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Letter to the Editor
Primary biliary cholangitis in a patient with metastatic breast cancer
Colangitis biliar primaria en una paciente con cáncer de mama metastásico
Kevin Doello
Corresponding author
kevindoello@gmail.com

Corresponding author.
, María Trinidad Rueda, Víctor Amezcua
Servicio de Oncología Médica, Hospital Virgen de las Nieves, Granada, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Primary biliary cholangitis &#40;PBC&#41; is a liver autoimmune disease characterized by laboratory &#40;increased ALP and GGT&#41; and clinical &#40;pruritus&#44; acholia and choluria&#41; signs of cholestasis and positive for anti-mitochondrial antibodies in titers greater than 1&#47;40&#46; Drugs such as ursodeoxycholic acid and cholestyramine resin are often used in its management&#44; and some cases are considered for liver transplantation&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Cases have been described in which this disease has preceded the diagnosis of breast cancer&#44; proposing it as a possible paraneoplastic syndrome&#46; However&#44; there is no reported case of onset in the course of breast cancer&#46; Next&#44; we report a case of PBC diagnosed during treatment for metastatic breast cancer&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 50-year-old woman diagnosed with triple negative metastatic breast cancer with liver involvement&#46; In July 2018&#44; she began with symptoms of acholia&#44; choluria&#44; and elevated cholestasis enzymes&#46; Coinciding with this phenomenon&#44; a metastatic tumour progression was observed in the liver&#44; for which these symptoms were attributed to her underlying cancer disease&#46; Treatment with Xeloda&#174; &#40;capecitabine&#41; 1000&#8239;mg&#47;m<span class="elsevierStyleSup">2</span>&#47;every 12&#8239;h was initiated&#46; At 3 months&#44; a re-evaluation CT scan was performed&#44; which indicated that the patient was in partial response&#44; so she continued with the treatment&#46; In January 2019&#44; the patient suffered an episode of hematemesis&#44; undergoing an upper digestive endoscopy in which oesophageal varices were observed&#46; The patient was admitted to the ward and an abdominal CT scan was performed considering portal hypertension associated with tumour progression&#46; However&#44; the CT scan showed a partial response to focal liver lesions and intense cirrhotic changes along with oesophageal varices&#46; As there was no clear explanation for this fact&#44; a complete liver disease study was requested including serologies for hepatitis B and C&#44; and a full autoimmunity study&#46; Finally&#44; positive results for anti-mitochondrial antibodies &#40;AMA&#41; were obtained at a titre of 1&#47;80&#46; For this reason&#44; treatment with nadolol&#44; ursodeoxycholic acid&#44; fenofibrate and cholestyramine resin was initiated&#44; despite which hematemesis persisted&#46; However&#44; due to the poor general condition of the patient and the frequent upper gastrointestinal bleeding as a result of oesophageal varices&#44; together with her advanced cancer and liver disease&#44; band ligation was ruled out and comfort measures were initiated&#44; and the patient died after 48&#8239;h&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">According to Mart&#237;n-Scapa and Cano<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> the PBC criteria are 3&#58; AMA titers greater than 1&#47;40&#44; an increase in ALP of 2&#8211;10 times the normal value for at least 6 months&#44; and compatible histology&#46; The diagnosis is accepted with 2 out of 3 of the above criteria&#46; Our patient only met the first 2 criteria since a liver biopsy was not performed due to her general condition&#46; Still&#44; these criteria would indicate the diagnosis of PBC&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Regarding the relationship between PBC and cancer&#44; Liang et al&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> published a meta-analysis in which they analysed the previous diagnosis of PBC and the risk of developing cancer&#46; They obtained an increased risk of cancer for PBC patients &#40;relative risk 1&#46;55&#41;&#44; mainly at the expense of liver cancer &#40;relative risk 18&#46;80&#41;&#44; although tumours from other locations &#40;breast&#44; colon&#44; pancreas&#44; etc&#46;&#41; were also included&#46; If we focus solely on breast cancer&#44; Wolke et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> showed that patients with PBC had an incidence 4&#46;4 times higher than the population without PBC&#46; For this reason&#44; some authors argue that PBC could be a paraneoplastic phenomenon prior to the clinical occurrence of breast cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The case discuss would have a peculiarity&#44; since it would be the first case of PBC diagnosed during the treatment of a metastatic breast cancer&#46; All the cases described to date have been prior to cancer&#46; This case makes us think that probably&#44; and as some authors claim&#44; PBC could be a paraneoplastic phenomenon associated with breast cancer&#46;</p></span>"
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Article information
ISSN: 23870206
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos