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Review
Orally-transmitted Chagas disease
Enfermedad de Chagas de transmisión oral
Maria Teresa Filigheddua,
Corresponding author
etafiligheddu@gmail.com

Corresponding author.
, Miguel Górgolasb,c, José Manuel Ramosd,e
a División de Enfermedades Infecciosas, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain
b División de Enfermedades Infecciosas, Fundación Jiménez Díaz, Madrid, Spain
c Departamento de Medicina, Universidad Autónoma de Madrid, Madrid, Spain
d Servicio de Medicina Interna, Hospital General Universitario de Alicante, Alicante, Spain
e Departamento de Medicina Clínica, Universidad Miguel Hernández de Elche, Elche, Alicante, Spain
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insect vectors were crushed during preparation or food was contaminated by their faeces&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">1</span></a> The scientific literature has also shown survival of <span class="elsevierStyleItalic">T&#46; cruzi</span> in beverages&#44; over 24<span class="elsevierStyleHsp" style=""></span>h from contamination&#44; a time frame that allows easy <span class="elsevierStyleItalic">oral</span> transmission of the parasite&#44;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">2&#44;3</span></a> which manifests itself with a high mortality and a poor prognosis&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The aim of this paper is to review the characteristics of orally-transmitted CD outbreaks&#44; sources of infection&#44; transmission mechanism&#44; virulence of the transmission and of the clinical forms&#44; and finally&#44; diagnostic tools and prevention&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Materials and methods</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Design</span><p id="par0020" class="elsevierStylePara elsevierViewall">A review of scientific studies was carried out in 3 databases&#58; PubMed&#44; EMBASE and Google Scholar&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Search strategy</span><p id="par0025" class="elsevierStylePara elsevierViewall">First&#44; searches were conducted in two databases&#44; PubMed and EMBASE&#44; using the following search equations&#58; &#8220;Chagas disease&#8221; and &#8220;oral transmission&#44;&#8221; &#8220;acute Chagas&#8221; and &#8220;oral Chagas&#8221; and &#8220;outbreaks&#8221;&#44; &#8220;<span class="elsevierStyleItalic">Trypanosoma cruzi&#8221;</span> and &#8220;oral route&#8221;&#46; No restrictions were used and all kinds of studies were considered&#46; In addition&#44; references from other articles found through Google Scholar were reviewed&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Data extraction</span><p id="par0030" class="elsevierStylePara elsevierViewall">After the search&#44; 80 studies were found&#44; of which 47 were relevant to the objective of this study&#46; To proceed with the selection&#44; abstracts and&#44; where necessary&#44; full papers were reviewed in order to decide whether the information they contained was or was not related to the objective&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Data analysis</span><p id="par0035" class="elsevierStylePara elsevierViewall">Once analyzed&#44; the information was divided into sub-sections&#44; and the following data was singled out from the revised articles&#58; authorship&#44; journal name and year of publication&#44; country where the study was conducted&#44; type of study&#44; subjects and origin&#44; outcome variable and conclusions made&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Orally-transmitted acute Chagas disease outbreaks</span><p id="par0040" class="elsevierStylePara elsevierViewall">The highest number of orally-transmitted acute Chagas disease outbreaks has been seen in the last decade&#44; all of which occurred in South America &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Outbreaks in Brazil</span><p id="par0045" class="elsevierStylePara elsevierViewall">In Brazil&#44; the first outbreak of acute CD was recorded in 1965&#44; which affected 18 people&#44; 6 of whom died of acute myocarditis&#44; suspecting intake of vegetables contaminated by opossum faeces&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">5</span></a> Between 1968 and 2005 there were a total of 437 cases of acute CD&#44; of which 311 were linked to 62 outbreaks caused by a&#231;ai ingestion&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">6</span></a> In contrast&#44; only in the period between 2000 and 2010&#44; there were more than 1000 acute cases in 138 outbreaks of which 776 cases &#40;71&#37;&#41; were attributed to orally-transmitted epidemics&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">In 2005&#44; an acute CD outbreak was recorded in the tourist area of Santa Caterina after the ingestion of sugar cane juice&#46; Remains of contaminated kissing bugs or insect faeces would have been processed while grinding the cane&#46; 25 cases were confirmed&#44; of which one was an Italian tourist&#46; 3 of them died&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">8&#44;9</span></a> Between January and November 2006 a total of 178 cases of CD were reported in the state of Para&#44; again being linked with consumption of a&#231;ai&#46; In the same year&#44; in Bahia&#44; 7 cases of acute CD transmitted by contaminated water were recorded&#44; with 28&#37; lethality<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">10</span></a> and 8 other cases were reported in Ceara by eating contaminated soup made with vegetables grown in a home family garden&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">11</span></a> In January 2010&#44; another outbreak was reported in the Brazilian Amazon region of 17 cases per consumption of a&#231;a&#237;&#44;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">12</span></a> with another outbreak of similar characteristics repeating in January 2015 &#40;in the press&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Outbreaks in Colombia</span><p id="par0055" class="elsevierStylePara elsevierViewall">Acute CD was rare in Colombia&#46; Between 1990 and 1999 two outbreaks associated with myocarditis were detected with possible oral transmission<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">13</span></a>&#59; and between 2002 and 2005&#44; 10 new cases &#40;8 confirmed by oral transmission and 2 with portal of entry&#41; were reported&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">14</span></a> However&#44; in later years a notable increase was observed&#44; so that&#44; from 2008&#44; more than 64 new acute cases have been detected&#44; including micro-outbreaks and isolated cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">7&#44;15&#8211;17</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">In 2008&#44; 10 cases of acute CD were recorded&#44; with <span class="elsevierStyleItalic">T&#46; cruzi</span> found in orange juice being the source of contamination&#46; 2 patients died of acute myocarditis and cardiogenic shock&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">15</span></a> In another outbreak caused by consumption of food contaminated with the parasite&#44; a 27-year-old woman and her 2-year-old son died&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">17</span></a> In 2010&#44; 11 cases of acute CD caused by oral ingestion of food contaminated with <span class="elsevierStyleItalic">T&#46; cruzi</span> were reported&#46; The source was either triatomine bug remnants or marsupial droppings&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">18</span></a> Another 11 acute CD cases were detected in one family due to food contamination with faeces from triatomines infected with <span class="elsevierStyleItalic">T&#46; cruzi</span> in <span class="elsevierStyleItalic">Attalea butyracea</span> and <span class="elsevierStyleItalic">Elaeis oleifera</span><a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">19&#44;20</span></a> palms&#46; In the outbreak occurred in the Department of Casanare&#44; in March 2014&#44; 40 workers of companies related to the mining sector were exposed to contaminated food&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">21</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Outbreaks in Venezuela</span><p id="par0065" class="elsevierStylePara elsevierViewall">In Venezuela&#44; there had been no reported cases of oral transmission in human groups until 2007&#44; when 103 members of a school group in the municipality of Chacao in Caracas were affected&#59; the disease was acquired by drinking guava juice made outside the school facilities&#46; A 5-year-old boy died in this first microepidemic&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">22</span></a> In May 2008&#44; 3 members of a family were diagnosed of acute <span class="elsevierStyleItalic">T&#46; cruzi</span> infection&#44; of probable oral transmission&#44; with prolonged febrile syndrome and chills&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">23</span></a> In April 2009&#44; in a coastal town&#44; there was another outbreak of acute CD &#40;71 children and 14 adults&#41; with the same characteristics as the 2007 one&#46; 4 deaths were recorded&#44; 3 children and a pregnant woman&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">24</span></a> Another documented episode occurred again in Caracas in May 2010 where 20 people were diagnosed and a 2-year-old died&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In October 2010&#44; <span class="elsevierStyleItalic">T&#46; cruzi</span> was observed in trypomastigote form in the peripheral blood of a 2-year-old girl&#44; 16 days after admission for pneumonia&#46; The patient developed fever&#44; pericarditis&#44; pleural effusion&#44; and pericardial effusion and finally died&#46; 5 other people from the same family were diagnosed with CD&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">25</span></a> In March 2012&#44; 4 construction workers who had been working in the basement of one of the Food Municipal Market&#39;s warehouses in Caracas&#44; simultaneously manifested prolonged febrile symptoms&#59; trypomastigote forms of <span class="elsevierStyleItalic">T&#46; cruzi</span> were isolated in blood&#46; Rats infected with <span class="elsevierStyleItalic">T&#46; cruzi</span><a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">26</span></a> were later caught in the warehouse&#46; In July 2012&#44; an outbreak of acute CD in 5 members of the same family was recorded&#44; 2 had acute myocarditis and one died&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">27</span></a> In June 2013&#44; a case of celiac disease was diagnosed in a 16-year-old with high parasitemia and febrile syndrome&#46; Similar symptoms were also identified in 8 other people&#44; including a pregnant woman who died&#46; <span class="elsevierStyleItalic">Panstrongylus geniculatus &#40;P&#46; geniculatus&#41;</span> was isolated in the house where the mango juice was made and later drunk by all individuals diagnosed&#46;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">28</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">In February 2014&#44; another case of acute CD was diagnosed in a 16-year-old and his parents who had fever&#44; pericardial effusion&#44; acute myocarditis and high parasitemia&#59; they all died&#46; In July 2014&#44; there was an orally-transmitted CD outbreak that affected 5 individuals of the same family&#44; 3 of whom were hospitalized for myocarditis&#46;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">28</span></a> In June 2015&#44; 12 people from the same family had CD associated with unhygienic handling of food&#46; 2 infants and one adult died&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">29</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">In Venezuela&#44; therefore&#44; two types of oral transmission infection have been observed&#58; microepidemics in which the number of infected individuals is high&#59; and small group outbreaks &#40;households&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">30</span></a></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Outbreaks in Bolivia</span><p id="par0085" class="elsevierStylePara elsevierViewall">The first orally-transmitted acute CD outbreak in Bolivia occurred in October 2010&#44; due to majo &#40;<span class="elsevierStyleItalic">Oenocarpus bataua</span>&#41; consumption&#44; a local fruit whose juice is made by crushing the same&#46; The juice is drunk without cooking&#46; 24 people were exposed&#44; 16 of which developed the disease&#44; there were no deaths&#46; The most common signs and symptoms were fever and headache &#40;100&#37;&#41; followed by vomiting&#44; diarrhoea&#44; splenomegaly and increases in liver enzymes&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">31</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Other outbreaks</span><p id="par0090" class="elsevierStylePara elsevierViewall">In 2010&#44; in French Guyana&#44; 8 patients of the same family presented with epidemiological histories and clinical data consistent with recent <span class="elsevierStyleItalic">T&#46; cruzi</span> infection due to ingestion of contaminated <span class="elsevierStyleItalic">Oenocarpus bacaba</span> palm juice&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">32</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Sporadic cases have been reported in Ecuador and Argentina in relation to the consumption of undercooked meat from contaminated animals&#46;<a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">33&#44;34</span></a></p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Vectors and reservoirs</span><p id="par0100" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">T&#46; cruzi</span> is a parasite capable of infecting dozens of species of wild and domestic mammals and is transmitted by several species of hematophagous triatomine insects&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Of the 125 species of triatomine bugs described in America&#44; the following have been linked to oral transmission&#58; <span class="elsevierStyleItalic">P&#46; geniculatus</span> and <span class="elsevierStyleItalic">Rhodnius pallescens</span> in Colombia&#44;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">16</span></a><span class="elsevierStyleItalic">P&#46; geniculatus</span> in Venezuela<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">30</span></a> and <span class="elsevierStyleItalic">Triatoma tibiamaculata&#44; T&#46; sordida&#44; T&#46; braziliensis</span> and <span class="elsevierStyleItalic">P&#46; lutzi</span> in Brazil&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">8&#44;35</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">The natural reservoir is constituted by armadillos&#44; marsupials &#40;<span class="elsevierStyleItalic">Didelphis</span> or opossums&#41;&#44; rodents&#44; coatis&#44; ferrets&#44; bats and wild primates besides pets like dogs&#44; cats and even rats <span class="elsevierStyleItalic">&#40;Rattus rattus&#41;</span>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">As a result of the alteration of peri-urban wooded areas and increased luminosity&#44; wild vectors and reservoirs reach residential areas and pollute the nearby palm trees and banana and fruit plantations<a class="elsevierStyleCrossRefs" href="#bib0445"><span class="elsevierStyleSup">36&#8211;38</span></a>&#59; thus&#44; preparing beverages from fruits cooked overnight favours exposure to infected vectors and reservoirs&#44; attracted by the smell of these fruits and artificial lighting&#44; this is reflected in an increase in oral transmission cases&#46;<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">39</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Other contributing factors are the increase of street vending of food and beverages&#44; transport of contaminated fruit and vegetables and distant consumption of the same&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">40</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Type of food involved</span><p id="par0125" class="elsevierStylePara elsevierViewall">Oral transmission of <span class="elsevierStyleItalic">T&#46; cruzi</span> is common during the enzootic cycle of this parasite through ingestion &#40;by susceptible mammals&#41; of infected vectors&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">41</span></a> In the case of man&#44; it occurs circumstantially by the ingestion of beverages or food contaminated with faeces or the whole infected triatomine&#44; or fruit or vegetables sprayed with secretions from the odoriferous anal glands of infected animals&#46; Another source of infection is the consumption of undercooked animal meat or blood from some reservoirs of the parasite such as the armadillo &#40;<span class="elsevierStyleItalic">Dasypus</span> spp&#46;&#41;<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">22&#44;31</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">Transmission usually coincides with hot weather&#44; the busiest time for triatomines &#40;greater mobility&#44; hematophagy&#44; and contamination of the environment with infected faeces&#41; and&#44; depending on the temperature&#44; humidity and desiccation&#44; <span class="elsevierStyleItalic">T&#46; cruzi</span> may stay alive for a few hours or days&#44; and at low temperatures its viability can last for weeks&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Therefore&#44; contaminated food must be kept wet or partially liquid to allow transmission of the parasite and in this sense the palm&#44; sugar cane and fruit juices are ideal sources of transmission&#44; because they often are cultivated&#44; harvested and handled with the help of artificial light&#44; in rural or peri-urban areas where triatomines are abundant&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">33</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Such is the case of acai and sugar cane juice in Brazil&#44; palm wine and orange juice in Colombia&#44; guava juice in Venezuela&#44; &#8220;comou&#8221; juice in French Guyana and more recently&#44; majo &#40;<span class="elsevierStyleItalic">Oenocarpus bataua</span>&#41; palm juice in Bolivia&#46; The risk of infection is higher if the fresh pulp is eaten and almost null if it goes through a washer-pasteurizer process&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Virulence of orally-transmitted acute Chagas disease</span><p id="par0145" class="elsevierStylePara elsevierViewall">There are few significant studies on the pathophysiology of orally-transmitted acute CD&#44; since most of the immunological knowledge we have derives from experimental studies with intraperitoneally&#47;subcutaneously infected mice&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">4</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">The first demonstrations of <span class="elsevierStyleItalic">T&#46; cruzi</span> invasion and replication in the gastric mucosa were performed in mouse models &#40;BALB&#47;cAnNHsd&#41; after oral ingestion of residues with 10&#44;000&#8211;40&#44;000 parasites&#46; The mice were examined 2 weeks after infection&#44; performing cuts of different organs&#44; which allowed to determine their anatomical localization in the stomach by immunohistochemical colourations&#44; observing intracellular amastigote forms of <span class="elsevierStyleItalic">T&#46; cruzi</span> in the gastric mucosa&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">42</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">The gastric epithelium invasion is mediated by proteins of metacyclic trypomastigotes that allow their adherence and penetration&#46;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">43</span></a> The gp82 glycoprotein is resistant to acidic pH and is able to bind to the gastric mucosa through Ca<span class="elsevierStyleSup">2&#43;</span> ion mobilization&#44; allowing the parasite to enter the cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0485"><span class="elsevierStyleSup">44&#8211;46</span></a> Once in the cytoplasm&#44; it transforms into amastigote&#44; and then into the metacyclic stage&#44; when it is detectable in blood&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">7</span></a> Gp30 glycoprotein also has affinity for the gastric mucosa although to a lesser extent&#44; whereas the gp90 is widely degraded by gastric juice&#44; therefore its expression is inversely correlated with parasite infectivity&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">42</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">The gastric mucosa invasion results in a progressive gastritis and&#44; despite the short period of replication&#44; it induces specific immunity&#44; involving the production of IgA and IgG&#46;<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">47</span></a> Intraepithelial and lamina propria lymphocytes produce IFN-&#947; but not IL-4&#44; suggesting the possibility that this type of route of infection does not affect the response of CD8&#43; T cells&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">4</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">The different modulation of the local and systemic immune system influences the different expression of such outbreaks&#44; which often emphasizes the seriousness of the clinical manifestations compared to other types of transmission route&#46;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">34</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">Penetration by the oral cavity and esophagus<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">27</span></a> has also been described&#44; showing&#44; at local level&#44; facial oedema on the inside of the cheeks&#44; paraesthesia&#44; lingual oedema and&#44; at systemic level&#44; high parasitaemia&#44; elevated serum levels of TNF&#44; carditis and hepatitis&#44; with high mortality rates&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">4</span></a></p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Clinical manifestations</span><p id="par0175" class="elsevierStylePara elsevierViewall">The latency period after ingestion of contaminated food is 3&#8211;30 days &#40;4&#8211;15 days in vector transmission and 30&#8211;112 days in transfusion transmission&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">35</span></a> Unlike the vector route&#44; the oral route is characterized by a large number of signs and symptoms and high mortality&#59; probably due&#44; not only to the more efficient penetration at gastric mucosa level&#44; but also because greater inoculum amounts can be transmitted orally compared to those who can penetrate through the skin&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The most characteristic clinical manifestation is prolonged fever&#44; which can be associated with non-specific symptoms &#40;prostration&#44; diarrhoea&#44; vomiting&#44; headache&#44; myalgia&#44; skin rash&#44; lymphadenopathy&#41; and&#47;or specific symptoms &#40;acute myocarditis&#44; acute pericarditis&#44; acute heart failure&#44; cardiac tamponade&#44; pleural effusion&#44; epigastric pain&#44; jaundice&#44; hematemesis&#44; haematochezia or melena<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">33</span></a> and in some cases meningoencephalitis&#41; or frequent &#40;face&#44; lower limbs or generalized oedema&#44; cough&#44; dyspnoea&#44; chest pain&#44; palpitations&#44; arrhythmias&#44; hepatosplenomegaly&#41;&#46; These manifestations &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; match the descriptions of acute CD outbreaks reported by several researchers in different regions of Latin America&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Diagnosis of orally-transmitted acute Chagas disease</span><p id="par0185" class="elsevierStylePara elsevierViewall">Epidemiological history is essential to raise the diagnosis&#58; recent travel&#44; intake of home-prepared food with no cooking involved&#44; simultaneous presence of other similar cases&#46; The clinical approach should be careful&#44; ruling out other diseases such as visceral leishmaniosis&#44; malaria&#44; mononucleosis&#44; typhoid fever&#44; toxoplasmosis&#44; hepatitis&#44; hantavirus&#44; leptospirosis&#44; yellow fever&#44; arbovirus &#40;Dengue&#44; Chikungunya&#44; Zika&#41; and rickettsiosis&#44; among others&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Laboratory tests include direct parasitological methods in which the parasite is observed in blood and indirect immunological methods that detect specific antibodies&#46;<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">7&#44;28&#44;48</span></a><a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> shows the diagnostic methods used in orally-transmitted acute CD outbreaks&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0195" class="elsevierStylePara elsevierViewall">Among the parasitological examinations&#44; direct examination of peripheral blood stands out&#44; it is fast and inexpensive&#44; specific but not always sensitive&#59; alternatively&#44; in the presence of symptoms for more than 30 days&#44; concentration methods &#40;microhematocrit&#44; Stourt method&#41; are used&#46; In developing countries&#44; thick blood film is also used&#44; as it may also rule out malaria&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">Among the serological methods&#44; indirect hemagglutination&#44; indirect immunofluorescence and the immunosorbent assay use as antigen the whole parasite or soluble extracts&#59; in contrast&#44; immunochromatography and <span class="elsevierStyleItalic">Western Blot</span> use recombinant antigens or synthetic peptides&#46; If the initial serology is negative&#44; it is repeated 3 weeks later and diagnosis would be confirmed if there is seroconversion or variation of 3 serologic titres by indirect immunofluorescence&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Xenodiagnosis is not a method used in Europe as it requires the vector&#46; The molecular diagnosis by polymerase chain reaction is used only in reference centres&#44; but allows the identification of the parasite in the acute phase before serological positivity&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">The use of these methodologies is reflected in the outbreaks described in the medical literature&#44; being the direct examination&#44; serology by indirect immunofluorescence and the enzyme immunoassay method the most commonly used tests&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Treatment</span><p id="par0215" class="elsevierStylePara elsevierViewall">Specific treatment is standard for all modes of transmission of <span class="elsevierStyleItalic">T&#46; cruzi</span> and it should be initiated as soon as possible&#46; The goal is to cure the infection&#44; prevent organ damage or the development of the same&#44; and reduce the possibility of transmission &#40;vertical&#44; transfusion&#44; transplantation&#41;&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Benznidazole is the drug of choice &#40;100<span class="elsevierStyleHsp" style=""></span>mg tablets&#41; and dose varies depending on age and weight&#46; It is taken orally in 2 daily doses for 60 days &#40;adults&#58; 5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#44; children 5&#8211;10<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day and infants 10<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">48</span></a> The drug can be given in shorter cycles or intermittently if there is a case of intolerance&#46;<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">49</span></a></p><p id="par0225" class="elsevierStylePara elsevierViewall">The most common adverse reactions are skin disease&#44; neuropathy&#44; nausea&#44; vomiting and diarrhoea&#46; In mild cases&#44; the treatment is maintained&#44; in moderate cases&#44; it is better to interrupt temporarily&#44; treat the symptoms and gradually reintroduce the drug&#46; In case of serious side effects&#44; augesia &#40;complete loss of taste&#41; or marrow hypoplasia &#40;&#60;1&#37;&#41;&#44; the treatment is discontinued&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">48</span></a></p><p id="par0230" class="elsevierStylePara elsevierViewall">An alternative is nifurtimox &#40;120<span class="elsevierStyleHsp" style=""></span>mg tablets&#41;&#44; whose dose also depends on the patient&#39;s age and weight&#44; administered in 3 and 4 times daily during 90 days &#40;adults&#58; 8&#8211;10<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#44; children&#58; 15<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;day&#41;&#46; The most common side effects are anorexia&#44; weight loss&#44; psychic disorders&#44; irritability&#44; drowsiness&#44; nausea&#44; vomiting&#44; cramps and diarrhoea&#46; Testicular damage&#44; ovarian toxicity and deleterious effects on adrenal&#44; colon&#44; oesophagus and breast tissue have also been observed&#46;<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">50</span></a></p><p id="par0235" class="elsevierStylePara elsevierViewall">Both drugs showed significant mutagenic effects and proved carcinogenic in some studies&#46;<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">50</span></a> Treatment should be postponed until after the first trimester&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Remission involves serological negativity which in most cases occurs up to 5 years after treatment&#44; so the performance of serological tests &#40;IgG&#41; every 6 months or annually until 2 successive tests are nonreactive is recommended&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">48</span></a></p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Preventing orally-transmitted acute Chagas disease</span><p id="par0245" class="elsevierStylePara elsevierViewall">Orally-transmitted acute CD is a preventable disease if proper measures are taken&#46; In this