metricas
covid
Buscar en
Medicina Clínica (English Edition)
Toda la web
Inicio Medicina Clínica (English Edition) Warthin-like variant of thyroid papillary carcinoma
Journal Information

Statistics

Follow this link to access the full text of the article

Scientific letter
Warthin-like variant of thyroid papillary carcinoma
Carcinoma papilar de tiroides variante Warthin-like
Pedro Antonio Sánchez Fuentes
Corresponding author
fuentes_2005@hotmail.com

Corresponding author.
, Antonio Ríos, José Manuel Rodríguez
Unidad de Cirugía Endocrina, Servicio de Cirugía General y del Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain
Read
Not available
Times
was read the article
Total PDF
Total HTML
Share statistics
 array:24 [
  "pii" => "S2387020617307106"
  "issn" => "23870206"
  "doi" => "10.1016/j.medcle.2017.10.033"
  "estado" => "S300"
  "fechaPublicacion" => "2017-12-07"
  "aid" => "4236"
  "copyright" => "Elsevier España, S.L.U.. All rights reserved"
  "copyrightAnyo" => "2017"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Med Clin. 2017;149:505-6"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0025775317306383"
      "issn" => "00257753"
      "doi" => "10.1016/j.medcli.2017.07.014"
      "estado" => "S300"
      "fechaPublicacion" => "2017-12-07"
      "aid" => "4236"
      "copyright" => "Elsevier España, S.L.U."
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Med Clin. 2017;149:505-6"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 12
        "formatos" => array:2 [
          "HTML" => 10
          "PDF" => 2
        ]
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fica</span>"
        "titulo" => "Carcinoma papilar de tiroides variante Warthin-like"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "505"
            "paginaFinal" => "506"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Warthin-like variant of thyroid papillary carcinoma"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 2185
                "Ancho" => 2917
                "Tamanyo" => 1498211
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Histolog&#237;a del carcinoma papilar tipo Warthin-like&#46;</p> <p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">1&#46;1&#44; 1&#46;2 y 1&#46;3&#41; Tinci&#243;n hematoxilina-eosina&#44; en distintos aumentos x10&#44; x15 y x30&#44; respectivamente&#46; En las im&#225;genes se objetiva un par&#233;nquima tiroideo con intenso infiltrado inflamatorio cr&#243;nico linfoplasmocitario &#40;&#42;&#41; que desestructura los fol&#237;culos tiroideos&#44; junto a la neoplasia &#40;&#42;&#42;&#41; constituida por ejes conectivos tapizados por c&#233;lulas de citoplasmas amplios eosin&#243;filos y n&#250;cleos con hendiduras en la membrana nuclear&#46; El estroma circundante presenta un intenso infiltrado inflamatorio linfoplasmocitario con formaci&#243;n de agregados linfoides tipo centro germinal primario&#46;</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">1&#46;4&#41; Tinci&#243;n inmunohistoqu&#237;mica para citoqueratina 19&#46; Se visualiza la neoplasia &#40;&#42;&#42;&#41; que es intensamente positiva para citoqueratina 19&#44; caracter&#237;stica del carcinoma papilar&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Pedro Antonio S&#225;nchez Fuentes, Antonio R&#237;os, Jos&#233; Manuel Rodr&#237;guez"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "Pedro Antonio"
                "apellidos" => "S&#225;nchez Fuentes"
              ]
              1 => array:2 [
                "nombre" => "Antonio"
                "apellidos" => "R&#237;os"
              ]
              2 => array:2 [
                "nombre" => "Jos&#233; Manuel"
                "apellidos" => "Rodr&#237;guez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2387020617307106"
          "doi" => "10.1016/j.medcle.2017.10.033"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020617307106?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775317306383?idApp=UINPBA00004N"
      "url" => "/00257753/0000014900000011/v2_201804270431/S0025775317306383/v2_201804270431/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S238702061730699X"
    "issn" => "23870206"
    "doi" => "10.1016/j.medcle.2017.10.022"
    "estado" => "S300"
    "fechaPublicacion" => "2017-12-07"
    "aid" => "4125"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46;"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Med Clin. 2017;149:507"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Prognostic value of interleukin-6 for death in patients with sepsis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "507"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Valor pron&#243;stico de la interleucina-6 en la mortalidad de los pacientes con sepsis"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Lu&#237;s Mart&#237; Arjona, Asunci&#243;n Moreno Camacho"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "Lu&#237;s"
              "apellidos" => "Mart&#237; Arjona"
            ]
            1 => array:2 [
              "nombre" => "Asunci&#243;n"
              "apellidos" => "Moreno Camacho"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0025775317304116"
        "doi" => "10.1016/j.medcli.2017.05.023"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775317304116?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S238702061730699X?idApp=UINPBA00004N"
    "url" => "/23870206/0000014900000011/v1_201712130718/S238702061730699X/v1_201712130718/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2387020617306939"
    "issn" => "23870206"
    "doi" => "10.1016/j.medcle.2017.10.016"
    "estado" => "S300"
    "fechaPublicacion" => "2017-12-07"
    "aid" => "4242"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46;"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Med Clin. 2017;149:504-5"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
      "titulo" => "Atrioventricular block due to papillary fibroelastoma"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "504"
          "paginaFinal" => "505"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Bloqueo auriculoventricular por fibroelastoma papilar"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Elvis Amao-Ruiz, Ana Mar&#237;a Correa-Fern&#225;ndez, Isabel Viqueira-Rodr&#237;guez"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Elvis"
              "apellidos" => "Amao-Ruiz"
            ]
            1 => array:2 [
              "nombre" => "Ana Mar&#237;a"
              "apellidos" => "Correa-Fern&#225;ndez"
            ]
            2 => array:2 [
              "nombre" => "Isabel"
              "apellidos" => "Viqueira-Rodr&#237;guez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0025775317306449"
        "doi" => "10.1016/j.medcli.2017.07.017"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775317306449?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020617306939?idApp=UINPBA00004N"
    "url" => "/23870206/0000014900000011/v1_201712130718/S2387020617306939/v1_201712130718/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Scientific letter</span>"
    "titulo" => "Warthin-like variant of thyroid papillary carcinoma"
    "tieneTextoCompleto" => true
    "saludo" => "<span class="elsevierStyleItalic">Dear Editor</span>&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "505"
        "paginaFinal" => "506"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Pedro Antonio S&#225;nchez Fuentes, Antonio R&#237;os, Jos&#233; Manuel Rodr&#237;guez"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "Pedro Antonio"
            "apellidos" => "S&#225;nchez Fuentes"
            "email" => array:1 [
              0 => "fuentes&#95;2005&#64;hotmail&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "Antonio"
            "apellidos" => "R&#237;os"
          ]
          2 => array:2 [
            "nombre" => "Jos&#233; Manuel"
            "apellidos" => "Rodr&#237;guez"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Unidad de Cirug&#237;a Endocrina&#44; Servicio de Cirug&#237;a General y del Aparato Digestivo&#44; Hospital Cl&#237;nico Universitario Virgen de la Arrixaca&#44; El Palmar&#44; Murcia&#44; Spain"
            "identificador" => "aff0005"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Carcinoma papilar de tiroides variante Warthin-like"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2185
            "Ancho" => 2917
            "Tamanyo" => 1506029
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Histology of Warthin-like papillary carcinoma&#46; &#40;1&#8211;3&#41; Haematoxylin&#8211;eosin staining&#44; at various magnifications &#215;10&#44; &#215;15 and &#215;30&#44; respectively&#46; The images show a thyroid parenchyma with intense chronic lymphoplasmacytic inflammatory infiltrate &#40;&#42;&#41;&#44; which disassociates the thyroid follicles&#44; together with the neoplasm &#40;&#42;&#42;&#41; consisting of connective axes lined by cells with large eosinophilic cytoplasm and nuclei with clefts in the nuclear membrane&#46; The surrounding stroma has an intense lymphoplasmacytic inflammatory infiltrate with formation of primary germinal centre lymphoid aggregates&#46; &#40;4&#41; Immunohistochemical staining for cytokeratin 19&#46; The neoplasm &#40;&#42;&#42;&#41; shown is intensely positive for cytokeratin 19&#44; characteristic of papillary carcinoma&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The Warthin-like variant of papillary thyroid carcinoma is classified within the oncocytic variants and its prevalence is less than 2&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Apel et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> first described it in 1995 as an oncocytic papillary carcinoma with lymphatic stroma&#46; They proposed to call it Warthin-like thyroid tumour&#44; due to its histological resemblance to the papillary cystadenoma lymphomatosum of the salivary gland&#46; The scarcity of published cases makes it difficult to determine their biological behaviour&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 33-year-old woman who presented with multinodular goitre and local compressive symptoms&#46; A grade III goitre was observed on examination&#46; The analysis showed subclinical hypothyroidism &#40;TSH 4&#46;6<span