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Letter to the Editor
Morvan syndrome: case report
Síndrome de Morvan: Presentación de un caso
Anna Esquerràa,
Corresponding author
anna.esquerra.molas@gmail.com

Corresponding author.
, Marta Álvarez-Larruyb, Juan J. López-Núñeza
a Servicio Medicina Interna. Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain
b Servicio Neurología. Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain
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electromyogram compatible with muscular hyperactivity syndrome and electroencephalogram showing an organised waking background tracing&#44; with no interictal epileptiform discharges&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">On suspicion of autoimmune encephalitis&#44; a cerebrospinal fluid &#40;CSF&#41; study was performed&#44; which confirmed the absence of oligoclonal bands&#44; but was positive for <span class="elsevierStyleItalic">anti</span>-<span class="elsevierStyleItalic">contactin-associated protein-like 2</span> &#40;CASPR2&#41; and <span class="elsevierStyleItalic">anti</span>-<span class="elsevierStyleItalic">leucine rich glioma inactivated protein 1</span> &#40;LGI1&#41; antibodies &#40;Ab&#41;&#44; leading to a diagnosis of probable Morvan syndrome &#40;MS&#41;&#46; Treatment was started with intravenous &#40;IV&#41; immunoglobulins at a dose of 2&#8239;g&#47;kg for three days with little clinical improvement&#44; so corticotherapy was started with IV methylprednisolone bolus &#40;1g&#47;day&#41; for five days and then maintenance with prednisone at a dose of 1&#8239;mg&#47;kg&#47;day orally&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Given the presence of toxic syndrome and the association between autoimmune encephalitis and underlying neoplasm&#44; a screening for malignancy was performed&#44; which was negative&#46; The patient progresses unfavourably&#44; so it is agreed to start treatment with i&#46;v&#46; rituximab &#40;2g distributed over two weeks&#44; then 1g every six months&#41; without complications&#46; After the first cycle&#44; the symptoms resolved&#44; although they returned later&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The MS is a rare channelopathy with a high mortality that gives rise to heterogeneous subacute clinical features such as the presence of myokymia&#44; insomnia&#44; dysautonomia and central nervous system involvement<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; It mainly affects middle-aged men and its prevalence is unknown&#44; with less than 100 cases in the literature&#44; none in the Spanish literature so far&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Although its etiopathogenesis is not well defined&#44; the presence of Ab against voltage-gated potassium channels and the response to immunosuppressive treatment support the autoimmune aetiology of the syndrome<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46; Specifically&#44; two neuronal proteins have been identified as targets&#58; CASPR2 and LGI1&#46; In a review of 29 patients with MS&#44; positive anti-VGKC was identified in 24 patients &#40;79&#37;&#41;&#44; anti-CASPR2 in six patients&#44; anti-LGI1 in three patients&#44; anti-CASPR2 and anti-LGI1 in 12 patients&#44; and anti-CASPR2&#44; anti-LGI1 and anti-contactin 2 in three patients<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Clinically it manifests as the association of multifocal or diffuse encephalitis&#44; hyperexcitability of the peripheral nerve in the form of neuromyotonia and dysautonomia<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a>&#46; Sleep disorders and neuropathic pain are common&#44; with areflexia and stocking and glove hypesthesia&#46; The presence of epileptic seizures of diverse semiology is not uncommon<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">While the diagnosis is clinical&#44; 25&#37; of patients have CSF abnormalities and neuroimaging is usually normal<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">With regard to tumour association&#44; the data available in the literature are mixed&#58; some groups identify an underlying tumour in around 20-41&#37; of cases&#44; predominantly thymomas&#44; while other groups suggest that they are less common<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Although there is little literature on treatment&#44; experts recommend immunosuppressive treatment<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5</span></a>&#44; with steroids&#44; IV immunoglobulins and plasma exchange being the first-line therapies&#46; In the absence of a clinical response&#44; therapies such as rituximab and&#47;or cyclophosphamide are then considered&#46; Overall&#44; the prognosis is good&#44; but recurrence is not uncommon<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Out of a published series of 12 cases<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#44; most patients responded to immunosuppressive treatment &#40;plasmapheresis or immunoglobulins&#44; steroid-associated or not&#41;&#44; although most required chronic treatment to remain stable&#46; None of them improved spontaneously before starting treatment<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;5</span></a>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Early detection of this syndrome is paramount&#44; in order to initiate treatment and tumour search within an appropriate therapeutic window&#46; Regarding our patient&#44; despite the multiple complementary examinations carried out&#44; to date&#44; no concomitant malignancy has been identified&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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