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Letter to the Editor
Refractory hypoglycemia as a presentation of lymphoma
Hipoglucemia refractaria como forma de presentación de linfoma
Antonio Rosales-Castillo
Corresponding author
anrocas90@hotmail.com

Corresponding author.
, Antonio Bustos-Merlo
Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, Granada, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Hypoglycaemia&#44; defined by Whipple&#39;s triad&#44; can be a medical emergency depending on its characteristics&#44; and occurs most commonly in diabetic patients&#44; predominantly in type 1 diabetes&#46; Pharmacological causes &#40;insulin&#44; sulphonylureas&#8230;&#41;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> must always be ruled out initially and&#44; depending on the patient&#8217;s condition&#44; their association with serious emerging pathology&#44; such as liver failure or sepsis&#46; However&#44; on certain occasions it may be the presenting symptom of a neoplasm unrelated to pancreatic islets&#44; secondary to secretion of various factors&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a diffuse large B-cell lymphoma&#44; which started with refractory hypoglycaemia&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">A 62-year-old woman with a history of arterial hypertension and type 2 diabetes mellitus on treatment with metformin&#44; presented with a 5&#8239;kg weight loss&#44; asthenia and hyporexia&#44; together with episodes of night sweats and dizziness with blood glucose levels of up to 55&#8239;mg&#47;dL that had started a month and a half earlier&#46; She associated intermittent epigastric discomfort together with abdominal distension and early satiety&#46; Vital signs were normal&#44; except for the increase in blood pressure &#40;160&#47;90&#8239;mmHg&#41;&#46; Physical examination revealed a palpation of a hard&#44; non-painful&#44; hard mass in the umbilical region&#44; with no palpation of peripheral lymph nodes&#46; Initial laboratory tests showed elevated lactate dehydrogenase &#40;LDH&#58; 951&#8239;U&#47;L&#59; NV 10&#8211;247&#41; and C-reactive protein &#40;150&#46;3&#8239;mg&#47;L&#59; NV 0&#46;1&#8211;5&#41;&#59; chest X-ray was normal&#44; and the patient was admitted for further investigation&#46; An abdominal ultrasound scan showed a 10&#8239;&#215;&#8239;8&#8239;cm infiltrating retroperitoneal mass with irregular contours and no vascular invasion&#44; which was confirmed by computed tomography&#46; Laboratory tests showed very high levels of vitamin B12 &#40;2000&#8239;pg&#47;mL&#59; VN 180&#8211;890&#41;&#46; During admission&#44; there was a tendency to hypoglycaemia both fasting and postprandial&#44; with levels ranging from 55&#8239;mg&#47;dL to 110&#8239;mg&#47;dL&#44; with episodes of sweating&#44; tachycardia&#44; pallor and associated dizziness&#44; despite discontinuation of the oral antidiabetic drug at admission&#46; A sample was taken for hormone determination and continuous perfusion with glucose saline &#40;5&#37;&#41; was started&#46; Despite this&#44; episodes of hypoglycaemia persisted&#44; so glucocorticoid treatment was started&#46; Hormonal determinations showed normal thyroid and adrenal axis&#44; together with insulin 3&#46;9&#8239;&#956; IU&#47;mL &#40;NV 1&#46;9&#8211;23&#41;&#44; C-peptide 0&#46;75&#8239;ng&#47;mL &#40;NV 0&#46;8&#8211;4&#46;2&#41;&#59; IGF-I 58&#46;6&#8239;ng&#47;mL &#40;NV 75&#8211;212&#41;&#44; IGFBP3 1&#46;61&#8239;&#956; g&#47;mL &#40;NV 3&#46;4&#8211;7&#41;&#46; IGF-II&#58; 555&#8239;ng&#47;mL &#40;NV 396&#8211;1000&#41;&#46; IGF-II&#47;IGF-I ratio&#58; 9&#46;47&#46; Negative anti-insulin antibodies&#46; It was decided to approach the mass by ultrasound-guided core needle biopsy&#44; the result being compatible with a centroblastic-type diffuse large B-cell lymphoma with germ cell phenotype&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The patient&#8217;s general condition improved with dexamethasone 4&#8239;mg&#47;12&#8239;h&#44; and glycaemia levels reached &#62;&#8239;80&#8239;mg&#47;dL&#46; She was referred to haematology&#44; where after 5 cycles of chemotherapy &#40;EPOCH-R&#41; there was complete remission of the disease and absence of new hypoglycaemia episodes&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Within tumour-associated hypoglycaemias&#44; three main groups can be distinguished&#58; tumours of the pancreatic islets &#40;insulin-producing&#41;&#59; hypoglycaemias secondary to hepatic&#47;adrenal infiltration&#47;destruction&#59; and hypoglycaemias induced by non-islet tumours&#46; Within the latter group&#44; the aetiopathogenesis is usually explained by the release of various factors that alter glucose metabolism&#58; tumour necrosis factor-alpha&#44; interleukin-6&#44; catecholamines&#44; IGF-I&#44; IGF-II or precursors&#8230; Cases mediated by IGF-II or its precursors are sometimes encompassed under the term &#8220;non-islet cell tumour hypoglycaemia&#8221;&#46; The proposed mechanisms are derived from increased tumour production of IGF-II forms &#40;pro-IGF-II&#44; big-IGF-II&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> This is usually reflected in a hormonal profile with increased levels of pro-IGF-II or IGF-II&#44; normal-low or decreased levels of IGFBP3&#44; insulin&#47;proinsulin and C-peptide&#46; Another parameter usually determined is the IGF-II&#47;IGF-I ratio&#44; which in these cases is usually greater than 3&#58;1 and more typically 10&#58;1&#44; as IGF-II levels are sometimes normal&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The tumours most commonly associated with this process are mesenchymal&#44; epithelial&#44; haematological<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a> and neuroendocrine tumours&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Curative treatment is excision or tumour cure&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;5</span></a> which is often not possible&#59; in addition&#44; effective and rapid measures are required to control blood glucose levels&#44; among which the following have been described&#58; continuous glucose administration&#44; somatostatin analogues&#44; glucocorticoids&#44; growth hormone and glucagon infusion&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Ethical considerations</span><p id="par0040" class="elsevierStylePara elsevierViewall">Informed consent was obtained for imaging and subsequent publication&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0045" class="elsevierStylePara elsevierViewall">No funding was received&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflict of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">No conflict of interest&#46;</p></span></span>"
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ISSN: 23870206
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos