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Frozen embryo transfer after PGT-A cycles: To wait or not to wait?
Transferencia de embriones congelados tras ciclos de FIV con PGT-A: ¿esperar o no esperar?
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Estudio retrospectivo multicéntrico" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 971 "Ancho" => 2501 "Tamanyo" => 130356 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Description of the results after fertilization evaluation in the group of patients in which sperm were exposed or not to calcium ionophore. Results are expressed as means and 95% confidence intervals, along with inferior and superior limits. pn<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>pronuclei; DEG<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>degenerated.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jesus Aguilar, Elkin Munoz, Lucia Alegre, Zaloa Larreategui, Jose Remohi, Marcos Meseguer" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Jesus" "apellidos" => "Aguilar" ] 1 => array:2 [ "nombre" => "Elkin" "apellidos" => "Munoz" ] 2 => array:2 [ "nombre" => "Lucia" "apellidos" => "Alegre" ] 3 => array:2 [ "nombre" => "Zaloa" "apellidos" => "Larreategui" ] 4 => array:2 [ "nombre" => "Jose" "apellidos" => "Remohi" ] 5 => array:2 [ "nombre" => "Marcos" "apellidos" => "Meseguer" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2340932020300244?idApp=UINPBA00004N" "url" => "/23409320/0000000700000003/v1_202012020723/S2340932020300244/v1_202012020723/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2340932020300165" "issn" => "23409320" "doi" => "10.1016/j.medre.2020.09.002" "estado" => "S300" "fechaPublicacion" => "2020-09-01" "aid" => "94" "copyright" => "Asociación para el Estudio de la Biología de la Reproducción y Sociedad Española de Fertilidad" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Medicina Reproductiva y Embriología Clínica. 2020;7:75-82" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Transferencia de embriones congelados y riesgo de parto prematuro: estudio de la cohorte española" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "75" "paginaFinal" => "82" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Transfer of frozen embryos and the risk of premature birth: Study of the Spanish cohort" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1355 "Ancho" => 2508 "Tamanyo" => 172281 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Esquema representativo de la distribución de los casos en la población de estudio.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jose Moreno-Sepulveda, Miguel A. Checa" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Jose" "apellidos" => "Moreno-Sepulveda" ] 1 => array:2 [ "nombre" => "Miguel A." "apellidos" => "Checa" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2340932020300165?idApp=UINPBA00004N" "url" => "/23409320/0000000700000003/v1_202012020723/S2340932020300165/v1_202012020723/es/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Frozen embryo transfer after PGT-A cycles: To wait or not to wait?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "83" "paginaFinal" => "88" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Maria Cerrillo, Maria Cruz, Natalia Basile, Alfredo Guillen, Fernando Bronet, Juan Antonio García-Velasco" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Maria" "apellidos" => "Cerrillo" "email" => array:1 [ 0 => "Maria.cerrillo@ivirma.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Maria" "apellidos" => "Cruz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Natalia" "apellidos" => "Basile" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Alfredo" "apellidos" => "Guillen" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Fernando" "apellidos" => "Bronet" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Juan Antonio" "apellidos" => "García-Velasco" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "IVIRMA Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Rey Juan Carlos University, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Transferencia de embriones congelados tras ciclos de FIV con PGT-A: ¿esperar o no esperar?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1656 "Ancho" => 1583 "Tamanyo" => 93335 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">ROC curve.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Since the development of in vitro fertilization (IVF), controlled ovarian stimulation with gonadotropins has been used to develop multiple follicles in a single cycle and therefore more oocytes. This increased follicular recruitment that is associated with supraphysiological levels of estradiol and premature elevations of progesterone, has sometimes been described as detrimental to the endometrium (<a class="elsevierStyleCrossRefs" href="#bib0105">Labarta et al., 2011; Roque et al., 2013; Shapiro et al., 2011</a>). An alternative to minimize these effects could be to cryopreserve all viable embryos and to transfer them in a subsequent frozen embryo transfer (FET) cycle (<a class="elsevierStyleCrossRef" href="#bib0120">Basile and Garcia-Velasco, 2016</a>). The freeze-all strategy, which is usually applied to prevent ovarian hyperstimulation syndrome, or in the presence of high progesterone levels in the follicular phase, has been associated to a better synchrony between embryo development and the endometrial window of implantation, to better pregnancy rates and to the avoidance of certain risks (<a class="elsevierStyleCrossRef" href="#bib0125">Devroey et al., 2011</a>). All these benefits are only be possible due to the establishment of reliable vitrification programmes yielding to good embryo survival and implantation rates after warming (<a class="elsevierStyleCrossRef" href="#bib0130">Cobo et al., 2012</a>).</p><p id="par0010" class="elsevierStylePara elsevierViewall">On the other hand, the use of a preimplantation genetic test for aneuplodies (PGT-A) is increasing, with embryo biopsies been performed normally at the blastocyst stage (<a class="elsevierStyleCrossRefs" href="#bib0135">Forman et al., 2012; Schoolcraft and Katz-Jaffe, 2013</a>). This policy, however, requires the cryopreservation of all the embryos while waiting for the genetic diagnosis and, therefore, delaying the ET procedure (<a class="elsevierStyleCrossRefs" href="#bib0145">Horcajadas et al., 2005; Scott et al., 2013</a>).</p><p id="par0015" class="elsevierStylePara elsevierViewall">Thus it is common practice to perform FET 1 or 2 months after embryo biopsy (<a class="elsevierStyleCrossRef" href="#bib0155">Aflatoonian et al., 2010</a>), causing a significant amount of stress and anxiety to the patients and increasing the time to pregnancy (TTP). For this reason some studies have focused on evaluating whether if waiting, or not, for one menstrual cycle or more, before performing embryo transfer (ET) can affect live-birth rates, suggesting that it is not necessary to wait (<a class="elsevierStyleCrossRef" href="#bib0160">Santos-Ribeiro et al., 2016</a>).</p><p id="par0020" class="elsevierStylePara elsevierViewall">The objective of this retrospective study was to compare clinical outcomes when ET was performed immediately after ovarian stimulation, or after one (or more) menstrual cycles in patients undergoing PGT-A considering a bigger data set than previously published studies.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">This large, non-interventional, retrospective multicentre cohort study included 5104 cycles of patients<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>35 years old (5104 cycles) who underwent PGT-A cycles between May 2016 and March 2017. Patients were stimulated following antagonist stimulation protocols with different kinds of gonadotropins (FSHr, FSH/LHr or HMG) with dosages between 150 and 300<span class="elsevierStyleHsp" style=""></span>UI and with 0.2<span class="elsevierStyleHsp" style=""></span>mg GnRHa (Decapeptyl 0.1<span class="elsevierStyleHsp" style=""></span>mg IPSEN PHARMA, Barcelona, Spain) triggering when more than 1 follicle achieved a size over<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>17<span class="elsevierStyleHsp" style=""></span>mm. Briefly oocyte pick-up took place 36<span class="elsevierStyleHsp" style=""></span>hs post trigger. Cumulus-corona complexes were denuded 3<span class="elsevierStyleHsp" style=""></span>hours post retrieval and all MII oocytes were inseminated through intracytoplasmic sperm injection (ICSI) immediately afterwards. Fertilization check was performed 18–19 hs post injection and all fertilized oocytes were cultured individually. On day 5 or day 6 of development embryo biopsy (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>6423) was performed using Octax laser and the preimplantational genetic test was performer by NGS. Only cavitated, expanded, hatching or fully hatched blastocysts with a clear ICM were biopsied. After biopsy was confirmed embryos were vitrified following a standard vitrification protocol using an open system as described elsewhere.</p><p id="par0030" class="elsevierStylePara elsevierViewall">FETs were scheduled once genetic results were available and the presence of euploid embryos was confirmed. FETs took place either in a natural or artificial cycle. All the procedures were approved by an institutional review board (1704-MAD-025-MC) in IVI Madrid and complied with the Spanish law on assisted reproductive technologies (14/2006). Only the first FET following the fresh cycle was included in the study. For that reason only 913 were analyzed, because we wanted to know if delay or not the transfer affect or not in results.</p><p id="par0035" class="elsevierStylePara elsevierViewall">913 FET were included, 712 with an endometrial artificial preparation and 201 with natural cycle. The artificial preparation was doing with oral oestradiol valerate (Progynova®; Schering, Madrid, Spain) on day 2–3 of the cycle by the classic endometrium built-preparation protocol started with 2<span class="elsevierStyleHsp" style=""></span>mg/day on days 1–4, 4<span class="elsevierStyleHsp" style=""></span>mg/day on days 5–8 and 6<span class="elsevierStyleHsp" style=""></span>mg/day from day 9 onwards. After 10–12 days of oestrogen treatment a transvaginal ultrasound was performed. Frozen embryo transfers were scheduled once endometrial thickness was at least 6<span class="elsevierStyleHsp" style=""></span>mm and triple lined, there was neither a dominant follicle nor signs of ovulation, and serum P4 levels were confirmed below 1 ng/ml. Natural micronized progesterone was administered vaginally (Utrogestan®; Seid, Barcelona, Spain) at a dose of 400<span class="elsevierStyleHsp" style=""></span>mg/12<span class="elsevierStyleHsp" style=""></span>h during 5 complete days before ET. Progesterone and estradiol supplementation continued if pregnancy occurred and until week 12 of gestation.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Natural cycles (<span class="elsevierStyleItalic">n</span>: 201) were performed after spontaneous menses to detect the dominant follicle. Once the dominant follicle had a mean diameter of 17<span class="elsevierStyleHsp" style=""></span>mm, and the endometrial thickness was at least 6<span class="elsevierStyleHsp" style=""></span>mm and triple lined, hCG (Ovitrelle® 250<span class="elsevierStyleHsp" style=""></span>μg; Merck, Madrid, Spain) was administered subcutaneously. Seven days later, embryos were warmed and transferred. Luteal phase support began 5 days before ET (embryo age<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>0 days) by administering micronized vaginal progesterone at a dose of 200<span class="elsevierStyleHsp" style=""></span>mg/12<span class="elsevierStyleHsp" style=""></span>h daily (Utrogestan®, 200<span class="elsevierStyleHsp" style=""></span>mg; Seid, Barcelona, Spain) until week 5 of gestation.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The primary outcome of this study was clinical pregnancy rate (CPR), defined as the presence of a gestational sac with foetal heart beat observed by ultrasound determination. Secondary end-points included implantation rate (IR), calculated as the number of intrauterine gestational sacs observed by transvaginal ultrasound divided by the number of transferred embryos. And miscarriage rate (MR), which refers to the number of pregnancies lost before week 12 of gestation divided by the number of patients with positive β-hCG</p><p id="par0155" class="elsevierStylePara elsevierViewall">All the procedures were approved by an institutional review board (1704-MAD-025-MC) in IVI Madrid and complied with the Spanish law on assisted reproductive technologies (14/2006).</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Statistical analysis</span><p id="par0050" class="elsevierStylePara elsevierViewall">All the calculations were done on a “per embryo transfer” basis. Values were expressed as means with standard deviations (SDs). One-way analysis of variance was applied for continuous variables and chi-squared test for categorical ones. All the data were analyzed by SPPS 13 (IBM Corporation, NY, USA), and <span class="elsevierStyleItalic">p</span> value<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05 was considered statistically significant.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Considering the sample size of the study, the statistical power to detect a 5% improvement in a unilateral test was 80.4%, with a 95% significance level.</p><p id="par0060" class="elsevierStylePara elsevierViewall">The odds ratio (OR) of all the variables generated for pregnancy were expressed in terms of 95% confidence intervals (CI). Multivariate logistic regression was performed to quantify the effect of the different variables on pregnancy. Furthermore, a receiver operating characteristic (ROC) curve was used to test the predictive value of “time to FET” and was included in the model compared to the CPR. The receiver operating characteristic (ROC) analysis provided values for the area under the curve (AUC), which were between 0.5 and 1.0, and can be interpreted as the measurement of the model's global classification ability.</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0065" class="elsevierStylePara elsevierViewall">A total of 913 patients underwent FET either in an artificial cycle (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>712) or natural one (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>201) FET occurred in any of the 13 clinics of our group in Spain.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Results were compared according to the first FET between patients whose transfer took place immediately after ovarian stimulation (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>198) and those who did it afterwards (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>715).</p><p id="par0075" class="elsevierStylePara elsevierViewall">Baseline characteristics were similar in both groups (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Statistical differences were only observed in HMG doses and number of euploid embryos. There was no significant difference in cumulative pregnancy rate (CPR), implantation rate (IR) and miscarriage rate (MR) between both groups.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">When analyze the results based on the type of endometrial preparation, natural or artificial cycles, we didn’t find differences between both (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). The pregnancy rates in NC were 46.9% in the group of immediate transfer vs 54.8% in the group of delay transfer (<span class="elsevierStyleItalic">p</span>: 0.284); and in Artificial cycles, the PR were 53.9% vs 55.2% (<span class="elsevierStyleItalic">p</span>: 0.429). There were no differences based in the type of cycle used.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">In order to assess if the CPR for FET remained unaltered after adjusting for the measured confounding factors, a mixed-effects multivariate regression analysis was performed (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). For the CPR, the number of biopsied embryos, euploid embryos and transferred embryos significantly affected the probability of getting pregnant, which seemed normal in a PGT-A cycle. However, when analyzing the effect of the time to perform the FET, this was not significantly relevant.</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Finally, the predictive value of the time to FET regarding the CPR was analyzed by a ROC curve (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The AUC was 0.507 (95%CI: 0.469–0.545), which indicates that the area under curve (AUC) analysis for this parameter was not conclusive, and the time that wait for the transfer didn’t affect the IR.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0095" class="elsevierStylePara elsevierViewall">FETs are frequently postponed (besides the necessary wait for genetic results) in an attempt to minimize effects derived from recent ovarian simulations on window implantation (<a class="elsevierStyleCrossRef" href="#bib0170">Miravet-Valenciano et al., 2015</a>). Although this empirical decision may be well intended, the elective deferral of FETs, with no proved clinical benefit, may unnecessarily frustrate couples who wish to get pregnant quickly. In this study we proved that there are no differences in CPR, IR and MR between patients that wait to have a FET versus those that don’t. Therefore, in our opinion, postponing FETs, would only represent a potential source of stress to the patients due to discontinuation of the treatment and an increased time to pregnancy.</p><p id="par0100" class="elsevierStylePara elsevierViewall">There is no doubt that the percentage of “freeze-all” cycles has increased mainly due to: prevention of ovarian hyperstimulation syndrome (OHSS), an increase in genetic screening at the blastocyst stage, which forces clinics to freeze all embryos while awaiting genetic results (<a class="elsevierStyleCrossRef" href="#bib0165">Garcia-Herrero et al., 2016</a>), cases of high progesterone levels at triggering and women with implantation failure who may present a displaced window of implantation (<a class="elsevierStyleCrossRef" href="#bib0170">Miravet-Valenciano et al., 2015</a>); Given all these indications, the “freeze-all” (<a class="elsevierStyleCrossRef" href="#bib0115">Shapiro et al., 2011</a>) strategy is common practice these days. Therefore, the question whether is it necessary or not to wait to schedule a future FET is worth answering.</p><p id="par0105" class="elsevierStylePara elsevierViewall">There are 3 studies that have evaluated the impact of the time of the first FET on clinical outcomes. Two of them (<a class="elsevierStyleCrossRefs" href="#bib0160">Santos-Ribeiro et al., 2016; Ozgur et al., 2018</a>) analyzed it after patients having a failed fresh embryo transfer. The first one, with a “good sample size” reported benefits for the immediate FET group versus the delayed one while the second one, included over 1000 patients, showed no benefit at all.</p><p id="par0110" class="elsevierStylePara elsevierViewall">The third one, a retrospective study based on 333 FETs, analyzed the same question but with patients undergoing elective freeze-all cycles, an approach that the authors considered crucial taking in consideration that the luteal phase is considered to be substantially reduced after GnRH agonist triggering (<a class="elsevierStyleCrossRefs" href="#bib0180">Beckers et al., 2003; Acevedo et al., 2006</a>) thus dispelling the empirical notion that an artificially shortened luteal phase would have a negative impact on immediate FETs (<a class="elsevierStyleCrossRefs" href="#bib0160">Santos-Ribeiro et al., 2016; Lattes et al., 2017</a>).</p><p id="par0115" class="elsevierStylePara elsevierViewall">Our study, compared to this last one presents a similar rationale considering that patients undergoing genetic screening do electively freeze-all their embryos, although this indication was not included in Santos Ribeiro study (<a class="elsevierStyleCrossRef" href="#bib0160">Santos-Ribeiro et al., 2016</a>).</p><p id="par0120" class="elsevierStylePara elsevierViewall">Finally, the regression model and the data that derive from the ROC curve confirm that the time to perform ET does not influence the chances of getting pregnant. So we assume that ovarian stimulation does not affect endometrial receptivity, regardless of the stimulation protocol with an antagonist protocol, ovulation triggering with GnRHa or endometrial preparation, most cycles with an artificial protocol and oestrogens, and less with a natural cycle. These facts allow patients to choose when they wish to accomplish their FET when it is most convenient for them.</p><p id="par0125" class="elsevierStylePara elsevierViewall">It is important to believe in the future of our patients and to plan strategies that maximize success. In this context, the impact of psychosocial aspects should be taken in account (among many other things). It is important to identify possible causes of burden across patients, treatments and clinic domains, and to develop tailored interventions that can be easily included in the routine practice of a fertility clinic. In our group, and until quite recently, doctors were unaware about how long it was advisable to wait after oocyte retrieval before performing FET. However, the results of this study demonstrate that it is not necessary to delay FET to obtain good clinical outcomes, and this situation will relieve negative psychological impacts on couples. The strategy of cutting waiting times should imply better treatment experiences for patients, improved and adequate time planning, and lower stress alive (<a class="elsevierStyleCrossRefs" href="#bib0195">Aarts et al., 2012; Van Empel et al., 2011</a>).</p><p id="par0130" class="elsevierStylePara elsevierViewall">To the best of our knowledge, we have evaluated the largest data set by analysing the effect of the first FET timing of euploid embryos in PGT-A cycles, which reinforces our study. It is also important to emphasize the relevance of these results, especially if we consider that couples are increasingly delaying childbearing with the consequent higher demand of pre-implantation genetic diagnosis procedures. Apart from waiting, it is important to mention that these patients also suffer from anxiety from the genetic test itself. In short, performing FET in the immediate subsequent cycle favours them because we diminish their anxiety. The retrospective nature of this study is a limitation as not all risk factors may have been identified and subsequently recorded. Another limitation is the difference between the number of FET performed by natural or artificial cycle, is big (201 vs 712), but although there weren’t differences between them. Measuring risk factors and outcomes in a complete database may not be consistent or accurate enough. Therefore, only association, and not causation, can be inferred from the results.</p><p id="par0135" class="elsevierStylePara elsevierViewall">In conclusion, performing the FET of euploid embryos immediately after a freeze-all cycle does not vary significantly from delaying it in terms of pregnancy rates, but improves the IVF experience as it minimizes patient treatment and clinic sources of burden that can have a negative psychological impact on IVF couples.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Funding</span><p id="par0150" class="elsevierStylePara elsevierViewall">The present investigation has not received specific aid from public sector agencies, commercial sector or non-profit organizations.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of interest</span><p id="par0140" class="elsevierStylePara elsevierViewall">No conflict of interest exists.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1424459" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1301965" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1424458" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1301964" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Material and methods" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Statistical analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0020" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0025" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0030" "titulo" => "Funding" ] 9 => array:2 [ "identificador" => "sec0035" "titulo" => "Conflict of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-10-09" "fechaAceptado" => "2020-09-15" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1301965" "palabras" => array:3 [ 0 => "PGT-A" 1 => "FET" 2 => "Time to transfer" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1301964" "palabras" => array:3 [ 0 => "PGT-A" 1 => "TEC" 2 => "Tiempo de transferencia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The aim of the study is to assess whether delaying frozen embryo transfer (FET) after pre-implantation genetic testing for aneuploidy (PGT-A) cycle provides any benefit for reproductive outcomes.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Retrospective cohort study including a total of 913 frozen embryo transfers related to 5104 PGT-A cycles performed between May 2016 and March 2017 at IVI clinics. We compared the FET performed the month following the ovarian puncture (OPU) (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>184) with the FET delayed one or more months (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>700). The main outcome was clinical pregnancy rate (CPR) and the secondary outcomes were implantation (IR) and miscarriage rates.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">No significant statistical differences were detected between groups as regards patient age and cycle parameters. Similar results were also observed concerning metaphase II oocytes (11<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.8 vs 10<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.4, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.03), number of blastocysts (4.3<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.4 vs 3.8<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.2, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.122), euploid embryos (2.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.3 vs 1.8<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.1, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.039), or transferred embryos (1.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.1 vs 1.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.2, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.52). Finally, no significant differences were found in CPR (52.7% vs 54.9%, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.33). The multivariate logistic regression showed that the number of euploid (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.170, 1.062–1.288; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.001) and transferred embryos (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2.530, 1.703–1.509; <span class="elsevierStyleItalic">P</span><<span class="elsevierStyleHsp" style=""></span>.001) significantly affected the probability of getting pregnant, while the timing of the frozen embryo transfer (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.090, 0.787–1.509; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.604) did not have a significant effect on reproductive outcomes.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Delaying frozen embryo transfer after PGT-A cycles does not seem to improve outcomes in terms of pregnancy rates.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El principal objetivo del estudio fue evaluar si realizar la transferencia inmediata tras la estimulación ovárica en ciclos de FIV con PGT-A afectaba o no a los resultados clínicos.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio de cohortes retrospectivo que incluye los primeros 913 ciclos de transferencias de embriones congelados (TEC) de 5.104 ciclos de FIV con PGT-A realizados entre mayo de 2016 y marzo de 2017 en clínicas IVI. Comparamos las TEC realizadas en el ciclo inmediato de la punción ovárica (OPU) (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>184) con el TEC realizado descansando más de un mes tras la OPU (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>700). El resultado principal fue la tasa de embarazo clínico (TG) y los resultados secundarios fueron la implantación (TI) y las tasas de aborto espontáneo.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">No se encontraron diferencias estadísticas con respecto a la edad de los pacientes y las variables del ciclo entre los grupos. Además, se observaron resultados similares con respecto al número de ovocitos de metafase II (11<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,8 frente a 10<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,4; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,03), número de blastocistos (4,3<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,4 frente a 3,8<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,2; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,122), embriones euploides (2,1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,3 frente a 1,8<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,1; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,039) o embriones transferidos (1,1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,1 frente a 1,1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0,2; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,52). Finalmente, no encontramos diferencias significativas en la RCP (52,7 frente al 54,9%; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,33). La regresión logística multivariada mostró que el número de embriones euploides (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,170, 1,062-1,288; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,001) y transferidos (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2,530, 1,703-1,509; p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001) afectó significativamente la probabilidad de quedar embarazada, mientras que el momento de realizar la transferencia de embriones congelados (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,090, 0,787-1,509; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,604) no tuvo un efecto significativo en los resultados reproductivos.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Retrasar la transferencia de embriones congelados después de los ciclos de PGT-A no parece mejorar los resultados en términos de tasas de embarazo.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1656 "Ancho" => 1583 "Tamanyo" => 93335 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">ROC curve.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">FET<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>30 days (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>198) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">FET<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>30 days (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>715) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38.7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38.6<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.780 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Stimulation days \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>4.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.6<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.503 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Oestradiol_hCG (pg/ml) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2424<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>366 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2383<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>162 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.830 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Progesterone_hCG (pg/ml) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.399 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Doses of FSH (UI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1811<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1777<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.607 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Doses of HMG (UI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1266<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>131 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1110<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.011 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Doses of LH (UI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">675<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>168 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">658<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.844 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Retrieved oocytes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.0<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.471 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Metaphase II oocytes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.0<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.0<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.039 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total embryos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.5<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.122 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Biopsied embryos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.3<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.8<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.061 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Euploid embryos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.8<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.039 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Transferred embryos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.527 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Oestradiol levels before FET (pg/ml) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">258<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">300<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.384 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Implantation rate (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">52.9% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54.4% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.835 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pregnancy rate (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">52.7% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54.9% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.331 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Miscarriage rate (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.8% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.1% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.515 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2443059.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristics.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Natural cycle \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Artificial cycle \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Immediate transfer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46.9% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">53.9% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.28 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Delay transfer \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54.2% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">55.2% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.42 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2443060.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Comparative pregnancy rates between natural cycle and artificial cycle.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR IC(95%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.009 (0969–1.050) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.664 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Eggs retrieved \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.017 (0.998–1.035) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.074 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Biopsied embryos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.071 (1.020–1.124) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.006 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Euploid embryos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.170 (1.062–1.288) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Transferred embryos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.530 (1.703–3.759) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time to FET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.090 (0.787–1.509) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.604 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2443058.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Multivariate logistic regression to quantify the potential effect of different variables on pregnancy rate was performed; 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