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Editorial article
Hyperuricemia and gout: The impact of ultrasonography
Hiperuricemia y gota: impacto de la ecografía
Juan García Puiga,
Corresponding author
juangarciapuig@gmail.com

Corresponding author.
, Eugenio de Miguelb
a Unidad Metabólico-Vascular, Servicio de Medicina Interna, Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, Spain
b Servicio de Reumatología, Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Hyperuricemia is the increased levels of serum monosodium urate &#40;uric acid&#41;&#46; Gout is secondary to the inflammatory response that the deposit of monosodium urate causes in the tissues&#46; Gout is the most frequent inflammatory joint disease in the general population&#46; The prevalence of hyperuricemia and gout increases with age and depends on the population studied&#46; In the area of Madrid and in the general population&#44; we have found a hyperuricemia prevalence &#40;&#62;7&#46;0<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41; 11&#46;3&#37; &#40;95&#37; CI 8&#46;3&#8211;13&#46;9&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a> The prevalence of gout is up to 7&#37; of men aged over 65 and 3&#37; of women over 85&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a> In 2010 it was estimated that the gout disability-adjusted life years had increased from 76&#44;000 &#40;95&#37; CI 48&#8211;112&#41; in 1990 to 114&#44;000 &#40;95&#37; CI 72&#8211;167&#41; in 2010&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> This increased prevalence of hyperuricemia and gout can be related to the epidemic of overweight and obesity in developed countries&#44; and trend toward dietary modifications to increased consumption of foods high in purines&#44; alcoholic beverages &#40;beer&#41; and soft drinks sweetened with fructose&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">4&#44;5</span></a> In most patients&#44; increased serum urate concentration &#40;hyperuricemia&#41; is due to a diminished kidney excretion of uric acid&#44;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#44;7</span></a> which&#44; in many cases&#44; is determined by an increased or decreased function of certain kidney<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">7&#44;8</span></a> and intestinal transporters&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a> Hyperuricemia not only leads to an increased risk of gout&#46; It has also been associated with heart and kidney disease&#44; and can be expression of a widespread atherosclerosis&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a> It seems appropriate to know the phase or stage of a particular patient with hyperuricemia and&#47;or gout&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Every disease runs through different developmental stages&#59; hence the diversity of clinical manifestations&#46; The most common clinical manifestation of gout is acute inflammation &#40;&#60;24<span class="elsevierStyleHsp" style=""></span>h&#41; that involves the first metatarsophalangeal joint of the big toe &#40;podagra&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> The initial presentation may affect other joints such as forefoot&#44; ankles&#44; knees&#44; elbows&#44; wrists&#44; and metacarpophalangeal and interphalangeal joints&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">12</span></a> The pathogenesis of the inflammatory process lies in the phagocytosis of monosodium urate crystals deposited in the joints &#40;&#8220;microtophi&#8221;&#41;&#44; which may remain asymptomatic for many years&#46; Various imaging techniques have shown that many patients with gout &#40;Rx&#44; simple or dual power CT&#44; MRI&#44; ultrasound&#41; and asymptomatic hyperuricemia &#40;ultrasound&#44; dual power CT&#41;&#44; apparently non-tophaceous&#44; have deposits of monosodium urate &#40;&#8220;microtophi&#8221;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">13</span></a> This has led to a new classification of hyperuricemia and gout in 4 stages &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">14</span></a> which is a certain conceptual revolution for the diagnosis and treatment of hyperuricemia and gout&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Asymptomatic hyperuricemia is frequently associated with situations that increase vascular risk &#40;obesity&#44; hypertension&#44; diabetes&#44; dyslipidemia&#44; metabolic syndrome&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">15</span></a> and it has also been postulated as an independent vascular risk factor&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">16</span></a> Regardless of its etiology&#44; asymptomatic hyperuricemia is considered a benign entity that evolves only occasionally to gout&#46; The probability of this happening is proportional to serum urate concentrations and time of evolution&#46; When uric acid levels are &#8805;10&#46;0<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#44; after 5 years&#44; gout occurs in about 50&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">17</span></a> European and American guidelines do not recommend hypouricemic treatment in subjects with asymptomatic hyperuricemia&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">2&#44;18&#8211;21</span></a> For years we have hypothesized that prolonged high levels of uric acid &#40;&#8805;7&#46;0<span class="elsevierStyleHsp" style=""></span>mg&#47;dl&#41;&#44; might lead to monosodium urate crystals with subsequent inflammation&#46; We first report that one third of patients with