Hiperhomocisteinemia y preeclampsia | Progresos de Obstetricia y Ginecología

Article information

Resumen

Objetivo

Comparar las concentraciones plasmáticas de homocisteína en gestantes con preeclampsia con respecto a un grupo control de gestantes sanas durante el tercer trimestre de gestación, así como determinar la prevalencia de hiperhomocisteinemia entre ambos grupos

Sujetos y métodos

Estudio transversal de 100 gestantes durante el tercer trimestre de gestación (50 con preeclampsia y 50 gestantes sanas) en el Servicio de Obstetricia del Hopital La Paz entre enero y diciembre de 1999

Resultados

Las concentraciones de homocisteína plasmática están significativamente elevadas en las pacientes con preeclampsia con respecto a las gestantes normales (media ± desviación estándar [DE], 12,1 ± 4,2; intervalo de confianza [IC] del 95%, 11,7–12,9 frente a 5,9 ± 2,4; IC del 95%, 5,1–7,4 μmol/l; p = 0,01). La prevalencia de hiperhomocisteinemia (homocisteína > 8,3 μmol/l) es mayor en gestantes con preeclampsia respecto al grupo control (el 78 frente al 18%; p = 0,03)

Conclusiones

Las concentraciones plasmáticas de homocisteína están elevadas significativamente en gestantes con preeclampsia en comparación con gestantes sanas durante el tercer trimestre de gestación. La prevalencia de hiperhomocisteinemia es significativamente mayor en pacientes con preeclampsia respecto al grupo control

Palabras clave:

Homocisteína

Hiperhomocisteinemia

Preeclampsia

Gestación

Summary

Objective

To compare plasma concentrations of homocysteine in pregnant women with preeclampsia with those in a group of healthy pregnant women during the third trimester of pregnancy and to determine the prevalence of hyperhomocystinemia in both groups

Subjects and methods

Cross sectional study of 100 pregnant women during the third trimester of pregnancy (50 with preeclampsia and 50 with normal pregnancy) in the Department of Obstetrics of Hospital La Paz between January and December 1999

Results

Plasma concentrations of homocysteine were significantly higher in patients with preeclampsia than in non-preeclamptic women (mean ± SD: 12.1 ± 4.2; 95% CI: 11.7–12.9 vs 5.9 ± 2.4; 95% CI: 5.1–7.4 μmol/l; p = 0.01). The prevalence of hyperhomocystinemia (homocysteine > 8.3 μmol/l) was also higher in preeclamptic women than in non-preeclamptic women (78% vs 18%; p = 0.03)

Conclusions

Plasma concentrations of homocysteine were significantly higher in pregnant women with preeclampsia than in non-preeclamptic pregnant women in the third trimester of pregnancy. The prevalence of hyperhomocystinemia was significantly higher in preeclamptic pregnant women than in non-preeclamptic women

Key words:

Homocysteine

Hyperhomocystinemia

Preeclampsia

Pregnancy

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