Aim: Aim of the study was to compare total magnesium serum concentration between subjects with increased fat mass in the body composition and subjects with normal body composition as to determine the association between total magnesium serum level and parameters of the body composition and glucose metabolism.
Introduction: Metabolic disorders and chronic diseases may associate alterations in body composition and could be related with disturbances of the magnesium blood level. Obesity is a chronic disease characterized by disturbances of the body composition, commonly associated with disorders of carbohydrate metabolism.
Methods: The study included 40 women with body composition disturbances (increased percentage of the total fat mass) and 20 age matched women with normal percentage of the total fat mass. All subjects underwent analysis of the components of body composition [bioelectrical impedance analysis, fat mass percentage (FAT%), fat free mass percentage (FFM%)], laboratory analysis of blood samples (automated analyzer systems) with determining the parameters of glucose metabolism and total magnesium serum concentration. Insulin resistance index (HOMA-IR) was calculated using equation involving fasting insulin and glucose concentration.
Results: Women with increased percentage of the total fat mass had signifficantly lower total magnesium serum concentration comapared to control group (0.83±0.07 vs. 0.9±0.06mmol/l, p=0.00). Moderate correlation was found between serum concentrations of total magnesium and FAT% (r=−0.47, p=0.00), FFM% (r=0.44, p=0.00), fasting insulin levels (r=−0.43, p=0.00) and HOMA-IR (r=−0.44, p=0.00).
Conclusion: Women with increased total fat mass in the body composition have significantly lower total magnesium serum concentration, compared to women with normal body composition. Additionally to increased fat mass, insulin resistance is associated with total magnesium level in middle aged women.