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Space limitations meant that these were treated briefly, focusing on other aspects of greater interest to readers of Medicina Clínica.</p><p id="par0010" class="elsevierStylePara elsevierViewall">It is interesting to recall large studies conducted in our country some 15 years ago, which were difficult to find online through scientific literature search engines, as they were exclusively published on the official web pages of the Ministry of Health. The conclusions of the ENEAS<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and APEAS<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> studies are still valid and corroborate the importance of ADRs as the leading cause of adverse reactions (AR), exceeding in frequency nosocomial infections and other causes related to healthcare processes/procedures. Their results confirm the magnitude of this problem for patient safety and its budgetary impact on healthcare systems. Each autonomous community has pharmacovigilance systems with their own characteristics that facilitate the collection of information and the submission of data to the Spanish Agency of Medicines and Medical Devices (AEMPS). Some examples are: Madrid; <a href="https://www.comunidad.madrid/servicios/salud/farmacovigilancia">https://www.comunidad.madrid/servicios/salud/farmacovigilancia</a> or Extremadura; <a href="https://saludextremadura.ses.es/web/farmacovigilancia">https://saludextremadura.ses.es/web/farmacovigilancia</a>. In this regard, the Autonomous Community of Castilla y León also has a particular system for reporting incidents without damage (SISNOT) with certain advantages that favour local analysis.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Finally, since most ADRs result from errors in the preparation and administration of drugs, Dr. Sanchez's comments on the usefulness of recommendations aimed at avoiding errors that may occur during this process are very timely.</p><p id="par0020" class="elsevierStylePara elsevierViewall">ADR morbidity and mortality and their impact on healthcare expenditure is a major health and social problem. However, the care provided in an overcrowded clinical practice may be insufficient. Awareness of all healthcare personnel must be a cornerstone in the prevention of ADRs.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reacciones adversas a medicamentos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.F. Sánchez Muñoz-Torrero" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.medcli.2022.05.001" "Revista" => array:6 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2022" "volumen" => "159" "paginaInicial" => "385" "paginaFinal" => "387" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35760605" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Estudio Nacional sobre los Efectos Adversos ligados a la Hospitalización. ENEAS 2005. Secretaría General de Sanidad. Dirección General de la Agencia de Calidad del Sistema Nacional de Salud. Ministerio de Sanidad y Consumo; 2006; [Accessed 18 November 2022]. Available in: <a target="_blank" href="https://seguridaddelpaciente.es/resources/contenidos/castellano/2006/ENEAS.pdf">https://seguridaddelpaciente.es/resources/contenidos/castellano/2006/ENEAS.pdf</a>." ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Estudio APEAS. Estudio sobre la seguridad de los pacientes en atención primaria de salud. Madrid: Ministerio de Sanidad y Consumo; 2008; [Accessed 18 November 2022]. Available in: <a target="_blank" href="https://seguridaddelpaciente.es/resources/contenidos/castellano/2008/APEAS.pdf">https://seguridaddelpaciente.es/resources/contenidos/castellano/2008/APEAS.pdf</a>." ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000016000000007/v1_202304111558/S2387020623001067/v1_202304111558/en/main.assets" "Apartado" => array:4 [ "identificador" => "43309" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000016000000007/v1_202304111558/S2387020623001067/v1_202304111558/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020623001067?idApp=UINPBA00004N" ]