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Review
Pulmonary involvement in Sjögren’s syndrome
Síndrome de Sjögren y afectación pulmonar
Jaume Mestre-Torresa,b,
Corresponding author
jmestre@vhebron.net

Corresponding author.
, Roser Solans-Laquea,b
a Unidad de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Hospital Vall d‘Hebron, Barcelona, Spain
b Departamento de Medicina, Facultad de Medicina, Universidad Autónoma de Barcelona, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Sj&#246;gren&#8217;s syndrome &#40;SS&#41; is a systemic autoimmune disease characterised by the presence of exocrine glandular hypofunction&#44; predominantly ocular and oral&#44; expressed as xerophthalmia &#40;dry eyes&#41; and xerostomia &#40;dry mouth&#41;&#46; However&#44; SS can affect multiple organs<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> and the extraglandular or systemic involvement is what determines the prognosis of the disease&#46; Immunologically&#44; SS is characterised by the presence of antinuclear antibodies &#40;ANA&#41; with a speckled immunofluorescence pattern&#44; and anti-Ro60 and&#47;or anti-Ro52&#44; and anti-La antibodies&#46; Other antibodies associated with SS are rheumatoid factor &#40;RF&#41;&#44; present in 50&#37; of cases&#44; and anti-centromere antibodies&#44; present in 3&#37;&#8211;27&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The criteria for the classification of SS have varied over the last decades&#46; Currently they include the demonstration of a decrease in salivary and tear secretion&#44; and the presence of positive immunology &#40;anti-Ro60 antibodies&#41; and&#47;or a focal lymphocytic infiltrate in the salivary glands&#44; forming accumulations of more than 50 lymphocytes&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Although the extraglandular involvement is what determines the prognosis&#44; it has not been included in the different classification criteria&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">An index of disease activity has been developed&#44; the <span class="elsevierStyleItalic">EULAR Sj&#246;gren</span>&#8217;<span class="elsevierStyleItalic">s syndrome disease activity index</span> &#40;ESSDAI&#41;&#44; which assesses 12 different domains &#40;glandular&#44; joint&#44; pulmonary&#44; neurological&#44; haematological&#44; etc&#46;&#41;&#46; It is defined as low-grade activity when a patient has &#60;5 points on the ESSDAI score&#44; moderate between 5 and 13 points&#44; and high-grade when 14 or more points are obtained&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">SS can affect the bronchial respiratory system with the occurrence of bronchiectasis and&#47;or with involvement of the pulmonary interstitium&#46; Interstitial involvement can develop in the form of usual interstitial pneumonia &#40;UIP&#41;&#44; non-specific interstitial pneumonia &#40;NSIP&#41; or lymphoid pneumonitis&#44; among others&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The exact incidence of SS-associated lung involvement is not known&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> although it is estimated to be present in 15&#37;&#8211;35&#37; of patients&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Respiratory symptoms related to Sj&#246;gren&#8217;s syndrome</span><p id="par0020" class="elsevierStylePara elsevierViewall">JS-related respiratory symptoms are varied&#44; very often non-specific and usually develop progressively during disease follow-up&#44; although they may be present at the time of diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Clinically&#44; patients report dry cough&#44; xerotrachea and symptoms compatible with bronchial hyperresponsiveness&#46; In addition&#44; they may present with recurrent respiratory infections and dyspnoea&#46; It is not uncommon for these symptoms to precede the diagnosis of the disease and go unnoticed&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Systematic examination of the respiratory system is therefore important&#46; The prevalence of dry cough and xerotrachea&#44; defined as the persistent sensation of dryness in the pharyngeal and retrosternal area&#44; is 40&#37;&#8211;50&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Other less common symptoms are anosmia&#44; nasal crusts and nosebleed due to nasal dryness&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;11</span></a> Airway involvement may appear in the form of bronchiectasis or bronchial hyperresponsiveness and is associated with an increased frequency of respiratory infections&#46; The prevalence of bronchiectasis can be up to 10&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The development of interstitial lung disease &#40;ILD&#41; is more common in older patients and in those with Raynaud&#8217;s phenomenon and gastrointestinal involvement in the form of motility disorder and gastroesophageal reflux&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Its presence is not associated with specific clinical manifestations&#44; although progressive dyspnoea is its main symptom&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Immunology and diagnosis of Sj&#246;gren&#8217;s syndrome</span><p id="par0030" class="elsevierStylePara elsevierViewall">As already mentioned&#44; most patients with SS are ANA positive and approximately 50&#37; are RF positive&#46; However&#44; the 2016 classification criteria for SS only include anti-Ro-60&#47;SSA antibodies&#44; which are present in 60&#37;&#8211;70&#37; of cases&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Although anti-Ro&#47;SSA antigen is known to comprise two subunits &#40;Ro60 and Ro52&#41;&#44; many laboratory techniques cannot differentiate one subunit from another&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Anti-Ro52 antibodies are not considered diagnostic of SS&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Therefore&#44; although in an appropriate clinical context the presence of anti-Ro52 is suggestive of SS&#44; it should be borne in mind that it is of a more non-specific nature and can be found in various systemic autoimmune diseases such as systemic lupus erythematosus&#44; scleroderma or rheumatoid arthritis&#44; where its presence is associated with Raynaud&#8217;s phenomenon and&#47;or interstitial lung disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#8211;18</span></a> Similarly&#44; the finding of hypergammaglobulinemia&#44; positive ANA or RF results in a patient with sicca syndrome does not allow the patient to be classified as having SS&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Thus&#44; if positive ANA&#44; RF&#44; or anti-Ro52 results are detected&#44; a complete history-taking and physical examination should be performed to assess the possible presence of an autoimmune disease<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> and&#44; if SS is suspected&#44; a minor salivary gland biopsy should be performed to confirm the diagnosis&#46; In fact&#44; the histopathological study of the minor salivary gland is usually diagnostic in 37&#37;&#8211;50&#37; of patients with sicca syndrome&#44; ANA and&#47;or RF but negative for anti-Ro60&#47;SSA antibodies&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Regarding immunological findings&#44; the presence of anti-centromere antibodies &#40;ACA&#41;&#44; typically associated with scleroderma&#44; has been described in up to 20&#37; of patients with SS&#44; although it seems that these antibodies would recognize a different epitope&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> If present&#44; therefore&#44; an overlap between the two diseases must be ruled out&#44; especially if there is interstitial lung involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Diagnosis of patients with SS who do not have anti-Ro60 is often more complex&#44; as minor salivary gland biopsy is not always diagnostic&#46; Nevertheless&#44; the clinician should use all available options to achieve such a diagnosis&#44; as extraglandular complications can occur with similar severity in anti-Ro60 positive and anti-Ro60 negative patients and may be the initial manifestation of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> In these patients&#44; it is especially important to perform a minor salivary gland biopsy&#44; which would confirm the diagnosis and its classification&#44; or other tests such as parotid gland ultrasound&#44; salivary scintigraphy and a complete assessment of tear function&#44; which can reinforce the suspected diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Clinical-radiological diagnostic evaluation of lung involvement</span><p id="par0045" class="elsevierStylePara elsevierViewall">Characterization of pulmonary involvement in SS should be done in a multimodal way&#44; evaluating clinical manifestations&#44; respiratory function tests &#40;RFTs&#41; and radiological findings on chest high-resolution computed tomography &#40;HRCT&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Pulmonary function tests should include a complete spirometry&#44; including lung volumes with a bronchodilator test and the diffusing capacity of lung for CO test &#40;DLCO&#41;&#46; These tests will allow us to screen for the presence of airway and&#47;or parenchymal pathology&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> as well as detect significant changes that may lead to the initiation of immunosuppressive or antifibrotic treatment during disease progression&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> In addition&#44; they will allow us to rule out the possible existence of pulmonary arterial hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> Patients with SS may exhibit alterations in pulmonary function tests&#44; both obstructive and restrictive&#46; If a restrictive pattern and&#47;or a decrease in DLCO is found&#44; parenchymal or vascular involvement in the lungs should be considered&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> In patients with obstructive lung involvement&#44; whether or not associated with restrictive compromise&#44; consideration should be given to possible airway involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Radiologically&#44; the gold standard for the study of the airway and lung parenchyma is a chest HRCT&#44; which should include an expiratory phase study to assess the presence of air trapping&#46; The most commonly observed findings are a combination of ground glass opacities&#44; consolidations&#44; honeycombing&#44; cross-linking&#44; and the occurrence of cysts&#44; nodules&#44; and bronchiectasis&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> with the NSIP pattern being the most common in terms of interstitial involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The study by Roca et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> found such involvement in 33&#46;3&#37; of