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How much bone growth can occur in Paget's disease?
¿Cuánto puede crecer el hueso en la enfermedad del hueso de Paget?
Juan Pablo Baldivieso Achá
, Cristina Valero Martinez, Jesús Alberto García Vadillo
Corresponding author
Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain
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"tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "46" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Juan Pablo Baldivieso Achá, Cristina Valero Martinez, Jesús Alberto García Vadillo" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Juan Pablo" "apellidos" => "Baldivieso Achá" "email" => array:1 [ 0 => "juanpablobaldiviesoacha@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Cristina" "apellidos" => "Valero Martinez" ] 2 => array:2 [ "nombre" => "Jesús Alberto" "apellidos" => "García Vadillo" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Cuánto puede crecer el hueso en la enfermedad del hueso de Paget?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 955 "Ancho" => 600 "Tamanyo" => 50066 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Paget's disease of the radius with significant increase in bone volume, both transverse and longitudinal, causing bending and deformity of the forearm.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Paget's disease of bone is characterized by increased bone resorption, followed by abnormal and disorganized bone formation. The resulting bone is weak and tends to deform. Diagnosis is usually confirmed by radiological findings such as significant bone enlargement, widening and cortical thickening. This disease can usually be controlled with a course of nitrogen-containing bisphosphonates, especially intravenous zoledronate, entering long-term biochemical remission and avoiding major deformities. But sometimes there are cases in which one course is not enough.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The case is about an 82-year-old woman who was diagnosed in 1993 with polyostotic Paget's disease (as well as her two brothers). She was initially treated in the 1990s with one oral course of etidronate, then, since 2008, she received four courses of 5 mg of IV zoledronate, which, although temporarily restored her alkaline phosphatase to normal, have not prevented the growth and progressive deformity of her forearm (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0015" class="elsevierStylePara elsevierViewall">This article has not received any type of funding.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interests</span><p id="par0020" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interests" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Baldivieso Achá JP, Valero Martinez C, García Vadillo JA. ¿Cuánto puede crecer el hueso en la enfermedad del hueso de Paget? Med Clin (Barc). 2022;158:46.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 955 "Ancho" => 600 "Tamanyo" => 50066 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Paget's disease of the radius with significant increase in bone volume, both transverse and longitudinal, causing bending and deformity of the forearm.</p>" ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000015800000001/v2_202201200752/S2387020621006653/v2_202201200752/en/main.assets" "Apartado" => array:4 [ "identificador" => "51820" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in medicine" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000015800000001/v2_202201200752/S2387020621006653/v2_202201200752/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020621006653?idApp=UINPBA00004N" ]
