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Vol. 25. Issue 8.
Pages 491-497 (January 2010)
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Vol. 25. Issue 8.
Pages 491-497 (January 2010)
DOI: 10.1016/S2173-5808(10)70091-2
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Zolpidem-induced sleep-related behavioural disorders
Conductas complejas durante el sueño inducidas por zolpidem
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H. Pérez-Díaz, A. Iranzo, J. Santamaría
Corresponding author
JSANTAMA@clinic.ub.es

Corresponding author.
Servicio de Neurología y Unidad Multidisciplinar de Trastornos del Sueño, Hospital Clínico de Barcelona, Barcelona, Spain
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Abstract
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Abstract
Objective

To present five patients with zolpidem-induced sleep-related behavioural disorders.

Methods

Evaluation using a questionnaire designed to study sleep behaviours and past medical history in all patients.

Results

The patients performed complex actions while sleep-walking (telephoning, house-cleaning, feeding the dog or waxing their legs). Inappropriate feeding behaviour with excessive food intake during the night were reported by all patients. All had weight gain, which in one patient led to extreme obesity. Two patients suffered injuries (knife cuts and burns) related to attempting to prepare food. One patient took a laxative.

Conclusion

Withdrawal of zolpidem resolved the behaviours in all cases, highlighting the importance of an adequate diagnosis of this side effect.

Keywords:
Zolpidem
Sleep-related food disorder
Nocturnal eating syndrome
Sleepwalking
Sleep
Side effect
Obesity
Hyperphagia
Amnesia
Resumen
Objetivo

Presentar cinco pacientes con trastornos conductuales durante el sueño, sin conciencia posterior de los mismos, inducidos por zolpidem.

Métodos

Evaluación con un cuestionario diseñado para estudiar las características y las conductas realizadas durante el sueño por todos los pacientes.

Resultados

Las conductas realizadas por los pacientes fueron muy variadas (telefonear, limpieza y labores del hogar, alimentar al perro o depilarse), aunque en todos los pacientes se recogieron conductas alimentarias inapropiadas. Todos sufrieron una ganancia pon-deral importante, debido a su preferencia por alimentos hipercalóricos durante los episodios, que en una de las pacientes desembocó en una obesidad extrema. Dos de los pacientes sufrieron lesiones (cortes con cuchillo y quemaduras) en relación con el intento de elaboración de platos. Un paciente llegó a ingerir un laxante.

Conclusiones

La retirada de zolpidem resolvió de forma inmediata las conductas anormales durante el sueño en todos los casos. Esto subraya la importancia de diagnosticar adecuadamente este efecto secundario.

Palabras clave:
Zolpidem
Síndrome de la cena durante el sueño
Síndrome del comer nocturno
Sonambulismo
Sueño
Efecto secundario
Obesidad
Hiperfagia
Amnesia
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