asymptomatic hyperuricemia have silent monosodium urate crystal deposits &#40;&#8220;microtophi&#8221;&#41; and that 25&#37; of these patients show signs of inflammation&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a> Subsequently&#44; 3 other studies in patients with prolonged asymptomatic hyperuricemia &#40;&#8805;2 years&#41; have confirmed deposits of monosodium urate in 34&#8211;42&#37;&#44; and 24&#37; of these patients have obvious inflammation &#40;doppler signal&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">23&#8211;25</span></a> These reports lead to two important questions&#58; &#40;a&#41; if a patient with &#8220;asymptomatic hyperuricemia&#8221; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; A&#41; has tophi&#44; should the patient be considered a patient with asymptomatic gout or tophaceous gout &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; B or D&#41;&#63;&#44; and &#40;b&#41; if a patient has asymptomatic tophi with evidence of inflammation &#40;doppler signal&#41;&#44; should they be treated with hypouricemic drugs&#63; If the answer to both questions is yes&#44; this would be a major paradigm shift&#59; every patient with long-standing asymptomatic hyperuricemia should undergo a joint ultrasound &#40;knee and metatarsophalangeal joints&#41;&#46; The management of resources should consider that this examination can be performed in less than 10<span class="elsevierStyleHsp" style=""></span>min&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">26</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Clinicians know well that the manifestations of the disease depend largely on the sagacity of the observer and the availability of additional tests&#46; In a review of 14 studies&#44; about half of the patients with gout had tophi when they were examined under ultrasound&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">27</span></a> Therefore&#44; the clinical diagnosis of &#8220;nontophaceous gout&#8221; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; C&#41;&#44; nowadays&#44; is questionable if an ultrasound is not performed&#46; What would it mean to implement ultrasound examination of knees and metatarsophalangeal joints in all patients with gout&#63; Let&#39;s mention two apparent benefits&#58; &#40;a&#41; it would modify the classification &#40;a patient with non tophaceous gout would be reclassified in the tophaceous gout group &#91;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>C would become D&#93;&#41;&#44; and &#40;b&#41; in patients with urate deposits&#44; the hypouricemic treatment would be modulated in two aspects&#46; On the one hand&#44; we would try to keep the uric acid below 5&#46;0<span class="elsevierStyleHsp" style=""></span>mg&#47;dl for complete resorption of tophi as soon as possible&#46; Even 2 years after onset with hypouricemic treatment&#44; many patients with gout showed tophi and signs of inflammation&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">28</span></a> On the other hand&#44; the finding of tophi and signs of inflammation&#44; forces the hypouricemic treatment to be accompanied by appropriate prophylaxis to prevent attacks of acute inflammation&#44; allegedly triggered by reabsorption of urate crystals&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">29</span></a> The ultrasound follow-up&#44; when detecting tophi&#44; would let know its evolution and establish&#58; &#40;a&#41; the intensity of hypouricemic treatment&#44; and &#40;b&#41; whether or not it is advisable to maintain a preventive treatment of acute gout&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> The current availability of ultrasound makes it likely that before long we have the necessary studies to verify these possible &#8220;apparent benefits&#46;&#8221;</p><p id="par0025" class="elsevierStylePara elsevierViewall">One final thought&#58; imaging techniques can help to better clinical classification of asymptomatic hyperuricemia and gout&#44; and perhaps carry out a more rational treatment&#44; but never replace the clinician&#39;s judgment and individualized treatment&#46; This is the art of medicine&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Garc&#237;a Puig J&#44; de Miguel E&#46; Hiperuricemia y gota&#58; impacto de la ecograf&#237;a&#46; Med Clin &#40;Barc&#41;&#46; 2016&#59;146&#58;67&#8211;68&#46;</p>"
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                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Hyperuricemia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>A&#46; Patients with increased serum urate and no evidence of deposits of monosodium urate&#46; Examples&#58; heart failure&#44; metabolic syndrome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>B&#46; Patients with increased serum urate and evidence of deposits of monosodium urate&#46; Examples&#58; same patients as in A&#44; with &#8220;microtophi&#8221;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Gout</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>C&#46; Patients who report some characteristic gout attack&#44; with no evidence of deposits of monosodium urate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>D&#46; Patients who report some characteristic gout attack&#44; with evidence of deposits of monosodium urate &#40;&#8220;tophi or microtophi&#8221;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical stages in which patients with hyperuricemia or gout can be classified&#44; when using imaging techniques &#40;such as ultrasound&#41;&#46;</p>"
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