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(B) Deposits of amyloid of latent pattern, filling the red pulp of the spleen, confluently, respecting the follicles and a sinusoid outline around it. Inset: Deposits under polarised light that show apple green birefringence.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alba Manuel-Vázquez, Yuri Rodrigues Figueira, José Manuel Ramia" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Alba" "apellidos" => "Manuel-Vázquez" ] 1 => array:2 [ "nombre" => "Yuri" "apellidos" => "Rodrigues Figueira" ] 2 => array:2 [ "nombre" => "José Manuel" "apellidos" => "Ramia" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0025775318305372" "doi" => "10.1016/j.medcli.2018.07.019" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775318305372?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020619300956?idApp=UINPBA00004N" "url" => "/23870206/0000015200000008/v1_201904100623/S2387020619300956/v1_201904100623/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image in medicine</span>" "titulo" => "Job syndrome" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "331" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "José Ramón Vizán-Caravaca, José Miguel García-Castro, Sara López-García" "autores" => array:3 [ 0 => array:4 [ "nombre" => "José Ramón" "apellidos" => "Vizán-Caravaca" "email" => array:1 [ 0 => "joserra.vizan@gmai.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "José Miguel" "apellidos" => "García-Castro" ] 2 => array:2 [ "nombre" => "Sara" "apellidos" => "López-García" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Medicina Interna, Hospital Santa Ana, Motril, Granada, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome de Job" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 979 "Ancho" => 1400 "Tamanyo" => 163209 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 24-year-old man, with no personal or family history of interest, under study for recurrent staphylococcal skin infections such as folliculitis and abscesses, requiring surgical drainage in several occasions. In the anamnesis, he reported a history of atopic dermatitis and eczema since childhood, as well as recurrent otitis, bronchial asthma and delayed tooth eruption. Physical examination revealed coarse facies, oropharyngeal candidiasis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A), multiple folliculitis lesions and pustulosis in abdomen (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B) and limbs (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C), and several skin cold abscesses (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D). The additional tests, showed increased immunoglobulin E (IgE) levels up to 988.6<span class="elsevierStyleHsp" style=""></span>IU/ml (0–100). Given the suspicion of a primary immune deficiency such as hyper-immunoglobulin E syndrome (HIES), a specific genetic study was requested, which showed heterozygous mutation of STAT3 gene, which confirmed the diagnosis of autosomal dominant HIES. Antibiotic prophylaxis with trimethoprim–sulfamethoxazole significantly improved his symptomatology.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">HIES or Job syndrome is a rare primary immunodeficiency first described in 1966, clinically characterized by dermatitis and recurrent bacterial infections in skin and lungs. It also occurs with abnormalities in dental, musculoskeletal and facial development, neurological and vascular problems, along with an increased risk of lymphoma.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Vizán-Caravaca JR, García-Castro JM, López-García S. Síndrome de Job. Med Clin (Barc). 2019;152:331.</p>" ] ] "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 979 "Ancho" => 1400 "Tamanyo" => 163209 ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000015200000008/v1_201904100623/S2387020619300968/v1_201904100623/en/main.assets" "Apartado" => array:4 [ "identificador" => "51820" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in medicine" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000015200000008/v1_201904100623/S2387020619300968/v1_201904100623/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020619300968?idApp=UINPBA00004N" ]
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