Image in medicine
Cutaneous involvement of amyloidosis associated with multiple myeloma
Manifestaciones cutáneas de la amiloidosis sistémica asociada a mieloma múltiple
a Departamento de Dermatología, Hospital Dr. Sótero del Río, Santiago, Chile
b Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
c General Doctor, Universidad de los Andes, Santiago, Chile
d Departamento de Anatomía Patológica, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
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Chile, Santiago, Chile" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "General Doctor, Universidad de los Andes, Santiago, Chile" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Departamento de Anatomía Patológica, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Manifestaciones cutáneas de la amiloidosis sistémica asociada a mieloma múltiple" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1135 "Ancho" => 1001 "Tamanyo" => 185743 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Amyloidosis is characterized by an extracellular deposit consisting of insoluble, fibrillar proteinaceous material called amyloid. Primary systemic amyloidosis (AL) is the most frequent subtype and with the worst prognosis. We report the image of a male patient, aged 67, diagnosed with multiple myeloma, who after starting chemotherapy showed bullous lesions on face and limbs, with hemorrhagic content, and hematic scabs on face, arms and legs, without mucosal involvement. The skin biopsy was consistent with multiple myeloma-associated systemic amyloidosis. The AL is presented with a variety of symptoms. We would like to outline early identification of mucocutaneous involvement, which in many cases is the first clinical manifestation of amyloidosis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Correa H, Giesen L, Vial V, González S. 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