Letter to the Editor
Tuberculosis during lenalidomide maintenance in a patient with multiple myeloma
Tuberculosis durante el mantenimiento con lenalidomida en un paciente con mieloma múltiple
Read
Not available
Timeswas read the article
Total PDF
Total HTML
Share statistics
array:24 [ "pii" => "S2387020621000565" "issn" => "23870206" "doi" => "10.1016/j.medcle.2019.12.021" "estado" => "S300" "fechaPublicacion" => "2021-03-12" "aid" => "5073" "copyright" => "Elsevier España, S.L.U.. All rights reserved" "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2021;156:258-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "en" => array:19 [ "pii" => "S0025775320300890" "issn" => "00257753" "doi" => "10.1016/j.medcli.2019.12.010" "estado" => "S300" "fechaPublicacion" => "2021-03-12" "aid" => "5073" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2021;156:258-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Tuberculosis during lenalidomide maintenance in a patient with multiple myeloma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "258" "paginaFinal" => "259" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tuberculosis durante el mantenimiento con lenalidomida en un paciente con mieloma múltiple" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 776 "Ancho" => 2167 "Tamanyo" => 163550 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A and B) PET-CT with pulmonary nodule in the left lower lobe.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Gladys Ibarra Fernández, Josep Maria Ribera, Laura Abril Sabater" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Gladys Ibarra" "apellidos" => "Fernández" ] 1 => array:2 [ "nombre" => "Josep Maria" "apellidos" => "Ribera" ] 2 => array:2 [ "nombre" => "Laura Abril" "apellidos" => "Sabater" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2387020621000565" "doi" => "10.1016/j.medcle.2019.12.021" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621000565?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775320300890?idApp=UINPBA00004N" "url" => "/00257753/0000015600000005/v1_202102240836/S0025775320300890/v1_202102240836/en/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S2387020621000449" "issn" => "23870206" "doi" => "10.1016/j.medcle.2019.12.017" "estado" => "S300" "fechaPublicacion" => "2021-03-12" "aid" => "5083" "copyright" => "Elsevier España, S.L.U." "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Med Clin. 2021;156:260" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Image in medicine</span>" "titulo" => "Blue papule on a nevus spilus" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "260" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pápula azulada sobre <span class="elsevierStyleItalic">nevus spilus</span>" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1325 "Ancho" => 2258 "Tamanyo" => 245615 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Nicolás Silvestre Torner, Adrián Imbernón Moya, Marta Martínez García, Sergio Tabbara Carrascosa" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Nicolás" "apellidos" => "Silvestre Torner" ] 1 => array:2 [ "nombre" => "Adrián" "apellidos" => "Imbernón Moya" ] 2 => array:2 [ "nombre" => "Marta" "apellidos" => "Martínez García" ] 3 => array:2 [ "nombre" => "Sergio" "apellidos" => "Tabbara Carrascosa" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621000449?idApp=UINPBA00004N" "url" => "/23870206/0000015600000005/v1_202103120836/S2387020621000449/v1_202103120836/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2387020621000437" "issn" => "23870206" "doi" => "10.1016/j.medcle.2019.12.016" "estado" => "S300" "fechaPublicacion" => "2021-03-12" "aid" => "5082" "copyright" => "Elsevier España, S.L.U." "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Med Clin. 2021;156:257" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Ischemic ictus by calcium embolus in a patient in hemodialysis with secondary hyperparathyroidism" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "257" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Ictus isquémico por émbolo cálcico en un paciente en hemodiálisis con hiperparatiroidismo secundario" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 925 "Ancho" => 905 "Tamanyo" => 97431 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Calcified embolus in the M3 segment of the right middle cerebral artery.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Elena Hernández García, Lidia Díaz Gómez, Elena Borrego García" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Elena" "apellidos" => "Hernández García" ] 1 => array:2 [ "nombre" => "Lidia" "apellidos" => "Díaz Gómez" ] 2 => array:2 [ "nombre" => "Elena" "apellidos" => "Borrego García" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621000437?idApp=UINPBA00004N" "url" => "/23870206/0000015600000005/v1_202103120836/S2387020621000437/v1_202103120836/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Tuberculosis during lenalidomide maintenance in a patient with multiple myeloma" "tieneTextoCompleto" => true "saludo" => "Dear Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "258" "paginaFinal" => "259" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Gladys Ibarra Fernández, Josep Maria Ribera, Laura Abril Sabater" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Gladys Ibarra" "apellidos" => "Fernández" "email" => array:1 [ 0 => "gibarra2601@hotmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Josep Maria" "apellidos" => "Ribera" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Laura Abril" "apellidos" => "Sabater" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Hematología, ICO-Badalona, Hospital Germans Trias i Pujol, Badalona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Instituto de Investigación contra la Leucemia Josep Carreras. Universitat Autònoma de Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tuberculosis durante el mantenimiento con lenalidomida en un paciente con mieloma múltiple" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 776 "Ancho" => 2167 "Tamanyo" => 163550 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A and B) PET-CT with pulmonary nodule in the left lower lobe.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The development of the granuloma and its subsequent degeneration and necrosis, is the hallmark of infection caused by <span class="elsevierStyleItalic">Mycobacterium</span><span class="elsevierStyleItalic">tuberculosis</span>.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Immunosuppressed individuals are at high risk of developing active tuberculosis once infected.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> In patients with multiple myeloma, cell-mediated immunity is suppressed by both the primary disease and the treatments, such as steroids, proteasome inhibitors, and immunomodulatory drugs.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> Lenalidomide and pomalidomide, structural analogs of thalidomide, have been approved to treat multiple myeloma by FDA in 2006 and 2013, and significant toxicities such as neutropenia, myelosuppression, thrombocytopenia, and serious infections are commonly associated with their use. The mechanisms by which lenalidomide increases the risk of infections remain unclear.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">4</span></a> Maintenance with lenalidomide after autologous hematopoietic stem cell transplantation (HSCT) is currently used and although it improves progression-free survival, long-term adverse effects are still unknown. We report the case of a patient with a diagnosis of multiple myeloma receiving lenalidomide, who developed cough and a pulmonary nodule of tuberculous origin.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 49-year-old Chinese man, former smoker, was diagnosed with IgD lambda multiple myeloma, International Score System III, in November 2017. He initially received 5 cycles of bortezomib, thalidomide and dexamethasone, as well as radiotherapy (30<span class="elsevierStyleHsp" style=""></span>Gy) on a pelvic plasmocytoma. Autologous HSCT was subsequently performed, after which the patient showed partial response. In October 2018 the patient started maintenance treatment with lenalidomide 10<span class="elsevierStyleHsp" style=""></span>mg/day, p.o. In April 2019, being in complete remission of the myeloma, the patient presented cough and chest pain without fever. A PET/CT scan showed a pulmonary nodule in the left lower lobe, 4<span class="elsevierStyleHsp" style=""></span>cm in diameter with signs of necrosis (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Fiberoptic bronchoscopy with bronchoalveolar lavage showed tracheal distorsion, extrinsic compression and thickening of the bronchial mucosa. Microbiological culture was positive for <span class="elsevierStyleItalic">Mycobacterium tuberculosis complex</span>. Transbronchial biopsy demonstrated granulomatous inflammation with caseous necrosis and positive Ziehl-Neelsen stain. The patient was started antituberculous therapy with rifampicine, isoniazid, pyrazinamide and ethambutol hydrochloride, which led to rapid improvement of symptoms. Maintenance treatment with lenalidomide was discontinued and close monitoring of the monoclonal component was performed. Currently, 7 months after having discontinued maintenance the patient remains in complete response of myeloma with disappearance of the chest lesion.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Lenalidomide is an immunomodulatory drug widely used in myeloma treatment, either as front line or at relapse as well as in maintenance after autologous HSCT. Lenalidomide has impact on the immune system predisposing patients to opportunistic infections. Lenalidomide maintenance therapy has been associated with twice the risk of severe infection compared to thalidomide therapy.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Mycobacterium tuberculosis has not commonly reported in myeloma patients. Most cases reported involve newly diagnosed patients or patients in relapse under treatment for disease in activity. This was not the case of the patient herein reported, who was in complete response and only received maintenance therapy. In our patient, the appearance of the pulmonary nodule could have suggested relapse of the disease as a plasmocytoma, with erroneous indication of other line of antimyeloma therapy. Given the risks of misdiagnosis or delayed diagnosis, we highlight the importance of performing invasive diagnostic procedures, such as biopsy, to obtain samples for microbiological analysis in all cases of nodule pulmonary lesions, especially in the immunocompromised host even if the patients do not have clear signs of infection.</p><p id="par0025" class="elsevierStylePara elsevierViewall">We decided to interrupt the treatment because the patient was in remission and the interaction or toxicity of the concurrent use of lenalidomide and a cocktail of antituberculous drugs is unknown. In fact, at present there are no consensus regarding the management of this type of infections in myeloma patients who do not have active disease. We suggest routine screening for latent TB infection before starting lenalidomide maintenance.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 776 "Ancho" => 2167 "Tamanyo" => 163550 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A and B) PET-CT with pulmonary nodule in the left lower lobe.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0030" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The formation of the granuloma in tuberculosis infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "I.M. Orme" 1 => "R.J. Basaraba" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.smim.2014.09.009" "Revista" => array:6 [ "tituloSerie" => "Semin Immunol" "fecha" => "2014" "volumen" => "26" "paginaInicial" => "601" "paginaFinal" => "609" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25453231" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0035" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lenalidomide and the risk of serious infection in patients with multiple myeloma: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Ying" 1 => "T. YinHui" 2 => "Z. Yunliang" 3 => "H. Sun" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Oncotarget" "fecha" => "2017" "volumen" => "8" "paginaInicial" => "46593" "paginaFinal" => "46600" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0040" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infections in patients with multiple myeloma in the era of high-dose therapy and novel agents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Nucci" 1 => "E. Anaissie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/605664" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2009" "volumen" => "49" "paginaInicial" => "1211" "paginaFinal" => "1225" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19769539" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0045" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunomodulatory drugs and the risk of serious infection in multiple myeloma: systematic review and meta-analysis of randomized and observational studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Chen" 1 => "G. Zhao" 2 => "C. Xu" 3 => "X. Wang" 4 => "X. Zhang" 5 => "B. Mao" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00277-018-3284-y" "Revista" => array:6 [ "tituloSerie" => "Ann Hematol" "fecha" => "2018" "volumen" => "97" "paginaInicial" => "925" "paginaFinal" => "944" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29500711" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0050" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infection risk with inmunomodulatory and proteasome inhibitor-base therapies across treatment phases for multiple myeloma: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B.W. Ted" 1 => "S.J. Harrison" 2 => "L.J. Worth" 3 => "K.A. Thursky" 4 => "M.A. Slavin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejca.2016.07.025" "Revista" => array:6 [ "tituloSerie" => "Eur J Cancer" "fecha" => "2016" "volumen" => "67" "paginaInicial" => "21" "paginaFinal" => "37" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27592069" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000015600000005/v1_202103120836/S2387020621000565/v1_202103120836/en/main.assets" "Apartado" => array:4 [ "identificador" => "43309" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000015600000005/v1_202103120836/S2387020621000565/v1_202103120836/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621000565?idApp=UINPBA00004N" ]
