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Letter to the Editor
Tuberculous spondylodiscitis with a cervicothoracic spinal cord compression
Mielopatía compresiva cérvico-torácica por una espondilodiscitis tuberculosa
Javier Molina-Gila,
Corresponding author
javimol1993@hotmail.com

Corresponding author.
, Lucía Meijide Rodríguezb, Manuel Amorín-Díaza
a Servicio de Neurología, Hospital Universitario Central de Asturias, Oviedo, Spain
b Servicio de Medicina Interna, Hospital Universitario Central de Asturias, Oviedo, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Tuberculosis is the second most common infectious disease worldwide and the leading cause of osteomyelitis in certain regions&#46; Pulmonary involvement is the most common type&#44; but there are also other variants such as spinal tuberculosis&#44; which accounts for 1&#37; of all cases&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In this paper we present the case of a 50-year-old man from Equatorial Guinea who has been living in Spain since 2002 and has a history of liver cirrhosis secondary to hepatitis B and a chronic kidney disease of unknown etiology for which he undergoes hemodialysis&#46; He presented to another hospital for a ten-day episode of cervical pain&#44; paresthesia in his upper limbs&#44; and progressive weakness in his lower limbs&#46; Three days later&#44; he lost his ability to walk and consequently visited our clinic&#46; A physical examination revealed a positive Lhermitte&#39;s sign&#44; a muscle balance of 4&#47;5 in the upper limbs and of 2&#47;5 in the lower limbs&#44; patellar hyperreflexia&#44; a T8 medullary sensory level&#44; and no Babinski reflex bilaterally&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A basic blood count revealed no relevant findings&#46; A chest X-ray showed no signs of tuberculosis stigmas&#46; A spinal magnetic resonance imaging &#40;MRI&#41; scan was requested&#44; observing images of C7-T1 spondylodiscitis&#44; voluminous paravertebral collections&#44; and a 2&#46;4-cm epidural abscess with significant spinal cord involvement and protrusion through the intervertebral foramina&#44; all of which were compatible with a diagnosis of tuberculous myeloradiculopathy &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was also assessed in the Neurology Department&#44; where immediate spinal decompression surgery was ruled out and surgical drainage of the prevertebral collection was performed&#46; Although a sputum smear microscopy screening for acid-fast bacilli and a mycobacteria culture were both negative&#44; a polymerase chain reaction &#40;PCR&#41; test was positive for <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#46; A QuantiFERON-TB Gold test supported this finding&#46; A sputum microbiology study was also negative&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Based on the above&#44; tuberculostatic therapy with isoniazid&#44; rifampicin&#44; pyrazinamide&#44; and ethambutol was administered for two months&#44; followed by isoniazid and rifampicin for another four months&#46; A cervicothoracic computed tomography &#40;CT&#41; scan performed after one month of treatment revealed a C7-T1 vertebral collapse and a persistent epidural abscess&#44; which were treated by means of a corpectomy&#44; intervertebral fusion&#44; and aspiration of the collection&#46; The patient&#8217;s subsequent clinical evolution was torpid&#44; with persistent paraplegia&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Tuberculous spondylodiscitis&#44; also known as Pott&#39;s disease&#44; is a common cause of spinal infection in developing countries and endemic areas&#46; However&#44; its incidence has increased in our setting over the last decade as a result of immigration and immunosuppression in subjects with the human immunodeficiency virus &#40;HIV&#41;&#44; chronic kidney disease&#44; cancer&#44; or those receiving chemotherapy or next-generation biologics&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The predominant causative agent is <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#46; Hematogenous dissemination of the bacillus occurs after the primary pulmonary infection&#44; with colonization of the anterior region of the vertebral body&#44; where a granulomatous inflammatory reaction characterized by osteolysis develops&#46; This process preferentially affects the thoracic and thoracolumbar portions of the spine in more than 50&#37; of cases&#44; followed by the lumbar portion and&#44; rarely&#44; the cervical or cervicothoracic portions&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The disease follows an insidious course&#44; lasting between two and seven months&#44; and manifesting with dorsal pain&#44; kyphosis&#44; constitutional syndrome&#44; and fever&#46; Almost half of the patients that suffer from this disease develop neurological complications due to the spinal cord compression or its direct invasion&#44; developing myeloradiculopathy with secondary paraparesis or tetraparesis in 10&#8211;27&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The progression of the condition was faster in our patient&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">A high degree of clinical suspicion is crucial&#44; although the definitive diagnosis is usually reached through a combination of microbiological and histological analyses of a biopsy sample or an excisional surgery specimen&#44; with a yield of 70&#8211;80&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Imaging tests&#44; particularly MRI&#44; play a fundamental role in the diagnostic approach and follow-up&#46; The typical pattern of this condition consists in scarce vertebral involvement associated with extensive infiltration of the contiguous soft tissues&#44; as in the present case&#44; contrary to what occurs in spondylodiscitis caused by <span class="elsevierStyleItalic">Staphylococcus aureus&#46;</span><a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The combination of treatment with four tuberculostatic drugs &#40;isoniazid&#44; rifampicin&#44; pyrazinamide&#44; and ethambutol&#41; for six months&#44; which was the regimen prescribed to our patient&#44; represents the generally accepted therapeutic approach&#46; Some experts propose prolonging this treatment to up to nine or 12 months based on the condition&#8217;s clinical or radiological evolution&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Several authors also defend the need for surgery as a complement to the standard medical treatment in the case of acute spinal cord compromise or structural instability of the spine&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">In short&#44; because the continuous migratory flows and the immunosuppression of many patients have led to an increase in cases of tuberculous spondylodiscitis in our setting&#44; it is essential to consider this condition in the differential diagnosis of acute spinal cord syndrome&#44; as the diagnostic-therapeutic delay can be catastrophic&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors of this paper declare that they have not received funding from any public or private entity in the process of writing this manuscript&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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