Image in medicine
Acyclovir-induced acute kidney injury
Fracaso renal agudo secundario a aciclovir
Ana Coscojuela Otto
, Jose María Peña Porta, Rafael Álvarez Lipe
Corresponding author
Servicio de Nefrología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
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He consulted the emergency department because of general malaise, nausea and visual disturbances lasting 24 h. The patient had been discharged 24 h prior, after receiving treatment for a suspected viral encephalitis with intravenous acyclovir, diagnosis that was subsequently ruled out. The analytical blood and urine tests carried out in the emergency laboratory highlighted serum creatinine levels of 6 mg/dl (prior renal function normal) and the presence of intraleucocitarios crystals in urine sediment (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>), highly suggestive of pharmacological aetiology. These findings were associated with the recent treatment with acyclovir, a drug that is insoluble in urine and capable of precipitating in the form of intratubular crystals, causing tubular obstruction and inflammation, which caused the acute renal failure that this patient presented. Intensive fluid therapy treatment was initiated, creatinine levels normalised and the patient remained asymptomatic.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The importance of urinary sediment examination in the initial diagnosis of acute renal failure should be noted.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-03-06" "fechaAceptado" => "2019-03-31" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Coscojuela Otto A, et al. Fracaso renal agudo secundario a aciclovir. 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