Image in medicine
Pemphigoid gestationis
Penfigoide gestacional
Fernando García Souto
, Sandra Cases Mérida, Jerónimo Escudero Ordoñez
Corresponding author
Departamento de Dermatología, Hospital Universitario de Valme, Ctra. de Cádiz, Km. 548,9, 41001 Sevilla, Spain
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Physical examination revealed round urticarial plaques on her trunk and thighs, with characteristic involvement of the umbilical region (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). A closer view showed typical annular disposition of bullae around erythematous plaques (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). A skin biopsy exhibited spongiosis in combination with moderate superficial perivascular lymphocytic infiltrate with eosinophils. Direct immunofluorescence of perilesional skin exhibited linear deposition of complement (C3) along the basement membrane zone. Treatment with systemic corticosteroids was started with favorable response.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Pemphigoid gestationis is a rare autoimmune bullous disorder arising exclusively during pregnancy. 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