Pablo Tutor de Uretaa, Esther Rivera Ruizb, Susana Mellor Pitaa
a Servicio de Medicina Interna, Hospital Universitario Puerta de Hierro, Majadahonda , Madrid, Spain
b Servicio de Oftalmología, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain
Read
4
Times
was read the article
2
Total PDF
2
Total HTML
Share statistics
 array:24 [
  "pii" => "S2387020616301322"
  "issn" => "23870206"
  "doi" => "10.1016/j.medcle.2015.04.006"
  "estado" => "S300"
  "fechaPublicacion" => "2016-01-15"
  "aid" => "3290"
  "copyright" => "Elsevier España, S.L.U.. All rights reserved"
  "copyrightAnyo" => "2015"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Med Clin. 2016;146:93-4"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S002577531500216X"
      "issn" => "00257753"
      "doi" => "10.1016/j.medcli.2015.04.005"
      "estado" => "S300"
      "fechaPublicacion" => "2016-01-15"
      "aid" => "3290"
      "copyright" => "Elsevier España, S.L.U."
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Med Clin. 2016;146:93-4"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 30
        "formatos" => array:2 [
          "HTML" => 19
          "PDF" => 11
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Enfermedad de Vogt-Koyanagi-Harada"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "93"
            "paginaFinal" => "94"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Vogt-Koyanagi-Harada disease"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Jorge Ortiz Balbuena, Pablo Tutor de Ureta, Esther Rivera Ruiz, Susana Mellor Pita"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Jorge"
                "apellidos" => "Ortiz Balbuena"
              ]
              1 => array:2 [
                "nombre" => "Pablo"
                "apellidos" => "Tutor de Ureta"
              ]
              2 => array:2 [
                "nombre" => "Esther"
                "apellidos" => "Rivera Ruiz"
              ]
              3 => array:2 [
                "nombre" => "Susana"
                "apellidos" => "Mellor Pita"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2387020616301322"
          "doi" => "10.1016/j.medcle.2015.04.006"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616301322?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S002577531500216X?idApp=UINPBA00004N"
      "url" => "/00257753/0000014600000002/v1_201601130113/S002577531500216X/v1_201601130113/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2387020616301334"
    "issn" => "23870206"
    "doi" => "10.1016/j.medcle.2015.04.007"
    "estado" => "S300"
    "fechaPublicacion" => "2016-01-15"
    "aid" => "3308"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46;"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Med Clin. 2016;146:94-5"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to Editor</span>"
      "titulo" => "Clinical significance and prognosis of isolation of <span class="elsevierStyleItalic">Candida</span> spp&#46; in venous catheters"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "94"
          "paginaFinal" => "95"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Significado cl&#237;nico y pron&#243;stico del aislamiento de <span class="elsevierStyleItalic">Candida</span> spp&#46; en cat&#233;teres venosos"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ana Mart&#237;nez-Vidal, M&#46; Teresa P&#233;rez-Rodr&#237;guez, Luc&#237;a Mart&#237;nez-Lamas, Alberto Rivera"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "Mart&#237;nez-Vidal"
            ]
            1 => array:2 [
              "nombre" => "M&#46; Teresa"
              "apellidos" => "P&#233;rez-Rodr&#237;guez"
            ]
            2 => array:2 [
              "nombre" => "Luc&#237;a"
              "apellidos" => "Mart&#237;nez-Lamas"
            ]
            3 => array:2 [
              "nombre" => "Alberto"
              "apellidos" => "Rivera"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0025775315002584"
        "doi" => "10.1016/j.medcli.2015.04.015"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775315002584?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616301334?idApp=UINPBA00004N"
    "url" => "/23870206/0000014600000002/v1_201605240650/S2387020616301334/v1_201605240650/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2387020616301310"
    "issn" => "23870206"
    "doi" => "10.1016/j.medcle.2015.04.005"
    "estado" => "S300"
    "fechaPublicacion" => "2016-01-15"
    "aid" => "3289"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46;"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Med Clin. 2016;146:92-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1
      "PDF" => 1
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Partial 3<span class="elsevierStyleBold">&#946;</span>-hydroxysteroid dehydrogenase type 2 deficiency&#58; Diagnosis of a novel mutation after positive newborn screening for 21-hydroxylase deficiency"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "92"
          "paginaFinal" => "93"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Deficiencia parcial de 3<span class="elsevierStyleBold">&#946;</span>-hidroxiesteroide deshidrogenasa tipo 2&#58; diagn&#243;stico de una nueva mutaci&#243;n tras cribado neonatal positivo de deficiencia de 21-hidroxilasa"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Pilar Bah&#237;llo-Curieses, Lourdes Loidi Fern&#225;ndez de Troc&#243;niz, Agust&#237;n del Ca&#241;izo L&#243;pez, Mar&#237;a Jos&#233; Mart&#237;nez-Sopena"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46; Pilar"
              "apellidos" => "Bah&#237;llo-Curieses"
            ]
            1 => array:2 [
              "nombre" => "Lourdes"
              "apellidos" => "Loidi Fern&#225;ndez de Troc&#243;niz"
            ]
            2 => array:2 [
              "nombre" => "Agust&#237;n"
              "apellidos" => "del Ca&#241;izo L&#243;pez"
            ]
            3 => array:2 [
              "nombre" => "Mar&#237;a Jos&#233;"
              "apellidos" => "Mart&#237;nez-Sopena"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0025775315002158"
        "doi" => "10.1016/j.medcli.2015.04.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775315002158?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616301310?idApp=UINPBA00004N"
    "url" => "/23870206/0000014600000002/v1_201605240650/S2387020616301310/v1_201605240650/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Vogt-Koyanagi-Harada disease"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">Dear Editor</span>&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "93"
        "paginaFinal" => "94"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Jorge Ortiz Balbuena, Pablo Tutor de Ureta, Esther Rivera Ruiz, Susana Mellor Pita"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Jorge"
            "apellidos" => "Ortiz Balbuena"
            "email" => array:1 [
              0 => "jmob1982&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Pablo"
            "apellidos" => "Tutor de Ureta"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Esther"
            "apellidos" => "Rivera Ruiz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Susana"
            "apellidos" => "Mellor Pita"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital Universitario Puerta de Hierro&#44; Majadahonda &#44; Madrid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Oftalmolog&#237;a&#44; Hospital Universitario Puerta de Hierro&#44; Majadahonda&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Enfermedad de Vogt-Koyanagi-Harada"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Vogt-Koyanagi-Harada disease &#40;VKHD&#41; is a systemic entity characterized by bilateral diffuse granulomatous uveitis with serous retinal detachment&#44; with potential neurological&#44; hearing and dermatological impairment&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> It is more frequent in middle-aged &#40;20&#8211;50 years&#41; and dark skin color women &#40;2&#58;1&#41;&#46; The series published in North America and Europe have been limited&#44; perhaps because this syndrome is rare in Caucasian population&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2&#44;3</span></a> We report the clinical characteristics and evolution of a series of 4 patients with VKHD diagnosed and monitored in internal medicine unit of a tertiary hospital over a period of 33 months&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">All patients were women and the median age at diagnosis was 33 years&#46; Following the diagnostic guidelines of the American Society of Uveitis &#40;2001&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> one patient met the criteria for complete disease&#44; 2 for incomplete disease&#44; and one for probable disease&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The evolution time of symptoms before the first consultation ranged from 2 to 21 days&#46; The first symptom reported was headache in 3 patients&#46; The remaining case began with impaired visual acuity &#40;VA&#41;&#46; Subsequently&#44; all the patients developed progressive blurred vision&#59; photophobia in 2 of them&#46; As for extraocular symptoms&#44; 2 patients had tinnitus&#44; and one patient&#44; sensorineural hearing loss&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Eye examination showed choroiditis with bilateral exudative retinal detachment in all patients&#46; The VA to disease onset was 0&#46;9 in one case&#44; 0&#46;2&#8211;0&#46;5 in another&#44; and &#8220;counting fingers&#8221; to 50<span class="elsevierStyleHsp" style=""></span>cm in the remaining 2&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Other symptoms during follow-up included hair graying plus hair loss in an individual&#44; and skin hyperesthesia in another&#46; None developed vitiligo&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Blood analysis was unremarkable in all patients&#46; Lumbar puncture &#40;LP&#41; was performed in 3 patients&#44; showing lymphomononuclear pleocytosis and negative microbiological test in CSF compatible with aseptic meningitis&#46; On the other hand&#44; magnetic resonance imaging &#40;MRI&#41; and computed tomography were normal&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">During admission all received systemic glucocorticoids&#44; prednisone or equivalent&#44; at doses of 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#46; Two patients who developed more significant impaired VA required boluses of methylprednisolone &#40;250<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41; for 3 and 6 days respectively&#46; No further immunosuppressants were required in any case&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">At discharge&#44; all patients continued with prednisone 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day on a decreasing regimen&#44; which was held for four months in 2 patients&#44; and 8 and 9 months in the remaining&#46; At the end of treatment 3 subjects had a VA of 1 in the right eye and 0&#46;9 in the left eye&#59; the remaining patient had a VA of 1 in both eyes&#46; By optical coherence tomography&#44; ophthalmoscopy and control fluorescein angiography &#40;FA&#41; it was verified in all cases&#44; complete healing of exudative retinal detachment&#44; without occurrence of sequelae or relapses in the follow-up&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The VKHD usually begins with neurological and eye symptoms common to other diseases&#44; which&#44; along with its low incidence&#44; may cause a delayed diagnosis and the occurrence of complications or chronic and limiting visual sequelae&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The median age at onset of the disease and the predilection for females is consistent with the data from other medical literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4&#8211;6</span></a> Headache was the most common symptom&#44; being a typical manifestation of the prodromal phase&#44; characterized by meningeal symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> The exudative retinal detachment was the main ophthalmological finding&#44; also reflected in other series with an incidence over 90&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The 3 patients undergoing LP were found aseptic meningitis&#46; This procedure might be avoided if all the signs and symptoms of the disease are shown&#44; since the diagnosis might be established in a patient with indicative symptomatology and characteristic FA&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> Blood tests and imaging tests are often anodyne in this entity&#44; only providing better diagnostic certainty&#46; MRI is recommended&#44; especially to differentiate VKHD from posterior scleritis&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Glucocorticoids are the cornerstone of treatment&#44; sometimes requiring methylprednisolone pulses to control the choroidal inflammation&#44; as it occurred in 2 subjects in this series&#46; Subsequently&#44; all patients must follow a decreasing prednisone regimen&#44; starting by 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day for a minimum period of 6 months in order to obtain the best possible VA at the end of treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">No subject in this series required second-line immunosuppressants&#44; or reported complications or sequelae&#46; In other studies&#44; up to 43&#46;75&#37; of the patients required immunosuppressive agents &#40;cyclosporine and azathioprine&#41; to control inflammation&#44; and 36&#46;4&#37; developed complications &#40;cataracts&#44; synechiae&#44; etc&#46;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The good performance of the patients in this series might be due to the limited presence of factors associated with the development of complications&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> All subjects were female and developed the disease at an early age&#46; In addition&#44; only 2 had a serious illness onset &#40;with &#8220;counting fingers&#8221; vision&#41;&#44; and the time of symptomatology development was below one month before diagnosis&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Comparing this series with other Spanish reports&#44; we find similarity in the epidemiological spectrum&#44; the initial symptomatology and the high frequency of exudative retinal detachment&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">5&#44;6&#44;9</span></a> As for the differences&#44; healing occurs in 100&#37; of patients&#44; with no incidence of recurrence or chronic complications and no need for second-line immunosuppressants&#59; all of this probably due to the small number of poor prognostic factors or high initial clinical suspicion&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Ortiz Balbuena J&#44; Tutor de Ureta P&#44; Rivera Ruiz E&#44; Mellor Pita S&#46; Enfermedad de Vogt-Koyanagi-Harada&#46; Med Clin &#40;Barc&#41;&#46; 2016&#59;146&#58;93&#8211;94&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:9 [
            0 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enfermedad de Vogt-Koyanagi-Harada"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Riveros Frutos"
                            1 => "P&#46; Romera Romero"
                            2 => "S&#46; Holgado P&#233;rez"
                            3 => "J&#46;R&#46; Anglada Escalona"
                            4 => "M&#46; Mart&#237;nez-Morillo"
                            5 => "B&#46; Tejera Segura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Semin Fund Esp Reumatol"
                        "fecha" => "2012"
                        "volumen" => "13"
                        "paginaInicial" => "142"
                        "paginaFinal" => "146"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vogt-Koyanagi-Harada syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Ohno"
                            1 => "D&#46;H&#46; Char"
                            2 => "S&#46;J&#46; Kimura"
                            3 => "G&#46;R&#46; O&#8217;Connor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ophthalmol"
                        "fecha" => "1977"
                        "volumen" => "83"
                        "paginaInicial" => "735"
                        "paginaFinal" => "740"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/868972"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vogt-Koyanagi-Harada disease and HLA type in Italian patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Pivetti-Pezzi"
                            1 => "M&#46; Accorinti"
                            2 => "R&#46;A&#46; Colabelli-Gisoldi"
                            3 => "M&#46;P&#46; Pirraglia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Ophthalmol"
                        "fecha" => "1996"
                        "volumen" => "122"
                        "paginaInicial" => "889"
                        "paginaFinal" => "891"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8956647"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A nationwide survey on the occurrence of Vogt-Koyanagi-Harada disease in Japan"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Murakami"
                            1 => "Y&#46; Inaba"
                            2 => "M&#46; Mochizuki"
                            3 => "A&#46; Nakajima"
                            4 => "A&#46; Urayama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Jpn J Ophthalmol"
                        "fecha" => "1994"
                        "volumen" => "38"
                        "paginaInicial" => "208"
                        "paginaFinal" => "213"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7967215"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enfermedad de Vogt-Koyanagi-Harada&#46; Caracter&#237;sticas de un grupo de pacientes andaluces"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;J&#46; Garc&#237;a Hern&#225;ndez"
                            1 => "C&#46; Oca&#241;a Medina"
                            2 => "M&#46;J&#46; Castillo Palma"
                            3 => "J&#46; S&#225;nchez Rom&#225;n"
                            4 => "T&#46; Rueda Rueda"
                            5 => "M&#46;C&#46; Pulido Aguilera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Clin Esp"
                        "fecha" => "2006"
                        "volumen" => "206"
                        "paginaInicial" => "388"
                        "paginaFinal" => "391"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16863625"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enfermedad de Vogt-Koyanagi-Harada&#58; descripci&#243;n de diez casos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Mart&#237;nez-Berriotxoa"
                            1 => "S&#46; Egu&#237;luz"
                            2 => "J&#46; Artaraz"
                            3 => "A&#46; Fonollosa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Internistas"
                        "fecha" => "2013"
                        "paginaInicial" => "17"
                        "paginaFinal" => "24"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vogt-Koyanagi-Harada syndrome&#58; clinical course&#44; therapy&#44; and long-term visual outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;E&#46; Rubsamen"
                            1 => "J&#46;D&#46; Gass"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Ophthalmol"
                        "fecha" => "1991"
                        "volumen" => "109"
                        "paginaInicial" => "682"
                        "paginaFinal" => "687"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2025171"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic factors in Vogt-Koyanagi-Harada disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;S&#46; Al-Kharashi"
                            1 => "H&#46; Aldibhi"
                            2 => "H&#46; Al-Fraykh"
                            3 => "D&#46; Kangave"
                            4 => "A&#46;M&#46; Abu El-Asrar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10792-007-9062-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Ophthalmol"
                        "fecha" => "2007"
                        "volumen" => "27"
                        "paginaInicial" => "201"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17435968"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S&#237;ndrome de Vogt-Koyanagi-Harada&#58; revisi&#243;n en el &#225;rea de influencia de la CSUB"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Garc&#237;a"
                            1 => "M&#46;A&#46; Arcediano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Oftalmol"
                        "fecha" => "2001"
                        "volumen" => "9"
                        "paginaInicial" => "24"
                        "paginaFinal" => "28"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack218288"
        "titulo" => "Acknowledgements"
        "texto" => "<p id="par0080" class="elsevierStylePara elsevierViewall">To Dr&#46; Miguel Yebra Bango and Sergio Valverde Almohalla&#44; for review and correction of the original manuscript&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/23870206/0000014600000002/v1_201605240650/S2387020616301322/v1_201605240650/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "43309"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/23870206/0000014600000002/v1_201605240650/S2387020616301322/v1_201605240650/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616301322?idApp=UINPBA00004N"
]
Article information
ISSN: 23870206
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2023 March 2 2 4

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos