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Letter to the Editor
Nutcracker syndrome associated with thin basement membrane nephropathy
Síndrome del cascanueces asociado a la enfermedad de la membrana basal fina
Marta Cano-Megías
Corresponding author
mcanomegias@gmail.com

Corresponding author.
, Loreto Fernández-Rodríguez, Patricia Martínez-Miguel
Departamento de Nefrología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Nutcracker syndrome &#40;NCS&#41; is a rare cause of non-glomerular hematuria&#46; NCS is the compression of the left renal vein &#40;LRV&#41; between the angle formed by the superior mesenteric artery &#40;SMA&#41; and the aorta&#46; The most popular theory for its cause is an abnormal branching of the SMA from the aorta with compression of the underlying LRV&#44; causing retrograde venous hypertension&#44; renal hilar and ureteral varices&#46; Microscopic rupture of thin-walled collateral veins into the calyceal fornix results in hematuria and proteinuria into the renal collecting system&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The specific examinations include radiological tests such as renal venography&#44; computed tomography scanning &#40;CT&#41;&#44; contrast-enhanced magnetic resonance angiogram and renal Doppler ultrasound&#46; There is controversy about the specific radiological criteria&#44; because some degree of LRV entrapment is a common finding in asymptomatic children and young adults&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">There are reports of concomitant glomerular diseases associated with NCS but its physiopathology is not clear&#46; Hematuria and proteinuria are associated with orthostatism and intense exercise&#46; In cases of maintained or persistent proteinuria&#44; associated glomerulopathy should be suspected&#46; The most common glomerulopathy coexisting with NCS is IgA nephropathy&#46; The association with thin basement membrane nephropathy disease &#40;TBMN&#41; is exceptional&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> We present an unusual case of NCS associated with TBMN disease&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A 31-year-old male was referred to clinic with episodes of macroscopic gross hematuria&#44; anemia and 2 grams of proteinuria per day in the urine analysis&#46; He did not have a family history of chronic kidney disease or episodic hematuria&#46; He has not left flank pain or varicocele&#46; Several three-day long episodes of recurrent hematuria were described at the age of 17&#44; 23 and when he was 30 years old&#59; none of them with a trigger&#46; Glomerular filtration rate was normal&#46; The red blood cells observed in the urine were isomorphic&#44; compatible with non-glomerular origin&#46; Between these episodes&#44; the patient was asymptomatic and the urine analysis confirmed the absence of hematuria or proteinuria&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">CT and a Doppler sonographic were performed&#46; CT showed a decreased angle in the superior mesenteric artery origin&#44; with an entrapment of the LRV&#44; change in its caliber and retrograde venous congestion without increased of pressure measurements in Doppler&#46; Images of varicocele were not found&#46; A kidney biopsy was performed because of persistent proteinuria&#46; Renal biopsy only showed peritubular capillary dilation with hemosiderin pigment deposits in tubular epithelial cells&#46; However&#44; electron microscopy showed structural changes compatible with TBMN&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">NCS is a benign disease and treatment depends on the severity of symptoms&#46; Renin-angiotensin system inhibitors can improve orthostatic proteinuria&#46; Surgical treatment has been reported in severe cases&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">NCS pathophysiology and its association with renal glomerular disease is not clear&#46; Increased capillary wall permeability caused by LRV congestion and hemodynamic changes in glomerular capillaries could produce local tissue anoxia&#44; oxidative damage&#44; atrophy and necrosis of epithelial glomerular and tubular cells&#46; Also&#44; thickness of the glomerular capillary wall&#44; cell proliferation and immunological deposits have been described&#44; which suggests subclinical local immune damage&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The recommendation is to start performing Doppler ultrasound imaging studies&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Peak flow velocity of LRV is higher in symptomatic patients and the peak velocity ratio above and below the affected venous segment increases in children with NCS&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> In some difficult cases&#44; it is recommended to perform velocity measurements after the patient has been standing for 15<span class="elsevierStyleHsp" style=""></span>min so that hemodynamic changes can be detected&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Another helpful sonographic criterion is observing the change in the LRV diameter in relation to the stenosis of the aortomesenteric portion and to the expansion of the renal hilum portion&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> CT imaging may be useful&#46; A decreased aortomesenteric angle and a shortened aortomesenteric distance are complementary diagnostic measures&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">This clinical case highlights that NCS may coexist with a glomerulopathy that can establish the renal prognosis&#46; TBMN affects 1&#37; of the population and is caused by a heterozygous mutation in the collagen genes COL4A3 or COL4A4&#46; TBMN disease has an excellent prognosis&#46; It is characterized by persistent glomerular hematuria without proteinuria&#46; Renal biopsy should be done in cases of proteinuria&#44; hypertension or renal function deterioration&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p></span>"
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Article information
ISSN: 23870206
Original language: English
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