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Letter to the Editor
Malignant ventricular arrhythmias in a patient with Gitelman syndrome
Arritmias ventriculares malignas en un paciente con síndrome de Gitelman
Adrián Riaño Ondiviela
Corresponding author
arondiviela@gmail.com

Corresponding author.
, Daniel Meseguer González, Jose Ramón Ruiz Arroyo
Servicio de Cardiología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Gitelman syndrome is a tubule disease caused by defects in the sodium&#8211;chloride symporter located in the distal convoluted tubule of the nephron&#46; It is a rare genetic disorder&#44; with an autosomal recessive inheritance pattern&#44; which causes affected patients to have low potassium levels and&#44; unlike Bartter syndrome&#44; hypomagnesemia and hypocalciuria&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Although its phenotypic expression is highly variable and its diagnosis is often incidental or based on non-specific symptoms&#44; the electrolyte disturbances caused by this syndrome can often cause malignant ventricular arrhythmias&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In this paper we describe the case of a 31-year-old&#44; male&#44; active smoker without a previous relevant medical history&#46; He did not report a use of laxatives or diuretics&#46; He complained of asthenia&#44; generalized weakness&#44; and palpitations of several weeks evolution that had progressed gradually for several weeks and intensified over the last few hours&#44; which is why he decided to visit the Emergency Department&#46; A physical examination revealed muscle hypotonia and shallow breathing&#46; Blood pressure&#58; 113&#47;55&#8239;mmHg&#46; Heart rate&#58; 55 bpm&#46; Respiratory rate&#58; 12&#8239;bpm&#46; Basal oxygen saturation&#58; 96&#37;&#46; A cardiac auscultation revealed rhythmic heart sounds&#44; without murmurs nor signs suggestive of heart failure&#46; However&#44; additional monitoring in the Emergency Department recorded several bursts of non-sustained ventricular tachycardia&#46; Emergency blood work detected metabolic alkalosis compensated by a pH of 7&#46;42 and bicarbonate &#40;CO<span class="elsevierStyleInf">3</span>H&#41; levels of 31&#8239;mmol&#47;L&#44; creatinine levels of 1&#46;44&#8239;mg&#47;dl&#44; hypomagnesemia of 0&#46;87&#8239;mmol&#47;L &#40;normal range&#58; 1&#46;6&#8211;2&#46;6&#41;&#44; very intense hypokalemia of 1&#46;38 mEq&#47;L &#40;3&#46;5&#8211;5&#46;1&#41;&#44; and an otherwise normal blood count and electrolyte panel&#46; Because a surface electrocardiogram &#40;ECG&#41; documented a QT interval corrected by Bazett&#39;s formula &#40;QTc&#41; of 560&#8239;ms &#40;normal value in men &#60;440&#8239;ms&#41;&#44; intravenous treatment with potassium chloride and magnesium sulfate was started&#46; Shortly after starting the perfusion&#44; the patient developed hemodynamic instability due to a torsades de pointes rhythm&#44; owing to which electrical cardioversion at 200 J was required&#46; In the following hours&#44; he continued to experience different types of ventricular arrhythmias&#44; such that a sustained perfusion of high doses of potassium and magnesium was needed to finally achieve membrane stabilization and&#44; therefore&#44; reduce the arrhythmic load&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">During the hypokalemia study&#44; decreased calcium excretion was detected in a 24-h urine sample &#40;44&#8239;mg&#47;24&#8239;h&#59; normal range&#58; 100&#8211;250&#41;&#44; together with increased sodium &#40;360&#8239;mEq&#47;L&#59; normal range&#58; 50&#8211;210&#41;&#44; magnesium &#40;180&#8239;mg&#47;24&#8239;h&#59; normal range&#58; 73&#8211;121&#41;&#44; and chloride &#40;258&#8239;mEq&#47;L&#59; normal range&#58; 110&#8211;250&#41; excretion&#46; His renin&#44; aldosterone&#44; and glomerular filtration rate all fell within the normal range&#46; A heart and renal ultrasound were also performed&#44; without detecting any alterations&#46; Given the association of metabolic alkalosis with hypokalemia&#44; hypomagnesemia&#44; hypochloremia&#44; hypocalciuria&#44; and low to normal blood pressure levels&#44; the patient was diagnosed with Gitelman syndrome&#46; After a few days of intravenous therapy&#44; his hydroelectric figures returned to normal&#44; and subsequent correction of the electrocardiographic repolarization was observed&#44; with no new arrhythmic events being detected during the rest of his hospital stay&#46; At discharge&#44; he was prescribed home treatment with spironolactone 100&#8239;mg&#47;24&#8239;h&#44; chronic oral supplementation with magnesium and potassium&#44; as well as a diet rich in these electrolytes&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Gitelman syndrome is not a benign pathology&#44; as about half of patients with this condition have prolonged QT intervals&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> with the consequent risk of potentially severe ventricular arrhythmias&#46; Patients with this disease have myocardial perfusion alterations and microvascular dysfunction&#44; both of which could act as precipitating factors for arrhythmic events in the context of chronic hypokalemia&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> For this reason&#44; once other secondary causes of hypokalemia&#44; such as the use of laxatives or diuretics&#44; have been ruled out&#44; an early diagnostic suspicion of this disease based on clinical and biochemical parameters is very important&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">We consider this case to be of interest due to the rarity of this condition&#44; although with potentially serious consequences if it is not adequately managed and treated in a population that is usually young&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors of this paper declare no conflicts of interest&#46;</p></span></span>"
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Article information
ISSN: 23870206
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos