Behavioural and psychiatric symptoms in cognitive neurology

array:25 ["pii" => "S217358081730038X" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2015.01.003" "estado" => "S300" "fechaPublicacion" => "2017-03-01" "aid" => "728" "copyright" => "Sociedad Española de Neurología" "copyrightAnyo" => "2014" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Neurologia. 2017;32:81-91" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1364 "formatos" => array:3 [ "EPUB" => 58 "HTML" => 1029 "PDF" => 277 ] ] "Traduccion" => array:1 [ "es" => array:20 [ "pii" => "S0213485315000183" "issn" => "02134853" "doi" => "10.1016/j.nrl.2015.01.003" "estado" => "S300" "fechaPublicacion" => "2017-03-01" "aid" => "728" "copyright" => "Sociedad Española de Neurología" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Neurologia. 2017;32:81-91" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3737 "formatos" => array:3 [ "EPUB" => 66 "HTML" => 3049 "PDF" => 622 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "ORIGINAL" "titulo" => "Síntomas conductuales y psiquiátricos en neurología cognitiva" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "81" "paginaFinal" => "91" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Behavioural and psychiatric symptoms in cognitive neurology" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figura 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1292 "Ancho" => 1800 "Tamanyo" => 257378 ] ] "descripcion" => array:1 [ "es" => "Resonancia magnética cerebral de una mujer de 81 años. Un año antes comenzó ideación delirante y en los últimos meses muestra paramnesia reduplicativa y alteración de la conducta social y alimentaria. Se observa una lesión ocupante de espacio en la región temporal anterior-frontal posteroinferior del hemisferio derecho." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Robles Bayón, F. Gude Sampedro" "autores" => array:2 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Robles Bayón" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Gude Sampedro" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S217358081730038X" "doi" => "10.1016/j.nrleng.2015.01.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217358081730038X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485315000183?idApp=UINPBA00004N" "url" => "/02134853/0000003200000002/v3_201706020006/S0213485315000183/v3_201706020006/es/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S2173580817300329" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2014.12.020" "estado" => "S300" "fechaPublicacion" => "2017-03-01" "aid" => "724" "copyright" => "Sociedad Española de Neurología" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Neurologia. 2017;32:92-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1072 "formatos" => array:3 [ "EPUB" => 61 "HTML" => 698 "PDF" => 313 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Multiple sclerosis and pregnancy: A single-centre prospective comparative study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "92" "paginaFinal" => "98" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Esclerosis múltiple y embarazo: estudio unicéntrico prospectivo y comparativo" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.P. Cuello, M.L. Martínez Ginés, M.L. Martin Barriga, C. de Andrés" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.P." "apellidos" => "Cuello" ] 1 => array:2 [ "nombre" => "M.L." "apellidos" => "Martínez Ginés" ] 2 => array:2 [ "nombre" => "M.L." "apellidos" => "Martin Barriga" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "de Andrés" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0213485315000146" "doi" => "10.1016/j.nrl.2014.12.015" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485315000146?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580817300329?idApp=UINPBA00004N" "url" => "/21735808/0000003200000002/v1_201703191230/S2173580817300329/v1_201703191230/en/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S2173580817300378" "issn" => "21735808" "doi" => "10.1016/j.nrleng.2014.12.021" "estado" => "S300" "fechaPublicacion" => "2017-03-01" "aid" => "715" "copyright" => "Sociedad Española de Neurología" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Neurologia. 2017;32:74-80" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 845 "formatos" => array:3 [ "EPUB" => 57 "HTML" => 590 "PDF" => 198 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Reliability of the minimum basic dataset for diagnoses of cerebrovascular disease" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "74" "paginaFinal" => "80" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Fiabilidad del conjunto mínimo básico de datos en el diagnóstico de la enfermedad cerebrovascular" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Hernández Medrano, M. Guillán, J. Masjuan, A. Alonso Cánovas, M.A. Gogorcena" "autores" => array:5 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Hernández Medrano" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Guillán" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Masjuan" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Alonso Cánovas" ] 4 => array:2 [ "nombre" => "M.A." "apellidos" => "Gogorcena" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S021348531500002X" "doi" => "10.1016/j.nrl.2014.12.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021348531500002X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580817300378?idApp=UINPBA00004N" "url" => "/21735808/0000003200000002/v1_201703191230/S2173580817300378/v1_201703191230/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Behavioural and psychiatric symptoms in cognitive neurology" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "81" "paginaFinal" => "91" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Robles Bayón, F. Gude Sampedro" "autores" => array:2 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Robles Bayón" "email" => array:1 [ 0 => "alfredorobles@hospitalrosaleda.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "F." "apellidos" => "Gude Sampedro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Neurología cognitiva, Hospital La Rosaleda, Santiago de Compostela, La Coruña, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Epidemiología Clínica, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, La Coruña, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síntomas conductuales y psiquiátricos en neurología cognitiva" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1292 "Ancho" => 1800 "Tamanyo" => 258502 ] ] "descripcion" => array:1 [ "en" => "Cerebral MRI of an 81-year-old woman. One-year history of delusional ideation; in recent months, she had also exhibited reduplicative paramnesia and altered social and eating behaviours. A space-occupying lesion was detected in the anterior frontal posteroinferior region of the right temporal lobe." ] ] ] "textoCompleto" => "IntroductionCognitive neurology clinics evaluate and treat declining intellectual function. Furthermore, this decline is often associated with behaviour disorders and other typical symptoms of psychiatric diseases. These associated symptoms may indicate a psychological reaction to the self-perceived cognitive disorder, which may also be accompanied by other neurological and/or systemic manifestations. This perception can lead to different degrees of worry or alarm, depending on the patient's personality and intensity of symptoms; alarm may manifest in the form of behavioural changes and such psychiatric symptoms as depression and anxiety. In other cases, behavioural and psychiatric symptoms (BPS) are part of the array of changes arising from the dysfunction of neuronal circuits that also elicit the cognitive dysfunction. At times, both the primary and the reactive mechanisms contribute to these symptoms in varying degrees.This is a transcendent matter because the prevalence of BPS is high in patients with neurological disease<a class="elsevierStyleCrossRefs" href="#bib0340">1–4</a> and because these clinical manifestations increase disability,<a class="elsevierStyleCrossRef" href="#bib0360">5</a> lessen quality of life,<a class="elsevierStyleCrossRefs" href="#bib0365">6,7</a> and are very stressful for those living with the patient.<a class="elsevierStyleCrossRefs" href="#bib0365">6,8</a>The purpose of this study is to observe BPS frequency in a sample of patients seen at a cognitive neurology clinic. We also examine the association between these symptoms and specific diagnoses, or with structural changes in precise regions of the brain.Patients and methodsWe performed a transversal retrospective analysis of a register of 857 patients examined in a cognitive neurology clinic. Records lacking any of the essential data for this study were excluded. Patients were categorised in 2 groups. Those in group 1 had a syndromic diagnosis of mild cognitive impairment or dementia. In group 2, which served as a control, cognitive function was not considered pathological.We recorded age, sex, aetiological diagnosis, and the presence and type of BPS. If BPS were detected, we examined neuroimaging studies when available. To assess their potential influence on outcomes, we checked for presence or absence of sensory alterations (visual or auditory) and recorded the type of treatment for each patient.In a later stage, we estimated prevalence of BPS and examined the association between these symptoms and different aetiological diagnoses (disease types). We examined the possibility of a link between BPS and neuroimaging anomalies in specific regions (disease topography). We also compared results from groups 1 and 2.BPS occurring during sleep, such as somnambulism or REM sleep behaviour disorders, were not included. BPS recognised in this study were limited to those relevant to the diagnosis, affecting family life, or requiring treatment or modifying treatment. We did not examine sporadic or mild symptoms with no significance and no repercussions on treatment decisions.Sensory disorders were limited to changes interfering with functional capacity in patients who refused corrective lenses or hearing aids, or whose functions could not be corrected with these devices.We recorded any visible changes in MR or CT images that were considered symptomatic. Where such changes were present, we recorded the affected hemisphere and lobe; the deep subcortical area was considered separately. Type of alteration (atrophy, infarct, tumour, etc.) was not recorded.When recording treatments, we excluded eye drops and other occasional medications.Generic diagnoses and treatments were listed to ensure proper sample sizes for the analysis; specific diagnoses and treatments were recorded to detect any associations between them and presence of BPS.SPSS 15.0 software was used for the statistical analysis. Associations between qualitative variables were checked using the χ2 test or Fisher's exact test; the Mann-Whitney U test was used to compare quantitative variables between groups 1 and 2. Two significance levels were used: P<.05 and P<.01.ResultsWe analysed 843 subjects, 607 in group 1 and 236 in group 2. At least one BPS was present in 59.9% (61.3% in group 1 and 56.4% in group 2). Subjects could be divided further into those with one BPS (31.1% of the total, or 31.1% of group 1 and 30.9% of group 2); 2 BPS (17.4%, 18.0%, and 16.1% respectively); or more than 2 BPS (11.4%, 12.2%, and 9.3%). <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> displays prevalence of BPS (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a> shows the breakdown of the sample by age, sex, and presence or absence of sensory changes. Subjects aged 65 and older accounted for 80.5% of the total (89.3% of group 1 and 58% of group 2); the difference was significant (P<.01). Patients in group 1 were older overall and had a higher prevalence of visual changes than those in group 2.<elsevierMultimedia ident="fig0010"></elsevierMultimedia>In the full sample and in both subgroups, BPS was more frequently observed in women (65.2%, 64.7%, and 66.9% in women, vs 51.5%, 55.6%, and 42.7% in men; P<.01, P<.05, P<.01). Differences were marked for depression and anxiety. In men, more cases of BPS was detected overall in cases than in controls (55.6% vs 42.7%), whereas there were no significant differences between cases and controls in women.Presence of BPS was similar in subjects older than and younger than 65, although there was a higher rate of psychotic symptoms and behaviour disorders in older subjects, and of anxiety disorders in younger subjects (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). Specific BPS in the older subjects included hallucinations, dysidentity syndromes, and agitation; symptoms of anxiety were predominant in the younger group.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>Prevalence of BPS did not vary according to presence or absence of sensory changes, although we found psychotic symptoms to be more frequent in people with visual and/or auditory changes (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).We registered 84 aetiological diagnoses, distributed among 18 categories (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Degenerative and cerebrovascular diseases were predominant in group 1; in contrast, the frequency of pain disorders, sequelae of traumatic brain injury, and psychiatric illnesses, as well as the absence of objective neurological disease, was higher in group 2. Regarding specific diagnoses, we observed higher rates of Alzheimer disease, Lewy body dementia, frontotemporal dementia, and cerebrovascular disease in group 1. Group 2 also demonstrated a higher prevalence of dysthyroidism, sequelae of traumatic brain injury, somatic manifestations of anxiety, psychogenic or psychosomatic symptoms, familial essential tremor, muscle tension headaches, migraine, cervical brachiocephalic syndrome of cervical origin, polyneuropathy with pain or paraesthesia, and cases in which no neurological or pain disorders were present.<elsevierMultimedia ident="fig0015"></elsevierMultimedia><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> lists noteworthy types of BPS by diagnosis. Degenerative diseases were more likely to be associated with psychotic symptoms, personality changes, and behavioural disorders; patients exhibiting substance abuse showed a higher prevalence of anxiety and mood disorders; psychiatric diagnoses were associated with mood disorders, anxiety, and psychosomatic symptoms. Lastly, patients with no neurological or pain disorders displayed higher rates of affective disorders. Emotional lability was more common in individuals with metabolic or hormonal disorders; irritability in controls with cerebral hypoxia; and hypochondria symptoms in individuals experiencing pain of any type.<elsevierMultimedia ident="tbl0015"></elsevierMultimedia><a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a> shows the topography of changes observed in the neuroimaging studies of patients with BPS. Bihemispheric changes were more common in cases than in controls, and cases were particularly more likely to show changes in the frontal, temporal, or parietal lobes. Imaging studies from controls were less likely to show significant changes. Anomalies were more frequent in deep subcortical regions than in superficial regions, but intergroup differences were not significant.<elsevierMultimedia ident="tbl0020"></elsevierMultimedia>Bihemispheric presence of anomalies was associated with behaviour alterations (P<.01) and psychotic symptoms (P<.05), whereas patients with no changes in neuroimaging studies showed a higher prevalence of anxiety disorders (P<.01) and of mood disorders (P<.05). Changes in the frontal lobes and in the right temporal or parietal lobe (P<.01) or the left parietal lobe (P<.05) were associated with more behaviour disorders; changes in the right frontal lobe were linked to psychotic symptoms (P<.05). Examining the most frequent specific BPS (P<.01), we found an association between misidentification syndromes and right temporal lesions (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>); between agitation and left frontal, right frontal, and right temporal anomalies; social disinhibition and isolated right hemisphere or right frontal and left temporal anomalies; stereotyped behaviours and left frontal, right frontal, and right parietal anomalies; and eating behaviour disorders with right frontal, left frontal, and right temporal anomalies.<elsevierMultimedia ident="fig0020"></elsevierMultimedia>Reported medications included 172 substances, classified in 43 groups. <a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a> indicates that patients in group 1 took more drugs than those in group 2.<elsevierMultimedia ident="fig0025"></elsevierMultimedia>Lastly, <a class="elsevierStyleCrossRefs" href="#tbl0025">Tables 5 and 6</a> list associations between BPS and drug treatments. Given the high percentage of polymedicated patients and the influence of other factors (such as the diagnosis), drug associations were only evaluated if more than 1% of the cases showed the association with a significance level of P<.01.<elsevierMultimedia ident="tbl0025"></elsevierMultimedia><elsevierMultimedia ident="tbl0030"></elsevierMultimedia>DiscussionThis study aimed to calculate BPS prevalence in patients examined in a cognitive neurology clinic. It also examined associations between BPS and different factors in patients’ medical records, and compared findings between patients with and without objective cognitive impairment. The study did not enter into the genotypes that may affect susceptibility to developing BPS.<a class="elsevierStyleCrossRefs" href="#bib0380">9,10</a>It detected a high rate of BPS (59.9%) similar to those yielded by other studies reporting rates of over 50% in patients seen in outpatient neurology clinics.<a class="elsevierStyleCrossRefs" href="#bib0340">1,4</a> We also detected more BPS in patients with cognitive impairment (61.3%) than in patients in group 2 (56.4%), a difference that has already been reported.<a class="elsevierStyleCrossRefs" href="#bib0365">6,8,11</a>Frequencies of affective and anxiety symptoms, and of personality changes and psychosomatic symptoms (32.6%, 13.3%, 1.2%, and 4.3%, respectively), are similar to those reported by Jefferies et al.<a class="elsevierStyleCrossRef" href="#bib0345">2</a> in hospitalised neurological patients (24.8%, 12.7%, 2%, and 4.5%). The differences are due to the dissimilar percentages of patients with cognitive impairment (72% in this study vs 17.7% in Jefferies et al.<a class="elsevierStyleCrossRef" href="#bib0345">2</a>). Psychotic symptoms were more frequent in group 1 (16.8%) than in group 2 (4.2%), as were behavioural changes (29.3% vs 8.5%). In contrast, we observed a higher prevalence of anxiety and psychosomatic symptoms in group 2 (25.4% and 9.7% vs 8.6% and 2.1%). It is understood that dementia disorders are more likely than other neurological disorders to entail dysfunction of cerebral areas related to behavioural control and perception. This gives rise to behavioural and psychotic symptoms as a primary manifestation. On the other hand, the anosognosia displayed by these patients may actually reduce those symptoms of mental illness that require a greater degree of introspection and better cognitive functioning in order to manifest.A higher percentage of women than men display cognitive impairment; this is also the case of BPS, as has been reported by other studies.<a class="elsevierStyleCrossRef" href="#bib0395">12</a> The overall female predominance is accounted for by higher rates of depression and anxiety; these findings are supported by the literature.<a class="elsevierStyleCrossRefs" href="#bib0400">13,14</a>Psychotic and behavioural symptoms are predominant in subjects aged 65 and older; younger subjects are more likely to have anxiety. Older subjects in group 1 display more agitation and stereotyped behaviour, whereas younger subjects exhibit more behavioural changes, apathy, and agitation (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). These differences seem entirely logical. The older patients include those who have had psychotic symptoms from a younger age, as well as older patients who have developed symptoms of dementia or confusional syndrome.<a class="elsevierStyleCrossRef" href="#bib0410">15</a> Anxiety, on the other hand, often develops in young adults. When it is present in older patients, it often has a long-standing chronic profile or corresponds to an exacerbation due to incidental problems.<a class="elsevierStyleCrossRef" href="#bib0415">16</a>Sensory changes are associated with a higher incidence of psychotic symptoms. One study found a higher prevalence of visual disturbances in individuals with psychotic symptoms and schizophrenia.<a class="elsevierStyleCrossRef" href="#bib0420">17</a> Another study in patients with dementia found auditory and visual disorders to be associated with the appearance of psychotic symptoms.<a class="elsevierStyleCrossRef" href="#bib0425">18</a>Psychotic symptoms were more prevalent in group 1 than in group 2; this could be explained by the older age overall in patients with dementia, and the higher prevalence of sensory alterations that could contribute to these symptoms. Furthermore, dementia syndromes include psychotic symptoms; some are specific, such as the typical visual hallucinations in Lewy body dementia, while others are more varied, such as those in established Alzheimer disease and in vascular dementia.<a class="elsevierStyleCrossRefs" href="#bib0430">19–21</a>We can expect a higher incidence of anxiety and mood disorders among patients with psychiatric conditions, or those whose symptoms were solely derived from substance abuse. Likewise, hypochondria can be expected among individuals with pain disorders. Furthermore, irritability is a documented symptom of patients with chronic hypoxia, as seen in this study.<a class="elsevierStyleCrossRef" href="#bib0445">22</a> The higher rates of emotional lability observed in individuals with metabolic or hormonal disorders (17.2% vs 3.1% in the rest of the population) are not as easily justified. We know that this symptom commonly appears in different types of dementia,<a class="elsevierStyleCrossRef" href="#bib0450">23</a> and that corticotropin-releasing hormone and cerebral glucocorticoid receptors intervene in regulating emotional expression.<a class="elsevierStyleCrossRef" href="#bib0455">24</a> Therefore, it is understandable that emotional lability would be present in cognitive disorders arising from the hormonal or metabolic disorders that affect the hypothalamic-pituitary-adrenal axis.The topographical analysis shows that patients with cognitive impairment are more likely to display affectation of the frontal, temporal, and parietal lobes than of the occipital lobes. This is to be expected based on the typical impact pattern in degenerative dementias, and considering that strokes arise more frequently from the medial or anterior cerebral arteries than from the posterior cerebral artery. In the BPS correlation study, we observed that frontal lobe alterations, and right-hemisphere temporal or parietal lesions, were associated with higher numbers of behaviour disorders. Agitation was associated with alterations in the frontal lobes and right temporal lobe; disinhibition with the right frontal lobe; stereotyped behaviour with the frontal lobes and right parietal lobe; and eating behaviour disorders with the frontal lobes and right temporal lobe. These findings are supported by current research.<a class="elsevierStyleCrossRefs" href="#bib0460">25–33</a> The association between misidentification syndromes and the right temporal lobe is also compatible with earlier observations.<a class="elsevierStyleCrossRefs" href="#bib0505">34,35</a>Associations were also detected between certain BPS and drugs. We presume that most drugs were prescribed to treat BPS, but our methodology does not allow us to detect the cases in which BPS appeared as the side effects of treatment.Given that polymedication promotes confusional syndrome,<a class="elsevierStyleCrossRefs" href="#bib0515">36,37</a> the higher frequency of BPS in group 1 than in group 2 may be linked to their higher consumption of medications (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>).It is logical to find consumption of neuroleptics in patients with psychotic symptoms, benzodiazepine consumption in those with anxiety, and antidepressants for those with affective disorders. Use of antipsychotics was also higher among patients with non-psychotic behaviour disorders, including agitation, stereotyped behaviours, and logorrhoea. Antipsychotic agents are also often used to combat BPS arising in dementia, even though risks are present and the level of evidence of efficacy is lower.<a class="elsevierStyleCrossRefs" href="#bib0525">38,39</a> However, only a handful of published studies have examined the effectiveness of these drugs on different non-psychotic behaviour disorders, or whether they might elicit certain disorders.It should be noted that 18 of the patients with stereotypies were taking mirtazapine or trazodone. These patients had frontotemporal dementia, Lewy body dementia, or cerebrovascular disease; these disorders frequently feature frontal dysfunction, which may be accompanied by stereotyped behaviours.<a class="elsevierStyleCrossRefs" href="#bib0535">40,41</a> It is therefore more likely that the symptom would be due to the disease than to treatment.Psychotic symptoms are not uncommon in patients taking dopaminergic anti-Parkinson drugs; in fact, these drugs facilitate the appearance of such symptoms.<a class="elsevierStyleCrossRefs" href="#bib0545">42,43</a> Hallucinations are the most common symptom in dementia patients who take levodopa. This finding is consistent with the known high rate of hallucinations in patients with cortical Lewy bodies and dementia associated with Parkinson disease, or with Lewy body dementia.<a class="elsevierStyleCrossRefs" href="#bib0555">44–47</a>Some diseases are treated with anticholinesterase drugs, which also reduce BPS.<a class="elsevierStyleCrossRefs" href="#bib0575">48,49</a> Therefore, the association we found suggests that BPS are not an adverse effect of these drugs.Piracetam was prescribed to 18.8% of the patients with psychotic symptoms and to 30% of those with emotional lability. The first group was diagnosed with neoplasm or degenerative, vascular, or metabolic disease; the second had progressive supranuclear palsy or vascular cognitive impairment. Since the underlying diseases were capable of eliciting these BPS and patients were treated with a mean of 6.85 drugs, piracetam was not believed to be responsible for the BPS listed here.Treatment with opioid analgesics varies and the same drug may be employed at different doses. For this reason, and considering how different opioid receptors affect mood,<a class="elsevierStyleCrossRef" href="#bib0585">50</a> patients treated with opioids may experience changes in mood ranging from euphoria to depression. Dysthymia was the most prevalent mood disorder in our sample.Our study points to a link between vasodilators and hallucinations. Although these findings are infrequent, the literature has indicated associations between hallucinations and pentoxifylline,<a class="elsevierStyleCrossRefs" href="#bib0590">51–53</a> trimetazidine,<a class="elsevierStyleCrossRef" href="#bib0605">54</a> flunarizine,<a class="elsevierStyleCrossRef" href="#bib0610">55</a> and nitrovasodilators.<a class="elsevierStyleCrossRefs" href="#bib0590">51,56</a> The high frequency of BPS in cerebrovascular disease<a class="elsevierStyleCrossRefs" href="#bib0620">57–59</a> may explain the associations that have been found between betahistine and anti-platelet drugs.The association between statins and depression supports theories indicating that lower cholesterol levels in cerebral cell membranes, or the resulting weakened response of the serotonergic system, may promote depression.<a class="elsevierStyleCrossRefs" href="#bib0635">60–62</a> Nevertheless, some authors have found the opposite to be true.<a class="elsevierStyleCrossRefs" href="#bib0650">63–66</a>The agitation and hallucinations recorded in patients taking diuretics may be attributed to temporary electrolyte imbalances, especially if the patients were predisposed to these symptoms due to advanced age or cognitive impairment.<a class="elsevierStyleCrossRef" href="#bib0670">67</a>To summarise, BPS are frequent in neurological patients (affecting 59.9% of the sample); they are even more frequent in patients with impaired cognitive function (61.3%). Depressed mood is more common in women, patients diagnosed with a primary psychiatric disorder, users of intoxicating substances, and patients taking opioid analgesics, betahistine, or statin drugs. In our sample, anxiety was more prevalent among women, patients younger than 65, and those diagnosed with a psychiatric disorder or substance abuse. Psychotic symptoms were more frequent in patients aged 65 and older, those with visual or auditory changes or a neurodegenerative disease, and those taking levodopa, piracetam, or vasodilators. Behaviour disorders were predominant in the older group, in patients with degenerative disease, and those with structural changes in the frontal lobes or the right temporal or parietal lobes. Psychosomatic symptoms were associated with psychiatric disorders, hypochondria with pain disorders, emotional lability with metabolic or hormonal disorders plus treatment with piracetam, and irritability with chronic hypoxia.FundingNo funding.Conflicts of interestThe authors have no conflicts of interest to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres816751" "titulo" => "Abstract" "secciones" => array:3 [ 0 => array:1 [ "identificador" => "abst0005" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec813980" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres816752" "titulo" => "Resumen" "secciones" => array:3 [ 0 => array:1 [ "identificador" => "abst0020" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Resultados" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec813981" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Patients and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Funding" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflicts of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-12-31" "fechaAceptado" => "2015-01-06" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec813980" "palabras" => array:6 [ 0 => "Anxiety" 1 => "Dementia" 2 => "Depression" 3 => "Behavioural symptoms" 4 => "Psychotic symptoms" 5 => "Psychiatric symptoms" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec813981" "palabras" => array:6 [ 0 => "Ansiedad" 1 => "Demencia" 2 => "Depresión" 3 => "Síntomas conductuales" 4 => "Síntomas psicóticos" 5 => "Síntomas psiquiátricos" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "Behavioural and psychiatric symptoms (BPS) are frequent in neurological patients, contribute to disability, and decrease quality of life. We recorded BPS prevalence and type, as well as any associations with specific diagnoses, brain regions, and treatments, in consecutive outpatients examined in a cognitive neurology clinic. MethodA retrospective analysis of 843 consecutive patients was performed, including a review of BPS, diagnosis, sensory impairment, lesion topography (neuroimaging), and treatment. The total sample was considered, and the cognitive impairment (CI) group (n=607) was compared to the non-CI group. ResultsBPS was present in 59.9% of the patients (61.3% in the CI group, 56.4% in the non-CI group). One BPS was present in 31.1%, two in 17.4%, and three or more in 11.4%. BPS, especially depression and anxiety, are more frequent in women than in men. Psychotic and behavioural symptoms predominate in subjects aged 65 and older, and anxiety in those younger than 65. Psychotic symptoms appear more often in patients with sensory impairment. Psychotic and behavioural symptoms are more prevalent in patients with degenerative dementia; depression and anxiety in those who suffer a psychiatric disease or adverse effects of substances; emotional lability in individuals with a metabolic or hormonal disorder; hypochondria in those with a pain syndrome; and irritability in subjects with chronic hypoxia. Behavioural symptoms are more frequent in patients with anomalies in the frontal or right temporal or parietal lobes, and antipsychotics constitute the first line of treatment. Leaving standard treatments aside, associations were observed between dysthymia and opioid analgesics, betahistine and statins, and between psychotic symptoms and levodopa, piracetam, and vasodilators." "secciones" => array:3 [ 0 => array:1 [ "identificador" => "abst0005" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "Los síntomas conductuales y psiquiátricos (SCP) son frecuentes en el enfermo neurológico, contribuyen a producir discapacidad y reducen la calidad de vida. Se ha observado, en pacientes de neurología cognitiva, la prevalencia y tipo de SCP y su asociación con diagnósticos, regiones cerebrales o tratamientos específicos. MétodoAnálisis retrospectivo de 843 pacientes consecutivos de neurología cognitiva, revisando SCP, diagnóstico, alteración sensorial, topografía lesional en neuroimagen y tratamiento. Se contempló el total y se comparó el grupo de pacientes con deterioro cognitivo objetivo (n=607) y sin deterioro. ResultadosHubo SCP en el 59,9% de los pacientes (61,3% en los deteriorados y 56,4% en el resto). Un 31,1% tenía un SCP, 17,4% dos y 11,4% más de dos. Los SCP son más frecuentes en mujeres, sobre todo depresión y ansiedad. En los mayores de 64 años predominan los síntomas psicóticos y conductuales, y en los menores de 65 la ansiedad. Las personas con alteración sensorial tienen más síntomas psicóticos. Se aprecian más síntomas conductuales y psicóticos en personas con demencia degenerativa, depresión y ansiedad en las que tienen enfermedad psiquiátrica o efecto nocivo de sustancias, labilidad emocional en relación con trastorno metabólico u hormonal, hipocondría en los síndromes dolorosos e irritabilidad en la hipoxia crónica. Hay más alteraciones de la conducta en pacientes con anomalía en lóbulos frontales o temporal o parietal derechos, y se tratan preferentemente con antipsicóticos. Aparte de los tratamientos estándar, se observó asociación de distimia con opioides, betahistina y estatinas, y síntomas psicóticos con levodopa, piracetam y vasodilatadores." "secciones" => array:3 [ 0 => array:1 [ "identificador" => "abst0020" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Resultados" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Robles Bayón A, Gude Sampedro F. Síntomas conductuales y psiquiátricos en neurología cognitiva. Neurología. 2017;32:81–91." ] ] "multimedia" => array:11 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2124 "Ancho" => 1650 "Tamanyo" => 389935 ] ] "descripcion" => array:1 [ "en" => "Behavioural and psychiatric symptoms (BPS) examined in the study. List of BPS detected in our patient sample. The names of the symptom groups (A-G) are given in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1399 "Ancho" => 2650 "Tamanyo" => 114055 ] ] "descripcion" => array:1 [ "en" => "Breakdown of patients by sex, age, and sensory changes. Au-Vis: auditory and visual. #: mean±SD (range): Total, 72.9±14.4 (14-104); Group 1, 76.6±10.5 (19-104); Group 2, 63±18.3 (19-95). Intergroup differences are statistically significant for P<.01 (*: intergroup differences statistically significant for P<.05)." ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 3377 "Ancho" => 2077 "Tamanyo" => 293104 ] ] "descripcion" => array:1 [ "en" => "List of generic diagnoses and their frequencies in the sample (%). * Percentage significantly higher in one of the groups (P<.01)." ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1292 "Ancho" => 1800 "Tamanyo" => 258502 ] ] "descripcion" => array:1 [ "en" => "Cerebral MRI of an 81-year-old woman. One-year history of delusional ideation; in recent months, she had also exhibited reduplicative paramnesia and altered social and eating behaviours. A space-occupying lesion was detected in the anterior frontal posteroinferior region of the right temporal lobe." ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1147 "Ancho" => 1407 "Tamanyo" => 59698 ] ] "descripcion" => array:1 [ "en" => "Number of drugs patients were taking when their data were recorded. * Statistically significant difference (P<.01) compared to group 2. Total: N=839; Group 1: n=607; Group 2: n=232." ] ] 5 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "In parentheses: specific symptoms (see <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) that are significantly more frequent than in the other group (P<.05).Group 1: patients with dementia or mild cognitive impairment; Group 2: patients with no objective cognitive impairment (controls)." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " colspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic BPS</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total N=843 % \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group 1 n=607 % \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group 2 n=236 % \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Psychotic symptoms and paramnesias \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16.8<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> (i<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a>, ii, iv<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Mood and emotional disorders \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">37.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Anxiety disorders \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25.4<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> (xi<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a>, xii, xiv, xvi) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Psychosomatic symptoms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.7<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> (xviii<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a>) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">E \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Symptoms arising from objective personality change or disorder \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Behavioural disorders \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29.3<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> (xxiii<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a>, xxvi, xxix<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Other \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.4 (xxxv<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1372598.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "*" "nota" => "Difference compared to other group with P<.01." ] ] ] "descripcion" => array:1 [ "en" => "Behavioural and psychiatric symptoms (BPS) in patient sample." ] ] 6 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "When prevalence is higher in only one group, that group is indicated in superscript.G1: Group 1; G2: Group 2." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic BPS<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Specific BPS<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Men \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">AG1, CG2, DG2, FG1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">iG1, xiG2, xxiiiG1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Women \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">AG1, B, CG2, DG2, FG1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">vi, xi, xiG2, xviiiG2, xxiiiG1, xxixG1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">≤65 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">C, FG1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xi, xxiiiG1, xxxvG1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">>65 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A, CG2, DG2, F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i, iv, xiG2, xviiiG2, xxiii, xxixG1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top">Alteration</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Visual \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i, ii \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Auditory \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i, xxiii \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Both \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1372594.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "a" "nota" => "Headings in the “generic BPS” column (letters A-G) are defined in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>; headings in the “specific BPS” column (i-xxxvi) are listed in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>." ] ] ] "descripcion" => array:1 [ "en" => "Most prevalent behavioural and psychiatric symptoms (P<.01) broken down by sex, age, and presence of sensory changes." ] ] 7 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "When prevalence is higher in only one group, that group is indicated in superscript.G1: Group 1; G2: Group 2." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic diagnosis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic BPS<a class="elsevierStyleCrossRef" href="#tblfn0015">a</a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Specific BPS<a class="elsevierStyleCrossRef" href="#tblfn0015">a</a> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neurodegenerative disease with dementia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A, E, F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i, ii, iv, xv, xx, xxiii, xxvi, xxix, xxxii \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Metabolic or hormonal disorder affecting cognition \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">x \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cerebral hypoxia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xxxG2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Effect of substances harmful to cognition \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">B, C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">vii, xi \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Psychiatric disorder affecting cognition \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">B, C, D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">vii, xi \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Any type of process involving severe pain \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xviii \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Non-neurological, non-pain disorder \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top">Specific diagnosis</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lewy body dementia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A, F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i, ii, iv, xxiii \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Frontotemporal dementia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xxiii, xxvi, xix, xxxii \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Chronic kidney disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xxiii \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Drug-induced cognitive impairment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">B, C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">vi, vii, xi \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Depressive disorder \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">vii \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Psychogenic or psychosomatic symptoms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">C, D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xi \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Muscle tension headache \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xviii \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Non-neurological, non-pain disorder \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1372596.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "a" "nota" => "Headings in the “generic BPS” column (letters A-G) are defined in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>; headings in the “specific BPS” column (i-xxxvi) are listed in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>." ] ] ] "descripcion" => array:1 [ "en" => "Breakdown of the most common BPS (P<.01) by diagnosis." ] ] 8 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at4" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "95% CI: 95% confidence interval. Percentage is significantly higher than in the other group." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total (N=611) % (95% CI) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group 1 (n=493) % (95% CI) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group 2 (n=118) % (95% CI) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">No significant alterations \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">44.5 (41–48) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40.2 (36–45) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">62.7 (54–72)<a class="elsevierStyleCrossRef" href="#tblfn0025">**</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left hemisphere only \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.7 (4–7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.1 (4–8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.2 (1–8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right hemisphere only \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.9 (2–5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.7 (3–7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.8 (0–3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Both hemispheres \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">45.8 (42–50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49.1 (44–53)<a class="elsevierStyleCrossRef" href="#tblfn0025">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32.2 (24–41) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left frontal lobe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15.2 (12–18) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18.0 (15–21)<a class="elsevierStyleCrossRef" href="#tblfn0025">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.4 (0–7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right frontal lobe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.6 (12–17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17.4 (14–21)<a class="elsevierStyleCrossRef" href="#tblfn0025">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.5 (0–5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left temporal lobe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.4 (12–17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17.2 (14–21)<a class="elsevierStyleCrossRef" href="#tblfn0025">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.5 (0–5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right temporal lobe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.4 (10–15) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15.0 (12–18)<a class="elsevierStyleCrossRef" href="#tblfn0025">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.7 (0–4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left parietal lobe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8.3 (6–11) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.5 (7–12)<a class="elsevierStyleCrossRef" href="#tblfn0020">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.4 (0–7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right parietal lobe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.0 (4–8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.5 (5–10)<a class="elsevierStyleCrossRef" href="#tblfn0025">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.0 (0–3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left occipital lobe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.8 (1–3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.2 (1–4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.0 (0–3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right occipital lobe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.1 (1–3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.4 (1–4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.8 (0–3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Deep subcortical topography – left hemisphere \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32.4 (29–36) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32.9 (29–37) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30.5 (22–39) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Deep subcortical topography – right hemisphere \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30.8 (27–34) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31.0 (27–35) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29.7 (21–38) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1372595.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "*" "nota" => "Percentage is significantly higher than in the other group with P<.05." ] 1 => array:3 [ "identificador" => "tblfn0025" "etiqueta" => "**" "nota" => "Percentage is significantly higher than in the other group with P<.01." ] ] ] "descripcion" => array:1 [ "en" => "Topography of the changes observed in neuroimaging studies for cases with BPS examined using brain CT or MRI." ] ] 9 => array:8 [ "identificador" => "tbl0025" "etiqueta" => "Table 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at5" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "When prevalence is higher in only one group, that group is indicated in superscript.G1: Group 1; G2: Group 2." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic treatment \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic BPS<a class="elsevierStyleCrossRef" href="#tblfn0030">a</a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Specific BPS<a class="elsevierStyleCrossRef" href="#tblfn0030">a</a> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T1. Neuroleptics \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A, BG2, CG1, F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i, ii, viiG2, xxiii, xxix, xxxi \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T2. Benzodiazepines \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">B, C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">vi, vii, xi \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T7. Antidepressants \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">vi, xiG1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T8. Anti-Parkinson drugs with dopaminergic activity \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T9. Specific drugs for Alzheimer disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xxiii, xxix \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T11. Nootropic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">x \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T15. Vasodilators \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T18. Anti-platelet agents \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xxix \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T27. Lipid-lowering drugs \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">vii \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T28. Diuretics \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i, xxiii \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1372593.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0030" "etiqueta" => "a" "nota" => "Headings in the “generic BPS” column (letters A-G) are defined in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>; headings in the “specific BPS” column (i-xxxvi) are listed in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>." ] ] ] "descripcion" => array:1 [ "en" => "Breakdown of the most common BPS (P<.01) by drug therapeutic group." ] ] 10 => array:8 [ "identificador" => "tbl0030" "etiqueta" => "Table 6" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at6" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "When prevalence is higher in only one group, that group is indicated in superscript.G1: Group 1; G2: Group 2." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Specific treatment \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic BPS<a class="elsevierStyleCrossRef" href="#tblfn0035">a</a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Specific BPS<a class="elsevierStyleCrossRef" href="#tblfn0035">a</a> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t1. Typical antipsychotics \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xxiii \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t2. Atypical antipsychotics \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A, F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i, ii, xxiii, xxix \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t4. Benzodiazepines \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">B, C, D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">vi, vii, xi \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t6. Clomethiazole \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t13. Tricyclic antidepressants \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t16. Serotonin and noradrenalin reuptake inhibitors \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">B, CG2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">vi \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t17. Selective serotonin reuptake inhibitors \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">vi \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t20. Trazodone \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xxiii, xxix \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t21. Levodopa \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t27. Cholinesterase inhibitors \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xxix \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t40. Piracetam \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">x \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t42. Opioid analgesics \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">BG2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">viiG2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t50. Betahistine \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">viiG2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t66. Antiplatelet drugs \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">xxiii, xxix \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t96. Statins \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">vii \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t101. Diuretics \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">i, xxiii \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1372597.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0035" "etiqueta" => "a" "nota" => "Headings in the “generic BPS” column (letters A-G) are defined in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>; headings in the “specific BPS” column (i-xxxvi) are listed in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>." ] ] ] "descripcion" => array:1 [ "en" => "Breakdown of BPS associated with specific treatments (P<.01)." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:67 [ 0 => array:3 [ "identificador" => "bib0340" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychiatric disorders in neurology patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Moriarty" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/jnnp.2006.106401" "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "2007" "volumen" => "78" "paginaInicial" => "331" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17369587" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0168827808006351" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0345" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychiatric disorders in inpatients on a neurology ward: estimate of prevalence and usefulness of screening questionnaires" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Jefferies" 1 => "A. Owino" 2 => "H. Rickards" 3 => "N. Agrawal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/jnnp.2006.103044" "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "2007" "volumen" => "78" "paginaInicial" => "414" "paginaFinal" => "416" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17056626" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0350" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychiatric aspects of clinical neurology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.B. Schiffer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1176/ajp.140.2.205" "Revista" => array:6 [ "tituloSerie" => "Am J Psychiatry" "fecha" => "1983" "volumen" => "140" "paginaInicial" => "205" "paginaFinal" => "207" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6849436" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0355" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychiatric symptomatology in an outpatient neurology clinic" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.M. Berlin" 1 => "M. Ronthal" 2 => "E.O. Bixler" 3 => "J.D. Kales" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Psychiatry" "fecha" => "1983" "volumen" => "44" "paginaInicial" => "204" "paginaFinal" => "206" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6853458" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0360" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurological disease, emotional disorder, and disability: they are related. A study of 300 consecutive new referrals to a neurology outpatient department" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.J. Carson" 1 => "B. Ringbauer" 2 => "L. MacKenzie" 3 => "C. Warlow" 4 => "M. Sharpe" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "2000" "volumen" => "68" "paginaInicial" => "202" "paginaFinal" => "206" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10644788" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0365" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of neuropsychiatric symptoms on caregiver distress and quality of life in persons with dementia in an Asian tertiary hospital memory clinic" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.A. Khoo" 1 => "T.Y. Chen" 2 => "Y.H. Ang" 3 => "P. Yap" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1017/S1041610213001518" "Revista" => array:6 [ "tituloSerie" => "Int Psychogeriatr" "fecha" => "2013" "volumen" => "25" "paginaInicial" => "1991" "paginaFinal" => "1999" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24230964" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0370" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patient and caregiver perspectives of quality of life in dementia. An investigation of the relationship to behavioural and psychological symptoms in dementia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Hurt" 1 => "S. Bhattacharyya" 2 => "A. Burns" 3 => "V. Camus" 4 => "R. Liperoti" 5 => "A. Marriott" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000149584" "Revista" => array:6 [ "tituloSerie" => "Dement Geriatr Cogn Disord" "fecha" => "2008" "volumen" => "26" "paginaInicial" => "138" "paginaFinal" => "146" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18679028" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0375" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychiatric morbidity in dementia patients in a neurology-based memory clinic" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.S. Shih" 1 => "S.H. Yan" 2 => "Y.H. Ho" 3 => "Y.T. Lin" 4 => "J.Y. Li" 5 => "Y.K. Lo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Neurol Taiwan" "fecha" => "2005" "volumen" => "14" "paginaInicial" => "179" "paginaFinal" => "186" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16425544" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0380" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Proitsi" 1 => "M.K. Lupton" 2 => "S.J. Reeves" 3 => "G. Hamilton" 4 => "N. Archer" 5 => "B.M. Martin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.neurobiolaging.2010.06.011" "Revista" => array:6 [ "tituloSerie" => "Neurobiol Aging" "fecha" => "2012" "volumen" => "33" "paginaInicial" => "791" "paginaFinal" => "803" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20685009" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0385" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PRND 3′UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Flirski" 1 => "M. Sieruta" 2 => "E. Golańska" 3 => "I. Kłoszewska" 4 => "P.P. Liberski" 5 => "T. Sobów" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4161/pri.6.1.18428" "Revista" => array:6 [ "tituloSerie" => "Prion" "fecha" => "2012" "volumen" => "6" "paginaInicial" => "73" "paginaFinal" => "80" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22453181" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0390" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychiatric morbidity in a neurology-based memory clinic: the effect of systematic psychiatric evaluation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.M. Hejl" 1 => "M. Hørding" 2 => "E. Hasselbalch" 3 => "H. Dam" 4 => "R. Hemmingsen" 5 => "G. Waldemar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Geriatr Soc" "fecha" => "2003" "volumen" => "51" "paginaInicial" => "1773" "paginaFinal" => "1778" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14687357" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0395" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detecting psychogeriatric problems in primary care: factors related to psychiatric symptoms in older community patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Olivera" 1 => "S. Benabarre" 2 => "T. Lorente" 3 => "M. Rodríguez" 4 => "A. Barros" 5 => "C. Quintana" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ment Health Fam Med" "fecha" => "2011" "volumen" => "8" "paginaInicial" => "11" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22479288" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0400" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sex differences in anxiety and depression clinical perspectives" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Altemus" 1 => "N. Sarvaiya" 2 => "C. Neill Epperson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.yfrne.2014.05.004" "Revista" => array:6 [ "tituloSerie" => "Front Neuroendocrinol" "fecha" => "2014" "volumen" => "35" "paginaInicial" => "320" "paginaFinal" => "330" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24887405" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0405" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sex differences in anxiety and emotional behavior" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N.C. Donner" 1 => "C.A. Lowry" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00424-013-1271-7" "Revista" => array:6 [ "tituloSerie" => "Pflugers Arch" "fecha" => "2013" "volumen" => "465" "paginaInicial" => "601" "paginaFinal" => "626" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23588380" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0410" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychotic symptoms in the elderly" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.W. Brendel" 1 => "T.A. Stern" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Prim Care Companion J Clin Psychiatry" "fecha" => "2005" "volumen" => "7" "paginaInicial" => "238" "paginaFinal" => "241" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16308581" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0415" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology and comorbidity of anxiety disorders in later life: implications for treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.J. Flint" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Neurosci" "fecha" => "1997" "volumen" => "4" "paginaInicial" => "31" "paginaFinal" => "36" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9056120" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0420" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Visual impairment in persons with psychotic disorder" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Viertiö" 1 => "A. Laitinen" 2 => "J. Perälä" 3 => "S.I. Saarni" 4 => "S. Koskinen" 5 => "J. Lönnqvist" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00127-007-0252-6" "Revista" => array:6 [ "tituloSerie" => "Soc Psychiatry Psychiatr Epidemiol" "fecha" => "2007" "volumen" => "42" "paginaInicial" => "902" "paginaFinal" => "908" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17846698" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0425" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Associations of psychotic symptoms in dementia sufferers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Ballard" 1 => "C. Bannister" 2 => "C. Graham" 3 => "F. Oyebode" 4 => "G. Wilcock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Psychiatry" "fecha" => "1995" "volumen" => "167" "paginaInicial" => "537" "paginaFinal" => "540" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8829726" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0430" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anxiety, depression and psychosis in vascular dementia: prevalence and associations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Ballard" 1 => "D. Neill" 2 => "J. O’Brien" 3 => "I.G. McKeith" 4 => "P. Ince" 5 => "R. Perry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Affect Disord" "fecha" => "2000" "volumen" => "59" "paginaInicial" => "97" "paginaFinal" => "106" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10837878" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0435" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychotic symptoms in a population-based sample of 85-year-old individuals with dementia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Ostling" 1 => "D. Gustafson" 2 => "K. Blennow" 3 => "A. Börjesson-Hanson" 4 => "M. Waern" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0891988710373596" "Revista" => array:6 [ "tituloSerie" => "J Geriatr Psychiatry Neurol" "fecha" => "2011" "volumen" => "24" "paginaInicial" => "3" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20601646" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0440" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychotic symptoms in Alzheimer disease: evidence for a distinct phenotype" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.A. Sweet" 1 => "V.L. Nimgaonkar" 2 => "B. Devlin" 3 => "D.V. Jeste" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.mp.4001262" "Revista" => array:6 [ "tituloSerie" => "Mol Psychiatry" "fecha" => "2003" "volumen" => "8" "paginaInicial" => "383" "paginaFinal" => "392" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12740595" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0445" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Funcionamiento neuropsicológico bajo condiciones de hipoxia aguda y crónica asociada a la altitud" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Virués-Ortega" 1 => "E. Garrido" 2 => "C. Javierre" 3 => "P.D. Rivero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Biol Andina" "fecha" => "2008" "volumen" => "14" "paginaInicial" => "40" "paginaFinal" => "50" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0450" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pathophysiology of emotional lability: many paths to a common destination" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.W. Richter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Am J Geriatr Pharmacother" "fecha" => "2005" "volumen" => "3" "numero" => "Suppl. A" "paginaInicial" => "9" "paginaFinal" => "11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16305944" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0455" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Q. Wei" 1 => "X.Y. Lu" 2 => "L. Liu" 3 => "G. Schafer" 4 => "K.R. Shieh" 5 => "S. Burke" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.0402208101" "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci U S A" "fecha" => "2004" "volumen" => "101" "paginaInicial" => "11851" "paginaFinal" => "11856" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15280545" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0460" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Banno" 1 => "S. Nakaaki" 2 => "J. Sato" 3 => "K. Torii" 4 => "J. Narumoto" 5 => "J. Miyata" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/NDT.S57522" "Revista" => array:6 [ "tituloSerie" => "Neuropsychiatr Dis Treat" "fecha" => "2014" "volumen" => "10" "paginaInicial" => "339" "paginaFinal" => "348" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24600224" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0465" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Agitation in Alzheimer's disease is a manifestation of frontal lobe dysfunction" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Senanarong" 1 => "J.L. Cummings" 2 => "L. Fairbanks" 3 => "M. Mega" 4 => "D.M. Masterman" 5 => "S.M. O’Connor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000074080" "Revista" => array:6 [ "tituloSerie" => "Dement Geriatr Cogn Disord" "fecha" => "2004" "volumen" => "17" "paginaInicial" => "14" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14560060" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0470" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanism of disinhibition after brain lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.E. Starkstein" 1 => "R.G. Robinson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Nerv Ment Dis" "fecha" => "1997" "volumen" => "185" "paginaInicial" => "108" "paginaFinal" => "114" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9048703" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1521691815000219" "estado" => "S300" "issn" => "15216918" ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0475" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Repetitive and compulsive behavior in frontal lobe degenerations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Ames" 1 => "J.L. Cummings" 2 => "W.C. Wirshing" 3 => "B. Quinn" 4 => "M. Mahler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1176/jnp.6.2.100" "Revista" => array:7 [ "tituloSerie" => "J Neuropsychiatry Clin Neurosci" "fecha" => "1994" "volumen" => "6" "paginaInicial" => "100" "paginaFinal" => "113" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8044031" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510710020742" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0480" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Abnormal repetitive behaviours: shared phenomenology and pathophysiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.M. Muehlmann" 1 => "M.H. Lewis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2788.2011.01519.x" "Revista" => array:6 [ "tituloSerie" => "J Intellect Disabil Res" "fecha" => "2012" "volumen" => "56" "paginaInicial" => "427" "paginaFinal" => "440" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22283923" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0485" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.L. Whitwell" 1 => "E.L. Sampson" 2 => "C.T. Loy" 3 => "J.E. Warren" 4 => "M.N. Rossor" 5 => "N.C. Fox" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.neuroimage.2006.12.006" "Revista" => array:6 [ "tituloSerie" => "Neuroimage" "fecha" => "2007" "volumen" => "35" "paginaInicial" => "207" "paginaFinal" => "213" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17240166" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0490" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain lesions and eating disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Uher" 1 => "J. Treasure" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/jnnp.2004.048819" "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "2005" "volumen" => "76" "paginaInicial" => "852" "paginaFinal" => "857" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15897510" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0495" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dieting tendency and eating behavior problems in eating disorder correlate with right frontotemporal and left orbitofrontal cortex: a near-infrared spectroscopy study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Suda" 1 => "T. Uehara" 2 => "M. Fukuda" 3 => "T. Sato" 4 => "M. Kameyama" 5 => "M. Mikuni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jpsychires.2009.11.005" "Revista" => array:6 [ "tituloSerie" => "J Psychiatr Res" "fecha" => "2010" "volumen" => "44" "paginaInicial" => "547" "paginaFinal" => "555" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19962158" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0500" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Induction of hyperphagia and carbohydrate intake by μ-opioid receptor stimulation in circumscribed regions of frontal cortex" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.D. Mena" 1 => "K. Sadeghian" 2 => "B.A. Baldo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1523/JNEUROSCI.2050-10.2011" "Revista" => array:6 [ "tituloSerie" => "J Neurosci" "fecha" => "2011" "volumen" => "31" "paginaInicial" => "3249" "paginaFinal" => "3260" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21368037" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0505" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Isolated right temporal lobe stroke patients present with Geschwind Gastaut syndrome, frontal network syndrome and delusional misidentification syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Hoffmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3233/BEN-2008-0218" "Revista" => array:6 [ "tituloSerie" => "Behav Neurol" "fecha" => "2008" "volumen" => "20" "paginaInicial" => "83" "paginaFinal" => "89" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19641245" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0510" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Misidentification syndromes related to face specific area in the fusiform gyrus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.J. Hudson" 1 => "G.M. Grace" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "2000" "volumen" => "69" "paginaInicial" => "645" "paginaFinal" => "648" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11032619" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0515" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "e11-5" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of polypharmacy on occurrence of delirium in elderly emergency patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Hein" 1 => "A. Forgues" 2 => "A. Piau" 3 => "A. Sommet" 4 => "F. Nourhashémi" 5 => "B. Vellas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jamda.2014.08.012" "Revista" => array:5 [ "tituloSerie" => "J Am Med Dir Assoc" "fecha" => "2014" "volumen" => "15" "paginaInicial" => "850" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25405712" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0520" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Revisiting the O complex: urinary incontinence, delirium and polypharmacy in elderly patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.B. Hogan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "CMAJ" "fecha" => "1997" "volumen" => "157" "paginaInicial" => "1071" "paginaFinal" => "1077" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9347778" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0525" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety and efficacy of antipsychotic drugs for the behavioral and psychological symptoms of dementia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Andrade" 1 => "R. Radhakrishnan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Indian J Psychiatry" "fecha" => "2009" "volumen" => "51" "numero" => "Suppl. 1" "paginaInicial" => "S87" "paginaFinal" => "S92" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21416025" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0530" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Behavioral and psychological symptoms of dementia (BPSD) in elderly demented subjects: is the long lasting use of atypical antipsychotic drugs useful and safe?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Angelini" 1 => "C. Bendini" 2 => "F. Neviani" 3 => "M. Neri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.archger.2007.01.005" "Revista" => array:7 [ "tituloSerie" => "Arch Gerontol Geriatr" "fecha" => "2007" "volumen" => "44" "numero" => "Suppl. 1" "paginaInicial" => "35" "paginaFinal" => "43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17317431" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0535" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metabolic correlates of behavioral and affective disturbances in frontal lobe pathologies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Sarazin" 1 => "A. Michon" 2 => "B. Pillon" 3 => "Y. Samson" 4 => "A. Canuto" 5 => "G. Gold" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00415-003-1087-z" "Revista" => array:6 [ "tituloSerie" => "J Neurol" "fecha" => "2003" "volumen" => "250" "paginaInicial" => "827" "paginaFinal" => "833" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12883925" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0540" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The clinical spectrum of stereotypies in frontotemporal lobar degeneration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.J. Mateen" 1 => "K.A. Josephs" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/mds.22555" "Revista" => array:6 [ "tituloSerie" => "Mov Disord" "fecha" => "2009" "volumen" => "24" "paginaInicial" => "1237" "paginaFinal" => "1240" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19412926" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0545" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dopamine agonists and their risk to induce psychotic episodes in Parkinson's disease: a case–control study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Ecker" 1 => "A. Unrath" 2 => "J. Kassubek" 3 => "M. Sabolek" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-2377-9-23" "Revista" => array:5 [ "tituloSerie" => "BMC Neurol" "fecha" => "2009" "volumen" => "9" "paginaInicial" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19515253" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0550" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychotic complications of long-term levodopa treatment of Parkinson's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Friedman" 1 => "J. Sienkiewicz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Neurol Scand" "fecha" => "1991" "volumen" => "84" "paginaInicial" => "111" "paginaFinal" => "113" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1950448" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0555" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Visual hallucinations in PD and Lewy body dementias: old and new hypotheses" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Onofrj" 1 => "J.P. Taylor" 2 => "D. Monaco" 3 => "R. Franciotti" 4 => "F. Anzellotti" 5 => "L. Bonanni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3233/BEN-129022" "Revista" => array:6 [ "tituloSerie" => "Behav Neurol" "fecha" => "2013" "volumen" => "27" "paginaInicial" => "479" "paginaFinal" => "493" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23242366" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0560" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Visual hallucinations in the differential diagnosis of parkinsonism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K. Bertram" 1 => "D.R. Williams" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/jnnp-2011-300980" "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "2012" "volumen" => "83" "paginaInicial" => "448" "paginaFinal" => "452" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22228724" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0565" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hallucinations and psychosis in Parkinson's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.M. Rabey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1353-8020(09)70846-6" "Revista" => array:7 [ "tituloSerie" => "Parkinsonism Relat Disord" "fecha" => "2009" "volumen" => "15" "numero" => "Suppl. 4" "paginaInicial" => "S105" "paginaFinal" => "S110" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20123547" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0570" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hallucinations in neurodegenerative diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Burghaus" 1 => "C. Eggers" 2 => "L. Timmermann" 3 => "G.R. Fink" 4 => "N.J. Diederich" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1755-5949.2011.00247.x" "Revista" => array:6 [ "tituloSerie" => "CNS Neurosci Ther" "fecha" => "2012" "volumen" => "18" "paginaInicial" => "149" "paginaFinal" => "159" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21592320" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0575" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A meta-analysis of the efficacy of donepezil, rivastigmine, galantamine, and memantine in relation to severity of Alzheimer's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.G. Di Santo" 1 => "F. Prinelli" 2 => "F. Adorni" 3 => "C. Caltagirone" 4 => "M. Musicco" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3233/JAD-122140" "Revista" => array:6 [ "tituloSerie" => "J Alzheimers Dis" "fecha" => "2013" "volumen" => "35" "paginaInicial" => "349" "paginaFinal" => "361" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23411693" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0580" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Rolinski" 1 => "C. Fox" 2 => "I. Maidment" 3 => "R. McShane" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Cochrane Database Syst Rev" "fecha" => "2012" "volumen" => "3" "paginaInicial" => "CD006504" ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0585" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Opioid receptors: distinct roles in mood disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.E. Lutz" 1 => "B.L. Kieffer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.tins.2012.11.002" "Revista" => array:6 [ "tituloSerie" => "Trends Neurosci" "fecha" => "2013" "volumen" => "36" "paginaInicial" => "195" "paginaFinal" => "206" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23219016" …1 ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0590" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alucinaciones musicales: la música perpetua" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Neurol" "fecha" => "2014" "volumen" => "58" "paginaInicial" => "207" "paginaFinal" => "212" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0595" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pentoxifylline-induced musical hallucinations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology" "fecha" => "1993" "volumen" => "43" "paginaInicial" => "1621" "paginaFinal" => "1622" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0600" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pentoxifylline (Trental)-induced visual hallucinations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Geriatr Soc" "fecha" => "1993" "volumen" => "41" "paginaInicial" => "782" "paginaFinal" => "783" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0605" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Trimetazidine: abnormal movements and hallucinations. Should be withdrawn from the market" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Prescrire Int" "fecha" => "2009" "volumen" => "18" "paginaInicial" => "69" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0610" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alucinaciones inducidas por flunaricina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Neurol" "fecha" => "2006" "volumen" => "42" "paginaInicial" => "315" "paginaFinal" => "317" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0615" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Visual hallucinations and suicidal ideation attributed to isosorbide dinitrate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0033-3182(87)72471-2" "Revista" => array:6 [ "tituloSerie" => "Psychosomatics" "fecha" => "1987" "volumen" => "28" "paginaInicial" => "555" "paginaFinal" => "556" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0620" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Behavioral symptoms in vascular cognitive impairment and vascular dementia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1017/S1041610203009098" "Revista" => array:7 [ "tituloSerie" => "Int Psychogeriatr" "fecha" => "2003" "volumen" => "15" "numero" => "Suppl. 1" "paginaInicial" => "133" "paginaFinal" => "138" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0625" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Behavioural and psychological symptoms in vascular dementia; differences between small- and large-vessel disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/jnnp.2009.187500" "Revista" => array:7 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "2010" "volumen" => "81" "paginaInicial" => "547" "paginaFinal" => "551" "link" => array:1 [ 0 => array:2 [ …2] ] "itemHostRev" => array:3 [ "pii" => "S0016510714021968" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0630" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuropsychiatric profiles in patients with Alzheimer's disease and vascular dementia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/0972-2327.138520" "Revista" => array:6 [ "tituloSerie" => "Ann Indian Acad Neurol" "fecha" => "2014" "volumen" => "17" "paginaInicial" => "325" "paginaFinal" => "330" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0635" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychiatric adverse reactions with statins, fibrates and ezetimibe: implications for the use of lipid-lowering agents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Drug Saf" "fecha" => "2007" "volumen" => "30" "paginaInicial" => "195" "paginaFinal" => "201" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0640" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The relationship between statins and depression: a review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1517/14656566.2013.803067" "Revista" => array:7 [ "tituloSerie" => "Expert Opin Pharmacother" "fecha" => "2013" "volumen" => "14" "paginaInicial" => "1467" "paginaFinal" => "1476" "link" => array:1 [ 0 => array:2 [ …2] ] "itemHostRev" => array:3 [ "pii" => "S0016508513014601" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0645" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuropsychiatric adverse events associated with statins: epidemiology, pathophysiology, prevention and management" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s40263-013-0135-1" "Revista" => array:6 [ "tituloSerie" => "CNS Drugs" "fecha" => "2014" "volumen" => "28" "paginaInicial" => "249" "paginaFinal" => "272" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0650" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1741-7015-12-51" "Revista" => array:5 [ "tituloSerie" => "BMC Med" "fecha" => "2014" "volumen" => "12" "paginaInicial" => "51" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0655" "etiqueta" => "64" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Statins use and risk of depression: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jad.2013.11.026" "Revista" => array:6 [ "tituloSerie" => "J Affect Disord" "fecha" => "2014" "volumen" => "160" "paginaInicial" => "62" "paginaFinal" => "67" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0660" "etiqueta" => "65" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of statins on psychological wellbeing: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1741-7015-10-154" "Revista" => array:5 [ "tituloSerie" => "BMC Med" "fecha" => "2012" "volumen" => "10" "paginaInicial" => "154" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0665" "etiqueta" => "66" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between depressive symptoms and use of HMG-CoA reductase inhibitors (statins), corticosteroids and histamine H(2) receptor antagonists in community-dwelling older persons: cross-sectional analysis of a population-based cohort" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Drugs Aging" "fecha" => "2008" "volumen" => "25" "paginaInicial" => "795" "paginaFinal" => "805" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0670" "etiqueta" => "67" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sodium and potassium disturbances in the elderly: prevalence and association with drug use" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Clin Drug Investig" "fecha" => "2004" "volumen" => "24" "paginaInicial" => "535" "paginaFinal" => "544" "link" => array:1 [ 0 => array:2 [ …2] ] "itemHostRev" => array:3 [ "pii" => "S0016510711024977" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735808/0000003200000002/v1_201703191230/S217358081730038X/v1_201703191230/en/main.assets" "Apartado" => array:4 [ "identificador" => "9491" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735808/0000003200000002/v1_201703191230/S217358081730038X/v1_201703191230/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217358081730038X?idApp=UINPBA00004N"]

Statistics

Original article

Síntomas conductuales y psiquiátricos en neurología cognitiva

A. Robles Bayóna,

Corresponding author

alfredorobles@hospitalrosaleda.com

Corresponding author.

, F. Gude Sampedrob

a Neurología cognitiva, Hospital La Rosaleda, Santiago de Compostela, La Coruña, Spain

b Unidad de Epidemiología Clínica, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, La Coruña, Spain

Read

3373

Times
was read the article

800

Total PDF

2573

Total HTML

Share statistics

 array:25 [
  "pii" => "S217358081730038X"
  "issn" => "21735808"
  "doi" => "10.1016/j.nrleng.2015.01.003"
  "estado" => "S300"
  "fechaPublicacion" => "2017-03-01"
  "aid" => "728"
  "copyright" => "Sociedad Espa&#241;ola de Neurolog&#237;a"
  "copyrightAnyo" => "2014"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Neurologia. 2017;32:81-91"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1364
    "formatos" => array:3 [
      "EPUB" => 58
      "HTML" => 1029
      "PDF" => 277
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:20 [
      "pii" => "S0213485315000183"
      "issn" => "02134853"
      "doi" => "10.1016/j.nrl.2015.01.003"
      "estado" => "S300"
      "fechaPublicacion" => "2017-03-01"
      "aid" => "728"
      "copyright" => "Sociedad Espa&#241;ola de Neurolog&#237;a"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "Neurologia. 2017;32:81-91"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 3737
        "formatos" => array:3 [
          "EPUB" => 66
          "HTML" => 3049
          "PDF" => 622
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>"
        "titulo" => "S&#237;ntomas conductuales y psiqui&#225;tricos en neurolog&#237;a cognitiva"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "81"
            "paginaFinal" => "91"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Behavioural and psychiatric symptoms in cognitive neurology"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0020"
            "etiqueta" => "Figura 4"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr4.jpeg"
                "Alto" => 1292
                "Ancho" => 1800
                "Tamanyo" => 257378
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Resonancia magn&#233;tica cerebral de una mujer de 81 a&#241;os&#46; Un a&#241;o antes comenz&#243; ideaci&#243;n delirante y en los &#250;ltimos meses muestra paramnesia reduplicativa y alteraci&#243;n de la conducta social y alimentaria&#46; Se observa una lesi&#243;n ocupante de espacio en la regi&#243;n temporal anterior-frontal posteroinferior del hemisferio derecho&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "A&#46; Robles Bay&#243;n, F&#46; Gude Sampedro"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Robles Bay&#243;n"
              ]
              1 => array:2 [
                "nombre" => "F&#46;"
                "apellidos" => "Gude Sampedro"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S217358081730038X"
          "doi" => "10.1016/j.nrleng.2015.01.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217358081730038X?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485315000183?idApp=UINPBA00004N"
      "url" => "/02134853/0000003200000002/v3_201706020006/S0213485315000183/v3_201706020006/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:20 [
    "pii" => "S2173580817300329"
    "issn" => "21735808"
    "doi" => "10.1016/j.nrleng.2014.12.020"
    "estado" => "S300"
    "fechaPublicacion" => "2017-03-01"
    "aid" => "724"
    "copyright" => "Sociedad Espa&#241;ola de Neurolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Neurologia. 2017;32:92-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1072
      "formatos" => array:3 [
        "EPUB" => 61
        "HTML" => 698
        "PDF" => 313
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Multiple sclerosis and pregnancy&#58; A single-centre prospective comparative study"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "92"
          "paginaFinal" => "98"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Esclerosis m&#250;ltiple y embarazo&#58; estudio unic&#233;ntrico prospectivo y comparativo"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46;P&#46; Cuello, M&#46;L&#46; Mart&#237;nez Gin&#233;s, M&#46;L&#46; Martin Barriga, C&#46; de Andr&#233;s"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;P&#46;"
              "apellidos" => "Cuello"
            ]
            1 => array:2 [
              "nombre" => "M&#46;L&#46;"
              "apellidos" => "Mart&#237;nez Gin&#233;s"
            ]
            2 => array:2 [
              "nombre" => "M&#46;L&#46;"
              "apellidos" => "Martin Barriga"
            ]
            3 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "de Andr&#233;s"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0213485315000146"
        "doi" => "10.1016/j.nrl.2014.12.015"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0213485315000146?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580817300329?idApp=UINPBA00004N"
    "url" => "/21735808/0000003200000002/v1_201703191230/S2173580817300329/v1_201703191230/en/main.assets"
  ]
  "itemAnterior" => array:20 [
    "pii" => "S2173580817300378"
    "issn" => "21735808"
    "doi" => "10.1016/j.nrleng.2014.12.021"
    "estado" => "S300"
    "fechaPublicacion" => "2017-03-01"
    "aid" => "715"
    "copyright" => "Sociedad Espa&#241;ola de Neurolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Neurologia. 2017;32:74-80"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 845
      "formatos" => array:3 [
        "EPUB" => 57
        "HTML" => 590
        "PDF" => 198
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Reliability of the minimum basic dataset for diagnoses of cerebrovascular disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "74"
          "paginaFinal" => "80"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Fiabilidad del conjunto m&#237;nimo b&#225;sico de datos en el diagn&#243;stico de la enfermedad cerebrovascular"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "I&#46; Hern&#225;ndez Medrano, M&#46; Guill&#225;n, J&#46; Masjuan, A&#46; Alonso C&#225;novas, M&#46;A&#46; Gogorcena"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Hern&#225;ndez Medrano"
            ]
            1 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Guill&#225;n"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Masjuan"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Alonso C&#225;novas"
            ]
            4 => array:2 [
              "nombre" => "M&#46;A&#46;"
              "apellidos" => "Gogorcena"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S021348531500002X"
        "doi" => "10.1016/j.nrl.2014.12.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021348531500002X?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173580817300378?idApp=UINPBA00004N"
    "url" => "/21735808/0000003200000002/v1_201703191230/S2173580817300378/v1_201703191230/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Behavioural and psychiatric symptoms in cognitive neurology"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "81"
        "paginaFinal" => "91"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Robles Bay&#243;n, F&#46; Gude Sampedro"
        "autores" => array:2 [
          0 => array:4 [
            "nombre" => "A&#46;"
            "apellidos" => "Robles Bay&#243;n"
            "email" => array:1 [
              0 => "alfredorobles&#64;hospitalrosaleda&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "F&#46;"
            "apellidos" => "Gude Sampedro"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Neurolog&#237;a cognitiva&#44; Hospital La Rosaleda&#44; Santiago de Compostela&#44; La Coru&#241;a&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Epidemiolog&#237;a Cl&#237;nica&#44; Hospital Cl&#237;nico Universitario de Santiago de Compostela&#44; Santiago de Compostela&#44; La Coru&#241;a&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "S&#237;ntomas conductuales y psiqui&#225;tricos en neurolog&#237;a cognitiva"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1292
            "Ancho" => 1800
            "Tamanyo" => 258502
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Cerebral MRI of an 81-year-old woman&#46; One-year history of delusional ideation&#59; in recent months&#44; she had also exhibited reduplicative paramnesia and altered social and eating behaviours&#46; A space-occupying lesion was detected in the anterior frontal posteroinferior region of the right temporal lobe&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Cognitive neurology clinics evaluate and treat declining intellectual function&#46; Furthermore&#44; this decline is often associated with behaviour disorders and other typical symptoms of psychiatric diseases&#46; These associated symptoms may indicate a psychological reaction to the self-perceived cognitive disorder&#44; which may also be accompanied by other neurological and&#47;or systemic manifestations&#46; This perception can lead to different degrees of worry or alarm&#44; depending on the patient&#39;s personality and intensity of symptoms&#59; alarm may manifest in the form of behavioural changes and such psychiatric symptoms as depression and anxiety&#46; In other cases&#44; behavioural and psychiatric symptoms &#40;BPS&#41; are part of the array of changes arising from the dysfunction of neuronal circuits that also elicit the cognitive dysfunction&#46; At times&#44; both the primary and the reactive mechanisms contribute to these symptoms in varying degrees&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">This is a transcendent matter because the prevalence of BPS is high in patients with neurological disease<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">1&#8211;4</span></a> and because these clinical manifestations increase disability&#44;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">5</span></a> lessen quality of life&#44;<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">6&#44;7</span></a> and are very stressful for those living with the patient&#46;<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">6&#44;8</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The purpose of this study is to observe BPS frequency in a sample of patients seen at a cognitive neurology clinic&#46; We also examine the association between these symptoms and specific diagnoses&#44; or with structural changes in precise regions of the brain&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Patients and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">We performed a transversal retrospective analysis of a register of 857 patients examined in a cognitive neurology clinic&#46; Records lacking any of the essential data for this study were excluded&#46; Patients were categorised in 2 groups&#46; Those in group 1 had a syndromic diagnosis of mild cognitive impairment or dementia&#46; In group 2&#44; which served as a control&#44; cognitive function was not considered pathological&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We recorded age&#44; sex&#44; aetiological diagnosis&#44; and the presence and type of BPS&#46; If BPS were detected&#44; we examined neuroimaging studies when available&#46; To assess their potential influence on outcomes&#44; we checked for presence or absence of sensory alterations &#40;visual or auditory&#41; and recorded the type of treatment for each patient&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In a later stage&#44; we estimated prevalence of BPS and examined the association between these symptoms and different aetiological diagnoses &#40;disease types&#41;&#46; We examined the possibility of a link between BPS and neuroimaging anomalies in specific regions &#40;disease topography&#41;&#46; We also compared results from groups 1 and 2&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">BPS occurring during sleep&#44; such as somnambulism or REM sleep behaviour disorders&#44; were not included&#46; BPS recognised in this study were limited to those relevant to the diagnosis&#44; affecting family life&#44; or requiring treatment or modifying treatment&#46; We did not examine sporadic or mild symptoms with no significance and no repercussions on treatment decisions&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Sensory disorders were limited to changes interfering with functional capacity in patients who refused corrective lenses or hearing aids&#44; or whose functions could not be corrected with these devices&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">We recorded any visible changes in MR or CT images that were considered symptomatic&#46; Where such changes were present&#44; we recorded the affected hemisphere and lobe&#59; the deep subcortical area was considered separately&#46; Type of alteration &#40;atrophy&#44; infarct&#44; tumour&#44; etc&#46;&#41; was not recorded&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">When recording treatments&#44; we excluded eye drops and other occasional medications&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Generic diagnoses and treatments were listed to ensure proper sample sizes for the analysis&#59; specific diagnoses and treatments were recorded to detect any associations between them and presence of BPS&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">SPSS 15&#46;0 software was used for the statistical analysis&#46; Associations between qualitative variables were checked using the <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span> test or Fisher&#39;s exact test&#59; the Mann-Whitney <span class="elsevierStyleItalic">U</span> test was used to compare quantitative variables between groups 1 and 2&#46; Two significance levels were used&#58; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05 and <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Results</span><p id="par0065" class="elsevierStylePara elsevierViewall">We analysed 843 subjects&#44; 607 in group 1 and 236 in group 2&#46; At least one BPS was present in 59&#46;9&#37; &#40;61&#46;3&#37; in group 1 and 56&#46;4&#37; in group 2&#41;&#46; Subjects could be divided further into those with one BPS &#40;31&#46;1&#37; of the total&#44; or 31&#46;1&#37; of group 1 and 30&#46;9&#37; of group 2&#41;&#59; 2 BPS &#40;17&#46;4&#37;&#44; 18&#46;0&#37;&#44; and 16&#46;1&#37; respectively&#41;&#59; or more than 2 BPS &#40;11&#46;4&#37;&#44; 12&#46;2&#37;&#44; and 9&#46;3&#37;&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> displays prevalence of BPS &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a> shows the breakdown of the sample by age&#44; sex&#44; and presence or absence of sensory changes&#46; Subjects aged 65 and older accounted for 80&#46;5&#37; of the total &#40;89&#46;3&#37; of group 1 and 58&#37; of group 2&#41;&#59; the difference was significant &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41;&#46; Patients in group 1 were older overall and had a higher prevalence of visual changes than those in group 2&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">In the full sample and in both subgroups&#44; BPS was more frequently observed in women &#40;65&#46;2&#37;&#44; 64&#46;7&#37;&#44; and 66&#46;9&#37; in women&#44; vs 51&#46;5&#37;&#44; 55&#46;6&#37;&#44; and 42&#46;7&#37; in men&#59; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41;&#46; Differences were marked for depression and anxiety&#46; In men&#44; more cases of BPS was detected overall in cases than in controls &#40;55&#46;6&#37; vs 42&#46;7&#37;&#41;&#44; whereas there were no significant differences between cases and controls in women&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Presence of BPS was similar in subjects older than and younger than 65&#44; although there was a higher rate of psychotic symptoms and behaviour disorders in older subjects&#44; and of anxiety disorders in younger subjects &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Specific BPS in the older subjects included hallucinations&#44; dysidentity syndromes&#44; and agitation&#59; symptoms of anxiety were predominant in the younger group&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Prevalence of BPS did not vary according to presence or absence of sensory changes&#44; although we found psychotic symptoms to be more frequent in people with visual and&#47;or auditory changes &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">We registered 84 aetiological diagnoses&#44; distributed among 18 categories &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Degenerative and cerebrovascular diseases were predominant in group 1&#59; in contrast&#44; the frequency of pain disorders&#44; sequelae of traumatic brain injury&#44; and psychiatric illnesses&#44; as well as the absence of objective neurological disease&#44; was higher in group 2&#46; Regarding specific diagnoses&#44; we observed higher rates of Alzheimer disease&#44; Lewy body dementia&#44; frontotemporal dementia&#44; and cerebrovascular disease in group 1&#46; Group 2 also demonstrated a higher prevalence of dysthyroidism&#44; sequelae of traumatic brain injury&#44; somatic manifestations of anxiety&#44; psychogenic or psychosomatic symptoms&#44; familial essential tremor&#44; muscle tension headaches&#44; migraine&#44; cervical brachiocephalic syndrome of cervical origin&#44; polyneuropathy with pain or paraesthesia&#44; and cases in which no neurological or pain disorders were present&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> lists noteworthy types of BPS by diagnosis&#46; Degenerative diseases were more likely to be associated with psychotic symptoms&#44; personality changes&#44; and behavioural disorders&#59; patients exhibiting substance abuse showed a higher prevalence of anxiety and mood disorders&#59; psychiatric diagnoses were associated with mood disorders&#44; anxiety&#44; and psychosomatic symptoms&#46; Lastly&#44; patients with no neurological or pain disorders displayed higher rates of affective disorders&#46; Emotional lability was more common in individuals with metabolic or hormonal disorders&#59; irritability in controls with cerebral hypoxia&#59; and hypochondria symptoms in individuals experiencing pain of any type&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a> shows the topography of changes observed in the neuroimaging studies of patients with BPS&#46; Bihemispheric changes were more common in cases than in controls&#44; and cases were particularly more likely to show changes in the frontal&#44; temporal&#44; or parietal lobes&#46; Imaging studies from controls were less likely to show significant changes&#46; Anomalies were more frequent in deep subcortical regions than in superficial regions&#44; but intergroup differences were not significant&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">Bihemispheric presence of anomalies was associated with behaviour alterations &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41; and psychotic symptoms &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#44; whereas patients with no changes in neuroimaging studies showed a higher prevalence of anxiety disorders &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41; and of mood disorders &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; Changes in the frontal lobes and in the right temporal or parietal lobe &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41; or the left parietal lobe &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41; were associated with more behaviour disorders&#59; changes in the right frontal lobe were linked to psychotic symptoms &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46; Examining the most frequent specific BPS &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41;&#44; we found an association between misidentification syndromes and right temporal lesions &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#59; between agitation and left frontal&#44; right frontal&#44; and right temporal anomalies&#59; social disinhibition and isolated right hemisphere or right frontal and left temporal anomalies&#59; stereotyped behaviours and left frontal&#44; right frontal&#44; and right parietal anomalies&#59; and eating behaviour disorders with right frontal&#44; left frontal&#44; and right temporal anomalies&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Reported medications included 172 substances&#44; classified in 43 groups&#46; <a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a> indicates that patients in group 1 took more drugs than those in group 2&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">Lastly&#44; <a class="elsevierStyleCrossRefs" href="#tbl0025">Tables 5 and 6</a> list associations between BPS and drug treatments&#46; Given the high percentage of polymedicated patients and the influence of other factors &#40;such as the diagnosis&#41;&#44; drug associations were only evaluated if more than 1&#37; of the cases showed the association with a significance level of <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><elsevierMultimedia ident="tbl0030"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discussion</span><p id="par0120" class="elsevierStylePara elsevierViewall">This study aimed to calculate BPS prevalence in patients examined in a cognitive neurology clinic&#46; It also examined associations between BPS and different factors in patients&#8217; medical records&#44; and compared findings between patients with and without objective cognitive impairment&#46; The study did not enter into the genotypes that may affect susceptibility to developing BPS&#46;<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">9&#44;10</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">It detected a high rate of BPS &#40;59&#46;9&#37;&#41; similar to those yielded by other studies reporting rates of over 50&#37; in patients seen in outpatient neurology clinics&#46;<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">1&#44;4</span></a> We also detected more BPS in patients with cognitive impairment &#40;61&#46;3&#37;&#41; than in patients in group 2 &#40;56&#46;4&#37;&#41;&#44; a difference that has already been reported&#46;<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">6&#44;8&#44;11</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Frequencies of affective and anxiety symptoms&#44; and of personality changes and psychosomatic symptoms &#40;32&#46;6&#37;&#44; 13&#46;3&#37;&#44; 1&#46;2&#37;&#44; and 4&#46;3&#37;&#44; respectively&#41;&#44; are similar to those reported by Jefferies et al&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">2</span></a> in hospitalised neurological patients &#40;24&#46;8&#37;&#44; 12&#46;7&#37;&#44; 2&#37;&#44; and 4&#46;5&#37;&#41;&#46; The differences are due to the dissimilar percentages of patients with cognitive impairment &#40;72&#37; in this study vs 17&#46;7&#37; in Jefferies et al&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">2</span></a>&#41;&#46; Psychotic symptoms were more frequent in group 1 &#40;16&#46;8&#37;&#41; than in group 2 &#40;4&#46;2&#37;&#41;&#44; as were behavioural changes &#40;29&#46;3&#37; vs 8&#46;5&#37;&#41;&#46; In contrast&#44; we observed a higher prevalence of anxiety and psychosomatic symptoms in group 2 &#40;25&#46;4&#37; and 9&#46;7&#37; vs 8&#46;6&#37; and 2&#46;1&#37;&#41;&#46; It is understood that dementia disorders are more likely than other neurological disorders to entail dysfunction of cerebral areas related to behavioural control and perception&#46; This gives rise to behavioural and psychotic symptoms as a primary manifestation&#46; On the other hand&#44; the anosognosia displayed by these patients may actually reduce those symptoms of mental illness that require a greater degree of introspection and better cognitive functioning in order to manifest&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">A higher percentage of women than men display cognitive impairment&#59; this is also the case of BPS&#44; as has been reported by other studies&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">12</span></a> The overall female predominance is accounted for by higher rates of depression and anxiety&#59; these findings are supported by the literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0400"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">Psychotic and behavioural symptoms are predominant in subjects aged 65 and older&#59; younger subjects are more likely to have anxiety&#46; Older subjects in group 1 display more agitation and stereotyped behaviour&#44; whereas younger subjects exhibit more behavioural changes&#44; apathy&#44; and agitation &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; These differences seem entirely logical&#46; The older patients include those who have had psychotic symptoms from a younger age&#44; as well as older patients who have developed symptoms of dementia or confusional syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">15</span></a> Anxiety&#44; on the other hand&#44; often develops in young adults&#46; When it is present in older patients&#44; it often has a long-standing chronic profile or corresponds to an exacerbation due to incidental problems&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">16</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">Sensory changes are associated with a higher incidence of psychotic symptoms&#46; One study found a higher prevalence of visual disturbances in individuals with psychotic symptoms and schizophrenia&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">17</span></a> Another study in patients with dementia found auditory and visual disorders to be associated with the appearance of psychotic symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">18</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">Psychotic symptoms were more prevalent in group 1 than in group 2&#59; this could be explained by the older age overall in patients with dementia&#44; and the higher prevalence of sensory alterations that could contribute to these symptoms&#46; Furthermore&#44; dementia syndromes include psychotic symptoms&#59; some are specific&#44; such as the typical visual hallucinations in Lewy body dementia&#44; while others are more varied&#44; such as those in established Alzheimer disease and in vascular dementia&#46;<a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">19&#8211;21</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">We can expect a higher incidence of anxiety and mood disorders among patients with psychiatric conditions&#44; or those whose symptoms were solely derived from substance abuse&#46; Likewise&#44; hypochondria can be expected among individuals with pain disorders&#46; Furthermore&#44; irritability is a documented symptom of patients with chronic hypoxia&#44; as seen in this study&#46;<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">22</span></a> The higher rates of emotional lability observed in individuals with metabolic or hormonal disorders &#40;17&#46;2&#37; vs 3&#46;1&#37; in the rest of the population&#41; are not as easily justified&#46; We know that this symptom commonly appears in different types of dementia&#44;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">23</span></a> and that corticotropin-releasing hormone and cerebral glucocorticoid receptors intervene in regulating emotional expression&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">24</span></a> Therefore&#44; it is understandable that emotional lability would be present in cognitive disorders arising from the hormonal or metabolic disorders that affect the hypothalamic-pituitary-adrenal axis&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">The topographical analysis shows that patients with cognitive impairment are more likely to display affectation of the frontal&#44; temporal&#44; and parietal lobes than of the occipital lobes&#46; This is to be expected based on the typical impact pattern in degenerative dementias&#44; and considering that strokes arise more frequently from the medial or anterior cerebral arteries than from the posterior cerebral artery&#46; In the BPS correlation study&#44; we observed that frontal lobe alterations&#44; and right-hemisphere temporal or parietal lesions&#44; were associated with higher numbers of behaviour disorders&#46; Agitation was associated with alterations in the frontal lobes and right temporal lobe&#59; disinhibition with the right frontal lobe&#59; stereotyped behaviour with the frontal lobes and right parietal lobe&#59; and eating behaviour disorders with the frontal lobes and right temporal lobe&#46; These findings are supported by current research&#46;<a class="elsevierStyleCrossRefs" href="#bib0460"><span class="elsevierStyleSup">25&#8211;33</span></a> The association between misidentification syndromes and the right temporal lobe is also compatible with earlier observations&#46;<a class="elsevierStyleCrossRefs" href="#bib0505"><span class="elsevierStyleSup">34&#44;35</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Associations were also detected between certain BPS and drugs&#46; We presume that most drugs were prescribed to treat BPS&#44; but our methodology does not allow us to detect the cases in which BPS appeared as the side effects of treatment&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Given that polymedication promotes confusional syndrome&#44;<a class="elsevierStyleCrossRefs" href="#bib0515"><span class="elsevierStyleSup">36&#44;37</span></a> the higher frequency of BPS in group 1 than in group 2 may be linked to their higher consumption of medications &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">It is logical to find consumption of neuroleptics in patients with psychotic symptoms&#44; benzodiazepine consumption in those with anxiety&#44; and antidepressants for those with affective disorders&#46; Use of antipsychotics was also higher among patients with non-psychotic behaviour disorders&#44; including agitation&#44; stereotyped behaviours&#44; and logorrhoea&#46; Antipsychotic agents are also often used to combat BPS arising in dementia&#44; even though risks are present and the level of evidence of efficacy is lower&#46;<a class="elsevierStyleCrossRefs" href="#bib0525"><span class="elsevierStyleSup">38&#44;39</span></a> However&#44; only a handful of published studies have examined the effectiveness of these drugs on different non-psychotic behaviour disorders&#44; or whether they might elicit certain disorders&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">It should be noted that 18 of the patients with stereotypies were taking mirtazapine or trazodone&#46; These patients had frontotemporal dementia&#44; Lewy body dementia&#44; or cerebrovascular disease&#59; these disorders frequently feature frontal dysfunction&#44; which may be accompanied by stereotyped behaviours&#46;<a class="elsevierStyleCrossRefs" href="#bib0535"><span class="elsevierStyleSup">40&#44;41</span></a> It is therefore more likely that the symptom would be due to the disease than to treatment&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Psychotic symptoms are not uncommon in patients taking dopaminergic anti-Parkinson drugs&#59; in fact&#44; these drugs facilitate the appearance of such symptoms&#46;<a class="elsevierStyleCrossRefs" href="#bib0545"><span class="elsevierStyleSup">42&#44;43</span></a> Hallucinations are the most common symptom in dementia patients who take levodopa&#46; This finding is consistent with the known high rate of hallucinations in patients with cortical Lewy bodies and dementia associated with Parkinson disease&#44; or with Lewy body dementia&#46;<a class="elsevierStyleCrossRefs" href="#bib0555"><span class="elsevierStyleSup">44&#8211;47</span></a></p><p id="par0190" class="elsevierStylePara elsevierViewall">Some diseases are treated with anticholinesterase drugs&#44; which also reduce BPS&#46;<a class="elsevierStyleCrossRefs" href="#bib0575"><span class="elsevierStyleSup">48&#44;49</span></a> Therefore&#44; the association we found suggests that BPS are not an adverse effect of these drugs&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Piracetam was prescribed to 18&#46;8&#37; of the patients with psychotic symptoms and to 30&#37; of those with emotional lability&#46; The first group was diagnosed with neoplasm or degenerative&#44; vascular&#44; or metabolic disease&#59; the second had progressive supranuclear palsy or vascular cognitive impairment&#46; Since the underlying diseases were capable of eliciting these BPS and patients were treated with a mean of 6&#46;85 drugs&#44; piracetam was not believed to be responsible for the BPS listed here&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">Treatment with opioid analgesics varies and the same drug may be employed at different doses&#46; For this reason&#44; and considering how different opioid receptors affect mood&#44;<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">50</span></a> patients treated with opioids may experience changes in mood ranging from euphoria to depression&#46; Dysthymia was the most prevalent mood disorder in our sample&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Our study points to a link between vasodilators and hallucinations&#46; Although these findings are infrequent&#44; the literature has indicated associations between hallucinations and pentoxifylline&#44;<a class="elsevierStyleCrossRefs" href="#bib0590"><span class="elsevierStyleSup">51&#8211;53</span></a> trimetazidine&#44;<a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">54</span></a> flunarizine&#44;<a class="elsevierStyleCrossRef" href="#bib0610"><span class="elsevierStyleSup">55</span></a> and nitrovasodilators&#46;<a class="elsevierStyleCrossRefs" href="#bib0590"><span class="elsevierStyleSup">51&#44;56</span></a> The high frequency of BPS in cerebrovascular disease<a class="elsevierStyleCrossRefs" href="#bib0620"><span class="elsevierStyleSup">57&#8211;59</span></a> may explain the associations that have been found between betahistine and anti-platelet drugs&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">The association between statins and depression supports theories indicating that lower cholesterol levels in cerebral cell membranes&#44; or the resulting weakened response of the serotonergic system&#44; may promote depression&#46;<a class="elsevierStyleCrossRefs" href="#bib0635"><span class="elsevierStyleSup">60&#8211;62</span></a> Nevertheless&#44; some authors have found the opposite to be true&#46;<a class="elsevierStyleCrossRefs" href="#bib0650"><span class="elsevierStyleSup">63&#8211;66</span></a></p><p id="par0215" class="elsevierStylePara elsevierViewall">The agitation and hallucinations recorded in patients taking diuretics may be attributed to temporary electrolyte imbalances&#44; especially if the patients were predisposed to these symptoms due to advanced age or cognitive impairment&#46;<a class="elsevierStyleCrossRef" href="#bib0670"><span class="elsevierStyleSup">67</span></a></p><p id="par0220" class="elsevierStylePara elsevierViewall">To summarise&#44; BPS are frequent in neurological patients &#40;affecting 59&#46;9&#37; of the sample&#41;&#59; they are even more frequent in patients with impaired cognitive function &#40;61&#46;3&#37;&#41;&#46; Depressed mood is more common in women&#44; patients diagnosed with a primary psychiatric disorder&#44; users of intoxicating substances&#44; and patients taking opioid analgesics&#44; betahistine&#44; or statin drugs&#46; In our sample&#44; anxiety was more prevalent among women&#44; patients younger than 65&#44; and those diagnosed with a psychiatric disorder or substance abuse&#46; Psychotic symptoms were more frequent in patients aged 65 and older&#44; those with visual or auditory changes or a neurodegenerative disease&#44; and those taking levodopa&#44; piracetam&#44; or vasodilators&#46; Behaviour disorders were predominant in the older group&#44; in patients with degenerative disease&#44; and those with structural changes in the frontal lobes or the right temporal or parietal lobes&#46; Psychosomatic symptoms were associated with psychiatric disorders&#44; hypochondria with pain disorders&#44; emotional lability with metabolic or hormonal disorders plus treatment with piracetam&#44; and irritability with chronic hypoxia&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Funding</span><p id="par0225" class="elsevierStylePara elsevierViewall">No funding&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflicts of interest</span><p id="par0230" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres816751"
          "titulo" => "Abstract"
          "secciones" => array:3 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Method"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec813980"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres816752"
          "titulo" => "Resumen"
          "secciones" => array:3 [
            0 => array:1 [
              "identificador" => "abst0020"
            ]
            1 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "M&#233;todo"
            ]
            2 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Resultados"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec813981"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Patients and methods"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Funding"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Conflicts of interest"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-12-31"
    "fechaAceptado" => "2015-01-06"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec813980"
          "palabras" => array:6 [
            0 => "Anxiety"
            1 => "Dementia"
            2 => "Depression"
            3 => "Behavioural symptoms"
            4 => "Psychotic symptoms"
            5 => "Psychiatric symptoms"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec813981"
          "palabras" => array:6 [
            0 => "Ansiedad"
            1 => "Demencia"
            2 => "Depresi&#243;n"
            3 => "S&#237;ntomas conductuales"
            4 => "S&#237;ntomas psic&#243;ticos"
            5 => "S&#237;ntomas psiqui&#225;tricos"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Behavioural and psychiatric symptoms &#40;BPS&#41; are frequent in neurological patients&#44; contribute to disability&#44; and decrease quality of life&#46; We recorded BPS prevalence and type&#44; as well as any associations with specific diagnoses&#44; brain regions&#44; and treatments&#44; in consecutive outpatients examined in a cognitive neurology clinic&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective analysis of 843 consecutive patients was performed&#44; including a review of BPS&#44; diagnosis&#44; sensory impairment&#44; lesion topography &#40;neuroimaging&#41;&#44; and treatment&#46; The total sample was considered&#44; and the cognitive impairment &#40;CI&#41; group &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>607&#41; was compared to the non-CI group&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">BPS was present in 59&#46;9&#37; of the patients &#40;61&#46;3&#37; in the CI group&#44; 56&#46;4&#37; in the non-CI group&#41;&#46; One BPS was present in 31&#46;1&#37;&#44; two in 17&#46;4&#37;&#44; and three or more in 11&#46;4&#37;&#46; BPS&#44; especially depression and anxiety&#44; are more frequent in women than in men&#46; Psychotic and behavioural symptoms predominate in subjects aged 65 and older&#44; and anxiety in those younger than 65&#46; Psychotic symptoms appear more often in patients with sensory impairment&#46; Psychotic and behavioural symptoms are more prevalent in patients with degenerative dementia&#59; depression and anxiety in those who suffer a psychiatric disease or adverse effects of substances&#59; emotional lability in individuals with a metabolic or hormonal disorder&#59; hypochondria in those with a pain syndrome&#59; and irritability in subjects with chronic hypoxia&#46; Behavioural symptoms are more frequent in patients with anomalies in the frontal or right temporal or parietal lobes&#44; and antipsychotics constitute the first line of treatment&#46; Leaving standard treatments aside&#44; associations were observed between dysthymia and opioid analgesics&#44; betahistine and statins&#44; and between psychotic symptoms and levodopa&#44; piracetam&#44; and vasodilators&#46;</p></span>"
        "secciones" => array:3 [
          0 => array:1 [
            "identificador" => "abst0005"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Method"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0020" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los s&#237;ntomas conductuales y psiqui&#225;tricos &#40;SCP&#41; son frecuentes en el enfermo neurol&#243;gico&#44; contribuyen a producir discapacidad y reducen la calidad de vida&#46; Se ha observado&#44; en pacientes de neurolog&#237;a cognitiva&#44; la prevalencia y tipo de SCP y su asociaci&#243;n con diagn&#243;sticos&#44; regiones cerebrales o tratamientos espec&#237;ficos&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">M&#233;todo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis retrospectivo de 843 pacientes consecutivos de neurolog&#237;a cognitiva&#44; revisando SCP&#44; diagn&#243;stico&#44; alteraci&#243;n sensorial&#44; topograf&#237;a lesional en neuroimagen y tratamiento&#46; Se contempl&#243; el total y se compar&#243; el grupo de pacientes con deterioro cognitivo objetivo &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>607&#41; y sin deterioro&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Resultados</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hubo SCP en el 59&#44;9&#37; de los pacientes &#40;61&#44;3&#37; en los deteriorados y 56&#44;4&#37; en el resto&#41;&#46; Un 31&#44;1&#37; ten&#237;a un SCP&#44; 17&#44;4&#37; dos y 11&#44;4&#37; m&#225;s de dos&#46; Los SCP son m&#225;s frecuentes en mujeres&#44; sobre todo depresi&#243;n y ansiedad&#46; En los mayores de 64 a&#241;os predominan los s&#237;ntomas psic&#243;ticos y conductuales&#44; y en los menores de 65 la ansiedad&#46; Las personas con alteraci&#243;n sensorial tienen m&#225;s s&#237;ntomas psic&#243;ticos&#46; Se aprecian m&#225;s s&#237;ntomas conductuales y psic&#243;ticos en personas con demencia degenerativa&#44; depresi&#243;n y ansiedad en las que tienen enfermedad psiqui&#225;trica o efecto nocivo de sustancias&#44; labilidad emocional en relaci&#243;n con trastorno metab&#243;lico u hormonal&#44; hipocondr&#237;a en los s&#237;ndromes dolorosos e irritabilidad en la hipoxia cr&#243;nica&#46; Hay m&#225;s alteraciones de la conducta en pacientes con anomal&#237;a en l&#243;bulos frontales o temporal o parietal derechos&#44; y se tratan preferentemente con antipsic&#243;ticos&#46; Aparte de los tratamientos est&#225;ndar&#44; se observ&#243; asociaci&#243;n de distimia con opioides&#44; betahistina y estatinas&#44; y s&#237;ntomas psic&#243;ticos con levodopa&#44; piracetam y vasodilatadores&#46;</p></span>"
        "secciones" => array:3 [
          0 => array:1 [
            "identificador" => "abst0020"
          ]
          1 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "M&#233;todo"
          ]
          2 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Resultados"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0040">Please cite this article as&#58; Robles Bay&#243;n A&#44; Gude Sampedro F&#46; S&#237;ntomas conductuales y psiqui&#225;tricos en neurolog&#237;a cognitiva&#46; Neurolog&#237;a&#46; 2017&#59;32&#58;81&#8211;91&#46;</p>"
      ]
    ]
    "multimedia" => array:11 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2124
            "Ancho" => 1650
            "Tamanyo" => 389935
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Behavioural and psychiatric symptoms &#40;BPS&#41; examined in the study&#46; List of BPS detected in our patient sample&#46; The names of the symptom groups &#40;A-G&#41; are given in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1399
            "Ancho" => 2650
            "Tamanyo" => 114055
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Breakdown of patients by sex&#44; age&#44; and sensory changes&#46; Au-Vis&#58; auditory and visual&#46; &#35;&#58; mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD &#40;range&#41;&#58; Total&#44; 72&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>14&#46;4 &#40;14-104&#41;&#59; Group 1&#44; 76&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;5 &#40;19-104&#41;&#59; Group 2&#44; 63<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#46;3 &#40;19-95&#41;&#46; Intergroup differences are statistically significant for <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01 &#40;&#42;&#58; intergroup differences statistically significant for <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 3377
            "Ancho" => 2077
            "Tamanyo" => 293104
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">List of generic diagnoses and their frequencies in the sample &#40;&#37;&#41;&#46; &#42; Percentage significantly higher in one of the groups &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41;&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1292
            "Ancho" => 1800
            "Tamanyo" => 258502
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Cerebral MRI of an 81-year-old woman&#46; One-year history of delusional ideation&#59; in recent months&#44; she had also exhibited reduplicative paramnesia and altered social and eating behaviours&#46; A space-occupying lesion was detected in the anterior frontal posteroinferior region of the right temporal lobe&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 1147
            "Ancho" => 1407
            "Tamanyo" => 59698
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Number of drugs patients were taking when their data were recorded&#46; &#42; Statistically significant difference &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41; compared to group 2&#46; Total&#58; <span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>839&#59; Group 1&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>607&#59; Group 2&#58; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>232&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">In parentheses&#58; specific symptoms &#40;see <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; that are significantly more frequent than in the other group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#41;&#46;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Group 1&#58; patients with dementia or mild cognitive impairment&#59; Group 2&#58; patients with no objective cognitive impairment &#40;controls&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " colspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic BPS</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total<br><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>843<br>&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group 1<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>607<br>&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group 2<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>236<br>&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Psychotic symptoms and paramnesias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#46;8<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a> &#40;i<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&#44; ii&#44; iv<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mood and emotional disorders&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Anxiety disorders&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25&#46;4<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a> &#40;xi<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&#44; xii&#44; xiv&#44; xvi&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Psychosomatic symptoms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;7<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a> &#40;xviii<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">E&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Symptoms arising from objective personality change or disorder&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Behavioural disorders&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;3<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a> &#40;xxiii<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&#44; xxvi&#44; xxix<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Other&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;4 &#40;xxxv<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1372598.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Difference compared to other group with <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Behavioural and psychiatric symptoms &#40;BPS&#41; in patient sample&#46;</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">When prevalence is higher in only one group&#44; that group is indicated in superscript&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">G1&#58; Group 1&#59; G2&#58; Group 2&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic BPS<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Specific BPS<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Men</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A<span class="elsevierStyleSup">G1</span>&#44; C<span class="elsevierStyleSup">G2</span>&#44; D<span class="elsevierStyleSup">G2</span>&#44; F<span class="elsevierStyleSup">G1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i<span class="elsevierStyleSup">G1</span>&#44; xi<span class="elsevierStyleSup">G2</span>&#44; xxiii<span class="elsevierStyleSup">G1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Women</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A<span class="elsevierStyleSup">G1</span>&#44; B&#44; C<span class="elsevierStyleSup">G2</span>&#44; D<span class="elsevierStyleSup">G2</span>&#44; F<span class="elsevierStyleSup">G1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vi&#44; xi&#44; xi<span class="elsevierStyleSup">G2</span>&#44; xviii<span class="elsevierStyleSup">G2</span>&#44; xxiii<span class="elsevierStyleSup">G1</span>&#44; xxix<span class="elsevierStyleSup">G1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">&#8804;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">65 years</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">C&#44; F<span class="elsevierStyleSup">G1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xi&#44; xxiii<span class="elsevierStyleSup">G1</span>&#44; xxxv<span class="elsevierStyleSup">G1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">&#62;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">65 years</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&#44; C<span class="elsevierStyleSup">G2</span>&#44; D<span class="elsevierStyleSup">G2</span>&#44; F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&#44; iv&#44; xi<span class="elsevierStyleSup">G2</span>&#44; xviii<span class="elsevierStyleSup">G2</span>&#44; xxiii&#44; xxix<span class="elsevierStyleSup">G1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Alteration</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Visual&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&#44; ii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Auditory&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&#44; xxiii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Both&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1372594.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Headings in the &#8220;generic BPS&#8221; column &#40;letters A-G&#41; are defined in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#59; headings in the &#8220;specific BPS&#8221; column &#40;i-xxxvi&#41; are listed in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Most prevalent behavioural and psychiatric symptoms &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41; broken down by sex&#44; age&#44; and presence of sensory changes&#46;</p>"
        ]
      ]
      7 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">When prevalence is higher in only one group&#44; that group is indicated in superscript&#46;</p><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">G1&#58; Group 1&#59; G2&#58; Group 2&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic BPS<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Specific BPS<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Neurodegenerative disease with dementia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&#44; E&#44; F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&#44; ii&#44; iv&#44; xv&#44; xx&#44; xxiii&#44; xxvi&#44; xxix&#44; xxxii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Metabolic or hormonal disorder affecting cognition</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">x&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Cerebral hypoxia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xxx<span class="elsevierStyleSup">G2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Effect of substances harmful to cognition</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B&#44; C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vii&#44; xi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Psychiatric disorder affecting cognition</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B&#44; C&#44; D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vii&#44; xi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Any type of process involving severe pain</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xviii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Non-neurological&#44; non-pain disorder</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Specific diagnosis</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lewy body dementia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&#44; F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&#44; ii&#44; iv&#44; xxiii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Frontotemporal dementia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xxiii&#44; xxvi&#44; xix&#44; xxxii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Chronic kidney disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xxiii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Drug-induced cognitive impairment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B&#44; C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vi&#44; vii&#44; xi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Depressive disorder&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Psychogenic or psychosomatic symptoms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">C&#44; D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Muscle tension headache&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xviii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Non-neurological&#44; non-pain disorder&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1372596.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Headings in the &#8220;generic BPS&#8221; column &#40;letters A-G&#41; are defined in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#59; headings in the &#8220;specific BPS&#8221; column &#40;i-xxxvi&#41; are listed in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Breakdown of the most common BPS &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41; by diagnosis&#46;</p>"
        ]
      ]
      8 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0110" class="elsevierStyleSimplePara elsevierViewall">95&#37; CI&#58; 95&#37; confidence interval&#46; Percentage is significantly higher than in the other group&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total<br>&#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>611&#41;<br>&#37; &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group 1<br>&#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>493&#41;<br>&#37; &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Group 2<br>&#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>118&#41;<br>&#37; &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">No significant alterations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44&#46;5 &#40;41&#8211;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#46;2 &#40;36&#8211;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">62&#46;7 &#40;54&#8211;72&#41;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left hemisphere only&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;7 &#40;4&#8211;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;1 &#40;4&#8211;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;2 &#40;1&#8211;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right hemisphere only&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;9 &#40;2&#8211;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;7 &#40;3&#8211;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;8 &#40;0&#8211;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Both hemispheres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&#46;8 &#40;42&#8211;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49&#46;1 &#40;44&#8211;53&#41;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#46;2 &#40;24&#8211;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left frontal lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;2 &#40;12&#8211;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#46;0 &#40;15&#8211;21&#41;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;4 &#40;0&#8211;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right frontal lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#46;6 &#40;12&#8211;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#46;4 &#40;14&#8211;21&#41;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;5 &#40;0&#8211;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left temporal lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#46;4 &#40;12&#8211;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#46;2 &#40;14&#8211;21&#41;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;5 &#40;0&#8211;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right temporal lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#46;4 &#40;10&#8211;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;0 &#40;12&#8211;18&#41;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;7 &#40;0&#8211;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left parietal lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;3 &#40;6&#8211;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;5 &#40;7&#8211;12&#41;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;4 &#40;0&#8211;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right parietal lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;0 &#40;4&#8211;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;5 &#40;5&#8211;10&#41;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;0 &#40;0&#8211;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left occipital lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;8 &#40;1&#8211;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;2 &#40;1&#8211;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;0 &#40;0&#8211;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right occipital lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;1 &#40;1&#8211;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;4 &#40;1&#8211;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;8 &#40;0&#8211;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Deep subcortical topography &#8211; left hemisphere&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#46;4 &#40;29&#8211;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#46;9 &#40;29&#8211;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;5 &#40;22&#8211;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Deep subcortical topography &#8211; right hemisphere&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;8 &#40;27&#8211;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&#46;0 &#40;27&#8211;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;7 &#40;21&#8211;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1372595.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Percentage is significantly higher than in the other group with <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;05&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Percentage is significantly higher than in the other group with <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0105" class="elsevierStyleSimplePara elsevierViewall">Topography of the changes observed in neuroimaging studies for cases with BPS examined using brain CT or MRI&#46;</p>"
        ]
      ]
      9 => array:8 [
        "identificador" => "tbl0025"
        "etiqueta" => "Table 5"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at5"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0120" class="elsevierStyleSimplePara elsevierViewall">When prevalence is higher in only one group&#44; that group is indicated in superscript&#46;</p><p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">G1&#58; Group 1&#59; G2&#58; Group 2&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic BPS<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Specific BPS<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T1&#46; Neuroleptics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&#44; B<span class="elsevierStyleSup">G2</span>&#44; C<span class="elsevierStyleSup">G1</span>&#44; F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&#44; ii&#44; vii<span class="elsevierStyleSup">G2</span>&#44; xxiii&#44; xxix&#44; xxxi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T2&#46; Benzodiazepines&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B&#44; C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vi&#44; vii&#44; xi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T7&#46; Antidepressants&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vi&#44; xi<span class="elsevierStyleSup">G1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T8&#46; Anti-Parkinson drugs with dopaminergic activity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T9&#46; Specific drugs for Alzheimer disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xxiii&#44; xxix&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T11&#46; Nootropic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">x&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T15&#46; Vasodilators&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T18&#46; Anti-platelet agents&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xxix&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T27&#46; Lipid-lowering drugs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">T28&#46; Diuretics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&#44; xxiii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1372593.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0030"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0030">Headings in the &#8220;generic BPS&#8221; column &#40;letters A-G&#41; are defined in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#59; headings in the &#8220;specific BPS&#8221; column &#40;i-xxxvi&#41; are listed in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">Breakdown of the most common BPS &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41; by drug therapeutic group&#46;</p>"
        ]
      ]
      10 => array:8 [
        "identificador" => "tbl0030"
        "etiqueta" => "Table 6"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at6"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0135" class="elsevierStyleSimplePara elsevierViewall">When prevalence is higher in only one group&#44; that group is indicated in superscript&#46;</p><p id="spar0140" class="elsevierStyleSimplePara elsevierViewall">G1&#58; Group 1&#59; G2&#58; Group 2&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Specific treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Generic BPS<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Specific BPS<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t1&#46; Typical antipsychotics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xxiii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t2&#46; Atypical antipsychotics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&#44; F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&#44; ii&#44; xxiii&#44; xxix&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t4&#46; Benzodiazepines&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B&#44; C&#44; D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vi&#44; vii&#44; xi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t6&#46; Clomethiazole&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t13&#46; Tricyclic antidepressants&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t16&#46; Serotonin and noradrenalin reuptake inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B&#44; C<span class="elsevierStyleSup">G2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t17&#46; Selective serotonin reuptake inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t20&#46; Trazodone&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xxiii&#44; xxix&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t21&#46; Levodopa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t27&#46; Cholinesterase inhibitors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xxix&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t40&#46; Piracetam&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">x&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t42&#46; Opioid analgesics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">B<span class="elsevierStyleSup">G2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vii<span class="elsevierStyleSup">G2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t50&#46; Betahistine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vii<span class="elsevierStyleSup">G2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t66&#46; Antiplatelet drugs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">xxiii&#44; xxix&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t96&#46; Statins&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">vii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">t101&#46; Diuretics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">i&#44; xxiii&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1372597.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0035"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0035">Headings in the &#8220;generic BPS&#8221; column &#40;letters A-G&#41; are defined in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#59; headings in the &#8220;specific BPS&#8221; column &#40;i-xxxvi&#41; are listed in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">Breakdown of BPS associated with specific treatments &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>&#46;01&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:67 [
            0 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychiatric disorders in neurology patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Moriarty"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jnnp.2006.106401"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "2007"
                        "volumen" => "78"
                        "paginaInicial" => "331"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17369587"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0168827808006351"
                          "estado" => "S300"
                          "issn" => "01688278"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychiatric disorders in inpatients on a neurology ward&#58; estimate of prevalence and usefulness of screening questionnaires"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Jefferies"
                            1 => "A&#46; Owino"
                            2 => "H&#46; Rickards"
                            3 => "N&#46; Agrawal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jnnp.2006.103044"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "2007"
                        "volumen" => "78"
                        "paginaInicial" => "414"
                        "paginaFinal" => "416"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17056626"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychiatric aspects of clinical neurology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;B&#46; Schiffer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1176/ajp.140.2.205"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Psychiatry"
                        "fecha" => "1983"
                        "volumen" => "140"
                        "paginaInicial" => "205"
                        "paginaFinal" => "207"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6849436"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychiatric symptomatology in an outpatient neurology clinic"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;M&#46; Berlin"
                            1 => "M&#46; Ronthal"
                            2 => "E&#46;O&#46; Bixler"
                            3 => "J&#46;D&#46; Kales"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Psychiatry"
                        "fecha" => "1983"
                        "volumen" => "44"
                        "paginaInicial" => "204"
                        "paginaFinal" => "206"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6853458"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neurological disease&#44; emotional disorder&#44; and disability&#58; they are related&#46; A study of 300 consecutive new referrals to a neurology outpatient department"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;J&#46; Carson"
                            1 => "B&#46; Ringbauer"
                            2 => "L&#46; MacKenzie"
                            3 => "C&#46; Warlow"
                            4 => "M&#46; Sharpe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "2000"
                        "volumen" => "68"
                        "paginaInicial" => "202"
                        "paginaFinal" => "206"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10644788"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of neuropsychiatric symptoms on caregiver distress and quality of life in persons with dementia in an Asian tertiary hospital memory clinic"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;A&#46; Khoo"
                            1 => "T&#46;Y&#46; Chen"
                            2 => "Y&#46;H&#46; Ang"
                            3 => "P&#46; Yap"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1017/S1041610213001518"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int Psychogeriatr"
                        "fecha" => "2013"
                        "volumen" => "25"
                        "paginaInicial" => "1991"
                        "paginaFinal" => "1999"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24230964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patient and caregiver perspectives of quality of life in dementia&#46; An investigation of the relationship to behavioural and psychological symptoms in dementia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46; Hurt"
                            1 => "S&#46; Bhattacharyya"
                            2 => "A&#46; Burns"
                            3 => "V&#46; Camus"
                            4 => "R&#46; Liperoti"
                            5 => "A&#46; Marriott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000149584"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dement Geriatr Cogn Disord"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "paginaInicial" => "138"
                        "paginaFinal" => "146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18679028"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychiatric morbidity in dementia patients in a neurology-based memory clinic"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46;S&#46; Shih"
                            1 => "S&#46;H&#46; Yan"
                            2 => "Y&#46;H&#46; Ho"
                            3 => "Y&#46;T&#46; Lin"
                            4 => "J&#46;Y&#46; Li"
                            5 => "Y&#46;K&#46; Lo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neurol Taiwan"
                        "fecha" => "2005"
                        "volumen" => "14"
                        "paginaInicial" => "179"
                        "paginaFinal" => "186"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16425544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Proitsi"
                            1 => "M&#46;K&#46; Lupton"
                            2 => "S&#46;J&#46; Reeves"
                            3 => "G&#46; Hamilton"
                            4 => "N&#46; Archer"
                            5 => "B&#46;M&#46; Martin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.neurobiolaging.2010.06.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurobiol Aging"
                        "fecha" => "2012"
                        "volumen" => "33"
                        "paginaInicial" => "791"
                        "paginaFinal" => "803"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20685009"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PRND 3&#8242;UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Flirski"
                            1 => "M&#46; Sieruta"
                            2 => "E&#46; Gola&#324;ska"
                            3 => "I&#46; K&#322;oszewska"
                            4 => "P&#46;P&#46; Liberski"
                            5 => "T&#46; Sob&#243;w"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4161/pri.6.1.18428"
                      "Revista" => array:6 [
                        "tituloSerie" => "Prion"
                        "fecha" => "2012"
                        "volumen" => "6"
                        "paginaInicial" => "73"
                        "paginaFinal" => "80"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22453181"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychiatric morbidity in a neurology-based memory clinic&#58; the effect of systematic psychiatric evaluation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Hejl"
                            1 => "M&#46; H&#248;rding"
                            2 => "E&#46; Hasselbalch"
                            3 => "H&#46; Dam"
                            4 => "R&#46; Hemmingsen"
                            5 => "G&#46; Waldemar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Geriatr Soc"
                        "fecha" => "2003"
                        "volumen" => "51"
                        "paginaInicial" => "1773"
                        "paginaFinal" => "1778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14687357"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detecting psychogeriatric problems in primary care&#58; factors related to psychiatric symptoms in older community patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Olivera"
                            1 => "S&#46; Benabarre"
                            2 => "T&#46; Lorente"
                            3 => "M&#46; Rodr&#237;guez"
                            4 => "A&#46; Barros"
                            5 => "C&#46; Quintana"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ment Health Fam Med"
                        "fecha" => "2011"
                        "volumen" => "8"
                        "paginaInicial" => "11"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22479288"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sex differences in anxiety and depression clinical perspectives"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Altemus"
                            1 => "N&#46; Sarvaiya"
                            2 => "C&#46; Neill Epperson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.yfrne.2014.05.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Front Neuroendocrinol"
                        "fecha" => "2014"
                        "volumen" => "35"
                        "paginaInicial" => "320"
                        "paginaFinal" => "330"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24887405"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sex differences in anxiety and emotional behavior"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46;C&#46; Donner"
                            1 => "C&#46;A&#46; Lowry"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00424-013-1271-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pflugers Arch"
                        "fecha" => "2013"
                        "volumen" => "465"
                        "paginaInicial" => "601"
                        "paginaFinal" => "626"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23588380"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychotic symptoms in the elderly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;W&#46; Brendel"
                            1 => "T&#46;A&#46; Stern"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Prim Care Companion J Clin Psychiatry"
                        "fecha" => "2005"
                        "volumen" => "7"
                        "paginaInicial" => "238"
                        "paginaFinal" => "241"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16308581"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology and comorbidity of anxiety disorders in later life&#58; implications for treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;J&#46; Flint"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Neurosci"
                        "fecha" => "1997"
                        "volumen" => "4"
                        "paginaInicial" => "31"
                        "paginaFinal" => "36"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9056120"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Visual impairment in persons with psychotic disorder"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Vierti&#246;"
                            1 => "A&#46; Laitinen"
                            2 => "J&#46; Per&#228;l&#228;"
                            3 => "S&#46;I&#46; Saarni"
                            4 => "S&#46; Koskinen"
                            5 => "J&#46; L&#246;nnqvist"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00127-007-0252-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Soc Psychiatry Psychiatr Epidemiol"
                        "fecha" => "2007"
                        "volumen" => "42"
                        "paginaInicial" => "902"
                        "paginaFinal" => "908"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17846698"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Associations of psychotic symptoms in dementia sufferers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46; Ballard"
                            1 => "C&#46; Bannister"
                            2 => "C&#46; Graham"
                            3 => "F&#46; Oyebode"
                            4 => "G&#46; Wilcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Psychiatry"
                        "fecha" => "1995"
                        "volumen" => "167"
                        "paginaInicial" => "537"
                        "paginaFinal" => "540"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8829726"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anxiety&#44; depression and psychosis in vascular dementia&#58; prevalence and associations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Ballard"
                            1 => "D&#46; Neill"
                            2 => "J&#46; O&#8217;Brien"
                            3 => "I&#46;G&#46; McKeith"
                            4 => "P&#46; Ince"
                            5 => "R&#46; Perry"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Affect Disord"
                        "fecha" => "2000"
                        "volumen" => "59"
                        "paginaInicial" => "97"
                        "paginaFinal" => "106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10837878"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychotic symptoms in a population-based sample of 85-year-old individuals with dementia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Ostling"
                            1 => "D&#46; Gustafson"
                            2 => "K&#46; Blennow"
                            3 => "A&#46; B&#246;rjesson-Hanson"
                            4 => "M&#46; Waern"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0891988710373596"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Geriatr Psychiatry Neurol"
                        "fecha" => "2011"
                        "volumen" => "24"
                        "paginaInicial" => "3"
                        "paginaFinal" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20601646"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychotic symptoms in Alzheimer disease&#58; evidence for a distinct phenotype"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;A&#46; Sweet"
                            1 => "V&#46;L&#46; Nimgaonkar"
                            2 => "B&#46; Devlin"
                            3 => "D&#46;V&#46; Jeste"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.mp.4001262"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Psychiatry"
                        "fecha" => "2003"
                        "volumen" => "8"
                        "paginaInicial" => "383"
                        "paginaFinal" => "392"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12740595"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Funcionamiento neuropsicol&#243;gico bajo condiciones de hipoxia aguda y cr&#243;nica asociada a la altitud"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Viru&#233;s-Ortega"
                            1 => "E&#46; Garrido"
                            2 => "C&#46; Javierre"
                            3 => "P&#46;D&#46; Rivero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Biol Andina"
                        "fecha" => "2008"
                        "volumen" => "14"
                        "paginaInicial" => "40"
                        "paginaFinal" => "50"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathophysiology of emotional lability&#58; many paths to a common destination"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;W&#46; Richter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Geriatr Pharmacother"
                        "fecha" => "2005"
                        "volumen" => "3"
                        "numero" => "Suppl&#46; A"
                        "paginaInicial" => "9"
                        "paginaFinal" => "11"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16305944"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glucocorticoid receptor overexpression in forebrain&#58; a mouse model of increased emotional lability"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Q&#46; Wei"
                            1 => "X&#46;Y&#46; Lu"
                            2 => "L&#46; Liu"
                            3 => "G&#46; Schafer"
                            4 => "K&#46;R&#46; Shieh"
                            5 => "S&#46; Burke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1073/pnas.0402208101"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci U S A"
                        "fecha" => "2004"
                        "volumen" => "101"
                        "paginaInicial" => "11851"
                        "paginaFinal" => "11856"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15280545"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46; Banno"
                            1 => "S&#46; Nakaaki"
                            2 => "J&#46; Sato"
                            3 => "K&#46; Torii"
                            4 => "J&#46; Narumoto"
                            5 => "J&#46; Miyata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2147/NDT.S57522"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neuropsychiatr Dis Treat"
                        "fecha" => "2014"
                        "volumen" => "10"
                        "paginaInicial" => "339"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24600224"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Agitation in Alzheimer&#39;s disease is a manifestation of frontal lobe dysfunction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Senanarong"
                            1 => "J&#46;L&#46; Cummings"
                            2 => "L&#46; Fairbanks"
                            3 => "M&#46; Mega"
                            4 => "D&#46;M&#46; Masterman"
                            5 => "S&#46;M&#46; O&#8217;Connor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000074080"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dement Geriatr Cogn Disord"
                        "fecha" => "2004"
                        "volumen" => "17"
                        "paginaInicial" => "14"
                        "paginaFinal" => "20"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14560060"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanism of disinhibition after brain lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;E&#46; Starkstein"
                            1 => "R&#46;G&#46; Robinson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Nerv Ment Dis"
                        "fecha" => "1997"
                        "volumen" => "185"
                        "paginaInicial" => "108"
                        "paginaFinal" => "114"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9048703"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1521691815000219"
                          "estado" => "S300"
                          "issn" => "15216918"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0475"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Repetitive and compulsive behavior in frontal lobe degenerations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Ames"
                            1 => "J&#46;L&#46; Cummings"
                            2 => "W&#46;C&#46; Wirshing"
                            3 => "B&#46; Quinn"
                            4 => "M&#46; Mahler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1176/jnp.6.2.100"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Neuropsychiatry Clin Neurosci"
                        "fecha" => "1994"
                        "volumen" => "6"
                        "paginaInicial" => "100"
                        "paginaFinal" => "113"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8044031"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510710020742"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Abnormal repetitive behaviours&#58; shared phenomenology and pathophysiology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;M&#46; Muehlmann"
                            1 => "M&#46;H&#46; Lewis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2788.2011.01519.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Intellect Disabil Res"
                        "fecha" => "2012"
                        "volumen" => "56"
                        "paginaInicial" => "427"
                        "paginaFinal" => "440"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22283923"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0485"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Whitwell"
                            1 => "E&#46;L&#46; Sampson"
                            2 => "C&#46;T&#46; Loy"
                            3 => "J&#46;E&#46; Warren"
                            4 => "M&#46;N&#46; Rossor"
                            5 => "N&#46;C&#46; Fox"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.neuroimage.2006.12.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neuroimage"
                        "fecha" => "2007"
                        "volumen" => "35"
                        "paginaInicial" => "207"
                        "paginaFinal" => "213"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17240166"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0490"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Brain lesions and eating disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Uher"
                            1 => "J&#46; Treasure"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jnnp.2004.048819"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "2005"
                        "volumen" => "76"
                        "paginaInicial" => "852"
                        "paginaFinal" => "857"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15897510"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0495"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dieting tendency and eating behavior problems in eating disorder correlate with right frontotemporal and left orbitofrontal cortex&#58; a near-infrared spectroscopy study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Suda"
                            1 => "T&#46; Uehara"
                            2 => "M&#46; Fukuda"
                            3 => "T&#46; Sato"
                            4 => "M&#46; Kameyama"
                            5 => "M&#46; Mikuni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jpsychires.2009.11.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Psychiatr Res"
                        "fecha" => "2010"
                        "volumen" => "44"
                        "paginaInicial" => "547"
                        "paginaFinal" => "555"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19962158"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0500"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Induction of hyperphagia and carbohydrate intake by &#956;-opioid receptor stimulation in circumscribed regions of frontal cortex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;D&#46; Mena"
                            1 => "K&#46; Sadeghian"
                            2 => "B&#46;A&#46; Baldo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1523/JNEUROSCI.2050-10.2011"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosci"
                        "fecha" => "2011"
                        "volumen" => "31"
                        "paginaInicial" => "3249"
                        "paginaFinal" => "3260"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21368037"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0505"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Isolated right temporal lobe stroke patients present with Geschwind Gastaut syndrome&#44; frontal network syndrome and delusional misidentification syndromes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Hoffmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3233/BEN-2008-0218"
                      "Revista" => array:6 [
                        "tituloSerie" => "Behav Neurol"
                        "fecha" => "2008"
                        "volumen" => "20"
                        "paginaInicial" => "83"
                        "paginaFinal" => "89"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19641245"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0510"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Misidentification syndromes related to face specific area in the fusiform gyrus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;J&#46; Hudson"
                            1 => "G&#46;M&#46; Grace"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "2000"
                        "volumen" => "69"
                        "paginaInicial" => "645"
                        "paginaFinal" => "648"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11032619"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0515"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "e11-5"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of polypharmacy on occurrence of delirium in elderly emergency patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Hein"
                            1 => "A&#46; Forgues"
                            2 => "A&#46; Piau"
                            3 => "A&#46; Sommet"
                            4 => "F&#46; Nourhash&#233;mi"
                            5 => "B&#46; Vellas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jamda.2014.08.012"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Med Dir Assoc"
                        "fecha" => "2014"
                        "volumen" => "15"
                        "paginaInicial" => "850"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25405712"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0520"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Revisiting the O complex&#58; urinary incontinence&#44; delirium and polypharmacy in elderly patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;B&#46; Hogan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "CMAJ"
                        "fecha" => "1997"
                        "volumen" => "157"
                        "paginaInicial" => "1071"
                        "paginaFinal" => "1077"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9347778"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0525"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety and efficacy of antipsychotic drugs for the behavioral and psychological symptoms of dementia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46; Andrade"
                            1 => "R&#46; Radhakrishnan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Indian J Psychiatry"
                        "fecha" => "2009"
                        "volumen" => "51"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "S87"
                        "paginaFinal" => "S92"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21416025"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0530"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Behavioral and psychological symptoms of dementia &#40;BPSD&#41; in elderly demented subjects&#58; is the long lasting use of atypical antipsychotic drugs useful and safe&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Angelini"
                            1 => "C&#46; Bendini"
                            2 => "F&#46; Neviani"
                            3 => "M&#46; Neri"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.archger.2007.01.005"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arch Gerontol Geriatr"
                        "fecha" => "2007"
                        "volumen" => "44"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "35"
                        "paginaFinal" => "43"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17317431"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0535"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic correlates of behavioral and affective disturbances in frontal lobe pathologies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Sarazin"
                            1 => "A&#46; Michon"
                            2 => "B&#46; Pillon"
                            3 => "Y&#46; Samson"
                            4 => "A&#46; Canuto"
                            5 => "G&#46; Gold"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00415-003-1087-z"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol"
                        "fecha" => "2003"
                        "volumen" => "250"
                        "paginaInicial" => "827"
                        "paginaFinal" => "833"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12883925"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0540"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The clinical spectrum of stereotypies in frontotemporal lobar degeneration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46;J&#46; Mateen"
                            1 => "K&#46;A&#46; Josephs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/mds.22555"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mov Disord"
                        "fecha" => "2009"
                        "volumen" => "24"
                        "paginaInicial" => "1237"
                        "paginaFinal" => "1240"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19412926"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0545"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dopamine agonists and their risk to induce psychotic episodes in Parkinson&#39;s disease&#58; a case&#8211;control study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Ecker"
                            1 => "A&#46; Unrath"
                            2 => "J&#46; Kassubek"
                            3 => "M&#46; Sabolek"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2377-9-23"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Neurol"
                        "fecha" => "2009"
                        "volumen" => "9"
                        "paginaInicial" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19515253"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0550"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychotic complications of long-term levodopa treatment of Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Friedman"
                            1 => "J&#46; Sienkiewicz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neurol Scand"
                        "fecha" => "1991"
                        "volumen" => "84"
                        "paginaInicial" => "111"
                        "paginaFinal" => "113"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1950448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0555"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Visual hallucinations in PD and Lewy body dementias&#58; old and new hypotheses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Onofrj"
                            1 => "J&#46;P&#46; Taylor"
                            2 => "D&#46; Monaco"
                            3 => "R&#46; Franciotti"
                            4 => "F&#46; Anzellotti"
                            5 => "L&#46; Bonanni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3233/BEN-129022"
                      "Revista" => array:6 [
                        "tituloSerie" => "Behav Neurol"
                        "fecha" => "2013"
                        "volumen" => "27"
                        "paginaInicial" => "479"
                        "paginaFinal" => "493"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23242366"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0560"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Visual hallucinations in the differential diagnosis of parkinsonism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Bertram"
                            1 => "D&#46;R&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jnnp-2011-300980"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "2012"
                        "volumen" => "83"
                        "paginaInicial" => "448"
                        "paginaFinal" => "452"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22228724"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0565"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hallucinations and psychosis in Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;M&#46; Rabey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1353-8020(09)70846-6"
                      "Revista" => array:7 [
                        "tituloSerie" => "Parkinsonism Relat Disord"
                        "fecha" => "2009"
                        "volumen" => "15"
                        "numero" => "Suppl&#46; 4"
                        "paginaInicial" => "S105"
                        "paginaFinal" => "S110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20123547"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0570"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hallucinations in neurodegenerative diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Burghaus"
                            1 => "C&#46; Eggers"
                            2 => "L&#46; Timmermann"
                            3 => "G&#46;R&#46; Fink"
                            4 => "N&#46;J&#46; Diederich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1755-5949.2011.00247.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "CNS Neurosci Ther"
                        "fecha" => "2012"
                        "volumen" => "18"
                        "paginaInicial" => "149"
                        "paginaFinal" => "159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21592320"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0575"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A meta-analysis of the efficacy of donepezil&#44; rivastigmine&#44; galantamine&#44; and memantine in relation to severity of Alzheimer&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;G&#46; Di Santo"
                            1 => "F&#46; Prinelli"
                            2 => "F&#46; Adorni"
                            3 => "C&#46; Caltagirone"
                            4 => "M&#46; Musicco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3233/JAD-122140"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Alzheimers Dis"
                        "fecha" => "2013"
                        "volumen" => "35"
                        "paginaInicial" => "349"
                        "paginaFinal" => "361"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23411693"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0580"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cholinesterase inhibitors for dementia with Lewy bodies&#44; Parkinson&#39;s disease dementia and cognitive impairment in Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Rolinski"
                            1 => "C&#46; Fox"
                            2 => "I&#46; Maidment"
                            3 => "R&#46; McShane"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Cochrane Database Syst Rev"
                        "fecha" => "2012"
                        "volumen" => "3"
                        "paginaInicial" => "CD006504"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0585"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Opioid receptors&#58; distinct roles in mood disorders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46;E&#46; Lutz"
                            1 => "B&#46;L&#46; Kieffer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.tins.2012.11.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Trends Neurosci"
                        "fecha" => "2013"
                        "volumen" => "36"
                        "paginaInicial" => "195"
                        "paginaFinal" => "206"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23219016"
                             …1
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0590"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alucinaciones musicales&#58; la m&#250;sica perpetua"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Neurol"
                        "fecha" => "2014"
                        "volumen" => "58"
                        "paginaInicial" => "207"
                        "paginaFinal" => "212"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0595"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pentoxifylline-induced musical hallucinations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1993"
                        "volumen" => "43"
                        "paginaInicial" => "1621"
                        "paginaFinal" => "1622"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0600"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pentoxifylline &#40;Trental&#41;-induced visual hallucinations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Geriatr Soc"
                        "fecha" => "1993"
                        "volumen" => "41"
                        "paginaInicial" => "782"
                        "paginaFinal" => "783"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0605"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Trimetazidine&#58; abnormal movements and hallucinations&#46; Should be withdrawn from the market"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Prescrire Int"
                        "fecha" => "2009"
                        "volumen" => "18"
                        "paginaInicial" => "69"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0610"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Alucinaciones inducidas por flunaricina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Neurol"
                        "fecha" => "2006"
                        "volumen" => "42"
                        "paginaInicial" => "315"
                        "paginaFinal" => "317"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0615"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Visual hallucinations and suicidal ideation attributed to isosorbide dinitrate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0033-3182(87)72471-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Psychosomatics"
                        "fecha" => "1987"
                        "volumen" => "28"
                        "paginaInicial" => "555"
                        "paginaFinal" => "556"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0620"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Behavioral symptoms in vascular cognitive impairment and vascular dementia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [ …1]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1017/S1041610203009098"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int Psychogeriatr"
                        "fecha" => "2003"
                        "volumen" => "15"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "133"
                        "paginaFinal" => "138"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0625"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Behavioural and psychological symptoms in vascular dementia&#59; differences between small- and large-vessel disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jnnp.2009.187500"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "2010"
                        "volumen" => "81"
                        "paginaInicial" => "547"
                        "paginaFinal" => "551"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510714021968"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0630"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neuropsychiatric profiles in patients with Alzheimer&#39;s disease and vascular dementia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0972-2327.138520"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Indian Acad Neurol"
                        "fecha" => "2014"
                        "volumen" => "17"
                        "paginaInicial" => "325"
                        "paginaFinal" => "330"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0635"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psychiatric adverse reactions with statins&#44; fibrates and ezetimibe&#58; implications for the use of lipid-lowering agents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Drug Saf"
                        "fecha" => "2007"
                        "volumen" => "30"
                        "paginaInicial" => "195"
                        "paginaFinal" => "201"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0640"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship between statins and depression&#58; a review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1517/14656566.2013.803067"
                      "Revista" => array:7 [
                        "tituloSerie" => "Expert Opin Pharmacother"
                        "fecha" => "2013"
                        "volumen" => "14"
                        "paginaInicial" => "1467"
                        "paginaFinal" => "1476"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016508513014601"
                          "estado" => "S300"
                          "issn" => "00165085"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0645"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neuropsychiatric adverse events associated with statins&#58; epidemiology&#44; pathophysiology&#44; prevention and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s40263-013-0135-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "CNS Drugs"
                        "fecha" => "2014"
                        "volumen" => "28"
                        "paginaInicial" => "249"
                        "paginaFinal" => "272"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0650"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Unintended effects of statins from observational studies in the general population&#58; systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1741-7015-12-51"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Med"
                        "fecha" => "2014"
                        "volumen" => "12"
                        "paginaInicial" => "51"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0655"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Statins use and risk of depression&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jad.2013.11.026"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Affect Disord"
                        "fecha" => "2014"
                        "volumen" => "160"
                        "paginaInicial" => "62"
                        "paginaFinal" => "67"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0660"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of statins on psychological wellbeing&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1741-7015-10-154"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Med"
                        "fecha" => "2012"
                        "volumen" => "10"
                        "paginaInicial" => "154"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0665"
              "etiqueta" => "66"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between depressive symptoms and use of HMG-CoA reductase inhibitors &#40;statins&#41;&#44; corticosteroids and histamine H&#40;2&#41; receptor antagonists in community-dwelling older persons&#58; cross-sectional analysis of a population-based cohort"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Drugs Aging"
                        "fecha" => "2008"
                        "volumen" => "25"
                        "paginaInicial" => "795"
                        "paginaFinal" => "805"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0670"
              "etiqueta" => "67"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sodium and potassium disturbances in the elderly&#58; prevalence and association with drug use"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Drug Investig"
                        "fecha" => "2004"
                        "volumen" => "24"
                        "paginaInicial" => "535"
                        "paginaFinal" => "544"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510711024977"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735808/0000003200000002/v1_201703191230/S217358081730038X/v1_201703191230/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9491"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original Articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735808/0000003200000002/v1_201703191230/S217358081730038X/v1_201703191230/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217358081730038X?idApp=UINPBA00004N"
]

Article information

ISSN: 21735808
Original language: English

DOI:10.1016/j.nrleng.2015.01.003

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	2	0	2
2024 October	19	4	23
2024 September	43	8	51
2024 August	37	4	41
2024 July	26	5	31
2024 June	29	4	33
2024 May	17	8	25
2024 April	23	11	34
2024 March	45	9	54
2024 February	49	9	58
2024 January	50	4	54
2023 December	41	9	50
2023 November	48	13	61
2023 October	58	14	72
2023 September	20	4	24
2023 August	18	8	26
2023 July	24	12	36
2023 June	30	6	36
2023 May	24	6	30
2023 April	23	8	31
2023 March	20	3	23
2023 February	22	8	30
2023 January	24	7	31
2022 December	35	7	42
2022 November	38	7	45
2022 October	26	11	37
2022 September	46	7	53
2022 August	36	10	46
2022 July	17	7	24
2022 June	11	9	20
2022 May	49	6	55
2022 April	43	10	53
2022 March	51	12	63
2022 February	45	7	52
2022 January	25	8	33
2021 December	13	7	20
2021 November	23	11	34
2021 October	20	15	35
2021 September	19	12	31
2021 August	20	10	30
2021 July	9	7	16
2021 June	8	8	16
2021 May	19	14	33
2021 April	19	6	25
2021 March	18	22	40
2021 February	21	8	29
2021 January	23	17	40
2020 December	20	16	36
2020 November	17	6	23
2020 October	22	10	32
2020 September	24	15	39
2020 August	31	9	40
2020 July	15	11	26
2020 June	16	11	27
2020 May	17	18	35
2020 April	23	10	33
2020 March	26	11	37
2020 February	17	7	24
2020 January	19	7	26
2019 December	25	12	37
2019 November	13	11	24
2019 October	21	10	31
2019 September	23	7	30
2019 August	27	4	31
2019 July	38	14	52
2019 June	66	25	91
2019 May	158	35	193
2019 April	60	29	89
2019 March	16	6	22
2019 February	17	15	32
2019 January	16	3	19
2018 December	10	7	17
2018 November	30	9	39
2018 October	30	2	32
2018 September	83	5	88
2018 August	70	1	71
2018 July	21	3	24
2018 June	12	0	12
2018 May	15	4	19
2018 April	22	0	22
2018 March	8	2	10
2018 February	11	4	15
2018 January	21	3	24
2017 December	9	0	9
2017 November	15	5	20
2017 October	19	1	20
2017 September	13	6	19
2017 August	20	1	21
2017 July	21	3	24
2017 June	31	14	45
2017 May	30	8	38
2017 April	15	5	20
2017 March	14	13	27

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter