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Letter to the Editor
Recurrent reversible posterior encephalopathy syndrome with a response to nimodipine
Síndrome de encefalopatía posterior reversible recurrente con respuesta a nimodipino
J.A. Matías-Guiu
Corresponding author
jordimatiasguiu@hotmail.com

Corresponding author.
, S. García-Ptacek, C.M. Ordás, A. Marcos-Dolado, J. Porta-Etessam
Servicio de Neurología, Hospital Clínico San Carlos, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Posterior reversible encephalopathy syndrome &#40;PRES&#41; is the association of a set of clinical characteristics &#40;headache&#44; epileptic seizures&#44; changes in alertness&#44; visual loss and other focal deficits&#41; and radiological signs indicating reversible changes in white matter&#44; especially in the parietal-temporal-occipital area&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> It has been linked to high blood pressure and immunosuppressive agents&#44; among other factors&#46; Recurrence is infrequent&#59; a recent study of 25 patients with long-term follow-up<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> reported it in 8&#37; of the study cases&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Various physiopathological mechanisms have been suggested&#44; including vasoconstriction&#44; increased perfusion&#44; and endothelial damage&#46; A study of recurrent cases may help us answer some of the unresolved questions about this syndrome&#46; We present the case of a patient with recurrent PRES episodes which were effectively treated with nimodipine&#46; The patient was a 60-year-old female who came to the emergency department in May 2009&#46; She had a history of smoking&#44; high blood pressure&#44; high cholesterol&#44; and ischaemic heart disease&#46; She presented with headache&#44; drowsiness&#44; nausea&#44; vomiting&#44; and aphasic comprehension which had developed over 2 days&#44; coinciding with an attack of hypertension &#40;blood pressure 220&#47;110<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>Hg&#41;&#46; Once the hypertension had been resolved&#44; the patient gradually regained her baseline state and was asymptomatic 48 to 72<span class="elsevierStyleHsp" style=""></span>hours after being admitted&#46; The patient had been treated with chemotherapy during the preceding 2 years for stage IV ovarian adenocarcinoma&#46; Magnetic resonance &#40;MR&#41; scan showed predominantly parietal-occipital white matter lesions with no restrictions in the diffusion sequences&#46; The lesions disappeared one month later &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Following that&#44; the patient presented with 3 similar episodes in January&#44; April&#44; and June 2010&#59; all episodes coincided with a marked increase in blood pressure&#46; The MR scan showed changes similar to those described in PRES&#44; which disappeared once the episode had resolved&#46; The patient discontinued chemotherapy following the first episode and started antihypertensive treatment with beta blockers&#44; ARBs&#44; alpha blockers and diuretics&#59; blood pressure control between episodes was good&#46; Treatment with nimodipine was begun in June 2010&#59; at 15 months of follow-up&#44; no new episodes had occurred&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">There are currently 2 hypotheses regarding PRES physiopathology&#46; The first postulates that high blood pressure would cause arterial vasoconstriction&#44; thereby producing ischaemia and cytotoxic oedema&#46; The second supports there being a disturbance in cerebrovascular autoregulation secondary to uncontrolled high blood pressure&#46; That condition subsequently leads to vasodilation&#44; endothelial dysfunction and vasogenic oedema&#46; The fact that parietal-occipital areas are predominantly involved is probably due to the sparse sympathetic innervation in posterior circulation&#46; MRI findings seem to support the second hypothesis&#44; as they revealed no restrictions in the diffusion sequence&#46; However&#44; cerebral vasoconstriction may be common in PRES&#44; and it may also be related to reversible cerebral vasoconstriction syndrome &#40;RCVS&#41;&#46; Ducros et al&#46; describe radiological findings for PRES in 10&#37; of all cases of patients with RCVS&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In turn&#44; vasoconstriction has also been described in some published PRES case studies&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> It is not clear whether high blood pressure triggers the episode&#44; or if in fact the episode causes high blood pressure&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Recurrence is uncommon in this syndrome&#46; To our knowledge&#44; there are only 15 published cases of recurrence at present&#44; with a prevalence of 8&#37; according to the series published by Roth et al&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Various factors may be involved&#44; including high blood pressure&#44; chemotherapy&#44; kidney failure&#44; and eclampsia&#59; however&#44; persistence of these conditions has not been associated with episode recurrence&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> For example&#44; our patient left chemotherapy following the first episode&#46; Prior infection has been suggested as a possible episode trigger&#44; but no such infection was present during any of the episodes in the clinical case we present here&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Most published cases of recurrence list 2 episodes&#44; and the case we describe here has the highest number of recurrences recorded in the literature&#46; Favourable response to nimodipine may be due to its role in preventing vasospasm&#44; or caused by its effect on the endothelium&#46; In fact&#44; nimodipine has been put forth as a possible treatment for RCVS&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> but no clinical trials have been carried out for this use&#46; Although ours is merely an isolated case&#44; we suggest trying nimodipine as preventive treatment for new recurrent episodes of PRES&#46;</p></span>"
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                    0 => array:2 [
                      "titulo" => "A reversible posterior leukoencephalopathy syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            0 => "J&#46; Hinchey"
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                        "paginaFinal" => "500"
                      ]
                    ]
                  ]
                ]
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                          "autores" => array:2 [
                            0 => "C&#46; Roth"
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                    0 => array:2 [
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                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
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                        "volumen" => "81"
                        "paginaInicial" => "773"
                        "paginaFinal" => "777"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19955114"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "etiqueta" => "4"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The clinical and radiological spectrum of reversible cerebral vasoconstriction s&#237;ndromes&#46; A prospective series of 67 patients"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            3 => "M&#46; Sarov"
                            4 => "D&#46; Valade"
                            5 => "M&#46;G&#46; Bousser"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/brain/awm256"
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                        "tituloSerie" => "Brain"
                        "fecha" => "2007"
                        "volumen" => "130"
                        "paginaInicial" => "3091"
                        "paginaFinal" => "3101"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18025032"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Recurrent posterior reversible encephalopathy syndrome&#58; report of 3 cases&#58; PRES can strike twice&#33;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Sweany"
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                            2 => "J&#46;F&#46; Boardman"
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                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1097/01.rct.0000233127.21303.b9"
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                        "tituloSerie" => "J Comput Assist Tomogr"
                        "fecha" => "2007"
                        "volumen" => "31"
                        "paginaInicial" => "148"
                        "paginaFinal" => "156"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17259848"
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                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Reversible cerebral angiopathy&#58; efficacy of nimodipine"
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                        0 => array:2 [
                          "etal" => false
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                            0 => "M&#46; Zuber"
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                            2 => "V&#46; Domingo"
                            3 => "D&#46; Trystram"
                            4 => "C&#46; Lamy"
                            5 => "J&#46;L&#46; Mas"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "tituloSerie" => "J Neurol"
                        "fecha" => "2006"
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                        "paginaInicial" => "1585"
                        "paginaFinal" => "1588"
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