Letter to the Editor
Sarcoidosis and lymphoma
Sarcoidosis y linfoma
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In the section on imaging tests, they highlight the role of positron emission tomography (PET–CT) in cases in which a systemic evaluation of the disease is necessary.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The association of sarcoidosis and lymphoma is known and was named sarcoidosis–lymphoma syndrome by Brincker.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Patients with sarcoidosis have up to an 11-fold increased risk of developing lymphoma, usually Hodgkin’s lymphoma, which can occur simultaneously or within years of disease diagnosis, which is an even more challenging issue.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In the absence of clinical markers, PET–CT could probably be the best tool in the follow-up of patients in whom this complication is suspected.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">There are several questions that we will have to address:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">–</span><p id="par0025" class="elsevierStylePara elsevierViewall">Which patients are most at risk for sarcoidosis–lymphoma syndrome?</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">–</span><p id="par0030" class="elsevierStylePara elsevierViewall">Is the degree of activity in the PET–CT a risk factor for its development?</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">–</span><p id="par0035" class="elsevierStylePara elsevierViewall">In this case, even if the lymphadenopathies are asymptomatic, can their treatment prevent or delay progression to lymphoma?</p></li></ul></p><p id="par0040" class="elsevierStylePara elsevierViewall">Until answers are available, it is important never to forget this association and, in cases of suspected diagnosis, probably consider follow-up PET–CT scans and, of course, include biopsies of the most active lymph nodes.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0045" class="elsevierStylePara elsevierViewall">None.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interests" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sarcoidosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. 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