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Letter to the Editor
Cycas revoluta intoxication
Intoxicación por Cycas revoluta
Fernando Alonso Ecenarro, Francesc Puchades Gimeno
Corresponding author
francesc.puchades@gmail.com

Corresponding author.
, Benjamín Climent Díaz
Servicio de Medicina Interna, Consorcio Hospital General Universitario de Valencia, Valencia, Spain
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">a&#58; patient&#39;s place of work&#46; b&#58; remains brought from the patient to the emergency department&#46; c&#58; female <span class="elsevierStyleItalic">Cycas revoluta</span> detail &#40;macrosporangia&#41;&#46; d&#58; red-brown seed or fruit with whitish inner pinnae&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Cycas revoluta</span> or sago palm&#44; is an ornamental plant native to Madagascar&#44; Australia and Polynesia&#44; and is now widely distributed in public and private gardens in the Mediterranean basin&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> We report four clinical cases of ingestion of <span class="elsevierStyleItalic">C&#46; revoluta</span> in the city of Valencia and update the knowledge on the pathophysiology of the intoxication&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The first intoxication occurred in three members of the same family &#40;a 73-year-old man&#44; a 69-year-old woman and a 10-year-old girl&#41; who presented to the emergency department with abdominal pain&#44; nausea and uncontrollable vomiting 30&#8239;min after ingesting food&#46; They ate palm leaves from their garden&#44; fried in oil &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>b&#41;&#44; according to a recipe found on the Internet&#46; Physical examination showed diffuse abdominal pain without pseudoperitonitis&#46; Rehydration therapy was started and in the absence of neurological manifestations and normal complementary examinations&#44; the three patients were discharged 24&#8239;h after admission&#46; The second intoxication episode occurred in a 63-year-old woman who presented to the Emergency Department reporting nausea&#44; abdominal pain and vomiting for 20&#8239;min after eating two uncooked palm seeds&#46; She remarked that they tasted sweet and pleasant&#46; As a background of interest&#44; she worked as a gardener in a palm tree nursery &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>a&#44; c&#44; d&#41;&#46; Sweating but haemodynamically stable with no signs of respiratory distress on examination&#46; The abdomen was diffusely painful without pseudoperitonitis and the neurological examination was normal&#44; as were the complementary examinations&#46; The emergency department performed a gastric lavage&#44; which yielded abundant seed remains&#46; After 24&#8239;h of hospitalisation&#44; she was discharged from hospital&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The increasing use of ornamental plants&#44; as well as the growing interest in food innovation&#44; makes it necessary for the internist to be aware of their toxic potential&#46; Intoxications can be intentional &#40;oral intake or smoking of concentrated extract&#41; or accidental and the most common clinical consequences are mild physiological effects&#58; gastrointestinal&#44; cardiac&#44; pulmonary neurological&#44; dermatological or haematological&#46; Serious and&#47;or life-threatening intoxications are rare and have been reported in exposures to hemlock&#44; dandelion seed&#44; castor bean&#44; jequirity bean&#44; aconite&#44; autumn crocus and oleander&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a><span class="elsevierStyleItalic">C&#46; revoluta</span> is a plant classified as a pseudopalm tree&#46; Long-term consumption intoxication has been reported on the island of Guam and on the Kii Peninsula&#44; leading to amyotrophic lateral sclerosis parkinsonism-dementia complex&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4</span></a> In our setting&#44; intoxication is mainly described in animals&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Female plants have a central area where the seeds are located &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>c&#41;&#46; These seeds contain cycasin &#40;methylazoxymethanol &#946;-<span class="elsevierStyleSmallCaps">d</span>-glucoside&#41; and neocycasin&#44; substances belonging to the cyanogenic glycosides&#46; These compounds contain a cyanide group which&#44; when processed after ingestion&#44; gives rise to hydrocyanic acid &#40;HCN&#41;&#46; The mechanism of catabolism involves the enzyme &#946;-glycosidase which produces <span class="elsevierStyleSmallCaps">d</span>-glucose and aglycone &#40;MAM&#41;&#44; the latter dissociating into hydrocyanic acid and aldehyde&#46; The hydrocyanic compound forms a stable bond with the cytochrome&#44; resulting in inhibition of this enzyme and thus inhibition of aerobic metabolism with known lethality&#46; Although the cyanogenic potential of <span class="elsevierStyleItalic">C&#46; revoluta</span> is known&#44; no associated lethality has been described&#46; This suggests that it may be a pseudo-cyanogen&#44; which would have to be ingested in high concentrations and broken down under extreme conditions to cause cyanide intoxication&#46; The treatment used is mainly supportive&#44; and gastric lavage may be used to avoid absorption of the compounds in the seeds&#46; Observation for 24&#8239;h together with liver function tests and venous blood gas analysis are recommended&#46; We believe that we are currently witnessing an increase in the frequency of intoxication by ornamental plants&#46; Although in our cases only gastrointestinal symptoms occurred&#44; we should not forget the cyanogenic potential of the seeds of this plant and the possibility of using a specific antidote for cyanogenic poisoning &#40;hydroxocobalamin and sodium thiosulphate&#41;&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Ethical considerations</span><p id="par0025" class="elsevierStylePara elsevierViewall">Informed consent has been obtained from all four patients&#46;</p></span><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0020" class="elsevierStylePara elsevierViewall">This work has not received any funding&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflict of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos