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Anetoderma associated with antiphospholipid syndrome
Anetodermia asociada a síndrome antifosfolipídico
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class="elsevierStylePara elsevierViewall">A 35-year-old Argentine woman without a medical history of interest consulted for hyperpigmented soft-touch asymptomatic macules and plaques, located in the upper limbs (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A and B). While collecting a directed history, the patient also reported pain and inflammation in the proximal interphalangeal joints, asthenia of months of evolution, recurrent episodes of fever without focus and an abortion of more than 12 weeks. A complementary study was requested which included biochemistry, blood count, thyroid function, serology (HAV, HBV, HIV, <span class="elsevierStyleItalic">Borrelia burgdorferi</span> and syphilis) and autoimmunity, highlighting ANA 1/320 and anti-Ro positive, anticardiolipin and anti-lupus anticoagulant positive in two determinations. A biopsy of healthy perilesional skin and lesional skin was performed, showing a normal distribution of elastic fibres in healthy skin, compared with the affected skin that showed inflammatory phase anetoderma with absence of elastic fibres, using Van Gieson staining. Anetoderma secondary to antiphospholipid syndrome was diagnosed in a patient with systemic lupus erythematosus. The patient refused to start treatment for skin lesions.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Anetoderma, a rare connective tissue disorder, may be an early skin manifestation of autoimmune disease. Antiphospholipid syndrome and prothrombotic disorders are associated, so if suspected, the relevant study should be performed to rule out a systemic cause (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Carmona JM, Moyano EG, Blanca MA, Pilar LM. Anetodermia asociada a síndrome antifosfolipídico. 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