Auditory hallucinations in cognitive neurology | Neurología (English Edition)

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En la exploración se aprecia parálisis de la mirada hacia arriba. Las imágenes de resonancia muestran una lesión situada en la parte anterior del lemnisco lateral, en la confluencia pontomesencefálica izquierda (1 y 2: secuencias TSE-T2; 3 y 4: secuencias SE-T1)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Robles Bayón, M.G. Tirapu de Sagrario, F. Gude Sampedro" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Robles Bayón" ] 1 => array:2 [ "nombre" => "M.G." "apellidos" => "Tirapu de Sagrario" ] 2 => array:2 [ "nombre" => "F." 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Acosta Rodríguez, G.M. Ramírez Santana, S. Hernández Expósito" "autores" => array:3 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Acosta Rodríguez" ] 1 => array:2 [ "nombre" => "G.M." "apellidos" => "Ramírez Santana" ] 2 => array:2 [ "nombre" => "S." 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Robles Bayón, M.G. Tirapu de Sagrario, F. Gude Sampedro" "autores" => array:3 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Robles Bayón" "email" => array:1 [ 0 => "alfredorobles@hospitalrosaleda.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.G." "apellidos" => "Tirapu de Sagrario" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "F." "apellidos" => "Gude Sampedro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Unidad de Neurología Cognitiva, Hospital La Rosaleda, Santiago de Compostela, A Coruña, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Radiología, Hospital La Rosaleda, Santiago de Compostela, A Coruña, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Unidad de Epidemiología Clínica, Hospital Clínico Universitario, Santiago de Compostela, A Coruña, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Alucinaciones auditivas en neurología cognitiva" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 954 "Ancho" => 2000 "Tamanyo" => 146417 ] ] "descripcion" => array:1 [ "en" => "81-year-old woman with hypoacusis, diabetes, and dyslipidaemia who began to experience verbal and musical complex auditory hallucinations at the age of 78. The examination revealed upward gaze palsy. An MRI scan showed a lesion in the anterior part of the lateral lemniscus, at the level of the left pontomesencephalic junction (1 and 2: T2-weighted TSE sequences; 3 and 4: T1-weighted SE sequences)." ] ] ] "textoCompleto" => "IntroductionTinnitus (which comes from the Latin word tinnīre, meaning ‘to ring’) is an auditory perception in the absence of an external stimulus. Tinnitus may manifest as a wide range of sounds (whistling, hissing, shrieking, buzzing, ringing, sizzling, bubbling, hammering, drumming, gasping, thundering, fragments of music, clanging, sounds resembling waves or downpour, a river flowing, a waterfall, the steam valve on a pressure cooker, trees rustling, a grinder or blender, a train, animal noises, an engine, doorbells, wind, etc.) and may be due to multiple causes (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<a class="elsevierStyleCrossRef" href="#bib0305">1</a><elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Tinnitus that takes the form of more complex perceptions, such as voices, music, or a combination of both, is referred to as either verbal or musical complex auditory hallucinations (CAH). When the person is aware that no external stimulus exists, the perceptions may also be called hallucinosis (acoustic in the case of tinnitus). Tinnitus is called auditory Charles Bonnet syndrome when hearing loss appears to be the only causative factor<a class="elsevierStyleCrossRefs" href="#bib0310">2,3</a> and musical ear syndrome when hallucinations are predominantly musical.<a class="elsevierStyleCrossRef" href="#bib0320">4</a>CAH may be due to a wide range of aetiologies (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>), and it may also occur in healthy individuals.<a class="elsevierStyleCrossRefs" href="#bib0325">5–7</a> Patients with CAH frequently have both predisposing and trigger factors. For example, hallucinations triggered by medications are more likely in patients with hearing loss. In patients with brain lesions, hallucinations coincide with paroxysmal electrical activity. Furthermore, the literature describes the case of a patient with calcifications in the thalamus and striatum who experienced CAH due to low levels of calcium and phosphorus secondary to hypoparathyroidism. Her hallucinations disappeared once the electrolyte balance had been restored.<a class="elsevierStyleCrossRef" href="#bib0340">8</a> The reduction in cholinergic neurons occurring in old age may also act as a predisposing factor; this process, combined with visual or auditory deficiencies, may cause visual and/or auditory hallucinations (Charles Bonnet syndrome) that may respond to treatment with acetylcholinesterase inhibitors.<a class="elsevierStyleCrossRef" href="#bib0345">9</a><elsevierMultimedia ident="tbl0010"></elsevierMultimedia>We searched for patients with tinnitus or CAH in a sample of neurological patients and analysed predisposing factors, neuroimaging findings, and potential pathophysiological mechanisms for the symptoms.Patients and methodsWe used a register of 1000 patients seen at a cognitive neurology clinic to search for patients with tinnitus and/or CAH. We performed a descriptive analysis for age and sex and examined any associations with such potential risk factors as hearing loss and leukoaraiosis. Data on pharmacological treatments were also gathered to check for any associations between tinnitus/CAH and medication use. Patients were considered to be positive for white matter alterations in neuroimaging studies when they had scores ≥2 on Blenow's scale (CT) or ≥4 on the Fazekas scale (MRI).<a class="elsevierStyleCrossRef" href="#bib0350">10</a>In patients with CAH, we analysed the potential association between manifestations and the diagnosis (and location) of focal brain lesions, when present.Results are expressed as either means±SD or absolute frequencies (percentages). We used the chi square, exact Fisher, and t tests to analyse the association between variables. Values of P<0.05 were considered statistically significant.ResultsOf these 1000 patients, 69 had tinnitus and 9 CAH (including 2 with both entities). <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows sex, age, and presence of potential risk factors in our sample. We analysed regular pharmacological treatment in the subgroup of patients with symptoms: antiplatelet drugs (acetylsalicylic acid [ASA] was analysed separately), opioid and non-opioid analgesics, nonsteroidal anti-inflammatory drugs, benzodiazepines, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, neuroleptics, beta-blockers (propranolol was analysed separately), angiotensin II type 1 receptor blockers, calcium channel blockers, loop diuretics, statins, and proton pump inhibitors. <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a> displays demographic and clinical data of the patients with CAH.<elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia>DiscussionAuditory hallucinations were found in 7.6% of the patients included in our register (6.9% had tinnitus and 0.9% had CAH). Over 80% of the adult population has experienced tinnitus at some point in their lives; however, prevalence of persistent and obtrusive tinnitus ranges from 4.4% to 27.9%.<a class="elsevierStyleCrossRefs" href="#bib0355">11–13</a> In neurology consultations, patients with tinnitus describe their acoustic perceptions as disturbing and believe them to be linked to the reason for consultation. Two series of patients with no psychotic disorders reported CAH prevalences of 0.7% and 0.8%, respectively.<a class="elsevierStyleCrossRefs" href="#bib0370">14,15</a> Therefore, frequencies of tinnitus and CAH in our sample are in line with those described in other studies.The literature reports no sex-related differences in the presence of tinnitus<a class="elsevierStyleCrossRefs" href="#bib0355">11–13</a>; in contrast, CAH, both verbal<a class="elsevierStyleCrossRef" href="#bib0380">16</a> and musical,<a class="elsevierStyleCrossRefs" href="#bib0315">3,17</a> are more frequent in women. In our sample, most of the patients with paracusis were women, especially in the group with CAH (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>); however, sex-related differences between the groups with and without paracusis were not significant (there were also more women in the group without paracusis).Prevalence of tinnitus increases until the age of 70, after which it either stabilises or decreases.<a class="elsevierStyleCrossRefs" href="#bib0360">12,13</a> Verbal auditory hallucinations are more frequent in middle-aged patients, whereas<a class="elsevierStyleCrossRefs" href="#bib0335">7,14</a> a study of 132 patients with musical hallucinations reported a mean age of 61.5 years.<a class="elsevierStyleCrossRef" href="#bib0315">3</a> In our sample, patients with tinnitus were younger than those with no auditory phenomena and patients with CAH were older than the other patients (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). Prevalence of cognitive disorders increases with age, which explains the advanced mean age of our sample (73.6±13.6, median 77). This is consistent with the finding of tinnitus in the youngest patients in the sample (66.4±15.9): incidence of tinnitus does not increase in elderly patients, in contrast with the incidence of cognitive impairment. However, patients with CAH were older than the other patient group, which seems to contradict published evidence. A potential explanation is that most epidemiological studies include samples from the normal population; in these individuals, CAH may be caused by schizophrenia and other disorders that are more prevalent among young or middle-aged patients, such as epilepsy, multiple sclerosis, and alcoholic hallucinosis (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). In our subset of 9 patients with CAH, the concomitant disorders that are more frequent in older individuals (cerebrovascular disease, dementing degenerative disorder [<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>]), may be responsible for both auditory hallucinations and cognitive impairment.Hearing loss is a risk factor for paracusis<a class="elsevierStyleCrossRefs" href="#bib0310">2,3,11,18,19</a>: in our sample, this symptom was more frequently observed in patients with auditory hallucinations (differences were significant for the subgroup of patients with CAH) (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). In most published cases of CAH, patients have a trigger factor plus one or more predisposing factors; hypoacusis is a frequent predisposing factor, especially in the case of musical CAH.<a class="elsevierStyleCrossRefs" href="#bib0305">1–3,18,19</a> In our sample, 66.6% of the patients with CAH presented hypoacusis (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>).Studies mainly including patients with schizophrenia report white matter changes affecting connectivity among certain areas of the brain (especially in the left frontotemporal area); these changes cause auditory hallucinations.<a class="elsevierStyleCrossRefs" href="#bib0400">20,21</a> We may therefore hypothesise that multiple extensive or lacunar leukoaraiosis lesions may predispose to CAH. We observed leukoaraiosis in 31.3% of the sample; there were no significant differences between patients with and without paracusis (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). The potential association between leukoaraiosis and paracusis may be attenuated in our sample given that leukoaraiosis is a frequent cause of cognitive and behavioural symptoms.<a class="elsevierStyleCrossRefs" href="#bib0410">22,23</a>CAH are frequent in patients with schizophrenia (≅70%),<a class="elsevierStyleCrossRef" href="#bib0325">5</a> bipolar disorder (11%-67%),<a class="elsevierStyleCrossRefs" href="#bib0325">5,24</a> or obsessive-compulsive disorder.<a class="elsevierStyleCrossRef" href="#bib0425">25</a> They may be verbal or musical.<a class="elsevierStyleCrossRefs" href="#bib0430">26,27</a> While our sample contained 15 patients with any of the above diagnoses, none of them reported CAH. Auditory hallucinations in these patients are usually assessed by psychiatrists rather than neurologists, unless hallucinations have changed alongside neurological symptoms.Some drugs have been associated with tinnitus or CAH (<a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>). This study found a higher rate of use of ASA in patients with CAH (66.7% vs 26.5% in those without), non-opioid analgesics in patients with tinnitus (18.8% vs 7.4% in those without), and benzodiazepines in both paracusis groups (52.2% in patients with tinnitus vs 37.6% in those without; 44.4% in patients with CAH vs 38.5% in those without) (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). ASA in high doses or as long-term treatment leads to spiral ganglion neuron apoptosis, resulting in turn in hypoacusis and tinnitus, which are reversible in many cases.<a class="elsevierStyleCrossRef" href="#bib0440">28</a> In our sample, ASA was more frequently used by patients without tinnitus. The use of low doses (100mg/day) administered shortly before symptom onset in many cases, and the fact that these symptoms may be transient may explain why the frequency of ASA use is not higher in patients with tinnitus. However, ASA is more frequently given to patients with CAH than to those without. Six of the 9 patients with CAH were receiving ASA as antiplatelet therapy. Differences in rates of antiplatelet treatment between patients with and without CAH were not significant (66.7% vs 40.1%). We hypothesise that the effects of vascular disease on the brain, rather than treatment with ASA, may be involved in the pathogenesis of CAH. However, Allen<a class="elsevierStyleCrossRef" href="#bib0445">29</a> reported 18 cases of musical CAH or tinnitus attributable to ASA use. In any case, the size of our sample is insufficient to draw robust conclusions on the association between ASA and paracusis.Of the 69 patients with tinnitus, 13 (18.8%) were taking non-opioid analgesics regularly (ASA at antiplatelet doses in all cases; nonsteroidal anti-inflammatory drugs were analysed separately). Ten of the 69 were taking paracetamol. Of the patients without tinnitus, 7.4% were taking analgesics (statistically significant difference, P=.001). This finding may be explained by the little known fact that paracetamol has ototoxic effects and may cause both tinnitus and hypoacusis.<a class="elsevierStyleCrossRef" href="#bib0450">30</a>Tinnitus is also among the symptoms associated with benzodiazepine withdrawal.<a class="elsevierStyleCrossRef" href="#bib0455">31</a> While these drugs constitute a treatment option for tinnitus, their effectiveness is unknown.<a class="elsevierStyleCrossRef" href="#bib0460">32</a> However, the literature describes some cases of CAH triggered by benzodiazepines, even though they are cited as a possible treatment option for this condition.<a class="elsevierStyleCrossRefs" href="#bib0465">33,34</a> In some of our patients, benzodiazepines were prescribed before onset of paracusis. In others they were administered to treat anxiety or dysphoria, symptoms sometimes triggered or aggravated by paracusis. Although we do not know whether benzodiazepines triggered paracusis in some of the cases, no patients developed symptoms soon after treatment onset.Four of the 9 patients with CAH had a degenerative disease (2 with Lewy body dementia and 2 with Alzheimer disease [AD]); 5 had a cerebrovascular disease (associated with degenerative disease in 2 cases), and the remaining 2 had focal brain lesions secondary to either trauma or surgery (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>). Patients with Lewy body dementia frequently develop visual hallucinations and may also present other psychotic symptoms, including auditory hallucinations; these symptoms support diagnosis of the condition.<a class="elsevierStyleCrossRef" href="#bib0475">35</a> Psychotic symptoms are less frequent in AD, occurring in 12% of the cases (median),<a class="elsevierStyleCrossRef" href="#bib0480">36</a> and probably in one specific phenotype<a class="elsevierStyleCrossRefs" href="#bib0485">37,38</a> in which an association with the C102 allele of the gene coding for the 5-HT2A receptor has been observed.<a class="elsevierStyleCrossRef" href="#bib0495">39</a> In any case, CAH are more frequent in patients with α-synucleinopathies or AD than in those with other types of degenerative dementia; this may explain why none of the 9 patients with CAH displayed other degenerative diseases.Non-degenerative focal lesions affecting the circuits involved in auditory information management may cause auditory hallucinations. These lesions may result from tumours, infections, trauma, or surgery, among other causes, although they are usually vascular in origin.<a class="elsevierStyleCrossRef" href="#bib0500">40</a> It was therefore not surprising to find cerebrovascular disease in 5 of the 9 patients with CAH. Three of them had focal lesions potentially responsible for these symptoms whereas the remaining 2 also presented degenerative disease (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>).Lesions associated with paracusis may appear in a wide range of locations since the auditory pathway is long and includes multiple modulatory circuits. First, the information gathered by the organ of Corti travels to the cochlear nucleus. Some fibres of this pathway then pass through the nuclei of the superior olivary complex, after which the pathway ascends through the lateral lemniscus (mostly along the contralateral structure). Some axons terminate at the nucleus of the lateral lemniscus and the inferior colliculus. The pathway continues towards the medial geniculate nucleus, where it sends projections to the first temporal gyrus and subsequently to the associative areas. Regarding the modulatory aspect of this pathway, its peripheral fragment contains an olivocochlear bundle that protects against damage caused by excessive noise and mediates selective attention. Alterations in the peripheral afferent section cause ipsilateral hearing loss for certain frequencies; by a phenomenon of homeostatic plasticity, they also induce reactive hyperactivity in intact neurons of the cochlear nucleus which is transmitted to the brain and may cause unilateral tinnitus.<a class="elsevierStyleCrossRef" href="#bib0505">41</a> Furthermore, somatosensory afferences from the head and upper cervical region converge in the dorsal cochlear nucleus; the inputs are necessary to locate sound with respect to the position of the head. Both partial deafferentation of the auditory nerve fibres and excessive somatosensory stimulation of the head or neck may cause tinnitus (even in cases of normal auditory function).<a class="elsevierStyleCrossRefs" href="#bib0305">1,41</a> If alterations are mild, tinnitus appears when both factors co-occur. Tinnitus may also appear in patients with normal hearing due to dysfunctions of the outer hair cells as a result of excessive ‘otoacoustic emissions’ that surpass the compensatory capacity of the olivocochlear system.<a class="elsevierStyleCrossRef" href="#bib0510">42</a> This cause is responsible for less than 10% of all cases of tinnitus and generally appears in association with other causes. In summary, hypoacusis promotes tinnitus, but it is not a necessary or sufficient condition for the development of this disorder. In our sample, nearly one fourth of all patients with tinnitus also had hypoacusis (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).The section of the auditory pathway running through the brain contains several modulatory tracts. Multiple fibres run from the auditory cortex to the medial geniculate nucleus, the inferior colliculus, and other nuclei in the thalamus. Other neurons reach the cochlear nucleus from the inferior colliculus and the lateral lemniscus. The reticular formation manages bidirectional communication between the cochlear nucleus and the thalamus. These circuits are in turn influenced by other regions (prefrontal and parietal cortex, cingulate, insula, parahippocampus, amygdala, basal nuclei, and cerebellum).<a class="elsevierStyleCrossRefs" href="#bib0310">2,43,44</a> Hypofunction of the auditory pathway or the ascending reticular formation leads to thalamocortical dysrhythmia<a class="elsevierStyleCrossRefs" href="#bib0525">45,46</a>; deafferentation promotes hyperactivity in some cortical areas as a compensatory mechanism. Marked deafferentation may result in release of auditory information stored in mnestic circuits. When no deafferentation occurs, paracusis may be mediated not by thalamocortical dysrhythmia, but rather by deficiencies in descending modulatory circuits. In many cases, both mechanisms are involved. Paracusis secondary to alterations rostral to the cochlear nucleus may be simple or complex, and bilateral (most frequently) or unilateral.Lesions causing CAH may be located at any part of the auditory pathway (generally rostral to the cochlear nucleus), in adjacent areas (affecting modulatory fibres), and even in other regions linked to the ones mentioned previously due to a mechanism of diaschisis.<a class="elsevierStyleCrossRefs" href="#bib0535">47–50</a> The literature includes multiple cases of CAH secondary to lesions to the portion running from the pontine-mesencephalic tegmentum to the thalamus, the thalamus itself, and the area containing fibres which connect the thalamus to the temporal cortex. In other cases, lesions are located in the superior temporal region or adjacent areas (left or right) and have a stimulating effect. On rare occasions, lesions are located in other areas of the connectome that are functionally related to the regions mentioned previously (frontal lobe,<a class="elsevierStyleCrossRefs" href="#bib0555">51,52</a> parietal lobe,<a class="elsevierStyleCrossRef" href="#bib0565">53</a> hippocampus,<a class="elsevierStyleCrossRef" href="#bib0570">54</a> cerebellum<a class="elsevierStyleCrossRef" href="#bib0575">55</a>). Five of the 9 patients with CAH displayed focal lesions potentially responsible for the condition (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>). In 3 of these cases, lesions were located in the pontine or mesencephalic tegmentum. The literature reports many cases of verbal or musical CAH secondary to lesions to these regions. Symptoms are similar to those associated with peduncular hallucinosis, which is characterised by visual alterations and may also present with tactile or auditory dysfunction.<a class="elsevierStyleCrossRef" href="#bib0530">46</a><a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> shows neuroimages taken of a lesion at this location in a patient who had reported hearing fragments of the same songs for several years.<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Another 2 cases of paracusis (known as VAA and SMA) display pathophysiological differences. In the case of VAA, hypoacusis and unilateral tinnitus are secondary to vestibular schwannoma. SMA began to experience CAH after surgical resection of a vestibular schwannoma: postsurgical MR images reveal signal alterations in the adjacent pontine region. In VAA, in addition to hyperactivity of preserved fibres as a reaction to hypoacusis, paracusis may also be due to a transmission phenomenon caused by contact between adjacent compressed fibres.<a class="elsevierStyleCrossRef" href="#bib0305">1</a> In SMA, paracusis had to do with modulatory tracts of the central nervous system stemming from cortical association areas.In FMS (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>), partial seizures and CAH were caused by paroxysmal bioelectrical activity in a temporal cortical area with encephalomalacia surrounded by gliosis (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Epileptic activity in the superior temporal gyrus is a well-known cause of CAH.<a class="elsevierStyleCrossRef" href="#bib0580">56</a><elsevierMultimedia ident="fig0010"></elsevierMultimedia>One of our patients (AVM) displayed a lacunar lesion along the path of the projections running from the pulvinar nuclei and medial geniculate body to the temporal cortex (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). VRC showed a lacunar lesion in the posterior area of the left claustrum, adjacent to the insula, which caused musical CAH (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>, <a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). According to a meta-analysis, some of the brain areas that activate during CAH include the insulae and the left claustrum,<a class="elsevierStyleCrossRef" href="#bib0520">44</a> which are connected to auditory cortical areas<a class="elsevierStyleCrossRef" href="#bib0585">57</a> and involved in processing auditory information.<a class="elsevierStyleCrossRefs" href="#bib0585">57,58</a><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia>All 9 cases of CAH displayed more than one known cause of CAH (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). On many occasions, co-presence of 2 or 3 causative factors is necessary to exceed the brain's ability to adapt. In addition to the condition causing CAH (α-synucleinopathy, AD, or a focal lesion in a risk area for paracusis), the 9 patients with CAH displayed hypoacusis or were taking drugs potentially predisposing them to paracusis (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>). All patients were taking multiple drugs, which suggests that polymedication may be another risk factor for CAH; further studies with greater sample sizes are necessary to confirm this association.Paracusis, which is often not reported if doctors do not ask about it specifically, is one of a host of symptoms arising from a number of very different neurological disorders. Many tests and procedures are available for determining the multiple causes of paracusis (audiometry, auditory reflexes, dichotic listening test, auditory brainstem evoked potentials).<a class="elsevierStyleCrossRefs" href="#bib0385">17,59,60</a> However, working conditions in clinical practice force clinicians to use only such tests as are indispensable to determine the aetiology and choose the most appropriate treatment. In any case, brain MRI scans should be performed when patients report CAH or tinnitus without a well-defined peripheral cause, especially in cases of pulsatile tinnitus or paracusis accompanied by focal neurological signs.FundingThis study has not been presented at any scientific conferences nor has it received funding from any institutions.Conflicts of interestThe authors have no conflicts of interest to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres868499" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec857429" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres868500" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec857428" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Patients and methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Funding" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflicts of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-12-03" "fechaAceptado" => "2015-12-16" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec857429" "palabras" => array:6 [ 0 => "Paracusia" 1 => "Auditory hallucinations" 2 => "Musical hallucinations" 3 => "Verbal hallucinations" 4 => "Auditory hallucinosis" 5 => "Tinnitus" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec857428" "palabras" => array:6 [ 0 => "Acúfenos" 1 => "Alucinaciones auditivas" 2 => "Alucinaciones musicales" 3 => "Alucinaciones verbales" 4 => "Alucinosis auditiva" 5 => "Tinnitus" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "IntroductionDifferent types and localisations of neurological lesions can produce tinnitus and verbal or musical hallucinations (VMH). MethodThese symptoms were screened for in 1000 outpatients at a cognitive neurology clinic, and epidemiological and neuroimaging data were recorded. ResultsTinnitus was present in 6.9% of the total and VMH in 0.9%. The paracusia group was predominantly female but the difference was not statistically significant. Patients with tinnitus were younger and those with VMH were older than the rest of the sample (mean ages). Hearing loss was more prevalent in the paracusia group (difference was significant in VMH subgroup). There were no intergroup differences in the prevalence of psychotic and obsessive-compulsive disorders, or of leukoaraiosis. Treatment with acetylsalicylic acid was more frequent in the VMH group, whereas other non-opioid analgesics and benzodiazepines were more commonly prescribed to patients with tinnitus. The suspected cause of VMH was dementia with Lewy bodies (n=2, one with vascular disease), Alzheimer disease (n=2, one with vascular disease), isolated cerebrovascular disease (n=3), traumatic brain injury (n=1), and surgical brainstem lesion (n=1). All VMH cases displayed an underlying factor that might prompt this symptom, e.g., hearing loss (n=6), a predisposing drug (n=9), and polypharmacy (n=9). ConclusionsTreatment with benzodiazepines and non-opioid analgesics was more frequent in the tinnitus group, whereas the VMH group showed a higher prevalence of hearing loss and treatment with acetylsalicylic acid. The causes of VMH were dementia with Lewy bodies, Alzheimer disease, and focal lesions in the mesencephalon, pons, left temporal lobe, or left claustrum." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "IntroducciónLos tinnitus y las alucinaciones verbales o musicales (AVM) pueden deberse a lesiones neurológicas de naturaleza y topografía diversa. MétodoSe han rastreado estos síntomas en 1.000 pacientes de una consulta de neurología cognitiva, anotando datos epidemiológicos y de neuroimagen. ResultadosRefirieron tinnitus el 6,9% y AVM el 0,9%. Hubo predominio femenino no significativo en el grupo con paracusias. La edad media fue menor en los pacientes con tinnitus y mayor en los que tenían AVM. La hipoacusia mostró mayor prevalencia en los enfermos con paracusias (significativo con AVM). No hubo diferencias en la prevalencia de trastorno psicótico u obsesivo-compulsivo, o de leucoaraiosis. El tratamiento con ácido acetilsalicílico mostró mayor frecuencia en el grupo con AVM, y otros analgésicos no opioides y benzodiacepinas en los pacientes con tinnitus. La presunta causa de las AVM fue demencia con cuerpos de Lewy (n=2, uno con enfermedad vascular), enfermedad de Alzheimer (n=2, uno con enfermedad vascular), enfermedad vascular cerebral pura (n=3), lesión cerebral traumática (n=1) y lesión quirúrgica en el tronco encefálico (n=1). En los 9 casos había un elemento facilitador de la aparición de paracusias, como hipoacusia (n=6) o medicación de riesgo (n=9), además de polifarmacia (n=9). ConclusionesLos pacientes con tinnitus tomaban con frecuencia benzodiacepinas y analgésicos no opioides, y en los que tenían AVM había mayor prevalencia de hipoacusia y de tratamiento con ácido acetilsalicílico. Las causas de AVM fueron demencia con cuerpos de Lewy, enfermedad de Alzheimer y lesiones focales en mesencéfalo, protuberancia, lóbulo temporal izquierdo o claustro izquierdo." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Robles Bayón A, Tirapu de Sagrario MG, Gude Sampedro F. Alucinaciones auditivas en neurología cognitiva. Neurología. 2017;32:345–354." ] ] "multimedia" => array:8 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 954 "Ancho" => 2000 "Tamanyo" => 146417 ] ] "descripcion" => array:1 [ "en" => "81-year-old woman with hypoacusis, diabetes, and dyslipidaemia who began to experience verbal and musical complex auditory hallucinations at the age of 78. The examination revealed upward gaze palsy. An MRI scan showed a lesion in the anterior part of the lateral lemniscus, at the level of the left pontomesencephalic junction (1 and 2: T2-weighted TSE sequences; 3 and 4: T1-weighted SE sequences)." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1056 "Ancho" => 1900 "Tamanyo" => 257710 ] ] "descripcion" => array:1 [ "en" => "MRI scan of a 78-year-old patient with arterial hypertension and presbycusis who at the age of 53 experienced head trauma resulting in coma. When he was 76, he began to experience recurrent paroxysmal episodes of delusions with visual and auditory hallucinations. Neuroimages revealed encephalomalacia surrounded by gliosis in the left temporal area (upper and middle rows: FLAIR sequences; lower row: T1-weighted IR sequences)." ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 836 "Ancho" => 1400 "Tamanyo" => 116711 ] ] "descripcion" => array:1 [ "en" => "FLAIR MRI sequences from a 57-year-old woman who reported sudden-onset right hypoacusis starting 2 months before the consultation and persisting to date and hearing a sound resembling a waterfall or a river." ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 851 "Ancho" => 1400 "Tamanyo" => 125396 ] ] "descripcion" => array:1 [ "en" => "MR images (left: T1-weighted sequence; right: FLAIR sequence) from a 94-year-old woman with arterial hypertension, a 2-year history of bilateral hypoacusis and tinnitus, and a 9-month history of bilateral musical and verbal hallucinations that were repetitive but did not alter the patient's behaviour or mood." ] ] 4 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Spontaneous, transient increase in auditory neural activity \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pressure on the tympanic membrane (earwax, hair, or liquid) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Compression of the eighth cranial nerve \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Stapedius muscle contractions due to abnormal reinnervation after Bell palsy \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Semicircular canal dehiscence \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Otoacoustic emissions \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Autoimmune inner ear disease \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Extreme stress or fatigue \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Perilymph fistula \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Herpes zoster oticus (Ramsay Hunt syndrome) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hypoacusis (conductive or sensorineural, acute or chronic) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Idiopathic \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Brain lesion affecting circuits involved in auditory information processing \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Focal brainstem lesions \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Palatal myoclonus \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Otosclerosis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Postinfectious \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Medication (including drug withdrawal)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Meniere disease \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pulsatile tinnitus secondary to prolonged systolic time due to anaemia, hyperthyroidism, or aortic stenosis; carotid artery dissection, stenosis, or fibromuscular dysplasia; dural arteriovenous fistula; carotid-cavernous sinus fistula; dehiscent jugular bulb; glomus jugulare tumour; benign intracranial hypertension \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Somatic disorders affecting the head and upper cervical region (Costen syndrome, whiplash injury, etc.) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Acute acoustic trauma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Head trauma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Patulous Eustachian tube \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cerebellopontine angle tumour \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Disabling positional vertigo \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1460518.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "Cisplatin, aminoglycoside antibiotics, loop diuretics, acetylsalicylic acid (at high doses), quinine; discontinuation of benzodiazepines (due to ending treatment or transitioning to fluoroquinolones)." ] ] ] "descripcion" => array:1 [ "en" => "Causes of tinnitus." ] ] 5 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "* Published cases of musical hallucinations." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Disorders associated with hypoacusis as the main manifestation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Otosclerosis*, cochlear implant*, presbycusis*, lesions to the pontine-mesencephalic portion of the auditory pathway* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Primary psychiatric disorders \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Schizophrenia*, bipolar disorder*, obsessive-compulsive disorder*, depression*, anorexia nervosa, conversion disorder \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Disorders linked to detectable focal lesions in the central nervous system \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Vascular lesions (stroke*, intraparenchymal haemorrhage*, subarachnoid haemorrhage*, vascular malformations*, cerebral venous sinus thrombosis), neoplasia (meningioma*, glioma*, metastasis*, lipoma), radiotherapy*, epilepsy*<a class="elsevierStyleCrossRef" href="#tblfn0010">a</a> (especially when the epileptogenic area is located in the right temporal lobe), electroconvulsive therapy*, lobectomy for epilepsy*, abscesses*, viral encephalitis*, autoimmune limbic encephalitis, rhombencephalitis due to Listeria*, multiple sclerosis, migraine attacks (with and without aura)*, basal ganglia calcification*, schizencephaly \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neurological disorders with no apparent focal signs affecting the auditory pathway \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hallucinosis secondary to head trauma*, Hashimoto encephalopathy*, Lyme disease*, encephalitis due to virus or Taenia solium infection, neurosyphilis; α-synucleinopathies (multiple system atrophy, Lewy body dementia, Parkinson's disease*), Alzheimer disease* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Effect of substances \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Alcoholic hallucinosis*, other substances<a class="elsevierStyleCrossRef" href="#tblfn0015">b</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Idiopathic* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1460515.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "a" "nota" => "Many patients with concomitant entities and displaying focal lesions also experience seizures." ] 1 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "b" "nota" => "Amantadine*, tricyclic antidepressants*, antimalarial drugs (quinine, chloroquine, mefloquine), baclofen (sudden withdrawal), benzodiazepines* (and benzodiazepine discontinuation), biphosphonates, cocaine, corticosteroids*, bromocriptine*, digoxin, dipyridamole*, gentamicin*, selective serotonin reuptake inhibitors, ketamine, marijuana, mirtazapine*, opioids*, pentoxifylline*, psychostimulants (cocaine, amphetamines, methylphenidate), pramipexole*, prazosin, propranolol*, ranitidine, salicylates*, topiramate, trimethoprim/sulfamethoxazole, voriconazole*." ] ] ] "descripcion" => array:1 [ "en" => "Causes of complex auditory hallucinations according to the literature." ] ] 6 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "CAH: complex auditory hallucinations; ASA: acetylsalicylic acid; NOA: non-opioid analgesics; BZD: benzodiazepines; SD: standard deviation; LWM: moderate to severe leukoaraiosis or multiple lacunar lesions in white matter; ns: non-significant differences between patients with the condition analysed in that row and those without (marked in left column); PSchiz: patients with schizophrenia, bipolar disorder, or obsessive-compulsive disorder." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex, % women<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mean age±SD \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Hypoacusis, %<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">LWM, %<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PSchiz, %<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment<a class="elsevierStyleCrossRef" href="#tblfn0025">b</a>, %<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">No paracusis (n=924) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">61.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">74.0 (13.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ASA (26.5) NOA (7.4) BZD (37.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Paracusis (n=76) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">71.1ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">68.0 (16.0)<a class="elsevierStyleCrossRef" href="#tblfn0035">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.3<a class="elsevierStyleCrossRef" href="#tblfn0030">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29.6ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.3ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NOA (18.4<a class="elsevierStyleCrossRef" href="#tblfn0035">**</a>) BZD (50.0<a class="elsevierStyleCrossRef" href="#tblfn0030">*</a>) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tinnitus (n=69) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">69.6ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">66.4 (15.9)<a class="elsevierStyleCrossRef" href="#tblfn0035">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.2ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29.8ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.4ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NOA (18.8<a class="elsevierStyleCrossRef" href="#tblfn0035">**</a>) BZD (52.2<a class="elsevierStyleCrossRef" href="#tblfn0030">*</a>) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CAH (n=9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">80ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">83.8 (5.7)<a class="elsevierStyleCrossRef" href="#tblfn0030">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">66.7<a class="elsevierStyleCrossRef" href="#tblfn0030">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22.2ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0ns \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ASA (66.7<a class="elsevierStyleCrossRef" href="#tblfn0030">*</a>) NOA (11.1ns) BZD (44.4ns) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1460517.png" ] ] ] "notaPie" => array:4 [ 0 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "a" "nota" => "Percentage within the group indicated in the left column." ] 1 => array:3 [ "identificador" => "tblfn0025" "etiqueta" => "b" "nota" => "Drugs with significantly more frequent use in any of the groups of patients with paracusis." ] 2 => array:3 [ "identificador" => "tblfn0030" "etiqueta" => "*" "nota" => "P<.05." ] 3 => array:3 [ "identificador" => "tblfn0035" "etiqueta" => "**" "nota" => "P<.01." ] ] ] "descripcion" => array:1 [ "en" => "Sex, age, and possible risk factors in our sample (n=1000)." ] ] 7 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at4" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "ASA: acetylsalicylic acid; NOA: non-opioid analgesics; OA: opioid analgesics; BZD: benzodiazepines; W: woman; M: man; AI: active ingredients." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patient \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex-age \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Symptoms \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Focal lesion \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Other data \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BLM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">W-83 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Sees people and hears voices \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lewy body dementia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5 AI. L-dopa \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CMC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">W-81 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Always hears the same 2 songs \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cerebrovascular disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Infarct in the pontine-mesencephalic region bilaterally \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hypoacusis. 8 AI. ASA and BZD \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CAM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">W-85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Unspecified visual and auditory hallucinations \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cerebrovascular disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lacunar lesions in the centrum ovale and pons \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Leukoaraiosis. 11 AI. ASA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CRM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">W-84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hears television \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Alzheimer disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hypoacusis. 10 AI. ASA, BZD, NOA, and OA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FMS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M-78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hears people talking \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Encephalopathy secondary to head trauma associated with complex partial seizures \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cortico-subcortical encephalomalacia in the left temporal lobe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hypoacusis. Leukoaraiosis. 12 AI. ASA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">GPM \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">W-83 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Sees people and hears voices \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lewy body dementia, cerebrovascular disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Leukoaraiosis. 5 AI. ASA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">RGD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">W-91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Sees people and hears voices \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Alzheimer disease, cerebrovascular disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hypoacusis. 7 AI. ASA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SMA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">W-76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hears songs \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Systemic lupus erythematosus, surgical lesion to the brainstem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Surgical malacic lesion in the left side of the pons \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hypoacusis. 6 AI. BZD \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">VRC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">W-94 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hears voices and a gramophone playing music \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cerebrovascular lesion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lacunar infarction in left claustrum \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hypoacusis. 5 AI. 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Auditory hallucinations in cognitive neurology

Alucinaciones auditivas en neurología cognitiva

A. Robles Bayóna,

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alfredorobles@hospitalrosaleda.com

Corresponding author.

, M.G. Tirapu de Sagrariob, F. Gude Sampedroc

a Unidad de Neurología Cognitiva, Hospital La Rosaleda, Santiago de Compostela, A Coruña, Spain

b Servicio de Radiología, Hospital La Rosaleda, Santiago de Compostela, A Coruña, Spain

c Unidad de Epidemiología Clínica, Hospital Clínico Universitario, Santiago de Compostela, A Coruña, Spain

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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">81-year-old woman with hypoacusis&#44; diabetes&#44; and dyslipidaemia who began to experience verbal and musical complex auditory hallucinations at the age of 78&#46; The examination revealed upward gaze palsy&#46; An MRI scan showed a lesion in the anterior part of the lateral lemniscus&#44; at the level of the left pontomesencephalic junction &#40;1 and 2&#58; T2-weighted TSE sequences&#59; 3 and 4&#58; T1-weighted SE sequences&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Tinnitus &#40;which comes from the Latin word <span class="elsevierStyleItalic">tinn&#299;re</span>&#44; meaning &#8216;to ring&#8217;&#41; is an auditory perception in the absence of an external stimulus&#46; Tinnitus may manifest as a wide range of sounds &#40;whistling&#44; hissing&#44; shrieking&#44; buzzing&#44; ringing&#44; sizzling&#44; bubbling&#44; hammering&#44; drumming&#44; gasping&#44; thundering&#44; fragments of music&#44; clanging&#44; sounds resembling waves or downpour&#44; a river flowing&#44; a waterfall&#44; the steam valve on a pressure cooker&#44; trees rustling&#44; a grinder or blender&#44; a train&#44; animal noises&#44; an engine&#44; doorbells&#44; wind&#44; etc&#46;&#41; and may be due to multiple causes &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">1</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Tinnitus that takes the form of more complex perceptions&#44; such as voices&#44; music&#44; or a combination of both&#44; is referred to as either verbal or musical complex auditory hallucinations &#40;CAH&#41;&#46; When the person is aware that no external stimulus exists&#44; the perceptions may also be called hallucinosis &#40;acoustic in the case of tinnitus&#41;&#46; Tinnitus is called auditory Charles Bonnet syndrome when hearing loss appears to be the only causative factor<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">2&#44;3</span></a> and musical ear syndrome when hallucinations are predominantly musical&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">CAH may be due to a wide range of aetiologies &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#44; and it may also occur in healthy individuals&#46;<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">5&#8211;7</span></a> Patients with CAH frequently have both predisposing and trigger factors&#46; For example&#44; hallucinations triggered by medications are more likely in patients with hearing loss&#46; In patients with brain lesions&#44; hallucinations coincide with paroxysmal electrical activity&#46; Furthermore&#44; the literature describes the case of a patient with calcifications in the thalamus and striatum who experienced CAH due to low levels of calcium and phosphorus secondary to hypoparathyroidism&#46; Her hallucinations disappeared once the electrolyte balance had been restored&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">8</span></a> The reduction in cholinergic neurons occurring in old age may also act as a predisposing factor&#59; this process&#44; combined with visual or auditory deficiencies&#44; may cause visual and&#47;or auditory hallucinations &#40;Charles Bonnet syndrome&#41; that may respond to treatment with acetylcholinesterase inhibitors&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">9</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">We searched for patients with tinnitus or CAH in a sample of neurological patients and analysed predisposing factors&#44; neuroimaging findings&#44; and potential pathophysiological mechanisms for the symptoms&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Patients and methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">We used a register of 1000 patients seen at a cognitive neurology clinic to search for patients with tinnitus and&#47;or CAH&#46; We performed a descriptive analysis for age and sex and examined any associations with such potential risk factors as hearing loss and leukoaraiosis&#46; Data on pharmacological treatments were also gathered to check for any associations between tinnitus&#47;CAH and medication use&#46; Patients were considered to be positive for white matter alterations in neuroimaging studies when they had scores &#8805;2 on Blenow&#39;s scale &#40;CT&#41; or &#8805;4 on the Fazekas scale &#40;MRI&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In patients with CAH&#44; we analysed the potential association between manifestations and the diagnosis &#40;and location&#41; of focal brain lesions&#44; when present&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Results are expressed as either means<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD or absolute frequencies &#40;percentages&#41;&#46; We used the chi square&#44; exact Fisher&#44; and <span class="elsevierStyleItalic">t</span> tests to analyse the association between variables&#46; Values of <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 were considered statistically significant&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">Of these 1000 patients&#44; 69 had tinnitus and 9 CAH &#40;including 2 with both entities&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> shows sex&#44; age&#44; and presence of potential risk factors in our sample&#46; We analysed regular pharmacological treatment in the subgroup of patients with symptoms&#58; antiplatelet drugs &#40;acetylsalicylic acid &#91;ASA&#93; was analysed separately&#41;&#44; opioid and non-opioid analgesics&#44; nonsteroidal anti-inflammatory drugs&#44; benzodiazepines&#44; selective serotonin reuptake inhibitors&#44; serotonin-norepinephrine reuptake inhibitors&#44; neuroleptics&#44; beta-blockers &#40;propranolol was analysed separately&#41;&#44; angiotensin II type 1 receptor blockers&#44; calcium channel blockers&#44; loop diuretics&#44; statins&#44; and proton pump inhibitors&#46; <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a> displays demographic and clinical data of the patients with CAH&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">Auditory hallucinations were found in 7&#46;6&#37; of the patients included in our register &#40;6&#46;9&#37; had tinnitus and 0&#46;9&#37; had CAH&#41;&#46; Over 80&#37; of the adult population has experienced tinnitus at some point in their lives&#59; however&#44; prevalence of persistent and obtrusive tinnitus ranges from 4&#46;4&#37; to 27&#46;9&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">11&#8211;13</span></a> In neurology consultations&#44; patients with tinnitus describe their acoustic perceptions as disturbing and believe them to be linked to the reason for consultation&#46; Two series of patients with no psychotic disorders reported CAH prevalences of 0&#46;7&#37; and 0&#46;8&#37;&#44; respectively&#46;<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">14&#44;15</span></a> Therefore&#44; frequencies of tinnitus and CAH in our sample are in line with those described in other studies&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">The literature reports no sex-related differences in the presence of tinnitus<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">11&#8211;13</span></a>&#59; in contrast&#44; CAH&#44; both verbal<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">16</span></a> and musical&#44;<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">3&#44;17</span></a> are more frequent in women&#46; In our sample&#44; most of the patients with paracusis were women&#44; especially in the group with CAH &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#59; however&#44; sex-related differences between the groups with and without paracusis were not significant &#40;there were also more women in the group without paracusis&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Prevalence of tinnitus increases until the age of 70&#44; after which it either stabilises or decreases&#46;<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">12&#44;13</span></a> Verbal auditory hallucinations are more frequent in middle-aged patients&#44; whereas<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">7&#44;14</span></a> a study of 132 patients with musical hallucinations reported a mean age of 61&#46;5 years&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">3</span></a> In our sample&#44; patients with tinnitus were younger than those with no auditory phenomena and patients with CAH were older than the other patients &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Prevalence of cognitive disorders increases with age&#44; which explains the advanced mean age of our sample &#40;73&#46;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;6&#44; median 77&#41;&#46; This is consistent with the finding of tinnitus in the youngest patients in the sample &#40;66&#46;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;9&#41;&#58; incidence of tinnitus does not increase in elderly patients&#44; in contrast with the incidence of cognitive impairment&#46; However&#44; patients with CAH were older than the other patient group&#44; which seems to contradict published evidence&#46; A potential explanation is that most epidemiological studies include samples from the normal population&#59; in these individuals&#44; CAH may be caused by schizophrenia and other disorders that are more prevalent among young or middle-aged patients&#44; such as epilepsy&#44; multiple sclerosis&#44; and alcoholic hallucinosis &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; In our subset of 9 patients with CAH&#44; the concomitant disorders that are more frequent in older individuals &#40;cerebrovascular disease&#44; dementing degenerative disorder &#91;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#93;&#41;&#44; may be responsible for both auditory hallucinations and cognitive impairment&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Hearing loss is a risk factor for paracusis<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">2&#44;3&#44;11&#44;18&#44;19</span></a>&#58; in our sample&#44; this symptom was more frequently observed in patients with auditory hallucinations &#40;differences were significant for the subgroup of patients with CAH&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; In most published cases of CAH&#44; patients have a trigger factor plus one or more predisposing factors&#59; hypoacusis is a frequent predisposing factor&#44; especially in the case of musical CAH&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">1&#8211;3&#44;18&#44;19</span></a> In our sample&#44; 66&#46;6&#37; of the patients with CAH presented hypoacusis &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Studies mainly including patients with schizophrenia report white matter changes affecting connectivity among certain areas of the brain &#40;especially in the left frontotemporal area&#41;&#59; these changes cause auditory hallucinations&#46;<a class="elsevierStyleCrossRefs" href="#bib0400"><span class="elsevierStyleSup">20&#44;21</span></a> We may therefore hypothesise that multiple extensive or lacunar leukoaraiosis lesions may predispose to CAH&#46; We observed leukoaraiosis in 31&#46;3&#37; of the sample&#59; there were no significant differences between patients with and without paracusis &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; The potential association between leukoaraiosis and paracusis may be attenuated in our sample given that leukoaraiosis is a frequent cause of cognitive and behavioural symptoms&#46;<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">22&#44;23</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">CAH are frequent in patients with schizophrenia &#40;&#8773;70&#37;&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">5</span></a> bipolar disorder &#40;11&#37;-67&#37;&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0325"><span class="elsevierStyleSup">5&#44;24</span></a> or obsessive-compulsive disorder&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">25</span></a> They may be verbal or musical&#46;<a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">26&#44;27</span></a> While our sample contained 15 patients with any of the above diagnoses&#44; none of them reported CAH&#46; Auditory hallucinations in these patients are usually assessed by psychiatrists rather than neurologists&#44; unless hallucinations have changed alongside neurological symptoms&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Some drugs have been associated with tinnitus or CAH &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>&#41;&#46; This study found a higher rate of use of ASA in patients with CAH &#40;66&#46;7&#37; vs 26&#46;5&#37; in those without&#41;&#44; non-opioid analgesics in patients with tinnitus &#40;18&#46;8&#37; vs 7&#46;4&#37; in those without&#41;&#44; and benzodiazepines in both paracusis groups &#40;52&#46;2&#37; in patients with tinnitus vs 37&#46;6&#37; in those without&#59; 44&#46;4&#37; in patients with CAH vs 38&#46;5&#37; in those without&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; ASA in high doses or as long-term treatment leads to spiral ganglion neuron apoptosis&#44; resulting in turn in hypoacusis and tinnitus&#44; which are reversible in many cases&#46;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">28</span></a> In our sample&#44; ASA was more frequently used by patients without tinnitus&#46; The use of low doses &#40;100<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41; administered shortly before symptom onset in many cases&#44; and the fact that these symptoms may be transient may explain why the frequency of ASA use is not higher in patients with tinnitus&#46; However&#44; ASA is more frequently given to patients with CAH than to those without&#46; Six of the 9 patients with CAH were receiving ASA as antiplatelet therapy&#46; Differences in rates of antiplatelet treatment between patients with and without CAH were not significant &#40;66&#46;7&#37; vs 40&#46;1&#37;&#41;&#46; We hypothesise that the effects of vascular disease on the brain&#44; rather than treatment with ASA&#44; may be involved in the pathogenesis of CAH&#46; However&#44; Allen<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">29</span></a> reported 18 cases of musical CAH or tinnitus attributable to ASA use&#46; In any case&#44; the size of our sample is insufficient to draw robust conclusions on the association between ASA and paracusis&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Of the 69 patients with tinnitus&#44; 13 &#40;18&#46;8&#37;&#41; were taking non-opioid analgesics regularly &#40;ASA at antiplatelet doses in all cases&#59; nonsteroidal anti-inflammatory drugs were analysed separately&#41;&#46; Ten of the 69 were taking paracetamol&#46; Of the patients without tinnitus&#44; 7&#46;4&#37; were taking analgesics &#40;statistically significant difference&#44; <span class="elsevierStyleItalic">P<span class="elsevierStyleHsp" style=""></span></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;001&#41;&#46; This finding may be explained by the little known fact that paracetamol has ototoxic effects and may cause both tinnitus and hypoacusis&#46;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">30</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Tinnitus is also among the symptoms associated with benzodiazepine withdrawal&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">31</span></a> While these drugs constitute a treatment option for tinnitus&#44; their effectiveness is unknown&#46;<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">32</span></a> However&#44; the literature describes some cases of CAH triggered by benzodiazepines&#44; even though they are cited as a possible treatment option for this condition&#46;<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">33&#44;34</span></a> In some of our patients&#44; benzodiazepines were prescribed before onset of paracusis&#46; In others they were administered to treat anxiety or dysphoria&#44; symptoms sometimes triggered or aggravated by paracusis&#46; Although we do not know whether benzodiazepines triggered paracusis in some of the cases&#44; no patients developed symptoms soon after treatment onset&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Four of the 9 patients with CAH had a degenerative disease &#40;2 with Lewy body dementia and 2 with Alzheimer disease &#91;AD&#93;&#41;&#59; 5 had a cerebrovascular disease &#40;associated with degenerative disease in 2 cases&#41;&#44; and the remaining 2 had focal brain lesions secondary to either trauma or surgery &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; Patients with Lewy body dementia frequently develop visual hallucinations and may also present other psychotic symptoms&#44; including auditory hallucinations&#59; these symptoms support diagnosis of the condition&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">35</span></a> Psychotic symptoms are less frequent in AD&#44; occurring in 12&#37; of the cases &#40;median&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">36</span></a> and probably in one specific phenotype<a class="elsevierStyleCrossRefs" href="#bib0485"><span class="elsevierStyleSup">37&#44;38</span></a> in which an association with the C102 allele of the gene coding for the 5-HT<span class="elsevierStyleInf">2A</span> receptor has been observed&#46;<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">39</span></a> In any case&#44; CAH are more frequent in patients with &#945;-synucleinopathies or AD than in those with other types of degenerative dementia&#59; this may explain why none of the 9 patients with CAH displayed other degenerative diseases&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Non-degenerative focal lesions affecting the circuits involved in auditory information management may cause auditory hallucinations&#46; These lesions may result from tumours&#44; infections&#44; trauma&#44; or surgery&#44; among other causes&#44; although they are usually vascular in origin&#46;<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">40</span></a> It was therefore not surprising to find cerebrovascular disease in 5 of the 9 patients with CAH&#46; Three of them had focal lesions potentially responsible for these symptoms whereas the remaining 2 also presented degenerative disease &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Lesions associated with paracusis may appear in a wide range of locations since the auditory pathway is long and includes multiple modulatory circuits&#46; First&#44; the information gathered by the organ of Corti travels to the cochlear nucleus&#46; Some fibres of this pathway then pass through the nuclei of the superior olivary complex&#44; after which the pathway ascends through the lateral lemniscus &#40;mostly along the contralateral structure&#41;&#46; Some axons terminate at the nucleus of the lateral lemniscus and the inferior colliculus&#46; The pathway continues towards the medial geniculate nucleus&#44; where it sends projections to the first temporal gyrus and subsequently to the associative areas&#46; Regarding the modulatory aspect of this pathway&#44; its peripheral fragment contains an olivocochlear bundle that protects against damage caused by excessive noise and mediates selective attention&#46; Alterations in the peripheral afferent section cause ipsilateral hearing loss for certain frequencies&#59; by a phenomenon of homeostatic plasticity&#44; they also induce reactive hyperactivity in intact neurons of the cochlear nucleus which is transmitted to the brain and may cause unilateral tinnitus&#46;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">41</span></a> Furthermore&#44; somatosensory afferences from the head and upper cervical region converge in the dorsal cochlear nucleus&#59; the inputs are necessary to locate sound with respect to the position of the head&#46; Both partial deafferentation of the auditory nerve fibres and excessive somatosensory stimulation of the head or neck may cause tinnitus &#40;even in cases of normal auditory function&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">1&#44;41</span></a> If alterations are mild&#44; tinnitus appears when both factors co-occur&#46; Tinnitus may also appear in patients with normal hearing due to dysfunctions of the outer hair cells as a result of excessive &#8216;otoacoustic emissions&#8217; that surpass the compensatory capacity of the olivocochlear system&#46;<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">42</span></a> This cause is responsible for less than 10&#37; of all cases of tinnitus and generally appears in association with other causes&#46; In summary&#44; hypoacusis promotes tinnitus&#44; but it is not a necessary or sufficient condition for the development of this disorder&#46; In our sample&#44; nearly one fourth of all patients with tinnitus also had hypoacusis &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The section of the auditory pathway running through the brain contains several modulatory tracts&#46; Multiple fibres run from the auditory cortex to the medial geniculate nucleus&#44; the inferior colliculus&#44; and other nuclei in the thalamus&#46; Other neurons reach the cochlear nucleus from the inferior colliculus and the lateral lemniscus&#46; The reticular formation manages bidirectional communication between the cochlear nucleus and the thalamus&#46; These circuits are in turn influenced by other regions &#40;prefrontal and parietal cortex&#44; cingulate&#44; insula&#44; parahippocampus&#44; amygdala&#44; basal nuclei&#44; and cerebellum&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">2&#44;43&#44;44</span></a> Hypofunction of the auditory pathway or the ascending reticular formation leads to thalamocortical dysrhythmia<a class="elsevierStyleCrossRefs" href="#bib0525"><span class="elsevierStyleSup">45&#44;46</span></a>&#59; deafferentation promotes hyperactivity in some cortical areas as a compensatory mechanism&#46; Marked deafferentation may result in release of auditory information stored in mnestic circuits&#46; When no deafferentation occurs&#44; paracusis may be mediated not by thalamocortical dysrhythmia&#44; but rather by deficiencies in descending modulatory circuits&#46; In many cases&#44; both mechanisms are involved&#46; Paracusis secondary to alterations rostral to the cochlear nucleus may be simple or complex&#44; and bilateral &#40;most frequently&#41; or unilateral&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Lesions causing CAH may be located at any part of the auditory pathway &#40;generally rostral to the cochlear nucleus&#41;&#44; in adjacent areas &#40;affecting modulatory fibres&#41;&#44; and even in other regions linked to the ones mentioned previously due to a mechanism of diaschisis&#46;<a class="elsevierStyleCrossRefs" href="#bib0535"><span class="elsevierStyleSup">47&#8211;50</span></a> The literature includes multiple cases of CAH secondary to lesions to the portion running from the pontine-mesencephalic tegmentum to the thalamus&#44; the thalamus itself&#44; and the area containing fibres which connect the thalamus to the temporal cortex&#46; In other cases&#44; lesions are located in the superior temporal region or adjacent areas &#40;left or right&#41; and have a stimulating effect&#46; On rare occasions&#44; lesions are located in other areas of the connectome that are functionally related to the regions mentioned previously &#40;frontal lobe&#44;<a class="elsevierStyleCrossRefs" href="#bib0555"><span class="elsevierStyleSup">51&#44;52</span></a> parietal lobe&#44;<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">53</span></a> hippocampus&#44;<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">54</span></a> cerebellum<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">55</span></a>&#41;&#46; Five of the 9 patients with CAH displayed focal lesions potentially responsible for the condition &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; In 3 of these cases&#44; lesions were located in the pontine or mesencephalic tegmentum&#46; The literature reports many cases of verbal or musical CAH secondary to lesions to these regions&#46; Symptoms are similar to those associated with peduncular hallucinosis&#44; which is characterised by visual alterations and may also present with tactile or auditory dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">46</span></a><a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a> shows neuroimages taken of a lesion at this location in a patient who had reported hearing fragments of the same songs for several years&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">Another 2 cases of paracusis &#40;known as VAA and SMA&#41; display pathophysiological differences&#46; In the case of VAA&#44; hypoacusis and unilateral tinnitus are secondary to vestibular schwannoma&#46; SMA began to experience CAH after surgical resection of a vestibular schwannoma&#58; postsurgical MR images reveal signal alterations in the adjacent pontine region&#46; In VAA&#44; in addition to hyperactivity of preserved fibres as a reaction to hypoacusis&#44; paracusis may also be due to a transmission phenomenon caused by contact between adjacent compressed fibres&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">1</span></a> In SMA&#44; paracusis had to do with modulatory tracts of the central nervous system stemming from cortical association areas&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">In FMS &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#44; partial seizures and CAH were caused by paroxysmal bioelectrical activity in a temporal cortical area with encephalomalacia surrounded by gliosis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Epileptic activity in the superior temporal gyrus is a well-known cause of CAH&#46;<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">56</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">One of our patients &#40;AVM&#41; displayed a lacunar lesion along the path of the projections running from the pulvinar nuclei and medial geniculate body to the temporal cortex &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; VRC showed a lacunar lesion in the posterior area of the left claustrum&#44; adjacent to the insula&#44; which caused musical CAH &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#44; <a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; According to a meta-analysis&#44; some of the brain areas that activate during CAH include the insulae and the left claustrum&#44;<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">44</span></a> which are connected to auditory cortical areas<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">57</span></a> and involved in processing auditory information&#46;<a class="elsevierStyleCrossRefs" href="#bib0585"><span class="elsevierStyleSup">57&#44;58</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">All 9 cases of CAH displayed more than one known cause of CAH &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; On many occasions&#44; co-presence of 2 or 3 causative factors is necessary to exceed the brain&#39;s ability to adapt&#46; In addition to the condition causing CAH &#40;&#945;-synucleinopathy&#44; AD&#44; or a focal lesion in a risk area for paracusis&#41;&#44; the 9 patients with CAH displayed hypoacusis or were taking drugs potentially predisposing them to paracusis &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46; All patients were taking multiple drugs&#44; which suggests that polymedication may be another risk factor for CAH&#59; further studies with greater sample sizes are necessary to confirm this association&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Paracusis&#44; which is often not reported if doctors do not ask about it specifically&#44; is one of a host of symptoms arising from a number of very different neurological disorders&#46; Many tests and procedures are available for determining the multiple causes of paracusis &#40;audiometry&#44; auditory reflexes&#44; dichotic listening test&#44; auditory brainstem evoked potentials&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0385"><span class="elsevierStyleSup">17&#44;59&#44;60</span></a> However&#44; working conditions in clinical practice force clinicians to use only such tests as are indispensable to determine the aetiology and choose the most appropriate treatment&#46; In any case&#44; brain MRI scans should be performed when patients report CAH or tinnitus without a well-defined peripheral cause&#44; especially in cases of pulsatile tinnitus or paracusis accompanied by focal neurological signs&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Funding</span><p id="par0140" class="elsevierStylePara elsevierViewall">This study has not been presented at any scientific conferences nor has it received funding from any institutions&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflicts of interest</span><p id="par0145" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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    "fechaRecibido" => "2015-12-03"
