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Vesicular eruption in a patient under antituberculosis treatment
Erupción vesiculosa en paciente en tratamiento antituberculoso
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The patient is referred to dermatology due to vesicular eruption (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A) is pruritic, in the upper part of the back (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B), chest (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C), nose, cheeks and forehead (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D). The initial diagnosis was herpetic eczema, prescribing treatment with valaciclovir 1<span class="elsevierStyleHsp" style=""></span>g/8<span class="elsevierStyleHsp" style=""></span>h for 7 days and cloxacillin 500<span class="elsevierStyleHsp" style=""></span>mg/6<span class="elsevierStyleHsp" style=""></span>h for 5 days. Ten days after treatment, lesions persisted. The result of virus and bacteria culture was negative. A second skin biopsy was performed with direct immunofluorescence, conducting differential diagnosis procedures between: drug-induced lupus, prurigo pigmentosa, bullous pemphigoid (BP) and linear IgA dermatosis. Direct immunofluorescence showed linear C3 deposits (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>), being diagnostic of BP. Prednisone treatment was started at down-titration doses with good response although there was intense residual hyperpigmentation (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>A and B). BP is an acquired autoimmune disease characterized by subepidermal blister formation, affecting mainly the elderly population. As regards the drugs taken by the patient, only rifampin has been previously reported as a causative agent in the BP. The development of vesicles and blisters in a young patient who has been recently administered new drugs requires ruling out BP.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Garrido-Colmenero C, Ruiz-Villaverde R, Martínez-López A, Aneiros-Fernández J. Erupción vesiculosa en paciente en tratamiento antituberculoso. 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