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Letter to the Editor
Adult diagnosis of temporo-occipital leptomeningeal angiomatosis
Angiomatosis leptomeníngea temporo-occipital de diagnóstico en edad adulta
M. Gómez-Morenoa,
Corresponding author
mayragomezmoreno@yahoo.es

Corresponding author.
, C. Murrieta-Urruticoecheab, E. Martinez-Acebesa, R. Gordo-Mañasa
a Sección de Neurología, Hospital Universitario Infanta Leonor, Madrid, Spain
b Servicio de Neurología, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier, France
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Sturge-Weber syndrome &#40;SWS&#41; or encephalotrigeminal angiomatosis is a sporadically presenting neuroectodermatosis characterised by a facial port-wine stain in the trigeminal distribution&#44; ipsilateral leptomeningeal angioma&#44; and ipsilateral choroidal angioma&#46; Studies have described clinical variants with different combinations within this triad&#46; SWS is primarily diagnosed in children&#44; but it has also been diagnosed in adults in exceptional cases&#46; We present a case of isolated leptomeningeal angiomatosis and symptom onset in an adult patient&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 44-year-old woman with no relevant medical history came to the emergency department due to sudden-onset right hemicranial headache that was intense&#44; oppressive&#44; and responding poorly to analgesics&#46; Twenty-four hours later&#44; symptoms also included disorientation&#44; psychomotor agitation&#44; and visual hallucinations&#46; Physical examination revealed a herpes labialis sore on her upper lip&#46; Laboratory analyses revealed leukocytosis with left shift and elevated C-reactive protein &#40;CRP&#41;&#46; Cranial axial computed tomography with and without contrast &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; showed a right parietal-occipital gyriform hyperdensity and focal meningeal enhancement that was initially reported as being compatible with chronic meningitis&#46; Lumbar puncture yielded acellular CSF with elevated protein levels&#44; so the emergency department started provisional treatment with IV vancomycin&#44; ceftriaxone&#44; and acyclovir for possible meningoencephalitis&#46; The patient was admitted to the neurology department and remained afebrile with an intense headache accompanied by nausea&#44; vomiting&#44; and fluctuating episodes of visual and auditory hallucinations&#46; Neurological examination detected homonymous hemianopsia&#46; Brain MRI scans performed with and without gadolinium contrast &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; showed leptomeningeal angiomatosis in the right hemisphere &#40;parietal-occipital-temporal area&#41;&#46; Basal amplitude on the electroencephalogram was attenuated in the right temporal-occipital area&#46; There were no data indicating infection &#40;results from 2 blood and CSF cultures and CRP tests were all negative&#41;&#59; since a second lumbar puncture yielded acellular CSF with elevated opening pressure and protein levels&#44; antibiotics were discontinued&#46; A consultation with the ophthalmology department ruled out ocular vascular malformation&#46; The patient was diagnosed with SWS without facial angioma and exhibiting temporal-occipital partial seizures and possible venous thrombosis&#47;stasis at the angiomatous lesion&#46; She was treated with acetazolamide &#40;for intracranial hypertension&#41;&#44; levetiracetam&#44; and acetylsalicylic acid&#46; Both the headache and the confusional episodes&#47;hallucinations resolved&#59; the latter were thought to be caused by seizure or vascular migraine-like phenomena&#46; The patient subsequently attended follow-up visits as a neurology outpatient&#46; After an additional lumbar puncture yielded acellular CSF with normal opening pressure and protein levels&#44; the dose of acetazolamide was gradually reduced until it could be discontinued&#46; The patient remained asymptomatic at a year of follow-up&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Encephalotrigeminal angiomatosis or SWS is an uncommon neurocutaneous syndrome affecting brain microvasculature that presents sporadically and is usually diagnosed in childhood&#46; Clinical characteristics of its typical form include a flat facial angioma &#40;port-wine stain&#41; in the distribution of the ophthalmic branch of the trigeminal nerve&#44; ipsilateral leptomeningeal angiomatosis at the level of the occipital and parietal lobes&#44; and ocular vascular malformation&#46; Incomplete variants of the syndrome<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> include the following&#58; &#40;a&#41; facial and leptomeningeal angioma&#44; without choroid angioma&#59; &#40;b&#41; leptomeningeal and choroid angioma without facial nevus&#59; &#40;c&#41; facial nevus and choroid angioma with no clinical or imaging signs of cerebral angiomatosis&#59; and <span class="elsevierStyleItalic">d&#41;</span> isolated cerebral and pial angiomatosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Although descriptions of SWS date back to 1879 &#40;Sturge&#41;&#44; Van Bogaert described a form of corticomeningeal telangiectasia without facial angioma as a variant of SWS in 1935&#46; In Lund&#39;s 1949 review of the 144 reported patients affected by the syndrome&#44; he identifies 7 cases with typical radiography images and no facial angiomas&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The medical literature describes few cases of SWS without facial angioma&#44;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;9</span></a> and a diagnosis in an adult patient&#44; as in our case&#44; is very rare&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Neurological manifestations of SWS are related to the presence of leptomeningeal angioma&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> The most consistent sign is the presence of epileptic seizures&#44; which affect 75&#37; to 90&#37; of all patients<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#59; only 7&#37; experience the initial seizure after the age of 5 years&#46; Neurological deficits may appear slowly over time&#44; or as stroke-like episodes associated with seizures and&#47;or headaches resembling migraines as in the clinical case described here&#46; The most frequently observed signs of neurological deficit are motor hemiparesis&#44; hemianopsia&#44; and hemiatrophy&#44; which present in 65&#37; of all patients&#46; Cognitive changes are frequent and they are related to early onset of refractory seizures and bihemispheric dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Depressive symptoms are also common&#46; Migraines and other headaches appear frequently&#44; and this type is included in the second edition of the International Classification of the Headache Society &#40;ICHD-II&#41; among the secondary headaches in section 6&#46;3&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">If there is a clinical suspicion of cerebral impairment&#44; the condition is diagnosed using neuroimaging techniques&#44; which provide very useful information in the absence of typical cutaneous or ocular signs&#46; The characteristic radiography findings are gyriform cortical calcifications appearing adjacent to the leptomeningeal angioma in head CT images&#46; Cranial MRI displays the typical vascular malformation&#59; IV contrast provokes enhancement in T1-weighted images&#46; In addition to these findings&#44; we may also observe dilation and enhancement in the ipsilateral choroid plexus and enlargement of deep venous drainage underlying the affected cortical region&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Long-term treatment with antiepileptic drugs is fundamental for those patients with seizures&#46; Since venous stasis and microvascular thrombosis probably contribute to the neurological decline occurring in SWS&#44; the empirical recommendation calls for daily antiplatelet treatment with low doses of acetylsalicylic acid&#44;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> which has been shown to decrease the frequency of seizures and stroke-like events&#46; Headaches and migraines are treated with conventional abortive drugs &#40;including triptans<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a>&#41;&#59; preventive drugs may also be used if required due to episode frequency or severity&#46; Surgery &#40;resection of the malformation or even hemispherectomy&#41; provides effective treatment&#44; but it should not be considered at time of diagnosis because it is currently indicated only in cases of seizures refractory to drug treatment&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; G&#243;mez-Moreno M&#44; Murrieta-Urruticoechea C&#44; Martinez-Acebes E&#44; Gordo-Ma&#241;as R&#46; Angiomatosis leptomen&#237;ngea temporo-occipital de diagn&#243;stico en edad adulta&#46; Neurolog&#237;a&#46; 2015&#59;30&#58;64&#8211;66&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cranial CT without contrast&#58; cortical calcification and discrete atrophy of the right occipital lobe&#44; and calcification and enlargement of the choroid plexus of the occipital horn of the right ventricle&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cranial MRI&#58; axial T1-weighted contrast-enhanced images with striking meningeal enhancement mainly observed in the parietal-occipital-temporal regions&#46; Enhancement in cerebral sulci was both dural and leptomeningeal &#40;pial&#41;&#44; but especially leptomeningeal&#46; Size difference between choroid plexi of the temporal horns of the lateral ventricles&#59; choroid plexi are larger and show more enhancement in the right lateral ventricle&#46;</p>"
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                      "Revista" => array:6 [
                        "tituloSerie" => "J Child Neurol"
                        "fecha" => "2007"
                        "volumen" => "22"
                        "paginaInicial" => "720"
                        "paginaFinal" => "726"
                        "link" => array:1 [
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        "identificador" => "xack284537"
        "titulo" => "Acknowledgement"
        "texto" => "<p id="par0040" class="elsevierStylePara elsevierViewall">The authors thank Dr&#46; Noelia Ar&#233;valo Galeano at the Central Radiodiagnostics Unit for her assistance with this case&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
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Article information
ISSN: 21735808
Original language: English
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es en pt

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