Sensitization to indoor aeroallergens in children who attended the Allergy Service of the “Dr. José Eleuterio González” University Hospital of Monterrey, Mexico
S.. González-Díaza, A.. Arias-Cruza, I. V.. Yáñez-Péreza, L.. Rangel-Garzaa, H.. Hernández-Sáncheza, A.. Macías-Weinmanna, C.. Gallego-Corellaa
a Regional Center of Allergy and Clinical Immunology (CRAIC), Dr. José Eleuterio González University Hospital, Universidad Autónoma de Nuevo León, Monterrey, N.L., Mexico
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E. de la O-Cavazos, C. Treviño-Garza, I. Rodríguez-Balderrama, J. Z. Villarreal-Pérez, R. Elizondo-Omaña, R. Montes de Oca-Luna, S. Sánchez-González, D. Cantú-Moreno, P. Rodríguez-Calderón, J. Argente-Oliver" "autores" => array:10 [ 0 => array:2 [ "Iniciales" => "M. E." "apellidos" => "de la O-Cavazos" ] 1 => array:2 [ "Iniciales" => "C." "apellidos" => "Treviño-Garza" ] 2 => array:2 [ "Iniciales" => "I." "apellidos" => "Rodríguez-Balderrama" ] 3 => array:2 [ "Iniciales" => "J. Z." "apellidos" => "Villarreal-Pérez" ] 4 => array:2 [ "Iniciales" => "R." "apellidos" => "Elizondo-Omaña" ] 5 => array:2 [ "Iniciales" => "R." "apellidos" => "Montes de Oca-Luna" ] 6 => array:2 [ "Iniciales" => "S." "apellidos" => "Sánchez-González" ] 7 => array:2 [ "Iniciales" => "D." "apellidos" => "Cantú-Moreno" ] 8 => array:2 [ "Iniciales" => "P." "apellidos" => "Rodríguez-Calderón" ] 9 => array:2 [ "Iniciales" => "J." 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"apellidos" => "González-Díaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 1 => array:3 [ "Iniciales" => "A." "apellidos" => "Arias-Cruz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 2 => array:3 [ "Iniciales" => "I. V." "apellidos" => "Yáñez-Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 3 => array:3 [ "Iniciales" => "L." "apellidos" => "Rangel-Garza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 4 => array:3 [ "Iniciales" => "H." "apellidos" => "Hernández-Sánchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] 5 => array:3 [ "Iniciales" => "A." 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"apellidos" => "Gallego-Corella" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Regional Center of Allergy and Clinical Immunology (CRAIC), “Dr. José Eleuterio González” University Hospital, Universidad Autónoma de Nuevo León, Monterrey, N.L., Mexico " "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "affa" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "304v16n64-90367587fig3.jpg" "Alto" => 795 "Ancho" => 1008 "Tamanyo" => 79169 ] ] "descripcion" => array:1 [ "en" => "Distribution of sensitization to aeroallergens by age group." ] ] ] "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold">Introduction </span></p><p class="elsevierStylePara"> The prevalence of organ-specific allergic diseases, such as allergic rhinitis, asthma and atopic dermatitis is on the rise worldwide.<span class="elsevierStyleSup">1</span> There is substantial evidence associating allergic sensitization and a hike in allergy and asthma morbidity to early exposure to environmental allergens.<span class="elsevierStyleSup">2</span> Atopic children usually begin with monosensitization (sensitization to a single allergen), however, with time they begin sensitizing to other allergens.<span class="elsevierStyleSup">3</span> Identification during the early stages of life is required in order to start a specific treatment and be able to modify the allergic disease’s natural history. Skin tests are used to assess Ige-mediated hypersensitivity, and confirm clinical sensitivity induced by allergens and other agents.<span class="elsevierStyleSup">4,5</span></p><p class="elsevierStylePara"> The objective of this study was to identify the most frequent indoor aeroallergens which cause sensitization in children who attend the allergy outpatient clinic of <span class="elsevierStyleItalic">“Dr. José Eleuterio González”</span> University Hospital of the <span class="elsevierStyleItalic">Universidad Autónoma de Nuevo León </span>(UANL, by its Spanish acronym).</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Methods </span></p><p class="elsevierStylePara"> We conducted an observational and descriptive study. We reviewed the results of the skin tests for the most common indoor aeroallergens on children under 16 who went for a consult at the Allergy and Immunology Regional Center Clinic of <span class="elsevierStyleItalic">“Dr. José Eleuterio González”</span> University Hospital of the UANL, Mexico between 2011 and 2012.</p><p class="elsevierStylePara"> We collected demographic data: age, gender, clinical diagnosis and skin test results for 6 common indoor aeroallergens: <span class="elsevierStyleItalic">Dermatophagoides farinae </span>(<span class="elsevierStyleItalic">D. farinae</span>)<span class="elsevierStyleItalic">, Dermatophagoides pteronyssinus </span>(<span class="elsevierStyleItalic">D. pteronyssinus</span>)<span class="elsevierStyleItalic">, Canis familiaris </span>(<span class="elsevierStyleItalic">C. familiaris</span>)<span class="elsevierStyleItalic">, Felis domesticus </span>(<span class="elsevierStyleItalic">F. domesticus</span>)<span class="elsevierStyleItalic">, Blattella germanica </span>(<span class="elsevierStyleItalic">B. germanica</span>) and<span class="elsevierStyleItalic"> Periplaneta americana </span>(<span class="elsevierStyleItalic">P. americana</span>). Skin prick tests were performed using commercial allergen extracts, Duotip-Test<span class="elsevierStyleSup">®</span> (Lincoln Diagnostics, Decatur, IL) or Multi-Test<span class="elsevierStyleSup">®</span> (Lincoln Diagnostics, Decatur, IL), as well as a negative control with a saline solution of 0.9% and a positive one with 10 mg/mL of histamine. We considered a positive test that which caused a ≥ 3 mm wheal compared to the negative control.</p><p class="elsevierStylePara"> The collected data was analyzed using Statistical Product and Service Solutions 17 (SPSS<span class="elsevierStyleSup">®</span> Statistics v. 17.0). We evaluated nominal and ordinal variables, and determined frequencies and percentages.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Results </span></p><p class="elsevierStylePara"> We evaluated a total of 439 skin tests to indoor aeroallergens in children under 16. The 57.6% of children were male and 42.4% female (Table 1). The most utilized device for skin tests was Multi-Test<span class="elsevierStyleSup">®</span> (58.5%). On the other hand, Duotip-Test<span class="elsevierStyleSup">®</span> was used in 41.5% of the cases. There were no reports of complications with either device.</p><p class="elsevierStylePara"><img alt="Table 1 Demographic data." src="304v16n64-90367587fig1.jpg"></img></p><p class="elsevierStylePara"> The clinical diagnoses included: allergic rhinitis (71.8%), asthma (16.6%), and atopic dermatitis (4.3%). The 7.3% of children had 2 or more of these allergic diseases.</p><p class="elsevierStylePara"> Two hundred and fifty-four of studied patients (57.9%) showed sensitization to at least one of the 6 tested aeroallergens. The main indoor aeroallergens causing sensitization in children included <span class="elsevierStyleItalic">D. pteronyssinus </span>(49%), <span class="elsevierStyleItalic">D. farinae</span> (44.6%) and <span class="elsevierStyleItalic">B. germanica</span> (13.9%) (Table 2).</p><p class="elsevierStylePara"><img alt="Table 2 Sensitization to indoor aeroallergens." src="304v16n64-90367587fig2.jpg"></img></p><p class="elsevierStylePara"> The rate of specific sensitization per age group was as follows: 38% in children under 3 years, 51.3% in children between 3 and 5 years, 69% in children between 6 and 12 years and 73% in children between 13 and 16 years of age (Fig. 1).</p><p class="elsevierStylePara"><img alt="Figure 1 Distribution of sensitization to aeroallergens by age group." src="304v16n64-90367587fig3.jpg"></img></p><p class="elsevierStylePara"><span class="elsevierStyleBold">Figure 1 </span>Distribution of sensitization to aeroallergens by age group.</p><p class="elsevierStylePara"> The older the child, the more frequent the sensitization to indoor aeroallergens. Sensitization to dust house mites -mainly <span class="elsevierStyleItalic">D. pteronyssinus</span>- occurred in all age groups. Cockroach sensitization displayed a directly proportional relationship with age, with a greater prevalence to <span class="elsevierStyleItalic">B. germanica</span> in children over 6 years of age. Sensitization rate for <span class="elsevierStyleItalic">C. familiaris</span> displayed a higher proportion in children under 3 years with 27%, decreasing as children get older, reaching 3% in the 13 to 16 group.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Discussion </span></p><p class="elsevierStylePara"> Indoor aeroallergen sensitization increases the risk of developing allergic diseases, including asthma, allergic rhinitis and atopic dermatitis.<span class="elsevierStyleSup">6</span> Different studies conducted in pediatric populations, as well as in adults who suffered from allergies, have shown that as time passes monosensitization leads to allergenic polysensitization, which constitutes a characteristic of the natural history of atopia.<span class="elsevierStyleSup">7,8</span> In our study, the rate of indoor allergen sensitization was 57.7%, similar to the results obtained in a study conducted by Sheehan et al. in a pediatric population in Boston, where they reported a sensitization of 51.3% for at least one indoor allergen,<span class="elsevierStyleSup">2</span> whereas in the general population sensitization to indoor allergens occurs up 30% of people.<span class="elsevierStyleSup">9 </span><span class="elsevierStyleItalic">D. pteronyssinus</span> and<span class="elsevierStyleItalic"> D. farinae</span> were the most prevalent indoor aeroallergens as a cause of sensitization in the children in our study. In a study conducted by Kim et al. in a pediatric population in Korea, they found a prevalence of sensitization to <span class="elsevierStyleItalic">D. pteronyssinus </span>of 32.1% and 42.7%, and to <span class="elsevierStyleItalic">D. farinae </span>of 32.4% and 41.9%, in children between 6 and 7 years of age and between 12 and 13 years of age, respectively.<span class="elsevierStyleSup">10</span> On the other hand, the prevalence of sensitization to dust house mites had been reported up to 27.5% of people in the general population in the US.<span class="elsevierStyleSup">11</span> This shows that indoor allergen sensitization prevalence is greater in the studies where a pediatric population is included and in those studies where the patients are assessed by an allergy specialist.</p><p class="elsevierStylePara"> Sensitization to cockroaches was at 13.9% for <span class="elsevierStyleItalic">B. germanica</span> and of 10.9% for <span class="elsevierStyleItalic">P. Americana</span>. Calabria et al. reported a general sensitization to cockroaches of 12.5% in children with rhinitis.<span class="elsevierStyleSup">12</span> In our study, sensitization to cat was 5.9%, similar to the data found in a cohort study from birth to 4 years of age, with a sensitization of 5.1%.<span class="elsevierStyleSup">13</span> On the other hand, espinoza et al. found sensitization to cat at 10%, in children up to 4 years old,<span class="elsevierStyleSup">14</span> which differs from our study, where sensitization to cat in children up to 5 years old was just 3.8%.</p><p class="elsevierStylePara"> Sensitization to aeroallergens can occur in the early stages of life, increasing as the person ages, in many cases going through monosensitization to polysensitization.<span class="elsevierStyleSup">15</span> It is possible to see this transition from monosensitization to polysensitization in pre-school and school-aged children.</p><p class="elsevierStylePara"> In a meta-analysis published by Goldhahn et al., they found a rise in aeroallergen sensitization from 14.2% to 21.6% in patients from 7 to 23 years of age.<span class="elsevierStyleSup">16</span> Similar data can be found in a study of children conducted in Turkey where the prevalence in children from 2 to 6 years of age was at 16.1% increasing up to 55.1% in patients 12-18 years of age.<span class="elsevierStyleSup">17</span> In pediatric population, the prevalence of sensitization to dust mites, cockroaches, dog and cat appears to be higher in older patients.<span class="elsevierStyleSup">2</span> Sensitization to dust mites, and to a lesser degree to pollens seems to have a “triggering” effect in the developing of polysensitization, due to the large number of children who are initially monosensitized to mites.<span class="elsevierStyleSup">18</span> A recent preliminary study suggests that a defect in the function of regulatory T cells can explain the tendency to develop polysensitization in this population, because children with persistent monosensitization produce a larger amount of interleukin 10 and interferon gamma than the children who develop polysensitization.<span class="elsevierStyleSup">19</span></p><p class="elsevierStylePara"> In the pediatric population that goes to see the doctor at the Allergy Outpatient Clinic of the <span class="elsevierStyleItalic">“Dr. José Eleuterio González”</span> University Hospital of the UANL, indoor aeroallergen sensitization is around 50% and <span class="elsevierStyleItalic">D. pteronyssinus</span> and <span class="elsevierStyleItalic">D. farinae</span> are the main involved allergens. In the atopic population, frequency of sensitization directly increases with the patient’s age; however it may be present from the early stages of life. Early detection is recommended using skin tests on all children under suspicion of allergy, in order to begin a timely treatment and modify the natural history of the allergic disease.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Conflicts of interest </span></p><p class="elsevierStylePara"> The authors have no conflicts of interest to declare.</p><p class="elsevierStylePara"><span class="elsevierStyleBold">Funding </span></p><p class="elsevierStylePara"> No financial support was provided.</p><hr></hr><p class="elsevierStylePara"> Received: February 2014; <br></br> Accepted: June 2014</p><p class="elsevierStylePara"> * Corresponding author: <br></br> Regional Center of Allergy and Clinical Immunology (CRAIC), <span class="elsevierStyleItalic"><br></br> “Dr. José Eleuterio González”</span> University Hospital. Francisco I. <br></br> Madero and Gonzalitos Avenue, Mitras Centro, <br></br> Z.P. 64460, Monterrey, N.L., Mexico. <br></br> Telephone: (81) 8346 2515. Fax: (81) 8347 6798. <br></br><span class="elsevierStyleItalic">E-mail address</span>: <a href="mailto:aarias45@hotmail.com" class="elsevierStyleCrossRefs">aarias45@hotmail.com</a> (A. Arias-Cruz).</p>" "pdfFichero" => "304v16n64a90367587pdf001.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec686872" "palabras" => array:4 [ 0 => "Sensitization" 1 => "Aeroallergen" 2 => "Indoor" 3 => "Pediatric; Mexico" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:1 [ "resumen" => "<p class="elsevierStylePara"> <span class="elsevierStyleItalic">Background</span>: Indoor aeroallergens are the main cause of sensitization in children and represent a risk factor for the development of allergic diseases.</p> <p class="elsevierStylePara"> <span class="elsevierStyleItalic">Objective</span>: Identify the major indoor aeroallergens most often sensitized to pediatric patients treated at the Allergy Service at the <span class="elsevierStyleItalic">“Dr. José Eleuterio González”</span> University Hospital of Monterrey</p> <p class="elsevierStylePara"> <span class="elsevierStyleItalic">Methods</span>: We performed an observational and descriptive study where we reviewed reports of positive skin tests to the following common indoor aeroallergens: <span class="elsevierStyleItalic">Dermatophagoides farinae </span>(<span class="elsevierStyleItalic">D. farinae</span>)<span class="elsevierStyleItalic">, Dermatophagoides pteronyssinus </span>(<span class="elsevierStyleItalic">D. pteronyssinus</span>)<span class="elsevierStyleItalic">, Canis familiaris </span>(<span class="elsevierStyleItalic">C. familiaris</span>)<span class="elsevierStyleItalic">, Felis domesticus </span>(<span class="elsevierStyleItalic">F. domesticus</span>)<span class="elsevierStyleItalic">, Blattella germanica </span>(<span class="elsevierStyleItalic">B. germanica</span>) and<span class="elsevierStyleItalic"> Periplaneta americana </span>(<span class="elsevierStyleItalic">P. americana</span>), found in patients under 16 years with symptoms of allergy, during the period of 2011-2012.</p> <p class="elsevierStylePara"> <span class="elsevierStyleItalic">Results</span>: We performed 439 skin tests to aeroallergens in pediatric patients. Of these, 57.6% were male and 42.4% were female. Mean age was 6.3 years. The age groups were under 3 years: 17.8%, 3-5 years: 35%, 6-12 years: 36%, and 13-16 years: 11.2%. The main diagnoses were: allergic rhinitis (71.8%), asthma (16.6%), and atopic dermatitis (4.3%). In 57.9% of the cases, they had at least one positive skin test to any aeroallergen. The rate of sensitization to specific aeroallergens was: <span class="elsevierStyleItalic">D. Pteronyssinus</span> 49.0%<span class="elsevierStyleItalic">, D. farinae</span> 44.6%, <span class="elsevierStyleItalic">B. germanica</span> 13.9%<span class="elsevierStyleItalic">, P. Americana</span> 10.9%, <span class="elsevierStyleItalic">F. domesticus</span> 10.7%, and <span class="elsevierStyleItalic">C. familiaris</span> 5.9%.</p> <p class="elsevierStylePara"> <span class="elsevierStyleItalic">Conclusion</span>: Indoor aeroallergen sensitization can occur early in life, although it was more frequent in the preschooler and elementary school group. Dust house mites were the most commom cause of allergic sensitization.</p>" ] ] "multimedia" => array:6 [ 0 => array:8 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "304v16n64-90367587fig1.jpg" "imagenAlto" => 1079 "imagenAncho" => 1037 "imagenTamanyo" => 120390 ] ] ] ] ] "descripcion" => array:1 [ "en" => "Demographic data." ] ] 1 => array:8 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "304v16n64-90367587fig2.jpg" "imagenAlto" => 683 "imagenAncho" => 1045 "imagenTamanyo" => 99381 ] ] ] ] ] "descripcion" => array:1 [ "en" => "Sensitization to indoor aeroallergens." ] ] 2 => array:8 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "figura" => array:1 [ 0 => array:4 [ "imagen" => "304v16n64-90367587fig3.jpg" "Alto" => 795 "Ancho" => 1008 "Tamanyo" => 79169 ] ] "descripcion" => array:1 [ "en" => "Distribution of sensitization to aeroallergens by age group." ] ] 3 => array:7 [ "identificador" => "tbl3" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "descripcion" => array:1 [ "en" => "Demographic data." ] ] 4 => array:7 [ "identificador" => "tbl4" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "descripcion" => array:1 [ "en" => "Sensitization to indoor aeroallergens." ] ] 5 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "copyright" => "Elsevier España" "descripcion" => array:1 [ "en" => "Distribution of sensitization to aeroallergens by age group." ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Time trends in allergic disorders in the UK. Thorax 2007;62:91–96. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Time trends in allergic disorders in the UK." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Gupta R" 1 => "Sheikh A" 2 => "Strachan DP" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "fecha" => "Thorax 2007" "volumen" => "62" "paginaInicial" => "91–96" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Age-specific prevalence of outdoor and indoor aeroallergen sensitization in Boston. Clin Pediatr 2010;49:579-585. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Age-specific prevalence of outdoor and indoor aeroallergen sensitization in Boston." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Sheehan WJ" 1 => "Rangsithienchai PA" 2 => "Baxi SN" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "Clin Pediatr 2010" "volumen" => "49" "paginaInicial" => "579" "paginaFinal" => "585" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "The Ige repertoire in children and adolescents resolved al component level: a cross-sectional Study. Pediatr Allergy Immunol 2012;23:433-440. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "The Ige repertoire in children and adolescents resolved al component level: a cross-sectional Study." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Melioli G" 1 => "Marcomini L" 2 => "Agazzi A" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "Pediatr Allergy Immunol 2012" "volumen" => "23" "paginaInicial" => "433" "paginaFinal" => "440" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Allergy Diagnostic Testing: An Updated Practice Parameter. Ann Allergy Asthma Immunol 2008;100:S1-148. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Allergy Diagnostic Testing: An Updated Practice Parameter." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Bernstein IL" 1 => "Li JT" 2 => "Bernstein DI" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "Ann Allergy Asthma Immunol 2008" "volumen" => "100" "paginaInicial" => "S1" "paginaFinal" => "148" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Indoor environmental influences on children’s asthma. Pediatr Clin North Am 2007;54:103-120. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Indoor environmental influences on children’s asthma." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Sharma HP" 1 => "Hansel NN" 2 => "Matsui e" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "Pediatr Clin North Am 2007" "volumen" => "54" "paginaInicial" => "103" "paginaFinal" => "120" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Indoor allergen sensitization and the risk of asthma and eczema in children in Pittsburgh. Allergy Asthma Proc 2011;32:372-376. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Indoor allergen sensitization and the risk of asthma and eczema in children in Pittsburgh." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "McHugh BM" 1 => "MacGinnitie AJ." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "Allergy Asthma Proc 2011" "volumen" => "32" "paginaInicial" => "372" "paginaFinal" => "376" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Sensitization patterns to food and inhalant allergens in childhood: a comparison of non-sensitized, monosensitized, and polisensitized children. Pediatr Allergy Immunol 2011;22:166-171. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Sensitization patterns to food and inhalant allergens in childhood: a comparison of non-sensitized, monosensitized, and polisensitized children." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Baatenburg de Jong A" 1 => "Dikkeschel LD" 2 => "Brand PL." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "Pediatr Allergy Immunol 2011" "volumen" => "22" "paginaInicial" => "166" "paginaFinal" => "171" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "A survey of the burden of allergic rhinitis in europe. Allergy. 2007;62(suppl 85):17-25. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "A survey of the burden of allergic rhinitis in europe." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Canonica GW" 1 => "Bousquet J" 2 => "Mullol J" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1398-9995.2007.01549.x" "Revista" => array:6 [ "tituloSerie" => "Allergy. " "fecha" => "2007" "volumen" => "62" "paginaInicial" => "17" "paginaFinal" => "25" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17927674" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Prevalence of positive skin test responses to 53 allergens in patients with rhinitis symptoms. Allergy Asthma Proc 2007;28:442-448. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Prevalence of positive skin test responses to 53 allergens in patients with rhinitis symptoms." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Calabria CW" 1 => "Dice JP" 2 => "Hagan LL." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "Allergy Asthma Proc 2007" "volumen" => "28" "paginaInicial" => "442" "paginaFinal" => "448" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Sensitization to aeroallergens in Korean children: a population-based study in 2010. J Korean Med Sci 2011;26:1165-1172. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Sensitization to aeroallergens in Korean children: a population-based study in 2010." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Kim J" 1 => "Hahm MI" 2 => "Lee SY" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "J Korean Med Sci 2011" "volumen" => "26" "paginaInicial" => "1165" "paginaFinal" => "1172" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition examination Survey. J Allergy Clin Immunol 2005;116:377-383. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition examination Survey." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Arbes SJ Jr" 1 => "Gergen PJ" 2 => "elliott L" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "J Allergy Clin Immunol 2005" "volumen" => "116" "paginaInicial" => "377" "paginaFinal" => "383" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Aeroallergen sensitization rates in military children with rhinitis symptoms. Ann Allergy Asthma Immunol 2007;99:161-169. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Aeroallergen sensitization rates in military children with rhinitis symptoms." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Calabria CW" 1 => "Dice J." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "Ann Allergy Asthma Immunol 2007" "volumen" => "99" "paginaInicial" => "161" "paginaFinal" => "169" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study. Pediatrics 2001;108:e33. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Arshad SH" 1 => "Tariq SM" 2 => "Matthews S" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "fecha" => "Pediatrics 2001" "volumen" => "108" "paginaInicial" => "e33" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Sensibilización temprana a aeroalergenos en una población pediátrica mexicana. Alergia e Inmunol Pediatr 1999;8:165-169. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Sensibilización temprana a aeroalergenos en una población pediátrica mexicana." "idioma" => "es" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Espinosa Se" 1 => "Meza MR" 2 => "Orozco S" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "Alergia e Inmunol Pediatr 1999" "volumen" => "8" "paginaInicial" => "165" "paginaFinal" => "169" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Frequency and specific sensitization to inhalant allergens within nuclear families of children with asthma and/or rhinitis. Ann Allergy Asthma Immunol 1997;79:512-516. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Frequency and specific sensitization to inhalant allergens within nuclear families of children with asthma and/or rhinitis." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Silvestri M" 1 => "Oddera S" 2 => "Crimi P" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "Ann Allergy Asthma Immunol 1997" "volumen" => "79" "paginaInicial" => "512" "paginaFinal" => "516" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Sex-specific differences in allergic sensitization to house dust mites: a meta-analysis. Ann Allergy Asthma Immunol 2009;102:487-494. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Sex-specific differences in allergic sensitization to house dust mites: a meta-analysis." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Goldhahn K" 1 => "Bockelbrink A" 2 => "Nocon M" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "Ann Allergy Asthma Immunol 2009" "volumen" => "102" "paginaInicial" => "487" "paginaFinal" => "494" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Skin prick testing to aeroallergen extracts: what is the optimal panel in children and adolescents in Turkey? Int Arch Allergy Immunol 2012;157:391-398. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Skin prick testing to aeroallergen extracts: what is the optimal panel in children and adolescents in Turkey? Int Arch Allergy Immunol 2012." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "ªahiner UM" 1 => "Civelek E" 2 => "Yavuz ST" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "volumen" => "157" "paginaInicial" => "391" "paginaFinal" => "398" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Immunotherapy in polysensitized patients: new chances for the allergist? Ann Allergy Asthma Immunol 2012;109:392-394. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Immunotherapy in polysensitized patients: new chances for the allergist? Ann Allergy Asthma Immunol 2012." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Cipriandi G" 1 => "Melioli G" 2 => "Passalacqua G" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "volumen" => "109" "paginaInicial" => "392" "paginaFinal" => "394" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:3 [ "referenciaCompleta" => "Interferon-gamma and IL-10 may protect from allergy polysensibilization in children: preliminary evidence. Allergy 2010;65:740-742. " "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "Interferon-gamma and IL-10 may protect from allergy polysensibilization in children: preliminary evidence." "idioma" => "en" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Prigione I" 1 => "Morandi F" 2 => "Tosca MA" 3 => "et al." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "Allergy 2010" "volumen" => "65" "paginaInicial" => "740" "paginaFinal" => "742" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16655796/0000001600000064/v0_201607061456/X166557961467587X/v0_201607061458/en/main.assets" "Apartado" => array:4 [ "identificador" => "55396" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16655796/0000001600000064/v0_201607061456/X166557961467587X/v0_201607061458/en/304v16n64a90367587pdf001.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/X166557961467587X?idApp=UINPBA00004N" ]
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ISSN: 16655796Original language: English
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