sense&#44; traveller education is essential to ensure a responsible and qualitative food consumption&#44; which involves knowledge of the entire production chain&#44; from source to consumption&#46;<a class="elsevierStyleCrossRefs" href="#bib0505"><span class="elsevierStyleSup">48&#44;51&#8211;53</span></a><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows the prevention measures for orally-transmitted acute CD&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conclusions</span><p id="par0250" class="elsevierStylePara elsevierViewall">Proper care of persons infected with <span class="elsevierStyleItalic">T&#46; cruzi</span> is an essential strategy for a comprehensive control of the CD and its elimination as a public health problem&#46; Faced with the exponential increase in cases over the past decade&#44; it is important to have knowledge of the oral route as a mechanism of transmission of the disease&#44; to provide adequate information to travellers&#44; suggest measures for prevention and early diagnosis in case of epidemiological risk and&#47;or compatible clinical symptoms&#44; even away from vector transmission areas&#46;</p></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflict of interests</span><p id="par0255" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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          "titulo" => "Orally-transmitted acute Chagas disease outbreaks"
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              "titulo" => "Outbreaks in Brazil"
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              "titulo" => "Outbreaks in Venezuela"
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              "titulo" => "Outbreaks in Bolivia"
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              "titulo" => "Other outbreaks"
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          "titulo" => "Virulence of orally-transmitted acute Chagas disease"
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          "titulo" => "Clinical manifestations"
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          "titulo" => "Diagnosis of orally-transmitted acute Chagas disease"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chagas disease is a zoonosis caused by protozoan parasite <span class="elsevierStyleItalic">Trypanosoma cruzi</span>&#44; which is most frequently associated with a vectorial transmission&#46; However&#44; in recent years we have observed a significant increase in the oral transmission of the disease&#44; associated mainly with the consumption of drinks made from fruit or other vegetables contaminated with triatomine faeces or secretions from infected mammals&#46; After a latency period of 3&#8211;22 days after ingestion&#44; the oral infection is characterized by more severe manifestations than those associated with vectorial transmission&#58; prolonged fever&#44; acute myocarditis with heart failure and&#44; in some cases&#44; meningoencephalitis&#46; Mortality can reach up to 33&#37; of those infected&#46; The aim of this paper is to review this matter and to promote prevention practices&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La enfermedad de Chagas es una zoonosis causada por el par&#225;sito protozoario <span class="elsevierStyleItalic">Trypanosoma cruzi</span>&#44; transmitido con mayor frecuencia por v&#237;a vectorial&#46; En los &#250;ltimos a&#241;os&#44; sin embargo&#44; se est&#225; observando un aumento marcado de la transmisi&#243;n de la enfermedad por v&#237;a oral&#44; asociada al consumo de bebidas preparadas a base de frutas u otros vegetales contaminados con las heces de triatominos o secreciones de mam&#237;feros infectados&#46; Despu&#233;s de un per&#237;odo de latencia de 3-22 d&#237;as&#44; a partir de la ingesti&#243;n&#44; la infecci&#243;n oral se caracteriza por manifestaciones m&#225;s graves que la vectorial&#58; fiebre prolongada&#44; miocarditis aguda con insuficiencia card&#237;aca y en algunos casos meningoencefalitis&#46; La mortalidad puede llegar hasta un 33&#37; de los infectados&#46; El objetivo de este trabajo es realizar una revisi&#243;n del fen&#243;meno y promover pr&#225;cticas de prevenci&#243;n&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Filigheddu MT&#44; G&#243;rgolas M&#44; Ramos JM&#46; Enfermedad de Chagas de transmisi&#243;n oral&#46; Med Clin &#40;Barc&#41;&#46; 2017&#59;148&#58;125&#8211;131&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Year&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Country&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">City&#47;state&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Population group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No cases&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Transmission source&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">No deaths&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0430">33</a><br><a class="elsevierStyleCrossRef" href="#bib0435">34</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1936&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Argentina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chaco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Breastmilk<br>Inadequately cooked meat&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0430">33</a><br><a class="elsevierStyleCrossRef" href="#bib0435">34</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1936&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Ecuador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Meat of wild animals&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0290">5</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1965&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Brazil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Teutonia&#44; Rio Grande do Sul&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Community&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Contaminated vegetables &#40;marsupials&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6<br>&#40;Myocarditis&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0295">6</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1988&#8211;2005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Brazil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Para&#44; Amapa&#44; Maranhao&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Urban&#47;Rural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Community&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">181&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&#231;a&#237; juice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13<br>&#40;Myocarditis&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0335">14</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2002&#8211;2005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Colombia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Putumayo&#44; Arauca&#44; Casanare&#44; Santander&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Community&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Contaminated food&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><br>None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0310">9</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Brazil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">St&#46; Catarina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Urban&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Tourists&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sugar cane juice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3<br>&#40;Myocarditis&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0270">1</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Brazil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Par&#225;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Urban&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Reuni&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&#231;a&#237; juice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0315">10</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Brazil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Macaubas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Urban&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Family nucleus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Water&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2<br>&#40;Myocarditis&#47;respiratory failure&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0320">11</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Brazil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cear&#225;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Family nucleus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Vegetable soup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><br>None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0375">22</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Venezuela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chacao&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Urban&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Students<br>Workers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">103&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Guava juice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1<br>&#40;Myocarditis&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0425">32</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">French Guyana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Iracoubo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Urban&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Family nucleus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Palm juice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><br>None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0340">15</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Colombia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lebrija<br>&#40;Santander&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Community&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Orange juice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2<br>&#40;Myocarditis&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0385">24</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Venezuela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chichiriviche&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Urban&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Students<br>Workers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Guava juice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4<br>&#40;Myocarditis&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0390">25</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Venezuela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Tachira&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Urban&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Family nucleus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Contaminated food&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1<br>&#40;Myocarditis&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0355">18</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Colombia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Antioquia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Urban&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Community&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Contaminated food&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1<br>&#40;Unclear&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0360">19</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Colombia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Aguachica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Periurban&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Family nucleus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Contaminated food&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><br>None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0325">12</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Brazil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rio Negro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Tourist boat&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&#231;a&#237; juice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><br>None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0420">31</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Bolivia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Guayamer&#237;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Urban&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Family nucleus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Majo milk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><br>None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0400">27</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Venezuela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Merida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Family nucleus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Contaminated food&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1<br>&#40;Myocarditis&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0370">21</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Colombia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Casanare&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mining sector&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Contaminated food&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><br>None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0405">28</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Venezuela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mirmire&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Community&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mango juice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1<br>&#40;Myocarditis&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0410">29</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Venezuela&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Macarena&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Family nucleus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Natural juice&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3<br>&#40;Myocarditis&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Epidemiological characteristics of orally-transmitted acute Chagas disease outbreaks&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Source of infection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col">Animals of the <span class="elsevierStyleItalic">Didephix</span> genus &#40;opossum&#44; fara&#41; infected by <span class="elsevierStyleItalic">Trypanosoma cruzi</span></th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col">Insect vectors &#40;triatomine&#41; infected by <span class="elsevierStyleItalic">Trypanosoma cruzi</span></th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ingestion-acquired&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fruits or food sprayed with secretions from the odoriferous anal glands&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Undercooked game meat from infected animals&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Foods prepared with crushed insect vectors &#40;cane juice&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Food contaminated with triatomine droppings&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Forms of orally-transmitted acute Chagas disease&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Acquire fruits or other foods from registered suppliers&#44; if possible&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Evaluate food at the time of purchasing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ensure that the food has been stored in clean&#44; waterproof containers&#44; protected from potential contaminants and distant from light sources&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Food always needs to be washed and disinfected before preparing and eating&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Utensils that come into contact with food should be made with smooth&#44; washable&#44; easy to clean and corrosion-resistant materials&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Protect food and kitchen areas from insects or other animals&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Wash vegetables especially if they are eaten raw and store in the refrigerator after having washed them&#44; in dry plastic bags&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cooling or freezing food does not prevent the oral transmission of <span class="elsevierStyleItalic">T&#46; cruzi</span> but cooking<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>45&#176;&#44; pasteurization and freeze drying does&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cook food thoroughly&#44; especially meat&#46; The juice should be clear&#44; not pink&#44; the inner part should not be included&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Food ready for consumption should be protected from contamination&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">The vehicle used for food transport must be clean&#44; with a cover&#44; it should not carry animals&#44; toxic chemicals or other contaminants&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">The hands should always be washed before food ingestion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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      "titulo" => "References"
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                          "etal" => true
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            10 => array:3 [
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              "referencia" => array:1 [
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                  "contribucion" => array:1 [
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos