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Scientific letter
Upper gastrointestinal bleeding in a patient with Marfan’s disease
Hemorragia digestiva alta en un paciente con enfermedad de Marfan
Antonio José Ruiz-Rodrígueza,
Corresponding author
antjosruirod@outlook.es

Corresponding author.
, Adelina García Roblesa, Alberto Benavente Fernándezb
a Servicio de Aparato Digestivo, Hospital Universitario Clínico San Cecilio, Granada, Spain
b Servicio de Medicina Interna, Hospital Universitario Clínico San Cecilio, Granada, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Gastrointestinal bleeding in paediatric patients is rare and represents a diagnostic-therapeutic challenge&#46; The prevailing aetiological causes depend on the age range&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> with NSAID gastritis&#44; Dieulafoy&#8217;s lesion and caustic ingestion being the most common&#46; Less commonly&#44; they are also described in patients with structural abnormalities in blood vessels or internal organs&#44; due to vascular disease &#40;Wegener&#44; microscopic polyangiitis&#41;&#44; vascular malformations &#40;Rendu&#8211;Osler&#8211;Weber&#41; or connective tissue diseases &#40;pseudoxanthoma elasticum&#44; Marfan&#44; Ehlers&#8211;Danlos&#44; Loeys&#8211;Dietz&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 14-year-old male with no history of interest who went to the emergency department for coffee ground vomitus&#46; The patient&#8217;s past history included occasional use of NSAIDs in the previous week&#46; Laboratory tests showed haemoglobin of 9&#8239;g&#47;dl&#46; An upper gastrointestinal endoscopy &#40;UGE&#41; in retroversion showed the mucosa of the upper body of stomach and fundus to be erythematous and congestive with several superficial linear ulcerations without active bleeding &#40;Forrest III&#41;&#46; The patient developed massive haematemesis after 48&#8239;h&#44; and a second UGE was performed&#44; which showed a 1&#8239;cm ulcer in the subcardial region with mild drooling bleeding &#40;Forrest I-B&#41; and adjacent denuded and friable mucosa of the fundus and upper body&#46; Haemostatic treatment was applied to the ulcer and the bleeding was controlled&#46; Again&#44; 48&#8239;h later&#44; he presented with new haematemesis and haemodynamic instability&#44; which required a third UGE in the ICU&#58; drooling bleeding was observed in the previously described subcardial ulcer&#44; and&#44; in addition&#44; the adjacent mucosa of the upper body was very thin and friable&#44; with spontaneous and diffuse bleeding&#46; Given the recurrent nature of the bleeding&#44; superselective embolization of the right gastric artery branches was finally performed using microcoils&#44; without further episodes of bleeding&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The patient&#8217;s physical examination revealed an antimongoloid palpebral fissure and eyelid scars&#44; also highlighting generalized joint hyperlaxity&#46; Beighton&#8217;s score was completed and was positive &#40;4 points&#41;&#58; passive dorsiflexion of the 5th finger exceeding 90&#176; bilaterally and passive apposition of the thumbs to the flexor aspect of the forearm bilaterally&#46; Suspecting a connective tissue disorder&#44; a genetic study was requested&#44; the results of which indicated the presence of a heterozygous p&#46;Arg1125GIn mutation in the FBN1 gene&#44; with this mutation being autosomal dominant&#44; corresponding to Marfan syndrome&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Although the gastrointestinal bleeding was initially attributed to NSAIDs&#44; the course and recurrent nature of the bleeding&#44; the atypical endoscopic findings &#40;denuded and friable mucosa&#41; and the patient&#8217;s features on physical examination led to the establishment of a differential diagnosis with connective tissue diseases&#44; confirming a rare mutation of Marfan syndrome by genetic study&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Marfan syndrome is an autosomal dominant type 1 fibrinopathy caused by a heterozygous mutation of the FBN1 gene that encodes the protein fibrillin-1&#44; an essential component of the microfibrils that form part of the extracellular matrix&#44; giving it strength and structural integrity&#44; so that&#44; when deficient&#44; the connective tissue is fragile and unstructured&#44; facilitating its rupture&#46; Although any organ or system can be affected&#44; giving rise to very varied manifestations&#44; it is characterized by skeletal manifestations &#40;tall stature with trunk-limb disproportion&#44; scoliosis and&#47;or pectus excavatum&#41;&#44; ocular &#40;ectopia lentis&#41; and cardiovascular &#40;aortic aneurysm and&#47;or or mitral valve prolapse&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In the absence of family history and classic skeletal&#8211;ocular&#8211;cardiovascular manifestations&#44; a positive systemic score or the presence of a FBN1 gene mutation is required for diagnosis&#44; with the p&#46;Arg1125GIn mutation of said gene being the basis of diagnosis in our case&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This is especially important in paediatric or young adult patients as they potentially present incomplete conditions whose development is age-dependent&#44; requiring high suspicion for early diagnosis to allow early detection of cardiovascular malformations that compromise prognosis&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The gastrointestinal manifestations associated with Marfan&#8217;s disease are mainly functional and derive from abdominal wall or diaphragmatic hernias&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> with gastrointestinal bleeding being rare and caused by arterial or visceral rupture mechanisms&#46; In our patient&#44; these causes were ruled out by angio-CT and arteriography&#44; attributing the gastrointestinal bleeding to structural and functional alteration of the connective tissue&#44; both of the gastric submucosa&#44; since it is mainly made up of collagen fibres that surround and protect its abundant vasculature&#44; as well as the lamina propria of the gastric mucosa&#44; a tissue equally abundant in collagen&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical responsibilities</span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Protection of people and animals</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that no experiments on humans or animals have been performed for this research&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Data confidentiality</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have followed their centre&#8217;s protocols on the publication of patient data&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Right to privacy and informed consent</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46; Informed consent was not requested for the publication of this case because no personal data enabling the identification of the patient are published in this article&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Funding</span><p id="par0055" class="elsevierStylePara elsevierViewall">This research has not received specific funding from public or private sector agencies or non-profit organisations&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conflict of interests</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that there are no conflicts of interest&#46;</p></span></span>"
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Original language: English
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