patients&#44; followed by the UIP pattern &#40;23&#46;8&#37;&#41;&#44; lymphoid interstitial pneumonia &#40;9&#46;5&#37;&#41; and organising pneumonia &#40;9&#46;5&#37;&#41;&#46; 23&#46;8&#37; of patients had an indeterminate pattern on HRCT&#46; The possible existence of an underlying lymphoma should be assessed in any patient presenting with lymphoid interstitial pneumonia&#44; pulmonary cysts or nodules and a suggestive clinical context &#40;cytopenias&#44; C4 hypocomplementemia&#44; presence of rheumatoid factor or monoclonal gammopathy&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">34&#8211;36</span></a> It is noteworthy that&#44; unlike in scleroderma&#44; the EULAR guidelines for the management of SS do not assess the extent of interstitial involvement on chest HRCT to justify changes in treatment&#44; although symptoms and functional lung involvement do&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">37&#44;38</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The prevalence of bronchiectasis in SS is not well defined&#44; with a variable proportion between 7&#37;&#8211;54&#37;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> having been reported&#46; Bronchiectasis is usually cylindrical and predominantly occurs in the lower lobes of the lungs&#46; These findings have been associated with a higher frequency of hiatal hernia and an increased risk of respiratory infections&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">Consensus recommendations from <span class="elsevierStyleItalic">The Sj&#246;gren</span>&#8217;<span class="elsevierStyleItalic">s Foundation</span> &#40;USA&#41; have recently been published describing the pulmonary evaluation of patients with JS with and without known pulmonary involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> These recommendations can be differentiated according to the presence of airway and&#47;or interstitial involvement&#46; In patients without respiratory symptoms&#44; a chest X-ray and RFTs are recommended as a baseline evaluation&#46; Routine chest HRCT is not recommended&#46; Rather&#44; a chest HRCT and RFTs should be performed in patients with respiratory symptoms&#46; As there is insufficient evidence&#44; there is no established frequency for follow-up imaging or RFTs&#44; and it is recommended that follow-up be done on an individual basis&#46; Routine bronchoscopy with bronchoalveolar lavage or transbronchial biopsy is not recommended for the diagnosis of interstitial involvement&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Finally&#44; according to the ESSDAI index&#44; SS activity in the lungs is classified as absent&#44; mild&#44; moderate or severe&#47;intense&#44; depending on the findings in the complementary diagnostic tests and the patient&#8217;s symptoms &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Tests that define the severity of pulmonary involvement include RFTs and chest HRCT&#46; Other diagnostic tests used for respiratory evaluation include the six-minute walk test&#44; lung ultrasound&#44; or chest MRI&#46; ESSDAI considers chronic damage to be those symptoms&#44; findings on chest HRCT or RFTs&#44; which do not change over 12 months&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> Thus&#44; despite the abnormality in the examinations&#44; if there is no change in the previous 12 months&#44; these findings score zero on the ESSDAI index&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Pulmonary histopathology and Sj&#246;gren&#8217;s syndrome</span><p id="par0075" class="elsevierStylePara elsevierViewall">The most characteristic finding of pulmonary interstitium histology in SS is the combination of several pathological patterns&#46; The most commonly found pattern is NSIP&#44; described in up to 45&#37; of lung biopsies from patients with SS&#44; showing interstitial inflammation with varying degrees of fibrosis in a lung with preserved architecture&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The second histological pattern by frequency is UIP&#44; present in between 16&#37;&#8211;33&#37; of patients with ILD and SS&#46; Histological manifestations are characterized by honeycombing&#44; patchy fibrosis with isolated fibroblastic foci&#44; and mild interstitial inflammation along with patchy alveolar infiltrates of lymphocytes&#44; plasma cells&#44; and lymphoid follicles with germinal centres&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Lymphoid interstitial pneumonia is characterized by a diffuse lymphoid infiltrate&#46; These lymphocytes are polyclonal and are accompanied by plasma cells&#44; occasionally forming lymphoid follicles and even germinal centres&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> The possible existence of bronchus-associated lymphoid tissue &#40;BALT&#41; lymphoma should be taken into account in patients with interstitial involvement and SS&#44; considering that this may be low-grade and the morphological findings difficult to characterize&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">The study of other respiratory areas is also important&#46; Mononuclear cell infiltration of the airway has been demonstrated in the trachea&#44; bronchi and bronchioles and may affect the exocrine glands in this region&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> In addition&#44; bronchoalveolar lavage studies have also shown a CD4&#43; T lymphocyte predominance&#44; even in asymptomatic patients&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Lymphoma and lung involvement</span><p id="par0085" class="elsevierStylePara elsevierViewall">SS-associated lymphomas are usually <span class="elsevierStyleItalic">mucosa-associated lymphoid tissue</span> &#40;MALT&#41; type&#46; Radiographic findings on chest HRCT are in the form of pulmonary nodules or areas of consolidation&#44; often indistinguishable from benign processes or lymphocytic pneumonia&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">34&#44;41</span></a> The use of PET&#47;CT in the event of a clinical suspicion can be useful for its diagnosis when the patient reports B symptoms&#44; constitutional symptoms&#44; etc&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> as it is non-specific&#46; The clinical and laboratory factors most commonly associated with lymphoma are parotid gland enlargement&#44; cryoglobulinaemic vasculitis&#44; leukopenia &#40;&#60;3000&#8239;cells&#47;mm<span class="elsevierStyleSup">3</span>&#41;&#44; positive La immunology and C4 hypocomplementemia&#46; It has been shown that the higher the number of risk factors&#44; the higher the positive predictive value for lymphoma&#44; so the finding of such markers should alert us to this possibility&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">35&#44;43</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Differential diagnosis of pulmonary involvement in Sj&#246;gren&#8217;s syndrome</span><p id="par0090" class="elsevierStylePara elsevierViewall">ILDs are a group of entities that have in common the inflammatory and fibrosing involvement of the lung parenchyma&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> Primary pulmonary diseases and interstitial diseases associated with systemic diseases have been described&#46; For this reason&#44; it is recommended that its evaluation be carried out in a multidisciplinary manner&#44; including clinicians&#44; radiologists and pathologists&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">In recent years&#44; a new entity called interstitial pneumonia with autoimmune features &#40;IPAF&#41; has been defined but&#44; in reality&#44; it should be considered as a working diagnosis and not an entity <span class="elsevierStyleItalic">per se</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> A diagnosis of IPAF is considered in patients with ILD of unknown aetiology&#44; with clinical and serological findings or thoracic morphological changes suggestive of an underlying autoimmune disease&#44; but who cannot be diagnosed with any of them&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">In the case of a patient with IPAF&#44; it is important to perform a thorough history-taking and physical examination since these will allow us to classify the patient in some cases&#46; If SS is suspected&#44; a complete ophthalmological evaluation &#40;Schirmer&#8217;s test&#44; tear break-up time and corneal staining&#41; should be performed to rule out dry eye&#44; and salivary secretion should be assessed by salivary flow quantification or salivary scintigraphy&#44; and a minor salivary gland biopsy should be considered if the diagnosis of SS is still suspected but cannot be confirmed&#44; as they do not have specific anti-Ro60<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#44;25</span></a> antibodies&#46; It should be noted that sicca syndrome was not included in the definition of IPAF as it is not very specific and that anti-Ro52 and anti-Ro60<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> antibodies were not differentiated immunologically&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Therefore&#44; it is of particular interest to consider the possibility of SS in patients with interstitial lung involvement of non-infiltrative aetiology&#44; who present associated sicca syndrome&#44; even if they do not have specific immunology&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Treatment and lung involvement in Sj&#246;gren&#8217;s syndrome</span><p id="par0110" class="elsevierStylePara elsevierViewall">Guidelines published by the <span class="elsevierStyleItalic">European League Against Rheumatism</span> &#40;EULAR&#41; in 2019 recommend multidisciplinary assessment of patients with SS&#46; These recommendations were made through the evaluation of studies published up to 2017 using a Delphi process&#44; with no evidence of significant progress in recent years&#46; Treatment is mainly based on symptomatic control of the sicca syndrome&#44; glucocorticoids and immunosuppressants&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">The consensus guidelines of <span class="elsevierStyleItalic">The Sj&#246;gren&#8217;s Foundation</span> recommend treatment according to the site of the pathology&#44; airway or pulmonary interstitium&#44; and according to the severity of symptoms&#44; severity of organ involvement and treatment progression&#46; These include symptomatic treatment&#44; glucocorticoids&#44; immunosuppressants&#44; biological therapy&#44; and antifibrotic agents&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> Some authors have described that they use different treatments depending on the chest HRCT findings&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> However&#44; although it is known that different radiological patterns are associated with different prognosis&#44; no specific treatment guidelines have been described as the current evidence is scarce&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;29&#44;45</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Regarding SS-related pulmonary involvement&#44; the 2019 EULAR guidelines recommend a treatment adjusted to the clinical findings and the ESSDAI score&#46; Inhaled therapy is recommended in patients with bronchial involvement and systemic treatment when there is ILD&#46; If involvement is moderate&#44; glucocorticoid monotherapy is recommended&#44; and if activity is high&#44; glucocorticoid treatment followed by oral immunosuppression is proposed&#46; Glucocorticoids should be used at the lowest possible dose and for the shortest possible time to avoid side effects&#46; No immunosuppressive drug is prioritised but reports in the published literature suggest the more widespread use of azathioprine&#44; mycophenolate or cyclosporine A&#46; Intravenous pulsed cyclophosphamide or rituximab<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a> are proposed as rescue therapy&#46; Retrospective series of patients with SS or connective tissue diseases &#40;including SS&#41; have shown that azathioprine&#44; mycophenolate or rituximab are associated with improved pulmonary function tests&#44; with fewer complications than oral cyclophosphamide&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21&#44;46&#44;47</span></a> Rituximab has also shown encouraging results&#44; although with an increased risk of respiratory infections&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a> Despite these findings&#44; there are no randomized clinical trials comparing these treatments&#44; so the recommendations are not robust&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Antifibrotic therapy has shown promising results in patients with progressive fibrosing lung diseases&#46; The <span class="elsevierStyleItalic">INBUILD</span> clinical trial demonstrated a reduction in the annual fall in forced vital capacity in such patients&#44; including 170 participants &#40;25&#46;6&#37; of the total cohort&#41; with systemic autoimmune diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> Systemic diseases in this group included rheumatoid arthritis&#44; scleroderma&#44; Sj&#246;gren&#8217;s syndrome&#44; mixed connective tissue disease&#44; undifferentiated connective tissue disease and IPAF&#46; A <span class="elsevierStyleItalic">post-hoc</span> analysis of this cohort showed that in this subgroup of patients the effect of nintedanib was maintained&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a> It should be noted that specific studies have not been performed in patients with SS unlike other systemic autoimmune diseases such as scleroderma&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">If&#44; despite drug therapy&#44; there is a progression of the disease with a decline in lung function and a deterioration in quality of life&#44; patients should be evaluated by lung transplant teams&#46; There is no consensus regarding the indication for transplantation given the limited evidence available and the presence of contradictory results&#46; On the one hand&#44; a retrospective study in which patients with ILD related to connective tissue diseases were compared with patients with idiopathic pulmonary fibrosis&#44; showed that the clinical course was similar in both groups&#46; This progression was studied in relation to survival&#44; acute or chronic rejection and&#47;or existence of extrapulmonary dysfunction&#46; In this cohort&#44; patients with scleroderma were excluded&#44; but a total of 26 patients with Sj&#246;gren&#8217;s syndrome were included &#40;9&#46;5&#37; of the total cohort&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a> On the other hand&#44; a Spanish cohort including 26 patients &#40;4 of them with SJS&#41; showed a trend towards shorter survival in patients with connective tissue disease compared to those with idiopathic pulmonary fibrosis&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a> Thus&#44; more studies are needed to evaluate the indication for lung transplantation in the context of SS&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">The treatment protocol carried out in our center includes bronchodilator therapy for patients with predominantly obstructive airway involvement&#46; Patients with interstitial lung disease were initiated on prednisone at medium doses &#40;0&#46;5&#8239;mg&#47;kg bw&#47;day&#41;&#44; with a progressive decrease in dose to 5&#8239;mg&#47;day&#44; together with mycophenolate at progressive doses up to 720&#8239;mg&#47;12&#8239;h&#46; If the patient has bronchiectasis&#44; azathioprine &#40;1&#8722;2&#8239;mg&#47;kg bw&#47;day&#41; is prioritised over mycophenolate&#44; given the risk of respiratory infections associated with the use of this drug in this group of patients&#46; In patients with progressive lung disease despite immunosuppressive therapy&#44; treatment with rituximab is initiated&#46; Patients with progressive fibrosing ILD are started on antifibrotic therapy with nintedanib&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusions</span><p id="par0140" class="elsevierStylePara elsevierViewall">Pulmonary disease in SS is an understudied entity and often underdiagnosed in routine clinical practice&#44; as it presents with non-specific symptoms&#46; In all patients diagnosed with SS&#44; the presence of respiratory symptoms should be investigated and an extensive work-up by physical examination and additional tests should be performed when there is suspicion of both interstitial and airway involvement&#46; Further studies are needed to define a specific pulmonary treatment for this disease&#44; based on the extent of the disease and co-existence with other systemic conditions&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Funding</span><p id="par0145" class="elsevierStylePara elsevierViewall">This article has been prepared without funding&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflict of interests</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest in relation to the authorship and&#47;or publication of this article&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Sj&#246;gren&#8217;s syndrome is an autoimmune disease that involves exocrine glands&#46; The most characteristic symptoms consist of the <span class="elsevierStyleItalic">sicca syndrome</span> &#40;including xerostomia and dry eye - xerophtalmia&#41;&#44; but can involve multiple organs&#46; The extraglandular involvement determines the prognosis&#46; It is tipically associated with the presence of antinuclear antibodies&#44; including Ro-60 antibodies&#46; Pulmonary involvement appears as bronchiectasis and&#47;or interstitial pneumonia&#46; Considering its high prevalence&#44; it must be ruled out in all patients with respiratory symptoms by performing pulmonary function tests and high resolution computed tomography of the chest&#46; Evaluation can be completed with a transbronchial biopsy if diagnostic doubts persist&#46; Treatment includes steroid therapy&#44; inmunosupressive or antifibrotic drugs&#44; or biological therapy&#46; In selected cases pulmonary transplantation must be considered&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome de Sj&#246;gren es una enfermedad autoinmune que afecta a las gl&#225;ndulas exocrinas&#46; Su sintomatolog&#237;a caracter&#237;stica es el s&#237;ndrome seco en forma de xeroftalmia y xerostom&#237;a&#44; pero puede afectar a diversos &#243;rganos o sistemas&#44; y la afectaci&#243;n extraglandular es la que condiciona el pron&#243;stico de la enfermedad&#46; T&#237;picamente se asocia con la presencia de anticuerpos antinucleares&#44; que incluyen anti-Ro-60&#46; La afectaci&#243;n pulmonar aparece en forma de bronquiectasias y&#47;o neumopat&#237;a intersticial&#46; Dada la alta prevalencia de esta complicaci&#243;n&#44; su presencia debe descartarse en todos los pacientes con s&#237;ntomas respiratorios mediante pruebas de funci&#243;n respiratoria y tomograf&#237;a computarizada de alta resoluci&#243;n tor&#225;cica&#46; Se puede completar la valoraci&#243;n mediante biopsia transbronquial en aquellos casos en que existan dudas diagn&#243;sticas&#46; El tratamiento incluye glucocorticoterapia&#44; terapia inmunosupresora o antifibr&#243;tica&#44; y terapia biol&#243;gica&#46; En caso de mala evoluci&#243;n se debe valorar el trasplante pulmonar&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Mestre-Torres J&#44; Solans-Laque R&#46; S&#237;ndrome de Sj&#246;gren y afectaci&#243;n pulmonar&#46; Med Clin &#40;Barc&#41;&#46; 2022&#59;158&#58;181&#8211;185&#46;</p>"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">ESSDAI&#58; <span class="elsevierStyleItalic">EULAR Sj&#246;gren</span>&#8217;<span class="elsevierStyleItalic">s syndrome disease activity index</span>&#59; NYHA&#58; <span class="elsevierStyleItalic">New York Heart Association</span>&#59; RFTs&#58; respiratory function tests&#59; Chest HRCT&#58; Chest high-resolution computed tomography&#59; DLCO&#58; diffusing capacity of lung for CO&#59; FVC&#58; Forced vital capacity&#46;</p>"
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                  \t\t\t\t"><span class="elsevierStyleItalic">Without activity</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Pulmonary involvement should be ruled out by chest HRCT and RFTs&#46;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">The patient cannot have dyspnoea&#46;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Moderate</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Evidence of interstitial lung disease by chest HRCT&#46;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">There may be dyspnoea on exertion with a NYHA functional class II&#46;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">High</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Evidence of interstitial lung disease with dyspnoea NYHA functional class III-IV&#46;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">RFTs abnormalities&#58; DLCO&#8239;&#60;</span>&#8239;40&#37; <span class="elsevierStyleItalic">or FVC&#8239;&#60;</span>&#8239;60&#37;&#46;&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Classification of pulmonary signs and symptoms according to the Sjogren&#8217;s syndrome activity index &#40;ESSDAI&#41; of the <span class="elsevierStyleItalic">European League Against Rheumatism &#40;EULAR&#41;</span>&#46;</p>"
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      "titulo" => "References"
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        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:52 [
            0 => array:3 [
              "identificador" => "bib0005"
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                          "etal" => true
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ISSN: 23870206
Original language: English
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