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Diaz-Martinez, M. Antonia Fernández-Pugnaire" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Ana" "apellidos" => "Almodovar-Real" "email" => array:2 [ 0 => "aniuska_almodovar86@hotmail.com" 1 => "anamariaalmodovar@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "David" "apellidos" => "López-Delgado" ] 2 => array:2 [ "nombre" => "Miguel A." "apellidos" => "Diaz-Martinez" ] 3 => array:2 [ "nombre" => "M. Antonia" "apellidos" => "Fernández-Pugnaire" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Unidad de Gestión Clínica de Dermatología, Hospital Universitario San Cecilio, Granada, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pigmentación generalizada tras tratamiento a largo plazo con minociclina" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 500 "Ancho" => 375 "Tamanyo" => 58205 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Woman aged 46 with kidney failure and rheumatoid arthritis since age 5. She had been operated on multiple occasions. She is currently being treated with prednisone, denosumab and minocycline 100<span class="elsevierStyleHsp" style=""></span>mg every 12<span class="elsevierStyleHsp" style=""></span>h since 2011 for recurrent septic arthritis. She consulted for progressive pigmentation of 2 years of evolution. In the examination she showed widespread greyish pigmentation, most evident on face (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), accompanied by bluish macules of the upper, and lower limbs and abdomen (<a class="elsevierStyleCrossRefs" href="#fig0010">Figs. 2 and 3</a>) coinciding with areas of previous trauma (surgical interventions and heparin administration). Minocycline was discontinued and after 6 months the patient showed slightly decreased pigmentation. Minocycline is particularly useful in patients with rheumatoid arthritis and previous episodes of sepsis. Pigmentation is a well-documented side effect after long-term minocycline therapy. It is not limited to skin and nails, and can affect the conjunctiva and sclera, oral mucosa, bones, thyroid gland and aortic valves. Symptoms may remain several months or even years after treatment discontinuation.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Almodovar-Real A, López-Delgado D, Diaz-Martinez MA, Fernández-Pugnaire MA. Pigmentación generalizada tras tratamiento a largo plazo con minociclina. Med Clin (Barc). 2016;146:e11.</p>" ] ] "multimedia" => array:3 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 500 "Ancho" => 375 "Tamanyo" => 58205 ] ] ] 1 => array:6 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 500 "Ancho" => 867 "Tamanyo" => 61287 ] ] ] 2 => array:6 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 500 "Ancho" => 672 "Tamanyo" => 59753 ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000014600000002/v1_201605240650/S2387020616301346/v1_201605240650/en/main.assets" "Apartado" => array:4 [ "identificador" => "51820" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in medicine" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000014600000002/v1_201605240650/S2387020616301346/v1_201605240650/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020616301346?idApp=UINPBA00004N" ]