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Letter to the Editor
Influenza vaccine in patients on biologic therapy; also with belimumab
Vacuna de la gripe en pacientes tratados con fármacos biológicos; también con belimumab
José Luis Callejas Rubioa,
Corresponding author
jlcalleja@telefonica.net

Corresponding author.
, Carmen Valero Ubiernab, Norberto Ortego Centenoa
a Unidad de Enfermedades Sistémicas, Servicio de Medicina Interna, Hospital San Cecilio de Granada, Granada, Spain
b Servicio de Medicina Preventiva, Hospital San Cecilio de Granada, Granada, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We have read with interest the article recently published in your journal by Richi et al&#46; on influenza vaccine response in patients receiving biologic therapies<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; Multiple biologics were included in the study&#44; but we have missed belimumab&#44; a biologic agent approved for the treatment of systemic lupus erythematosus &#40;SLE&#41;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The pivotal study of belimumab in SLE&#44; BLISS-76&#44; which included patients treated with placebo or monthly intravenous belimumab for 76 weeks&#44; assessed a group of patients who had received different vaccinations&#44; including the influenza vaccine&#46; Antibodies were determined at baseline and at 52 weeks&#44; and the percentage of change in the levels and the proportion of patients who maintained the levels were assessed&#46; No significant changes were observed in the antigens of the vaccine received in 2007&#8211;8&#44; nor in the percentage that maintained titers&#46; In patients who received influenza vaccination&#44; overall&#44; the titers increased significantly&#44; although it was higher in patients with placebo than those treated&#44; although in some strains&#44; namely Brisbane 10 and 59&#44; the percentage of patients with titres &#62;1&#58;10 was lower in treated patients<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46; The authors conclude that belimumab treatment does not affect pre-existing antibodies in response to influenza vaccination in SLE patients&#44; and that there does not appear to be an increased risk of inadequate response to vaccination during belimumab treatment&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The current recommendations with the available results are in favour of influenza vaccination of patients with SLE under treatment with belimumab<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46; We vaccinate all our treated patients in our routine practice&#46;</p></span>"
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Original language: English
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