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Letter to the Editor
Hemorrhagic myositis as a complication of cancer-associated dermatomyositis
Miositis hemorrágica como complicación de una dermatomiositis asociada a neoplasia
Silvia Suárez-Díaza,
Corresponding author
silvia_porto@hotmail.es

Corresponding author.
, Nuria Pilar Riesco-Pérezb, Luis Caminal-Monteroc
a Servicio de Medicina Interna, Hospital Valle del Nalón, Langreo, Asturias, Spain
b Servicio de Neurología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
c Servicio de Medicina Interna, Unidad de Enfermedades Autoinmunes Sistémicas, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, Oviedo, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Idiopathic inflammatory myopathies &#40;IIM&#41; may be accompanied by cutaneous&#44; articular or pulmonary manifestations and may occur in the context of neoplasms&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Their association with specific autoantibodies has led to their being called autoimmune inflammatory myopathies&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Diagnosis is based on symptoms&#44; electromyographic findings&#44; elevated muscle enzymes&#44; imaging tests and muscle biopsy&#46; They are sometimes a diagnostic challenge&#44; such as the patient reported here with extensive skin and muscle bruising as a form of presentation&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 77-year-old male patient&#44; hypertensive and diabetic&#44; with a biological prosthetic cardiac valve and aortocoronary <span class="elsevierStyleItalic">bypass</span>&#44; for which he was being treated with 100&#8239;mg&#47;day of aspirin&#46; In 2018&#44; a multifocal BCLC-B stage liver cancer was diagnosed&#44; probably secondary to alcoholic liver disease&#44; and underwent transarterial chemoembolization and radiofrequency ablation&#44; with disease control&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In February 2019&#44; while he was asymptomatic and after undergoing a liver magnetic resonance imaging &#40;MRI&#41; scan&#44; where a diagnosis of recurrence of the neoplasm was made&#44; he went to the emergency department due to oedema and redness of the face&#44; neck&#44; arms and upper thoracic region&#46; A contrast-induced phototoxic rash was suspected and was treated with 20&#8239;mg&#47;day of prednisone&#46; Despite this&#44; he developed pain and muscle weakness and was hospitalised&#46; The examination showed pain in the proximal muscle masses and decreased strength in the shoulder and pelvic girdle&#46; The most striking features were heliotrope erythema&#44; lesions on the hands characteristic of dermatomyositis and ecchymosis on the trunk and limbs &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#8211;E&#41;&#46; Laboratory tests&#58; creatine kinase 1661&#8239;U&#47;L &#40;n&#58; 20&#8211;200&#41;&#44; troponin T 107&#8239;ng&#47;L &#40;n&#8239;&#60;&#8239;14&#41;&#44; creatinine 1&#46;34&#8239;mg&#47;dL&#44; with a normal blood count and basic coagulation study&#46; Electromyogram without myopathy symptomatology&#44; and a chest-abdominal computed tomography &#40;CT&#41;&#44; without pulmonary lesions or other neoplasms&#46; ANA 1&#47;320 speckled pattern&#44; without specificities&#44; with negative myositis-specific autoantibodies &#40;anti-Jo-1&#44; PL-7&#44; PL-12&#44; EJ&#44; SRP&#44; HMGCR&#44; Mi-2&#44; MDA-5&#44; TIF1-&#947;&#44; SAE&#44; NXP-2 and SSA&#47;Ro52&#41;&#46; Complement&#44; cryoglobulins and ANCA also negative&#46; A muscle biopsy on the right biceps showed no muscle swelling&#46; Despite this&#44; and with the suspicion of paraneoplastic dermatomyositis &#40;DM&#41;&#44; treatment was started with 40 methylprednisolone mg&#47;day and aspirin was discontinued&#46; Progression was poor&#44; with the development of oedema&#44; deterioration of renal function and new spontaneous hematomas&#46; An ultrasound and an MRI of the upper limbs identified muscle oedema&#44; and a PET&#47;CT scan detected an increase in carbohydrate metabolism in the upper limb muscles&#46; A new muscle biopsy guided by imaging tests demonstrated a predominantly perimysial inflammatory myopathy with MCH-1 expression&#46; The patient received three boluses of 125&#8239;mg methylprednisolone&#44; immunoglobulins and prednisone 0&#46;4&#8239;mg&#47;kg&#47;day in a tapering oral regimen&#44; which reduced oedema&#44; muscle pain and bruising&#44; improved myopathy and restored autonomy&#46; After the initial improvement&#44; he suffered dysphagia&#44; decompensation of his liver disease&#44; and died six months later&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Our patient presented with muscle haemorrhage as a form of presentation of DM&#44; following recurrence of his liver cancer&#44; a previously unreported event&#46; Cases have been described in which muscle bleeds of different characteristics occur within an inflammatory myopathy&#44; which are defined in the literature as &#8220;haemorrhagic myositis&#8221; &#40;HM&#41;&#44; given the atypical and rare nature of this complication&#46; Orrell et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> reported the first two cases in 1998&#44; one of them with hematomas in the rectus muscle of the thighs in a patient with calcinosis in that area&#44; and another in an 11-year-old girl with a retroperitoneal hematoma&#46; In both cases&#44; the diagnosis of DM was prior to the onset of bleeding&#44; and they had not received anticoagulants or antiplatelet agents&#46; Eleven cases have been described&#44; between 1998 and 2020&#44; which were collected by Chandler et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> They had a mean age of 50 years and a similar distribution by sex&#44; in IIM already diagnosed and receiving immunosuppressive treatment&#46; Haematomas appear in large muscle groups&#44; such as those of the abdomen or the psoas&#44; but also in the limbs&#44; such as the deltoid muscles&#46; Most received low molecular weight heparins &#40;LMWH&#41; or antiplatelet agents&#44; which has been suggested to be a risk factor for this complication&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> However&#44; at least three cases have been described where HM occurred in the absence of such treatments&#46; Two cases had autoantibodies&#44; anti-Ro52 and anti-Tif1&#947;&#44; without correlation between their presence and the occurrence of hemorrhages&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The pathophysiology of MH has been attributed to possible capillary vasculitis at the muscular level&#44; and tissue fragility induced by the steroids they often receive&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Our patient was receiving antiplatelet therapy and prophylactic LMWH&#44; which were subsequently discontinued&#44; with further progression of the haematomas&#46; Treatment of HM is based on hemorrhagic control &#40;embolization&#44; transfusions&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and its prognosis is usually poor&#44; with mortality in 50&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The improvement with steroids and immunoglobulins that we observed could support the inflammatory origin of HMs&#44; and the use of immunosuppressants or immunoglobulins to control bleeding &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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Original language: English
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