    "fechaAceptado" => "2015-12-16"
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          "palabras" => array:6 [
            0 => "Paracusia"
            1 => "Auditory hallucinations"
            2 => "Musical hallucinations"
            3 => "Verbal hallucinations"
            4 => "Auditory hallucinosis"
            5 => "Tinnitus"
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          "palabras" => array:6 [
            0 => "Ac&#250;fenos"
            1 => "Alucinaciones auditivas"
            2 => "Alucinaciones musicales"
            3 => "Alucinaciones verbales"
            4 => "Alucinosis auditiva"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Different types and localisations of neurological lesions can produce tinnitus and verbal or musical hallucinations &#40;VMH&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">These symptoms were screened for in 1000 outpatients at a cognitive neurology clinic&#44; and epidemiological and neuroimaging data were recorded&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Tinnitus was present in 6&#46;9&#37; of the total and VMH in 0&#46;9&#37;&#46; The paracusia group was predominantly female but the difference was not statistically significant&#46; Patients with tinnitus were younger and those with VMH were older than the rest of the sample &#40;mean ages&#41;&#46; Hearing loss was more prevalent in the paracusia group &#40;difference was significant in VMH subgroup&#41;&#46; There were no intergroup differences in the prevalence of psychotic and obsessive-compulsive disorders&#44; or of leukoaraiosis&#46; Treatment with acetylsalicylic acid was more frequent in the VMH group&#44; whereas other non-opioid analgesics and benzodiazepines were more commonly prescribed to patients with tinnitus&#46; The suspected cause of VMH was dementia with Lewy bodies &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#44; one with vascular disease&#41;&#44; Alzheimer disease &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#44; one with vascular disease&#41;&#44; isolated cerebrovascular disease &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#41;&#44; traumatic brain injury &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; and surgical brainstem lesion &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#46; All VMH cases displayed an underlying factor that might prompt this symptom&#44; e&#46;g&#46;&#44; hearing loss &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41;&#44; a predisposing drug &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#41;&#44; and polypharmacy &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Treatment with benzodiazepines and non-opioid analgesics was more frequent in the tinnitus group&#44; whereas the VMH group showed a higher prevalence of hearing loss and treatment with acetylsalicylic acid&#46; The causes of VMH were dementia with Lewy bodies&#44; Alzheimer disease&#44; and focal lesions in the mesencephalon&#44; pons&#44; left temporal lobe&#44; or left claustrum&#46;</p></span>"
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            "titulo" => "Method"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introducci&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los tinnitus y las alucinaciones verbales o musicales &#40;AVM&#41; pueden deberse a lesiones neurol&#243;gicas de naturaleza y topograf&#237;a diversa&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se han rastreado estos s&#237;ntomas en 1&#46;000 pacientes de una consulta de neurolog&#237;a cognitiva&#44; anotando datos epidemiol&#243;gicos y de neuroimagen&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Refirieron tinnitus el 6&#44;9&#37; y AVM el 0&#44;9&#37;&#46; Hubo predominio femenino no significativo en el grupo con paracusias&#46; La edad media fue menor en los pacientes con tinnitus y mayor en los que ten&#237;an AVM&#46; La hipoacusia mostr&#243; mayor prevalencia en los enfermos con paracusias &#40;significativo con AVM&#41;&#46; No hubo diferencias en la prevalencia de trastorno psic&#243;tico u obsesivo-compulsivo&#44; o de leucoaraiosis&#46; El tratamiento con &#225;cido acetilsalic&#237;lico mostr&#243; mayor frecuencia en el grupo con AVM&#44; y otros analg&#233;sicos no opioides y benzodiacepinas en los pacientes con tinnitus&#46; La presunta causa de las AVM fue demencia con cuerpos de Lewy &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#44; uno con enfermedad vascular&#41;&#44; enfermedad de Alzheimer &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#44; uno con enfermedad vascular&#41;&#44; enfermedad vascular cerebral pura &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#41;&#44; lesi&#243;n cerebral traum&#225;tica &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41; y lesi&#243;n quir&#250;rgica en el tronco encef&#225;lico &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#46; En los 9 casos hab&#237;a un elemento facilitador de la aparici&#243;n de paracusias&#44; como hipoacusia &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41; o medicaci&#243;n de riesgo &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#41;&#44; adem&#225;s de polifarmacia &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con tinnitus tomaban con frecuencia benzodiacepinas y analg&#233;sicos no opioides&#44; y en los que ten&#237;an AVM hab&#237;a mayor prevalencia de hipoacusia y de tratamiento con &#225;cido acetilsalic&#237;lico&#46; Las causas de AVM fueron demencia con cuerpos de Lewy&#44; enfermedad de Alzheimer y lesiones focales en mesenc&#233;falo&#44; protuberancia&#44; l&#243;bulo temporal izquierdo o claustro izquierdo&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0040">Please cite this article as&#58; Robles Bay&#243;n A&#44; Tirapu de Sagrario MG&#44; Gude Sampedro F&#46; Alucinaciones auditivas en neurolog&#237;a cognitiva&#46; Neurolog&#237;a&#46; 2017&#59;32&#58;345&#8211;354&#46;</p>"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">81-year-old woman with hypoacusis&#44; diabetes&#44; and dyslipidaemia who began to experience verbal and musical complex auditory hallucinations at the age of 78&#46; The examination revealed upward gaze palsy&#46; An MRI scan showed a lesion in the anterior part of the lateral lemniscus&#44; at the level of the left pontomesencephalic junction &#40;1 and 2&#58; T2-weighted TSE sequences&#59; 3 and 4&#58; T1-weighted SE sequences&#41;&#46;</p>"
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">MRI scan of a 78-year-old patient with arterial hypertension and presbycusis who at the age of 53 experienced head trauma resulting in coma&#46; When he was 76&#44; he began to experience recurrent paroxysmal episodes of delusions with visual and auditory hallucinations&#46; Neuroimages revealed encephalomalacia surrounded by gliosis in the left temporal area &#40;upper and middle rows&#58; FLAIR sequences&#59; lower row&#58; T1-weighted IR sequences&#41;&#46;</p>"
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">FLAIR MRI sequences from a 57-year-old woman who reported sudden-onset right hypoacusis starting 2 months before the consultation and persisting to date and hearing a sound resembling a waterfall or a river&#46;</p>"
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          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">MR images &#40;left&#58; T1-weighted sequence&#59; right&#58; FLAIR sequence&#41; from a 94-year-old woman with arterial hypertension&#44; a 2-year history of bilateral hypoacusis and tinnitus&#44; and a 9-month history of bilateral musical and verbal hallucinations that were repetitive but did not alter the patient&#39;s behaviour or mood&#46;</p>"
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                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Spontaneous&#44; transient increase in auditory neural activity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pressure on the tympanic membrane &#40;earwax&#44; hair&#44; or liquid&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Compression of the eighth cranial nerve&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Stapedius muscle contractions due to abnormal reinnervation after Bell palsy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Semicircular canal dehiscence&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Otoacoustic emissions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Autoimmune inner ear disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Extreme stress or fatigue&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Perilymph fistula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Herpes zoster oticus &#40;Ramsay Hunt syndrome&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hypoacusis &#40;conductive or sensorineural&#44; acute or chronic&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Idiopathic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Brain lesion affecting circuits involved in auditory information processing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Focal brainstem lesions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Palatal myoclonus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Otosclerosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Postinfectious&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Medication &#40;including drug withdrawal&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Meniere disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pulsatile tinnitus secondary to prolonged systolic time due to anaemia&#44; hyperthyroidism&#44; or aortic stenosis&#59; carotid artery dissection&#44; stenosis&#44; or fibromuscular dysplasia&#59; dural arteriovenous fistula&#59; carotid-cavernous sinus fistula&#59; dehiscent jugular bulb&#59; glomus jugulare tumour&#59; benign intracranial hypertension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Somatic disorders affecting the head and upper cervical region &#40;Costen syndrome&#44; whiplash injury&#44; etc&#46;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Acute acoustic trauma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Head trauma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Patulous Eustachian tube&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cerebellopontine angle tumour&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Disabling positional vertigo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Cisplatin&#44; aminoglycoside antibiotics&#44; loop diuretics&#44; acetylsalicylic acid &#40;at high doses&#41;&#44; quinine&#59; discontinuation of benzodiazepines &#40;due to ending treatment or transitioning to fluoroquinolones&#41;&#46;</p>"
            ]
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Causes of tinnitus&#46;</p>"
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">&#42;</span> Published cases of musical hallucinations&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Disorders associated with hypoacusis as the main manifestation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Otosclerosis<span class="elsevierStyleSup">&#42;</span>&#44; cochlear implant<span class="elsevierStyleSup">&#42;</span>&#44; presbycusis<span class="elsevierStyleSup">&#42;</span>&#44; lesions to the pontine-mesencephalic portion of the auditory pathway<span class="elsevierStyleSup">&#42;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Primary psychiatric disorders&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Schizophrenia<span class="elsevierStyleSup">&#42;</span>&#44; bipolar disorder<span class="elsevierStyleSup">&#42;</span>&#44; obsessive-compulsive disorder<span class="elsevierStyleSup">&#42;</span>&#44; depression<span class="elsevierStyleSup">&#42;</span>&#44; anorexia nervosa&#44; conversion disorder&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Disorders linked to detectable focal lesions in the central nervous system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Vascular lesions &#40;stroke<span class="elsevierStyleSup">&#42;</span>&#44; intraparenchymal haemorrhage<span class="elsevierStyleSup">&#42;</span>&#44; subarachnoid haemorrhage<span class="elsevierStyleSup">&#42;</span>&#44; vascular malformations<span class="elsevierStyleSup">&#42;</span>&#44; cerebral venous sinus thrombosis&#41;&#44; neoplasia &#40;meningioma<span class="elsevierStyleSup">&#42;</span>&#44; glioma<span class="elsevierStyleSup">&#42;</span>&#44; metastasis<span class="elsevierStyleSup">&#42;</span>&#44; lipoma&#41;&#44; radiotherapy<span class="elsevierStyleSup">&#42;</span>&#44; epilepsy<span class="elsevierStyleSup">&#42;</span><a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a> &#40;especially when the epileptogenic area is located in the right temporal lobe&#41;&#44; electroconvulsive therapy<span class="elsevierStyleSup">&#42;</span>&#44; lobectomy for epilepsy<span class="elsevierStyleSup">&#42;</span>&#44; abscesses<span class="elsevierStyleSup">&#42;</span>&#44; viral encephalitis<span class="elsevierStyleSup">&#42;</span>&#44; autoimmune limbic encephalitis&#44; rhombencephalitis due to <span class="elsevierStyleItalic">Listeria</span><span class="elsevierStyleSup">&#42;</span>&#44; multiple sclerosis&#44; migraine attacks &#40;with and without aura&#41;<span class="elsevierStyleSup">&#42;</span>&#44; basal ganglia calcification<span class="elsevierStyleSup">&#42;</span>&#44; schizencephaly&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neurological disorders with no apparent focal signs affecting the auditory pathway&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hallucinosis secondary to head trauma<span class="elsevierStyleSup">&#42;</span>&#44; Hashimoto encephalopathy<span class="elsevierStyleSup">&#42;</span>&#44; Lyme disease<span class="elsevierStyleSup">&#42;</span>&#44; encephalitis due to virus or <span class="elsevierStyleItalic">Taenia solium</span> infection&#44; neurosyphilis&#59; &#945;-synucleinopathies &#40;multiple system atrophy&#44; Lewy body dementia&#44; Parkinson&#39;s disease<span class="elsevierStyleSup">&#42;</span>&#41;&#44; Alzheimer disease<span class="elsevierStyleSup">&#42;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Effect of substances&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alcoholic hallucinosis<span class="elsevierStyleSup">&#42;</span>&#44; other substances<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Idiopathic<span class="elsevierStyleSup">&#42;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              "identificador" => "tblfn0010"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Many patients with concomitant entities and displaying focal lesions also experience seizures&#46;</p>"
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            1 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Amantadine<span class="elsevierStyleSup">&#42;</span>&#44; tricyclic antidepressants<span class="elsevierStyleSup">&#42;</span>&#44; antimalarial drugs &#40;quinine&#44; chloroquine&#44; mefloquine&#41;&#44; baclofen &#40;sudden withdrawal&#41;&#44; benzodiazepines<span class="elsevierStyleSup">&#42;</span> &#40;and benzodiazepine discontinuation&#41;&#44; biphosphonates&#44; cocaine&#44; corticosteroids<span class="elsevierStyleSup">&#42;</span>&#44; bromocriptine<span class="elsevierStyleSup">&#42;</span>&#44; digoxin&#44; dipyridamole<span class="elsevierStyleSup">&#42;</span>&#44; gentamicin<span class="elsevierStyleSup">&#42;</span>&#44; selective serotonin reuptake inhibitors&#44; ketamine&#44; marijuana&#44; mirtazapine<span class="elsevierStyleSup">&#42;</span>&#44; opioids<span class="elsevierStyleSup">&#42;</span>&#44; pentoxifylline<span class="elsevierStyleSup">&#42;</span>&#44; psychostimulants &#40;cocaine&#44; amphetamines&#44; methylphenidate&#41;&#44; pramipexole<span class="elsevierStyleSup">&#42;</span>&#44; prazosin&#44; propranolol<span class="elsevierStyleSup">&#42;</span>&#44; ranitidine&#44; salicylates<span class="elsevierStyleSup">&#42;</span>&#44; topiramate&#44; trimethoprim&#47;sulfamethoxazole&#44; voriconazole<span class="elsevierStyleSup">&#42;</span>&#46;</p>"
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          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Causes of complex auditory hallucinations according to the literature&#46;</p>"
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          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">CAH&#58; complex auditory hallucinations&#59; ASA&#58; acetylsalicylic acid&#59; NOA&#58; non-opioid analgesics&#59; BZD&#58; benzodiazepines&#59; SD&#58; standard deviation&#59; LWM&#58; moderate to severe leukoaraiosis or multiple lacunar lesions in white matter&#59; <span class="elsevierStyleSup">ns</span>&#58; non-significant differences between patients with the condition analysed in that row and those without &#40;marked in left column&#41;&#59; PSchiz&#58; patients with schizophrenia&#44; bipolar disorder&#44; or obsessive-compulsive disorder&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&#44; &#37; women<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mean age<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Hypoacusis&#44; &#37;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">LWM&#44; &#37;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PSchiz&#44; &#37;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">b</span></a>&#44; &#37;<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">No paracusis &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>924&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">61&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">74&#46;0 &#40;13&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ASA &#40;26&#46;5&#41;<br>NOA &#40;7&#46;4&#41;<br>BZD &#40;37&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Paracusis &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&#46;1<span class="elsevierStyleSup">ns</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">68&#46;0 &#40;16&#46;0&#41;<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&#46;3<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;6<span class="elsevierStyleSup">ns</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;3<span class="elsevierStyleSup">ns</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NOA &#40;18&#46;4<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">&#42;&#42;</span></a>&#41;<br>BZD &#40;50&#46;0<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">&#42;</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tinnitus &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">69&#46;6<span class="elsevierStyleSup">ns</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#46;4 &#40;15&#46;9&#41;<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">&#42;&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#46;2<span class="elsevierStyleSup">ns</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;8<span class="elsevierStyleSup">ns</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;4<span class="elsevierStyleSup">ns</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NOA &#40;18&#46;8<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">&#42;&#42;</span></a>&#41;<br>BZD &#40;52&#46;2<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">&#42;</span></a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CAH &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#41;&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">ASA&#58; acetylsalicylic acid&#59; NOA&#58; non-opioid analgesics&#59; OA&#58; opioid analgesics&#59; BZD&#58; benzodiazepines&#59; W&#58; woman&#59; M&#58; man&#59; AI&#58; active ingredients&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Focal lesion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Other data&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BLM&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sees people and hears voices&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lewy body dementia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 AI&#46; L-dopa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CMC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">W-81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Always hears the same 2 songs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cerebrovascular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Infarct in the pontine-mesencephalic region bilaterally&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoacusis&#46; 8 AI&#46; ASA and BZD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CAM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">W-85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Unspecified visual and auditory hallucinations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cerebrovascular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lacunar lesions in the centrum ovale and pons&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Leukoaraiosis&#46; 11 AI&#46; ASA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CRM&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hears television&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alzheimer disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoacusis&#46; 10 AI&#46; ASA&#44; BZD&#44; NOA&#44; and OA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FMS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hears people talking&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Encephalopathy secondary to head trauma associated with complex partial seizures&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cortico-subcortical encephalomalacia in the left temporal lobe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoacusis&#46; Leukoaraiosis&#46; 12 AI&#46; ASA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">GPM&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sees people and hears voices&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lewy body dementia&#44; cerebrovascular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Leukoaraiosis&#46; 5 AI&#46; ASA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">RGD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">W-91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sees people and hears voices&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Alzheimer disease&#44; cerebrovascular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoacusis&#46; 7 AI&#46; ASA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">SMA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">W-76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hears songs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Systemic lupus erythematosus&#44; surgical lesion to the brainstem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Surgical malacic lesion in the left side of the pons&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoacusis&#46; 6 AI&#46; BZD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">VRC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">W-94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hears voices and a gramophone playing music&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cerebrovascular lesion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Lacunar infarction in left claustrum&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoacusis&#46; 5 AI&#46; BZD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Patients with complex auditory hallucinations&#46;</p>"
        ]
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      "seccion" => array:1 [
        0 => array:2 [
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              "identificador" => "bib0310"
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                      "autores" => array:1 [
                        0 => array:2 [
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                            1 => "C&#46;A&#46; Tham"
                            2 => "V&#46;D&#46; D&#39;Souza"
                            3 => "S&#46;W&#46; Teng"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
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                        "fecha" => "2013"
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                  "contribucion" => array:1 [
                    0 => array:2 [
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                            0 => "F&#46; Waters"
                            1 => "P&#46; Allen"
                            2 => "A&#46; Aleman"
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                            4 => "T&#46;S&#46; Woodward"
                            5 => "J&#46;C&#46; Badcock"
                          ]
                        ]
                      ]
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                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                      "Revista" => array:6 [
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                        "fecha" => "2012"
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                        0 => array:2 [
                          "etal" => false
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                            1 => "M&#46; van Zandvoort"
                            2 => "F&#46; Bootsman"
                            3 => "M&#46; Boks"
                            4 => "R&#46; Kahn"
                            5 => "I&#46; Sommer"
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                  ]
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Article information

ISSN: 21735808
Original language: English

DOI:10.1016/j.nrleng.2015.12.008

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Year/Month	Html	Pdf	Total

2024 November	4	1	5
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2024 August	74	5	79
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2020 October	42	7	49
2020 September	37	21	58
2020 August	43	5	48
2020 July	33	12	45
2020 June	32	23	55
2020 May	52	16	68
2020 April	76	5	81
2020 March	50	5	55
2020 February	36	16	52
2020 January	30	16	46
2019 December	49	14	63
2019 November	25	10	35
2019 October	23	10	33
2019 September	33	9	42
2019 August	29	9	38
2019 July	24	7	31
2019 June	89	22	111
2019 May	146	27	173
2019 April	84	12	96
2019 March	23	7	30
2019 February	30	7	37
2019 January	14	2	16
2018 December	19	2	21
2018 November	19	4	23
2018 October	42	7	49
2018 September	42	6	48
2018 August	19	5	24
2018 July	28	6	34
2018 June	26	6	32
2018 May	33	8	41
2018 April	33	6	39
2018 March	21	3	24
2018 February	13	3	16
2018 January	17	6	23
2017 December	19	5	24
2017 November	37	2	39
2017 October	27	8	35
2017 September	24	8	32
2017 August	26	2	28
2017 July	23	7	30
2017 June	0	11	11
2017 May	1	2	3

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