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Cutaneous collagenous vasculopathy: A rare cause of generalized cutaneous telangiectasia
Vasculopatía colágena cutánea: una causa infrecuente de telangiectasias generalizadas
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She reported no family history of similar lesions or personal or family history of bleeding of mucous membranes. Multiple telangiectasias which turned white with finger pressure were observed on examination, distributed bilaterally and symmetrically in the four limbs (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Skin biopsy showed multiple dilated vessels in the superficial dermis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A), with walls remarkably thickened due to deposition of hyaline material (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B), which was stained with PAS-diastase (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>C) and showed positive immunostaining for collagen IV (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>D). Laboratory results showed no abnormalities.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Cutaneous collagenous vasculopathy is an acquired and idiopathic microangiopathy affecting individuals in the fourth or fifth decade of life. There is no association with systemic disease or specific laboratory findings. Although its definitive diagnosis is histological, an adequate case history is essential to rule out other entities that present with widespread telangiectasia and systemic involvement, such as generalized essential telangiectasia, hereditary hemorrhagic telangiectasia, connective tissue diseases, mastocytosis, amyloidosis, lymphoma or liver disease.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Telangiectasia distribution, age at onset and absence of symptoms and family history are key data.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Vázquez-Osorio I, Gonzalvo-Rodríguez P, Rodríguez-Díaz E. Vasculopatía colágena cutánea: una causa infrecuente de telangiectasias generalizadas. 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