class="elsevierStyleHsp" style=""></span>uUI&#47;ml&#44; T4 1&#46;06<span class="elsevierStyleHsp" style=""></span>ng&#47;dl&#41; and autoimmune thyroiditis &#40;anti-thyroperoxidase antibodies 2000<span class="elsevierStyleHsp" style=""></span>IU&#47;ml&#41;&#46; The ultrasound showed an enlarged thyroid gland&#44; with a dominant right lobe&#44; heterogeneous and hypoechogenic&#44; being classified as TIRADS 2&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A total thyroidectomy due to symptomatic goitre was performed in the context of Hashimoto&#39;s thyroiditis with subclinical hypothyroidism&#46; The histopathological study showed a Warthin-like variant papillary thyroid carcinoma of 0&#46;3<span class="elsevierStyleHsp" style=""></span>cm&#44; located in the left lobe&#44; unifocal&#44; without extrathyroidal invasion&#44; or lymphovascular&#44; with chronic lymphocytic thyroiditis in the rest of the parenchyma &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Curative treatment was considered&#44; starting outpatient follow-up without radioiodine ablation treatment&#46; After 1 year&#44; no recurrence of the disease was observed &#40;thyroglobulin &#60;0&#46;1<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The diagnosis of the Warthin-like variant is histological&#44; characterized by a papillary structure covered by tumour cells with oncocytic change and papillary carcinoma nuclear features&#46; These papillae are supported on fibrovascular stems infiltrated by lymphatic tissue&#46; Oncocytic or H&#252;rthle cells can be observed intertwined in the lymphatic infiltrate&#46; In addition&#44; they are also accompanied by lymphatic infiltrate in the rest of the healthy parenchyma&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The role of cytology is still doubtful because of the difficulty of distinguishing it from lymphocytic thyroiditis&#46; The oncocytic variant and the high cell variant are part of the differential diagnosis&#46; The first one is characterized by oncocytic cells with papillary carcinoma nuclear features and without lymphocytic infiltrate&#46; It has an uncertain prognosis&#46; And the second is characterized by elongated oncocytic cells with twice as much height as width&#44; eccentric nucleus and lymphocytic infiltrate&#46; Clinically&#44; this variant behaves more aggressively&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The pathological significance of the lymphatic infiltrate remains unclear&#46; It is unknown if its role is protective in response to the antigenic stimulus of the neoplasm&#44; or on the contrary&#44; represents a growth factor for the proliferation of the tumour cells&#46; With the current evidence it is considered that the coexistence of papillary carcinoma with thyroiditis results in reduced neoplastic aggressiveness&#44; with better long-term results than without thyroiditis&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">After having reviewed the cases described in the literature&#44; less than 30&#37; show extrathyroidal extension and&#47;or lymphatic invasion&#46; Recurrence was only reported in 3 cases<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">3&#8211;5</span></a> and in 2 others it was associated with undifferentiated carcinoma&#44; one of them being the only case of mortality associated with the Warthin-like variant &#40;10&#37; of tumour was undifferentiated&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Regarding tumour behaviour&#44; the study by Yeo et al&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> is the only one that compares the Warthin-like variant with the classical one&#44; and it was found that the former is associated more with Hashimoto&#39;s thyroiditis and less with the BRAF mutation&#44; being similar in the other variables&#46; In the absence of other studies&#44; the prognosis is considered similar to that of the classical variant&#46; Consequently&#44; treatment and follow-up is based on the current recommendations for classical papillary carcinoma&#46; In the case reported&#44; in addition to the histological type&#44; its size is subcentimetric&#44; so it was treated as a papillary microcarcinoma&#44; which justifies not performing central lymphadenectomy or administration of ablative radioiodine therapy&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion&#44; the identification of the histological variant in papillary thyroid carcinoma is essential for the therapeutic and follow-up approach&#46; And in the absence of more studies&#44; the Warthin-like variant has a behaviour similar to the classical variant&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; S&#225;nchez Fuentes PA&#44; R&#237;os A&#44; Rodr&#237;guez JM&#46; Carcinoma papilar de tiroides variante Warthin-like&#46; Med Clin &#40;Barc&#41;&#46; 2017&#59;149&#58;505&#8211;506&#46;</p>"
      ]
    ]
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2185
            "Ancho" => 2917
            "Tamanyo" => 1506029
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Histology of Warthin-like papillary carcinoma&#46; &#40;1&#8211;3&#41; Haematoxylin&#8211;eosin staining&#44; at various magnifications &#215;10&#44; &#215;15 and &#215;30&#44; respectively&#46; The images show a thyroid parenchyma with intense chronic lymphoplasmacytic inflammatory infiltrate &#40;&#42;&#41;&#44; which disassociates the thyroid follicles&#44; together with the neoplasm &#40;&#42;&#42;&#41; consisting of connective axes lined by cells with large eosinophilic cytoplasm and nuclei with clefts in the nuclear membrane&#46; The surrounding stroma has an intense lymphoplasmacytic inflammatory infiltrate with formation of primary germinal centre lymphoid aggregates&#46; &#40;4&#41; Immunohistochemical staining for cytokeratin 19&#46; The neoplasm &#40;&#42;&#42;&#41; shown is intensely positive for cytokeratin 19&#44; characteristic of papillary carcinoma&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:5 [
            0 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Warthin-Like variant of papillary thyroid carcinoma&#58; a comparison with classic type in the patients with coexisting Hashimoto&#39;s thyroiditis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;K&#46; Yeo"
                            1 => "J&#46;S&#46; Bae"
                            2 => "S&#46; Lee"
                            3 => "M&#46;H&#46; Kim"
                            4 => "D&#46;J&#46; Lim"
                            5 => "Y&#46;S&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2015/456027"
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Endocrinol"
                        "fecha" => "2015"
                        "volumen" => "2015"
                        "paginaInicial" => "456027"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25983754"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#8220;Warthin-like tumor&#8221; of the thyroid"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;L&#46; Apel"
                            1 => "S&#46;L&#46; Asa"
                            2 => "V&#46;A&#46; LiVolsi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Surg Pathol"
                        "fecha" => "1995"
                        "volumen" => "19"
                        "paginaInicial" => "810"
                        "paginaFinal" => "814"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7793479"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0890856714000483"
                          "estado" => "S300"
                          "issn" => "08908567"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Warthin-like tumor variant of papillary thyroid carcinoma&#58; case report and literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Urano"
                            1 => "M&#46; Abe"
                            2 => "M&#46; Kuroda"
                            3 => "Y&#46; Mizoguchi"
                            4 => "Y&#46; Horibe"
                            5 => "M&#46; Kasahara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pathol Int"
                        "fecha" => "2001"
                        "volumen" => "51"
                        "paginaInicial" => "707"
                        "paginaFinal" => "712"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11696174"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Warthin tumor-like variant of papillary thyroid carcinoma&#58; a case with dedifferentiation &#40;anaplastic changes&#41; and aggressive biological behavior"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;Y&#46; Lam"
                            1 => "C&#46;Y&#46; Lo"
                            2 => "W&#46;I&#46; Wei"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocr Pathol"
                        "fecha" => "2005"
                        "volumen" => "16"
                        "paginaInicial" => "83"
                        "paginaFinal" => "89"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16000851"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Warthin-like tumor of the thyroid a case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Sarkady"
                            1 => "Z&#46; S&#225;pi"
                            2 => "V&#46; T&#243;th"
                            3 => "S&#46; Kiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pathol Oncol Res"
                        "fecha" => "1999"
                        "volumen" => "5"
                        "paginaInicial" => "315"
                        "paginaFinal" => "317"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10607928"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/23870206/0000014900000011/v1_201712130718/S2387020617307106/v1_201712130718/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "43311"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Scientific letters"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/23870206/0000014900000011/v1_201712130718/S2387020617307106/v1_201712130718/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020617307106?idApp=UINPBA00004N"
]
Article information
ISSN: 23870206
Original language: English
The statistics are updated each day

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos