Human papillomavirus detection in Corrientes, Argentina: High prevalence of type 58 and its phylodynamics

array:24 ["pii" => "S0325754115001194" "issn" => "03257541" "doi" => "10.1016/j.ram.2015.09.001" "estado" => "S300" "fechaPublicacion" => "2015-10-01" "aid" => "59" "copyright" => "Asociación Argentina de Microbiología" "copyrightAnyo" => "2015" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Argent Microbiol. 2015;47:302-11" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1712 "formatos" => array:3 [ "EPUB" => 39 "HTML" => 1275 "PDF" => 398 ] ] "itemSiguiente" => array:19 [ "pii" => "S0325754115001212" "issn" => "03257541" "doi" => "10.1016/j.ram.2015.09.002" "estado" => "S300" "fechaPublicacion" => "2015-10-01" "aid" => "61" "copyright" => "Asociación Argentina de Microbiología" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Argent Microbiol. 2015;47:312-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1875 "formatos" => array:3 [ "EPUB" => 29 "HTML" => 1226 "PDF" => 620 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "ORIGINAL" "titulo" => "Evidencia serológica de circulación del virus de la encefalitis de San Luis en aves de la Ciudad Autónoma de Buenos Aires, Argentina" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "312" "paginaFinal" => "316" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Serological evidence of St. Louis encephalitis virus circulation in birds from Buenos Aires City, Argentina" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2730 "Ancho" => 2705 "Tamanyo" => 540081 ] ] "descripcion" => array:1 [ "es" => "Distribución espacial de las aves seropositivas para SLEV." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Fernando J. Beltrán, Luis A. Díaz, Brenda Konigheim, José Molina, Juan B. Beaudoin, Marta Contigiani, Lorena I. Spinsanti" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Fernando J." "apellidos" => "Beltrán" ] 1 => array:2 [ "nombre" => "Luis A." "apellidos" => "Díaz" ] 2 => array:2 [ "nombre" => "Brenda" "apellidos" => "Konigheim" ] 3 => array:2 [ "nombre" => "José" "apellidos" => "Molina" ] 4 => array:2 [ "nombre" => "Juan B." "apellidos" => "Beaudoin" ] 5 => array:2 [ "nombre" => "Marta" "apellidos" => "Contigiani" ] 6 => array:2 [ "nombre" => "Lorena I." "apellidos" => "Spinsanti" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0325754115001212?idApp=UINPBA00004N" "url" => "/03257541/0000004700000004/v2_201602050024/S0325754115001212/v2_201602050024/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0325754115000929" "issn" => "03257541" "doi" => "10.1016/j.ram.2015.07.002" "estado" => "S300" "fechaPublicacion" => "2015-10-01" "aid" => "51" "copyright" => "Asociación Argentina de Microbiología" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Argent Microbiol. 2015;47:295-301" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1678 "formatos" => array:3 [ "EPUB" => 51 "HTML" => 1083 "PDF" => 544 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Evaluation and comparison of serological methods for the detection of bovine neosporosis in Argentina" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "295" "paginaFinal" => "301" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Evaluación y comparación de pruebas serológicas para la detección de la neosporosis bovina en Argentina" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1254 "Ancho" => 1608 "Tamanyo" => 103743 ] ] "descripcion" => array:1 [ "en" => "Time course of antibody response in EI heifers (mean) determined by IFAT and p38-ELISA. Each data point represents the mean value and error bars represent standard deviations of mean (SEM)." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lucía M. Campero, Lieselotte Minke, Gastón Moré, Magdalena Rambeaud, Diana Bacigalupe, Dadin P. Moore, Yanina Hecker, Carlos M. Campero, Gereon Schares, María C. Venturini" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Lucía M." "apellidos" => "Campero" ] 1 => array:2 [ "nombre" => "Lieselotte" "apellidos" => "Minke" ] 2 => array:2 [ "nombre" => "Gastón" "apellidos" => "Moré" ] 3 => array:2 [ "nombre" => "Magdalena" "apellidos" => "Rambeaud" ] 4 => array:2 [ "nombre" => "Diana" "apellidos" => "Bacigalupe" ] 5 => array:2 [ "nombre" => "Dadin P." "apellidos" => "Moore" ] 6 => array:2 [ "nombre" => "Yanina" "apellidos" => "Hecker" ] 7 => array:2 [ "nombre" => "Carlos M." "apellidos" => "Campero" ] 8 => array:2 [ "nombre" => "Gereon" "apellidos" => "Schares" ] 9 => array:2 [ "nombre" => "María C." "apellidos" => "Venturini" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0325754115000929?idApp=UINPBA00004N" "url" => "/03257541/0000004700000004/v2_201602050024/S0325754115000929/v2_201602050024/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Human papillomavirus detection in Corrientes, Argentina: High prevalence of type 58 and its phylodynamics" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "302" "paginaFinal" => "311" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Héctor M. Marín, Carolina Torres, Gerardo D. Deluca, Viviana A. Mbayed" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Héctor M." "apellidos" => "Marín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Carolina" "apellidos" => "Torres" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "Gerardo D." "apellidos" => "Deluca" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 3 => array:4 [ "nombre" => "Viviana A." "apellidos" => "Mbayed" "email" => array:1 [ 0 => "vmbayed@ffyb.uba.ar" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Instituto de Medicina Regional, Universidad Nacional del Nordeste, Av Las Heras 727, Resistencia 3500, Chaco, Argentina" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 4° piso, Ciudad Autónoma de Buenos Aires 1113, Argentina" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "CONICET, Av. Rivadavia 1917, Ciudad Autónoma de Buenos Aires 1033, Argentina" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Detección del virus del papiloma humano en Corrientes, Argentina: alta prevalencia de genotipo 58 y su filodinámica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 3967 "Ancho" => 2800 "Tamanyo" => 390639 ] ] "descripcion" => array:1 [ "en" => "Maximum Clade Credibility Tree for the Alpha-9 species group (a) and for HPV type 58 (b) obtained with a substitution rate of 1×10−7s/s/y. The time to the most recent common ancestor (median and HPD95%) and posterior probability values for relevant groups are shown at nodes." ] ] ] "textoCompleto" => "IntroductionThe surveillance of Human papillomavirus (HPV) infection is epidemiologically relevant considering the incorporation of HPV prophylactic vaccines in different countries. In Argentina, where its general prevalence in 2010 was estimated in 20.1%<a class="elsevierStyleCrossRef" href="#bib0540">54</a>, vaccination was introduced into the immunization schedule for females aged 11 years in 2011<a class="elsevierStyleCrossRef" href="#bib0455">37</a>.Among the over 150 HPV types described, HPV-16 predominates, whereas the prevalence of other HPV types varies according to the geographic region<a class="elsevierStyleCrossRef" href="#bib0295">5</a>. It has been reported that about 70% of cervical cancers worldwide are due to HPV-16 and -18<a class="elsevierStyleCrossRefs" href="#bib0370">20,32</a>, which are the goals of commercial vaccines. However, there are still other prevalent high-risk HPV types, such as HPV-31, -33, -45 and -58<a class="elsevierStyleCrossRef" href="#bib0535">53</a>. In some provinces of Argentina (Chaco, Corrientes, Córdoba and Misiones), an important detection of HPV-33 and HPV-58 has been reported<a class="elsevierStyleCrossRefs" href="#bib0280">2,17,22,23,51</a>.Although there have been several studies on the genetic diversity and phylogenetics of HPV<a class="elsevierStyleCrossRefs" href="#bib0290">4,14,19,21,42</a>, most of them focused on the characterization of HPV-16 and HPV-18 variants and their associations with pathogenic potential and immunogenicity<a class="elsevierStyleCrossRefs" href="#bib0360">18,19</a>.Within HPV-58, several authors have identified four distinct clusters (A, B, C and D), being lineage A the most prevalent worldwide<a class="elsevierStyleCrossRefs" href="#bib0340">14,19</a>. Reports about the important detections of this high-risk type in regions of Argentina such as the Northeast<a class="elsevierStyleCrossRefs" href="#bib0380">22,23,25</a>, which has the highest mortality rates due to cervical cancer<a class="elsevierStyleCrossRef" href="#bib0275">1</a>, require a deeper characterization of viruses of HPV-58.The aim of this work was to study HPV sequences from the Province of Corrientes, Argentina, especially those belonging to HPV-58. We attempted to characterize the viruses from samples taken from different cervical lesions, their nucleotide changes, phylogenetic relationships and the evolutionary dynamics of HPV-58 in the context of the alpha-9 papillomavirus species.Materials and methodsPatientsSamples belonged to sexually active women who attended the Services of Gynecology and Obstetrics at hospitals “Angela Iglesia Llano” and “José Ramón Vidal” in the city of Corrientes, Province of Corrientes, Argentina, during 2005–2007 (n=255), and who had colposcopic or cytohistologic findings suggestive of HPV infection (according to the Bethesda System 2001). Epidemiological data were collected through a standardized questionnaire.All patients included in this study signed a written informed consent and the study was approved by the Ethics Committee of the Instituto de Medicina Regional of the Universidad Nacional del Nordeste, Corrientes, Argentina (Resolution No.: 435/05).Sample collection, HPV detection and typingEcto- and endocervical samples were obtained and DNA was extracted by the digestion method with cetyltrimethyl ammonium bromide (CTAB) and purification with isoamyl alcohol (24:1). DNA quality was evaluated by PCR targeted to 268 base pairs (bp) of the human beta-globin gene using primers GH20 (5′-GAAGAGCCAAGGACAGGTAC-3′) and PG04 (5′-CAACTTCATCCACGTTCACC-3′) under conditions previously described<a class="elsevierStyleCrossRef" href="#bib0445">35</a>. Negative samples for this test were discarded. Viral DNA was detected by PCR using consensus primers MY09/11<a class="elsevierStyleCrossRef" href="#bib0445">35</a>. Positive samples were typed by RFLP analysis, as previously described<a class="elsevierStyleCrossRefs" href="#bib0285">3,40</a>.E6/E7 gene amplification and sequencingSeventeen samples typified as HPV-58 were amplified and sequenced in the E6 (nt. 110–559) and E7 (nt. 574–870) genes. They were amplified by PCR using primers E6-P1/E6-P2 and E7-P1/E7-P2 as previously described<a class="elsevierStyleCrossRef" href="#bib0330">12</a>. Amplicons were purified using the Wizard SV gel and PCR Clean-up System extraction kits (Promega Corporation, USA) and sequenced in both directions (3500xl Genetic Analyzer, Applied Biosystems).Statistical analysisStatistical associations were evaluated with the chi-square test using the Epi-Info v3.5.1 program<a class="elsevierStyleCrossRef" href="#bib0310">8</a>. Logistic regression analyses were used to determine the odd ratios for HPV detection or high-risk HPV detection according to the cytological status of infections, using the Infostat v2004 program<a class="elsevierStyleCrossRef" href="#bib0400">26</a>. p-values≤0.05 were considered significant.Mutations and phylogenetic analysis of HPV-58Sequences from this work (n=17) were aligned with ClustalX v2.1 and edited with Bioedit v7.0. Mutations in the E6 and E7 genes were determined by comparison with the prototype genome of HPV-58 (GenBank accession number: <a id="intr0010" class="elsevierStyleInterRef" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=nucleotide&doptcmdl=genbank&term=NC_001443">NC_001443</a>).To classify sequences into HPV-58 lineages, a Bayesian phylogenetic analysis was performed using E6 and E7 concatenated sequences. Analysis was performed using an appropriate substitution model estimated with the jModeltest v2.1 software, the uncorrelated lognormal (UCLN) molecular clock model and a Bayesian Skyline Plot model implemented in BEAST v1.8. The Maximum Clade Credibility Tree (MCCT) was obtained using TreeAnnotator v1.8 from the BEAST package.Phylodynamic analysesThe phylodynamic patterns of the HPV type 58 and the alpha-9 species group of the genus Alphapapillomavirus (HPV types 16, 31, 33, 35, 52, 58 and 67) were studied using a Bayesian coalescent analysis. Estimations included the demographic reconstruction and the time to the most recent common ancestors (tMRCAs) for the different groups.Datasets included sequences from all groups of each type (dataset HPV-58: 154 sequences; dataset HPV-Alpha-9: 221 sequences) (available upon request). Analyses were performed on the E6 and E7 genes, using an appropriate substitution model and calibration for each gene. Analyses were carried out using the UCLN molecular clock model and the Skygrid model implemented in BEAST v1.8. A substitution rate of 1.0×10−7substitutions per site per year (s/s/y)<a class="elsevierStyleCrossRef" href="#bib0415">29</a> or previously proposed substitution rates for the E6 and E7 genes (2.39×10−8 and 1.44×10−8(s/s/y), respectively) were used for calibration<a class="elsevierStyleCrossRef" href="#bib0475">41</a>. The uncertainty in parameter estimates was evaluated in the 95% highest posterior density (HPD95%) interval.GenBank accession numbersSequences reported in this work have been deposited in GenBank under accession numbers KP161621 and KP161654.ResultsHPV detection and typingA total of 255 samples belonging to women with a median age of 29 years (range=15–62) and mode of 25 years (confidence interval 95%=16–34) were collected for this study. These samples were classified as having reactive cellular changes caused by inflammation (RCC; n=63, 24.7%), atypical squamous cells of undetermined significance (ASCUS; n=11, 4.3%), low-grade squamous intraepithelial lesions (LSIL; n=152, 59.6%), high-grade squamous intraepithelial lesions (HSIL; n=18, 7.1%) and cervical cancer (n=11, 4.3%).HPV DNA was detected in 56.1% of the cervical lesions (143/255). An increased severity of the cytological status was associated with a greater rate of HPV detection and especially, with a greater rate of high-risk HPV types detection (p<0.01) (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Twenty-two different HPV types were detected. The decreasing order of the main types detected, including their presence in multiple infections, were HPV-16, -58, -53, -31, -6 and -18 (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). Multiple infections were detected in 8 samples (3.1%). The frequency of the current vaccine viral types (-16, -18, -6, -11) was 44.8%, while the high-risk and probable high-risk HPV types not included in the vaccine reached 33.6%.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>The most prevalent types -16 and -58 represented 21.4 and 14.3% of the LSIL cases in which HPV was detected, respectively. HPV-58 predominated among the HSIL cases with HPV detection, reaching 37.5%, followed by HPV-16 in the 33.3%. In contrast, HPV-58 was not detected among cervical cancers, while HPV-16 was present in 80% of them.HPV DNA was not found in 43.9% of samples, possibly owing to low viral load or sample degradation, while indeterminate cases (n=3) presented an electrophoretic RFLP pattern that did not match any of the patterns currently taken as reference, according to Bernard et al<a class="elsevierStyleCrossRef" href="#bib0285">3</a>.Analysis of mutations in HPV-58A deeper molecular characterization of the HPV-58, the second most prevalent type in this study, was performed to analyze changes with respect to the prototype virus and to look for mutations previously associated with cervical lesions. Seventeen samples from women (22–33 years) with viruses typed as HPV-58 were sequenced along the E6 and E7 genes.The results showed substitutions in two nucleotide positions in the 450bp of the E6 gene (0.4%) and 11 in the 297bp of the E7 gene (3.7%). The genomes grouped into nine different variants named COR1 to COR9, according to the substitution patterns, compared with the prototype virus (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). Amino acid changes were observed only in the deduced E7 protein sequence.<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>The most frequent mutations were C307T (E6 gene, in 90% of the samples) and G694A (G41R), T744G, and A761G (G63D), found in 100% of the E7 sequences. Other seven mutations (A542C in the E6 gene and G634C, G686A, G691A, C767A, G859A, A866C in the E7 gene) were also found; however, their oncogenic potential has not been described or evaluated yet.Phylogenetic and phylodynamic analysesThe phylogenetic analysis showed that samples from Corrientes city belonged to lineage A, sublineage 2 (A2), according to the proposed intratypic taxonomy of HPV-58<a class="elsevierStyleCrossRefs" href="#bib0340">14,19</a>. Moreover, sequences from Corrientes were intermingled with sequences from all around the world: China, Japan, Taiwan, the USA, Scotland and Costa Rica (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Two substitution rates were used for calibrating the analyses of evolutionary dynamics of the alpha-9 species group and the HPV-58. These alternative hypotheses estimated that the tMRCA for the alpha-9 group originated 20.5 million years (My) ago (HPD95%=16.3–25.8My) or 3.7My (HPD95%=3.0–4.7My) for the slowest and the fastest substitution rates, respectively, whereas, the split up of HPV-58 and its closest cluster, type HPV-33, was dated 8.5My ago (HPD95%=5.4–11.5My) or 1.5My ago (HPD95%=1.0–2.1My). Moreover, type 16 resulted as the most ancient type (∼0.8 or 0.15My), followed by types 58, 33 and 52 (∼0.6 or ∼0.11My) (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>a).<elsevierMultimedia ident="fig0010"></elsevierMultimedia>A deeper analysis on type HPV-58 indicated that its diversification might have started ∼0.54 or 0.11My years ago, while the tMRCA for lineage A was estimated ∼300,000 or ∼65,800 years ago (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>b). Finally, diversification of main groups within the lineage A (sublineages A1–A3) might have started ∼70,000–200,000 or ∼23,900–41,000 years ago (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>b).DiscussionHPV is an important cofactor for cervical neoplasia, and in Argentina it is the most frequent neoplasia (20.9/100,000 women) after mammary cancer (71.2/100,000 women)<a class="elsevierStyleCrossRef" href="#bib0435">33</a>. Provinces in the North and Northeastern regions of the country exhibit the highest rates for cervical cancer mortality<a class="elsevierStyleCrossRef" href="#bib0275">1</a>, e.g. the Province of Corrientes shows a mortality rate due to cervical cancer of 14/100,000 women, which is three-fold higher than the rate for Buenos Aires, the Capital city of the country, and even exceeds the value of the mortality rate due to mammary cancer estimated by screening studies in Corrientes<a class="elsevierStyleCrossRefs" href="#bib0275">1,36</a>.The population under study gathered women with a low socioeconomic status, who are particularly vulnerable to this disease due to reduced access to prevention and control programs.Despite the studies performed in this region, the number of reported cases is still scarce to evaluate the role of high-risk types<a class="elsevierStyleCrossRefs" href="#bib0280">2,22–24,47,48</a>. However, it should be noted that we found a high diversity of oncogenic types, with an increased proportion of high-risk and probable high-risk types not included in the current vaccines. This is of concern since there are reports suggesting a limited cross-protection of the vaccines against non vaccine types<a class="elsevierStyleCrossRefs" href="#bib0485">43,50,53</a>. Therefore, it is necessary to strengthen the monitoring of regional circulation of these types in cases of intraepithelial lesions, contributing to impact assessment of current vaccines against HPV<a class="elsevierStyleCrossRef" href="#bib0540">54</a>.The description of the molecular epidemiology of HPV before the vaccine introduction in 2011 will lead to a better description of the dynamics of the circulation of different genotypes and their variants and also to a better understanding of the relationship between HPV types and cancer in our country, which is useful information for the evaluation of new vaccine formulations. Further studies in post-vaccinal stages will allow to evaluate the dynamics of high-risk HPV types and cross protection among different types<a class="elsevierStyleCrossRefs" href="#bib0320">10,54</a>. It is worth noting that HPV-58 is included in the nonavalent vaccine V503 formulation, which is still under evaluation<a class="elsevierStyleCrossRef" href="#bib0350">16</a>.The most frequently found type in Corrientes was HPV-16, as also observed all around the world in populations both with normal cytology and cervical abnormalities<a class="elsevierStyleCrossRefs" href="#bib0295">5,9,34,46</a>. However, the secondary types vary depending on the geographic region under study. In this work, the most important secondary type was HPV-58, as also observed in other studies in the cities of Corrientes and Resistencia<a class="elsevierStyleCrossRefs" href="#bib0380">22,23</a>. This result differs from the reference meta-analysis conducted by Bruni et al.<a class="elsevierStyleCrossRef" href="#bib0295">5</a> on samples with normal cytology, which showed that HPV-18 was the most important secondary type both globally and in Latin America and the Caribbean. In different regions of the world, and even in other regions of Argentina<a class="elsevierStyleCrossRefs" href="#bib0450">36,39,45</a>, HPV-58 was found to have low frequency (<2%) when samples with different grade of lesions were considered<a class="elsevierStyleCrossRefs" href="#bib0315">9,34,46</a>. However, HPV-58 displays a high prevalence in specific regions of the world, especially in Northeast Asia (4–15%), Mexico (24–28%), Costa Rica (12%) and Brazil (12–14%)<a class="elsevierStyleCrossRefs" href="#bib0305">7,11,28,30,38,52</a>.Four different lineages (A–D) have been identified within HPV-58<a class="elsevierStyleCrossRefs" href="#bib0340">14,19</a>. All the viruses reported in this work belonged to lineage A, sublineage A2, which is the most prevalent in the Americas<a class="elsevierStyleCrossRef" href="#bib0340">14</a>; none of them belonged to lineage D, which was previously reported in some samples from Argentina<a class="elsevierStyleCrossRef" href="#bib0340">14</a>.HPV-58 is considered a high-risk viral type. However, its disease impact shows geographic variation, since cervical cancer and HSIL are more prevalent in Asian women with HPV-58 than in women from other regions<a class="elsevierStyleCrossRef" href="#bib0500">46</a>.The association between pathogenicity and geographic location could be a consequence of specific genetic backgrounds of the host populations but it could also be related to a differential geographic distribution of distinct HPV variants. For other types it has been proposed that different variant lineages might display different pathogenic potentials<a class="elsevierStyleCrossRefs" href="#bib0425">31,44</a>. In line with this fact, subgroups within lineage A of HPV-58, which display a differential distribution worldwide, could be related to different clinical progression.Chan et al.<a class="elsevierStyleCrossRef" href="#bib0340">14</a> proposed to further investigate the possible association of oncogenicity with sublineage A1 of HPV-58 in Asia. Indeed, some mutations in the E7 gene showed a trend of association with the severity of the neoplasia<a class="elsevierStyleCrossRef" href="#bib0330">12</a>. In our work, we found no association between high pathogenicity and HPV-58 infections, neither with the mutations reported as involved in this phenotype; however, it should be noted that only sublineage A2 was detected and that the samples belonged to women under 35 years old, and therefore not included in the age range (35–64 years old) strongly associated with progression to cervical cancer<a class="elsevierStyleCrossRef" href="#bib0430">32</a>.The analysis of genome sequences showed that E7 mutations (the only ones rendering amino acid changes) were more frequent than E6 mutations. Neither mutations previously associated with the severity of neoplasia<a class="elsevierStyleCrossRefs" href="#bib0330">12,15,27</a>, nor cervical cancer associated to HPV-58 were found. However, other mutations not reported previously (such as C767A [T65K] and G859A [A96T]) were found among the samples and deserve further attention given that they localize in a highly reactive epitope among patients with cervical cancer<a class="elsevierStyleCrossRef" href="#bib0335">13</a>. Additional studies in the E6 protein assessing the presence of mutations in the protein binding motifs PDZ might help to study their impact on the low oncogenicity of HPV-58 in this population<a class="elsevierStyleCrossRef" href="#bib0515">49</a>.The evolutionary dynamics of the alpha-9 species group and particularly, of type HPV-58 was analyzed. The alpha-9 species separated into two highly supported groups, one formed by types 16, 31, 35 and, the other, by types 33, 52, 58, 67.Different substitutions rates – needed for phylodynamic analysis calibration – have been proposed for papillomaviruses, such as 1.0×10−7s/s/y (originally proposed for the L1 gene of mucosal HPV)<a class="elsevierStyleCrossRef" href="#bib0415">29</a>, 2.4×10−8 and 1.4×10−8s/s/y (from the Feline papillomavirus (FPV) for E6 and E7 genes, respectively)<a class="elsevierStyleCrossRef" href="#bib0475">41</a>. The use of these rates resulted in different diversification times of the viral types that belong to the alpha-9 species group, including HPV-58. For instance, at type level, the tMRCA of HPV-16, -33, -52 and -58 showed ancestral times within the last million years (∼0.6 to ∼0.8My) using the substitution rates proposed by Rector et al. or about 0.10–0.15My using those proposed by Halpern. Particularly, lineage A within HPV-58 would have diversified ∼65,800 or ∼300,000 years ago (depending on the calibration used), and the common ancestor of sublineages A1–A3 could have been dated ∼40,000 or ∼200,000 years ago, suggesting that their dispersion – even using the fastest substitution rate – accompanied or preceded human migration across the globe<a class="elsevierStyleCrossRef" href="#bib0300">6</a>.This hypothesis could explain the worldwide distribution of sublineage A2, whereas other factors might be involved in the emergence and dispersion of the others groups, as previously proposed<a class="elsevierStyleCrossRef" href="#bib0360">18</a>. Is it worth noting that none of the substitutions rates used to calibrate are proposed for the E6 or E7 genes in HPV, thus these estimations should be taken with caution.Summarizing, this study describes the molecular epidemiology of HPV in a region of Argentina with a high rate for cervical cancer mortality. The secondary type was HPV-58 (after HPV-16), sublineage A2. Although we found no association between this type and high pathogenicity, there are still some concerns about the extent of cross protection of the vaccines against the types not included in their design. In addition, we described genomic variants of HPV-58 and characterized the ancient origin of this type and its diversification, in the context of the alpha-9 papillomavirus species phylodynamics.Ethical disclosuresProtection of human and animal subjectsThe authors declare that no experiments were performed on humans or animals for this investigation.Confidentiality of dataThe authors declare that no patient data appear in this article.Right to privacy and informed consentThe authors must have obtained the informed consent of the patients and/or subjects mentioned in the article. The author for correspondence must be in possession of this document.Conflict of interestThe authors declare that they have no conflicts of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres602669" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec616720" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres602668" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec616719" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Materials and methods" "secciones" => array:7 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Patients" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Sample collection, HPV detection and typing" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "E6/E7 gene amplification and sequencing" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Statistical analysis" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Mutations and phylogenetic analysis of HPV-58" ] 5 => array:2 [ "identificador" => "sec0040" "titulo" => "Phylodynamic analyses" ] 6 => array:2 [ "identificador" => "sec0045" "titulo" => "GenBank accession numbers" ] ] ] 6 => array:3 [ "identificador" => "sec0050" "titulo" => "Results" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0055" "titulo" => "HPV detection and typing" ] 1 => array:2 [ "identificador" => "sec0060" "titulo" => "Analysis of mutations in HPV-58" ] 2 => array:2 [ "identificador" => "sec0065" "titulo" => "Phylogenetic and phylodynamic analyses" ] ] ] 7 => array:2 [ "identificador" => "sec0070" "titulo" => "Discussion" ] 8 => array:3 [ "identificador" => "sec0075" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0080" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0085" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0090" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0095" "titulo" => "Conflict of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-05-21" "fechaAceptado" => "2015-09-09" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec616720" "palabras" => array:5 [ 0 => "HPV-58" 1 => "Argentina" 2 => "E6" 3 => "E7" 4 => "Phylodynamics" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec616719" "palabras" => array:5 [ 0 => "HPV-58" 1 => "Argentina" 2 => "E6" 3 => "E7" 4 => "Filodinámica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Human papillomavirus (HPV) has the highest mortality rate due to cervical cancer in Northeastern Argentina. The aim of this work was to detect and characterize HPV in samples from the Province of Corrientes, Argentina. HPV detection and typing was performed using PCR-RFLP on samples with different cervical lesions (n=255). Seventeen viruses typified as HPV-58 were sequenced (E6 and E7 genes) and mutations were analyzed. HPV DNA was detected in 56.1% of the cervical lesions (143/255). Twenty-two different HPV types were detected. The type most frequently found among the total number of samples and HPV-positive samples was HPV-16 (14.5% and 25.9%, respectively), followed by HPV-58 (8.2%/14.7%, respectively), which is also considered a high-risk viral type. Increased severity of the cytological status was associated with greater rates of HPV detection and, especially, with the detection of greater rates of high-risk types. In addition, the evolutionary dynamics of the alpha-9 species group and HPV-58 was studied. All HPV-58 viruses reported in this work belonged to lineage A, sublineage A2. The phylodynamic analysis indicated that diversification of main groups within lineage A might have accompanied or preceded human migrations across the globe. Given that the most prevalent viruses found belonged to high-risk HPV types, some concerns might arise about the extent of cross protection of the vaccines against the types not included in their design." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "El virus del papiloma humano (Human papillomavirus [HPV]) tiene la mayor tasa de mortalidad por cáncer de cuello uterino en el noreste de Argentina. El objetivo de este trabajo fue detectar y caracterizar el HPV en muestras de la provincia de Corrientes, Argentina. La detección y la tipificación se realizó mediante PCR-RFLP en muestras con diferentes lesiones cervicales (n=255). Se secuenciaron 17 virus tipificados como HPV-58 (genes E6 y E7) y se analizaron sus mutaciones. Además, se estudió la dinámica evolutiva de los virus del grupo alfa-9 y, en particular, del HPV-58. Se detectó ADN viral en el 56,1% de las lesiones cervicales (143/255) y se detectaron 22 tipos del HPV. El tipo encontrado con mayor frecuencia entre el total de muestras y entre las HPV-positivas fue el HPV-16 (14,5%/25,9%, respectivamente), seguido por el HPV-58 (8,2%/14,7%, respectivamente), también considerado como de alto riesgo. El aumento de la gravedad de las lesiones se asoció a mayores tasas de detección del HPV y, en especial, con mayores tasas de detección de tipos de alto riesgo. Todos los HPV-58 encontrados pertenecieron al linaje A, sublinaje A2. El análisis filodinámico indicó que la diversificación de los grupos principales dentro del linaje A podría haber acompañado o precedido las migraciones humanas en todo el mundo. Dado que los virus más prevalentes pertenecieron a los tipos del HPV de alto riesgo, podrían surgir interrogantes sobre el alcance de la protección cruzada de las vacunas contra los tipos no incluidos en su diseño." ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3588 "Ancho" => 2986 "Tamanyo" => 457510 ] ] "descripcion" => array:1 [ "en" => "Bayesian phylogenetic tree of the E6 and E7 sequences of HPV-58. Posterior probability values higher than 0.5 are shown at nodes for relevant groups. Isolates reported in this work are shown in bold. Type HPV-33 was used as outgroup. The country of origin is indicated when available (abbreviated in uppercase). BF, Burkina Faso; CHI, China; CR, Costa Rica; ITA, Italy; RW, Rwanda; TW, Taiwan; ZAM, Zambia." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 3967 "Ancho" => 2800 "Tamanyo" => 390639 ] ] "descripcion" => array:1 [ "en" => "Maximum Clade Credibility Tree for the Alpha-9 species group (a) and for HPV type 58 (b) obtained with a substitution rate of 1×10−7s/s/y. The time to the most recent common ancestor (median and HPD95%) and posterior probability values for relevant groups are shown at nodes." ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cytology<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">n (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HPV positive (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Odd ratio (IC95%)<a class="elsevierStyleCrossRef" href="#tblfn0010">b</a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p-Value \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">High-risk HPV positive (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Odd ratio (IC95%)<a class="elsevierStyleCrossRef" href="#tblfn0015">c</a> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p-Value \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">RCC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">63 (24.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (19.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (7.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ASCUS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (4.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (63.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.4 (1.9–29.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.004 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (18.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.6 (0.4–15.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.298 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">L-SIL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">152 (59.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">98 (64.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.7 (3.8–15.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">60 (39.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.6 (2.9–20.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H-SIL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 (7.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 (88.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">34.0 (6.9–168.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (83.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">58.0 (12.4–270.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (4.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (90.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">42.5 (5.0–364.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (90.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">116.0 (12.2–1100.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top"></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">255 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">143 (56.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">92 (36.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab986748.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "RCC, reactive cellular changes; L-SIL, low-grade squamous intraepithelial lesion; H-SIL, high-grade squamous intraepithelial lesion; CC, cervical cancer." ] 1 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "b" "nota" => "OR for the rates of HPV detection for each cytological status in reference to the RCC status, obtained by a logistic regression analysis." ] 2 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "c" "nota" => "OR for the rates of high-risk HPV types detection for each cytological status with reference to the RCC status, obtained by a logistic regression analysis." ] ] ] "descripcion" => array:1 [ "en" => "Human papillomavirus infections stratified by cytological status" ] ] 3 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Type \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="6" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Number of cases</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">RCC \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">ASCUS \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">LSIL \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HSIL \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">CC \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total (%) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">36 (14.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21 (8.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (5.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (4.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (3.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (3.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (2.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (1.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (1.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (1.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">81 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6+33<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">31+45<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">66+45<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">66+31<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">66+84<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">16+31<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">18+55<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11+61<a class="elsevierStyleCrossRef" href="#tblfn0020">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Indeterminate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (1.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">112 (43.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">152 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">255 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab986747.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "a" "nota" => "Mixed infection." ] ] ] "descripcion" => array:1 [ "en" => "Distribution of types by cytological classification of cases" ] ] 4 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">E6</th><th class="td" title="table-head " colspan="11" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">E7</th><th class="td" title="table-head " align="left" valign="top" scope="col">AA \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col">LSIL (n=11) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col">HSIL (n=6) \t\t\t\t\t\t\n \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">307 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">542 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">634 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">686 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">691 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">694 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">744 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">756 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">761 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">767 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">801 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">859 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">866 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">A* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="middle">COR1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G41RG63D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="middle">COR2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G41RG63D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="middle">COR3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">D21HG41RG63D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="middle">COR4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N40DG41RG63D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="middle">COR5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G41RG63D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="middle">COR6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G41RG63DT65K \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="middle">COR7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G41RG63DA96T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="middle">COR8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G41RG63DD76E \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="middle">COR9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">G38DN40DG41RG63DA96TQ98P \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="middle">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab986749.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0025" "etiqueta" => "a" "nota" => "Nucleotide sequence alignment showing the mutations in variants named COR1 to COR9. AA, amino acid changes. A*, HPV-58 reference genome (accession number <a class="elsevierStyleInterRef" id="intr0005" href="ncbi-n:NC_001443">NC_001443</a>). Underlined letters indicate substitutions that result in an amino acid change." ] ] ] "descripcion" => array:1 [ "en" => "HPV-58 distribution of variants in LSIL and HSIL<a class="elsevierStyleCrossRef" href="#tblfn0025">a</a>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:54 [ 0 => array:3 [ "identificador" => "bib0275" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proyecto para el mejoramiento del Programa Nacional de Prevención de Cáncer de Cuello Uterino en Argentina: informe final: diagnóstico de situación del Programa Nacional y Programas Provinciales" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Arrosi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2008" "editorial" => "Organizacion Panamericana de la Salud" "editorialLocalizacion" => "Buenos Aires" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0280" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus (HPV) detection and Papanicolaou cytology in low-resource women in Posadas city, Misiones, Argentina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "I. Badano" 1 => "R.W. Pedrozo" 2 => "L.S. Ruiz Diaz" 3 => "J.A. Galuppo" 4 => "M.A. Picconi" 5 => "R.H. Campos" 6 => "D.J. Liotta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/S0325-75412011000400005" "Revista" => array:6 [ "tituloSerie" => "Rev Argent Microbiol" "fecha" => "2011" "volumen" => "43" "paginaInicial" => "263" "paginaFinal" => "267" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22274823" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0285" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification and assessment of known and novel human papillomaviruses by polymerase chain reaction amplification, restriction fragment length polymorphisms, nucleotide sequence, and phylogenetic algorithms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "H.U. Bernard" 1 => "S.Y. Chan" 2 => "M.M. Manos" 3 => "C.K. Ong" 4 => "L.L. Villa" 5 => "H. Delius" 6 => "C.L. Peyton" 7 => "H.M. Bauer" 8 => "C.M. Wheeler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1994" "volumen" => "170" "paginaInicial" => "1077" "paginaFinal" => "1085" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7963696" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0290" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.U. Bernard" 1 => "R.D. Burk" 2 => "Z. Chen" 3 => "K. van Doorslaer" 4 => "H. zur Hausen" 5 => "E.M. de Villiers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.virol.2010.02.002" "Revista" => array:6 [ "tituloSerie" => "Virology" "fecha" => "2010" "volumen" => "401" "paginaInicial" => "70" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20206957" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0295" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Bruni" 1 => "M. Diaz" 2 => "X. Castellsague" 3 => "E. Ferrer" 4 => "F.X. Bosch" 5 => "S. de Sanjose" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/657321" "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "2010" "volumen" => "202" "paginaInicial" => "1789" "paginaFinal" => "1799" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21067372" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0300" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.C. Campbell" 1 => "S.A. Tishkoff" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.genom.9.081307.164258" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Genomics Hum Genet" "fecha" => "2008" "volumen" => "9" "paginaInicial" => "403" "paginaFinal" => "433" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18593304" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0305" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High prevalence and low E6 genetic variability of human papillomavirus 58 in women with cervical cancer and precursor lesions in Southeast Mexico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "J.C. Canche" 1 => "I.R. Lopez" 2 => "N.G. Suarez" 3 => "G.C. Acosta" 4 => "L. Conde-Ferraez" 5 => "T.C. Cetina" 6 => "M.R. Losa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Mem Inst Oswaldo Cruz" "fecha" => "2010" "volumen" => "105" "paginaInicial" => "144" "paginaFinal" => "148" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20428672" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109712008741" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0310" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epi-Info v3.5.1" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "CDC" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2008" "editorial" => "Centers for Disease Control and Prevention" "editorialLocalizacion" => "Atlanta, GA" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0315" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.M. Clifford" 1 => "R.K. Rana" 2 => "S. Franceschi" 3 => "J.S. Smith" 4 => "G. Gough" 5 => "J.M. Pimenta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/1055-9965.EPI-04-0812" "Revista" => array:6 [ "tituloSerie" => "Cancer Epidemiol Biomarkers Prev" "fecha" => "2005" "volumen" => "14" "paginaInicial" => "1157" "paginaFinal" => "1164" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15894666" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0320" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global access to HPV vaccination: what are we waiting for" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.M. Clifford" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(09)61789-X" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2009" "volumen" => "374" "paginaInicial" => "1948" "paginaFinal" => "1949" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19962186" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0325" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.K. Chan" 1 => "W.H. Li" 2 => "M.Y. Chan" 3 => "W.L. Ma" 4 => "J.L. Cheung" 5 => "A.F. Cheng" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Med Virol" "fecha" => "1999" "volumen" => "59" "paginaInicial" => "232" "paginaFinal" => "238" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10459162" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0330" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of human papillomavirus type 58 variant with the risk of cervical cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "P.K. Chan" 1 => "C.W. Lam" 2 => "T.H. Cheung" 3 => "W.W. Li" 4 => "K.W. Lo" 5 => "M.Y. Chan" 6 => "J.L. Cheung" 7 => "A.F. Cheng" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2002" "volumen" => "94" "paginaInicial" => "1249" "paginaFinal" => "1253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12189229" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S073510970700633X" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0335" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "T-cell response to human papillomavirus type 58 L1, E6, And E7 peptides in women with cleared infection, cervical intraepithelial neoplasia, or invasive cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "P.K. Chan" 1 => "S.J. Liu" 2 => "T.H. Cheung" 3 => "W. Yeo" 4 => "S.M. Ngai" 5 => "J.L. Cheung" 6 => "P. Chong" 7 => "S. Man" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/CVI.00105-10" "Revista" => array:6 [ "tituloSerie" => "Clin Vaccine Immunol" "fecha" => "2010" "volumen" => "17" "paginaInicial" => "1315" "paginaFinal" => "1321" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20668141" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0340" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of human papillomavirus type 58 lineages and the distribution worldwide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:29 [ 0 => "P.K. Chan" 1 => "A.C. Luk" 2 => "J.S. Park" 3 => "K.K. Smith-McCune" 4 => "J.M. Palefsky" 5 => "R. Konno" 6 => "L. Giovannelli" 7 => "F. Coutlee" 8 => "S. Hibbitts" 9 => "T.Y. Chu" 10 => "W. Settheetham-Ishida" 11 => "M.A. Picconi" 12 => "A. Ferrera" 13 => "F. De Marco" 14 => "Y.L. Woo" 15 => "T. Raiol" 16 => "P. Pina-Sanchez" 17 => "J.L. Cheung" 18 => "J.H. Bae" 19 => "M.Z. Chirenje" 20 => "T. Magure" 21 => "A.B. Moscicki" 22 => "A.N. Fiander" 23 => "R. Di Stefano" 24 => "T.H. Cheung" 25 => "M.M. Yu" 26 => "S.K. Tsui" 27 => "D. Pim" 28 => "L. Banks" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/infdis/jir157" "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "2011" "volumen" => "203" "paginaInicial" => "1565" "paginaFinal" => "1573" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21592985" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0345" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:32 [ 0 => "P.K. Chan" 1 => "C. Zhang" 2 => "J.S. Park" 3 => "K.K. Smith-McCune" 4 => "J.M. Palefsky" 5 => "L. Giovannelli" 6 => "F. Coutlee" 7 => "S. Hibbitts" 8 => "R. Konno" 9 => "W. Settheetham-Ishida" 10 => "T.Y. Chu" 11 => "A. Ferrera" 12 => "M. Alejandra Picconi" 13 => "F. De Marco" 14 => "Y.L. Woo" 15 => "T. Raiol" 16 => "P. Pina-Sanchez" 17 => "J.H. Bae" 18 => "M.C. Wong" 19 => "M.Z. Chirenje" 20 => "T. Magure" 21 => "A.B. Moscicki" 22 => "A.N. Fiander" 23 => "G. Capra" 24 => "E. Young Ki" 25 => "Y. Tan" 26 => "Z. Chen" 27 => "R.D. Burk" 28 => "M.C. Chan" 29 => "T.H. Cheung" 30 => "D. Pim" 31 => "L. Banks" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.27932" "Revista" => array:7 [ "tituloSerie" => "Int J Cancer" "fecha" => "2013" "volumen" => "132" "paginaInicial" => "2528" "paginaFinal" => "2536" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23136059" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1933287414001603" "estado" => "S300" "issn" => "19332874" ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0350" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The next generation of HPV vaccines: nonavalent vaccine V503 on the horizon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Chatterjee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1586/14760584.2014.963561" "Revista" => array:6 [ "tituloSerie" => "Expert Rev Vaccines" "fecha" => "2014" "volumen" => "13" "paginaInicial" => "1279" "paginaFinal" => "1290" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25256262" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0355" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diversifying selection in human papillomavirus type 16 lineages based on complete genome analyses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Z. Chen" 1 => "M. Terai" 2 => "L. Fu" 3 => "R. Herrero" 4 => "R. DeSalle" 5 => "R.D. Burk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/JVI.79.11.7014-7023.2005" "Revista" => array:6 [ "tituloSerie" => "J Virol" "fecha" => "2005" "volumen" => "79" "paginaInicial" => "7014" "paginaFinal" => "7023" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15890941" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0360" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evolutionary dynamics of variant genomes of human papillomavirus types 18, 45, and 97" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Z. Chen" 1 => "R. DeSalle" 2 => "M. Schiffman" 3 => "R. Herrero" 4 => "R.D. Burk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/JVI.02068-08" "Revista" => array:6 [ "tituloSerie" => "J Virol" "fecha" => "2009" "volumen" => "83" "paginaInicial" => "1443" "paginaFinal" => "1455" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19036820" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0365" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evolution and taxonomic classification of alphapapillomavirus 7 complete genomes: HPV18, HPV39, HPV45, HPV59, HPV68 and HPV70" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:10 [ 0 => "Z. Chen" 1 => "M. Schiffman" 2 => "R. Herrero" 3 => "R. DeSalle" 4 => "K. Anastos" 5 => "M. Segondy" 6 => "V.V. Sahasrabuddhe" 7 => "P.E. Gravitt" 8 => "A.W. Hsing" 9 => "R.D. Burk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0072565" "Revista" => array:5 [ "tituloSerie" => "PLoS ONE" "fecha" => "2011" "volumen" => "8" "paginaInicial" => "e72565" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23977318" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0370" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:63 [ 0 => "S. de Sanjose" 1 => "W.G. Quint" 2 => "L. Alemany" 3 => "D.T. Geraets" 4 => "J.E. Klaustermeier" 5 => "B. Lloveras" 6 => "S. Tous" 7 => "A. Felix" 8 => "L.E. Bravo" 9 => "H.R. Shin" 10 => "C.S. Vallejos" 11 => "P.A. de Ruiz" 12 => "M.A. Lima" 13 => "N. Guimera" 14 => "O. Clavero" 15 => "M. Alejo" 16 => "A. Llombart-Bosch" 17 => "C. Cheng-Yang" 18 => "S.A. Tatti" 19 => "E. Kasamatsu" 20 => "E. Iljazovic" 21 => "M. Odida" 22 => "R. Prado" 23 => "M. Seoud" 24 => "M. Grce" 25 => "A. Usubutun" 26 => "A. Jain" 27 => "G.A. Suarez" 28 => "L.E. Lombardi" 29 => "A. Banjo" 30 => "C. Menendez" 31 => "E.J. Domingo" 32 => "J. Velasco" 33 => "A. Nessa" 34 => "S.C. Chichareon" 35 => "Y.L. Qiao" 36 => "E. Lerma" 37 => "S.M. Garland" 38 => "T. Sasagawa" 39 => "A. Ferrera" 40 => "D. Hammouda" 41 => "L. Mariani" 42 => "A. Pelayo" 43 => "I. Steiner" 44 => "E. Oliva" 45 => "C.J. Meijer" 46 => "W.F. Al-Jassar" 47 => "E. Cruz" 48 => "T.C. Wright" 49 => "A. Puras" 50 => "C.L. Llave" 51 => "M. Tzardi" 52 => "T. Agorastos" 53 => "V. Garcia-Barriola" 54 => "C. Clavel" 55 => "J. Ordi" 56 => "M. Andujar" 57 => "X. Castellsague" 58 => "G.I. Sanchez" 59 => "A.M. Nowakowski" 60 => "J. Bornstein" 61 => "N. Munoz" 62 => "F.X. Bosch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(10)70230-8" "Revista" => array:6 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2010" "volumen" => "11" "paginaInicial" => "1048" "paginaFinal" => "1056" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20952254" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0375" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Classification of papillomaviruses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E.M. de Villiers" 1 => "C. Fauquet" 2 => "T.R. Broker" 3 => "H.U. Bernard" 4 => "H. zur Hausen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.virol.2004.03.033" "Revista" => array:6 [ "tituloSerie" => "Virology" "fecha" => "2004" "volumen" => "324" "paginaInicial" => "17" "paginaFinal" => "27" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15183049" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0380" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus genotypes in women with cervical cytological abnormalities from an area with high incidence of cervical cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "G.D. Deluca" 1 => "R.H. Lucero" 2 => "M.T. Martin de Civetta" 3 => "L. Vicente" 4 => "O.L. de Gorodner" 5 => "E. Schelover" 6 => "J.M. Alonso" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Inst Med Trop Sao Paulo" "fecha" => "2004" "volumen" => "46" "paginaInicial" => "9" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15057326" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0385" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chlamydia trachomatis and papillomavirus infection in women with cytohistological abnormalities in uterine cervix" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "G.D. Deluca" 1 => "H.M. Marin" 2 => "E. Schelover" 3 => "E.M. Chamorro" 4 => "L. Vicente" 5 => "M. Albhom" 6 => "J.M. Alonso" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Medicina" "fecha" => "2006" "volumen" => "66" "paginaInicial" => "303" "paginaFinal" => "306" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16977964" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0390" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chlamydia trachomatis as a probable cofactor in human papillomavirus infection in aboriginal women from northeastern Argentina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "G.D. Deluca" 1 => "J. Basiletti" 2 => "E. Schelover" 3 => "N.D. Vasquez" 4 => "J.M. Alonso" 5 => "H.M. Marin" 6 => "R.H. Lucero" 7 => "M.A. Picconi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Braz J Infect Dis" "fecha" => "2011" "volumen" => "15" "paginaInicial" => "567" "paginaFinal" => "572" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22218516" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0395" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papilloma virus risk factors for infection and genotype distribution in aboriginal women from Northern Argentina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.D. Deluca" 1 => "J. Basiletti" 2 => "J.V. Gonzalez" 3 => "N. Diaz Vasquez" 4 => "R.H. Lucero" 5 => "M.A. Picconi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Medicina" "fecha" => "2012" "volumen" => "72" "paginaInicial" => "461" "paginaFinal" => "466" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23241287" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0400" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "InfoStat versión 2004" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.A. Di Rienzo" 1 => "F. Casanoves" 2 => "M.G. Balzarini" 3 => "L. Gonzalez" 4 => "M. Tablada" 5 => "C.W. Robledo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2004" "editorial" => "Grupo InfoStat, FCA, Universidad Nacional de Córdoba" "editorialLocalizacion" => "Argentina" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0405" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Distribution of human papillomavirus 58 and 52 E6/E7 variants in cervical neoplasia in Chinese women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "T. Ding" 1 => "X. Wang" 2 => "F. Ye" 3 => "X. Cheng" 4 => "D. Ma" 5 => "W. Lu" 6 => "X. Xie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ygyno.2010.08.032" "Revista" => array:6 [ "tituloSerie" => "Gynecol Oncol" "fecha" => "2010" "volumen" => "119" "paginaInicial" => "436" "paginaFinal" => "443" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20870281" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0410" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High prevalence of human papillomavirus type 58 in Mexican colposcopy patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Gonzalez-Losa" 1 => "I. Rosado-Lopez" 2 => "N. Valdez-Gonzalez" 3 => "M. Puerto-Solis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1386-6532(03)00138-0" "Revista" => array:6 [ "tituloSerie" => "J Clin Virol" "fecha" => "2004" "volumen" => "29" "paginaInicial" => "202" "paginaFinal" => "205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14962790" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0415" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of papillomavirus and immunodeficiency virus evolutionary patterns in the context of a papillomavirus vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.L. Halpern" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Clin Virol" "fecha" => "2000" "volumen" => "19" "paginaInicial" => "43" "paginaFinal" => "56" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11091147" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0002870314001653" "estado" => "S300" "issn" => "00028703" ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0420" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Population-based study of human papillomavirus infection and cervical neoplasia in rural Costa Rica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:13 [ 0 => "R. Herrero" 1 => "A. Hildesheim" 2 => "C. Bratti" 3 => "M.E. Sherman" 4 => "M. Hutchinson" 5 => "J. Morales" 6 => "I. Balmaceda" 7 => "M.D. Greenberg" 8 => "M. Alfaro" 9 => "R.D. Burk" 10 => "S. Wacholder" 11 => "M. Plummer" 12 => "M. Schiffman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2000" "volumen" => "92" "paginaInicial" => "464" "paginaFinal" => "474" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10716964" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109714017288" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0425" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus type 16 variants and risk of cervical cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:15 [ 0 => "A. Hildesheim" 1 => "M. Schiffman" 2 => "C. Bromley" 3 => "S. Wacholder" 4 => "R. Herrero" 5 => "A. Rodriguez" 6 => "M.C. Bratti" 7 => "M.E. Sherman" 8 => "U. Scarpidis" 9 => "Q.Q. Lin" 10 => "M. Terai" 11 => "R.L. Bromley" 12 => "K. Buetow" 13 => "R.J. Apple" 14 => "R.D. Burk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2001" "volumen" => "93" "paginaInicial" => "315" "paginaFinal" => "318" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11181779" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109711027677" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0430" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IARC monographs on the evaluation of carcinogenic risks to humans. Human papillomaviruses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "IARC" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "IARC Monogr" "fecha" => "2007" "volumen" => "90" "paginaInicial" => "1" "paginaFinal" => "678" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0435" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "IARC" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "2012" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0440" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: variation by geographical region, histological type and year of publication" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N. Li" 1 => "S. Franceschi" 2 => "R. Howell-Jones" 3 => "P.J. Snijders" 4 => "G.M. Clifford" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.25396" "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "2010" "volumen" => "128" "paginaInicial" => "927" "paginaFinal" => "935" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20473886" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0445" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of polymerase chain reaction amplification for the detection of genital human papillomaviruses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Manos" 1 => "Y. Ting" 2 => "D. Wright" 3 => "A. Lewis" 4 => "T. Brocker" 5 => "S. Wolinsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer Cells" "fecha" => "1989" "volumen" => "7" "paginaInicial" => "209" "paginaFinal" => "214" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0450" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of human papillomavirus infection among women in Concordia, Argentina: a population-based study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:11 [ 0 => "E. Matos" 1 => "D. Loria" 2 => "G.M. Amestoy" 3 => "L. Herrera" 4 => "M.A. Prince" 5 => "J. Moreno" 6 => "C. Krunfly" 7 => "A.J. van den Brule" 8 => "C.J. Meijer" 9 => "N. Munoz" 10 => "R. Herrero" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.OLQ.0000085181.25063.6C" "Revista" => array:6 [ "tituloSerie" => "Sex Transm Dis" "fecha" => "2003" "volumen" => "30" "paginaInicial" => "593" "paginaFinal" => "599" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12897679" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0455" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vacuna contra el Virus del Papiloma Humano (VPH)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "MSAL" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "2014" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0460" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High prevalence of human papillomavirus type 58 in patients with cervical pre-malignant lesions in southern Brazil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Paesi" 1 => "E.P. Serafini" 2 => "F. Barea" 3 => "S.R. Madi" 4 => "S. Echeverrigaray" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jmv.21410" "Revista" => array:7 [ "tituloSerie" => "J Med Virol" "fecha" => "2009" "volumen" => "81" "paginaInicial" => "1270" "paginaFinal" => "1275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19475616" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1933287414001585" "estado" => "S300" "issn" => "19332874" ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0465" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Herpes simplex virus and human papillomavirus infection in cervical disease in Argentine women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L.O. Perez" 1 => "G. Barbisan" 2 => "M.C. Abba" 3 => "R.M. Laguens" 4 => "F.N. Dulout" 5 => "C.D. Golijow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Gynecol Pathol" "fecha" => "2006" "volumen" => "25" "paginaInicial" => "42" "paginaFinal" => "47" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16306783" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0470" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus type-16 variants in Quechua aboriginals from Argentina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "M.A. Picconi" 1 => "L.V. Alonio" 2 => "L. Sichero" 3 => "V. Mbayed" 4 => "L.L. Villa" 5 => "J. Gronda" 6 => "R. Campos" 7 => "A. Teyssie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jmv.10343" "Revista" => array:6 [ "tituloSerie" => "J Med Virol" "fecha" => "2003" "volumen" => "69" "paginaInicial" => "546" "paginaFinal" => "552" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12601763" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0475" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ancient papillomavirus-host co-speciation in Felidae" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:15 [ 0 => "A. Rector" 1 => "P. Lemey" 2 => "R. Tachezy" 3 => "S. Mostmans" 4 => "S.J. Ghim" 5 => "K. Van Doorslaer" 6 => "M. Roelke" 7 => "M. Bush" 8 => "R.J. Montali" 9 => "J. Joslin" 10 => "R.D. Burk" 11 => "A.B. Jenson" 12 => "J.P. Sundberg" 13 => "B. Shapiro" 14 => "M. Van Ranst" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/gb-2007-8-4-r57" "Revista" => array:5 [ "tituloSerie" => "Genome Biol" "fecha" => "2007" "volumen" => "8" "paginaInicial" => "R57" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17430578" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0480" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:18 [ 0 => "M. Schiffman" 1 => "A.C. Rodriguez" 2 => "Z. Chen" 3 => "S. Wacholder" 4 => "R. Herrero" 5 => "A. Hildesheim" 6 => "R. Desalle" 7 => "B. Befano" 8 => "K. Yu" 9 => "M. Safaeian" 10 => "M.E. Sherman" 11 => "J. Morales" 12 => "D. Guillen" 13 => "M. Alfaro" 14 => "M. Hutchinson" 15 => "D. Solomon" 16 => "P.E. Castle" 17 => "R.D. Burk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/0008-5472.CAN-09-4179" "Revista" => array:7 [ "tituloSerie" => "Cancer Res" "fecha" => "2010" "volumen" => "70" "paginaInicial" => "3159" "paginaFinal" => "3169" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20354192" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673612607715" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0485" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An update of prophylactic human papillomavirus L1 virus-like particle vaccine clinical trial results" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.T. Schiller" 1 => "X. Castellsague" 2 => "L.L. Villa" 3 => "A. Hildesheim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.vaccine.2008.06.002" "Revista" => array:7 [ "tituloSerie" => "Vaccine" "fecha" => "2008" "volumen" => "26" "paginaInicial" => "K53" "paginaFinal" => "K61" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18847557" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1933287413000615" "estado" => "S300" "issn" => "19332874" ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0490" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High grade cervical lesions are caused preferentially by non-European variants of HPVs 16 and 18" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "L. Sichero" 1 => "S. Ferreira" 2 => "H. Trottier" 3 => "E. Duarte-Franco" 4 => "A. Ferenczy" 5 => "E.L. Franco" 6 => "L.L. Villa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.22481" "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "2007" "volumen" => "120" "paginaInicial" => "1763" "paginaFinal" => "1768" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17230525" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0495" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cervical infection epidemiology of human papillomavirus in Ushuaia, Argentina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "C.C. Sijvarger" 1 => "J.V. Gonzalez" 2 => "A. Prieto" 3 => "A.G. Messmer" 4 => "M.C. Mallimaci" 5 => "V.L. Alonio" 6 => "A.R. Teyssie" 7 => "M.A. Picconi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Argent Microbiol" "fecha" => "2006" "volumen" => "38" "paginaInicial" => "19" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16784128" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0500" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "J.S. Smith" 1 => "L. Lindsay" 2 => "B. Hoots" 3 => "J. Keys" 4 => "S. Franceschi" 5 => "R. Winer" 6 => "G.M. Clifford" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.22527" "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "2007" "volumen" => "121" "paginaInicial" => "621" "paginaFinal" => "632" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17405118" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0505" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "S.A. Tonon" 1 => "M.A. Picconi" 2 => "J.B. Zinovich" 3 => "D.J. Liotta" 4 => "P.D. Bos" 5 => "J.A. Galuppo" 6 => "L.V. Alonio" 7 => "J.A. Ferreras" 8 => "A.R. Teyssie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1098-0997(1999)7:5<237::AID-IDOG6>3.0.CO;2-4" "Revista" => array:6 [ "tituloSerie" => "Infect Dis Obstet Gynecol" "fecha" => "1999" "volumen" => "7" "paginaInicial" => "237" "paginaFinal" => "243" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10524669" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0510" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones, Argentina" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:10 [ 0 => "S.A. Tonon" 1 => "M.A. Picconi" 2 => "J.B. Zinovich" 3 => "W. Nardari" 4 => "M. Mampaey" 5 => "I. Badano" 6 => "F. Di Lello" 7 => "J.A. Galuppo" 8 => "L.V. Alonio" 9 => "A.R. Teyssie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Infect Dis" "fecha" => "2004" "volumen" => "8" "paginaInicial" => "13" "paginaFinal" => "19" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14690776" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0167527314011164" "estado" => "S300" "issn" => "01675273" ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0515" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Degradation of human PDZ-proteins by human alphapapillomaviruses represents an evolutionary adaptation to a novel cellular niche" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Van Doorslaer" 1 => "R. DeSalle" 2 => "M.H. Einstein" 3 => "R.D. Burk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.ppat.1004980" "Revista" => array:6 [ "tituloSerie" => "PLoS Pathog" "fecha" => "2015" "volumen" => "11" "paginaInicial" => "e1004980" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26086730" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109708007201" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0520" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of vaccination on 14 high-risk HPV type infections: a mathematical modelling approach" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "S. Vanska" 1 => "K. Auranen" 2 => "T. Leino" 3 => "H. Salo" 4 => "P. Nieminen" 5 => "T. Kilpi" 6 => "P. Tiihonen" 7 => "D. Apter" 8 => "M. Lehtinen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0072088" "Revista" => array:5 [ "tituloSerie" => "PLOS ONE" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "e72088" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24009669" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0525" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Circulation of human papillomavirus (HPV) genotypes in women from Cordoba, Argentina, with squamous intraepithelial lesions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.F. Venezuela" 1 => "A.X. Kiguen" 2 => "M.C. Frutos" 3 => "C.G. Cuffini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Rev Inst Med Trop Sao Paulo" "fecha" => "2012" "volumen" => "54" "paginaInicial" => "11" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22370748" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673604168955" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0530" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prevalence and role of human papillomavirus genotypes in primary cervical screening in the northeast of China" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:13 [ 0 => "S. Wang" 1 => "H. Wei" 2 => "N. Wang" 3 => "S. Zhang" 4 => "Y. Zhang" 5 => "Q. Ruan" 6 => "W. Jiang" 7 => "Q. Xiao" 8 => "X. Luan" 9 => "X. Qian" 10 => "L. Zhang" 11 => "X. Gao" 12 => "X. Sun" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-2407-12-160" "Revista" => array:5 [ "tituloSerie" => "BMC Cancer" "fecha" => "2012" "volumen" => "12" "paginaInicial" => "160" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22548873" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0535" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cross-protective efficacy of HPV-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by non-vaccine oncogenic HPV types: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:27 [ 0 => "C.M. Wheeler" 1 => "X. Castellsague" 2 => "S.M. Garland" 3 => "A. Szarewski" 4 => "J. Paavonen" 5 => "P. Naud" 6 => "J. Salmeron" 7 => "S.N. Chow" 8 => "D. Apter" 9 => "H. Kitchener" 10 => "J.C. Teixeira" 11 => "S.R. Skinner" 12 => "U. Jaisamrarn" 13 => "G. Limson" 14 => "B. Romanowski" 15 => "F.Y. Aoki" 16 => "T.F. Schwarz" 17 => "W.A. Poppe" 18 => "F.X. Bosch" 19 => "D.M. Harper" 20 => "W. Huh" 21 => "K. Hardt" 22 => "T. Zahaf" 23 => "D. Descamps" 24 => "F. Struyf" 25 => "G. Dubin" 26 => "M. Lehtinen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(11)70287-X" "Revista" => array:6 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2012" "volumen" => "13" "paginaInicial" => "100" "paginaFinal" => "110" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22075170" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0540" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Information Centre on HPV and Cervical Cancer (HPV Information Centre). Human papillomavirus and related cancers in Argentina. Fact Sheet 2013" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "WHO/ICO" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "2013" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03257541/0000004700000004/v2_201602050024/S0325754115001194/v2_201602050024/en/main.assets" "Apartado" => array:4 [ "identificador" => "37861" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Microbiología clínica y enfermedades infecciosas" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03257541/0000004700000004/v2_201602050024/S0325754115001194/v2_201602050024/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0325754115001194?idApp=UINPBA00004N"]

Statistics

Original article

Detección del virus del papiloma humano en Corrientes, Argentina: alta prevalencia de genotipo 58 y su filodinámica

Héctor M. Marína, Carolina Torresb,c, Gerardo D. Delucab, Viviana A. Mbayedb,c,

Corresponding author

vmbayed@ffyb.uba.ar

Corresponding author.

a Instituto de Medicina Regional, Universidad Nacional del Nordeste, Av Las Heras 727, Resistencia 3500, Chaco, Argentina

b Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 4° piso, Ciudad Autónoma de Buenos Aires 1113, Argentina

c CONICET, Av. Rivadavia 1917, Ciudad Autónoma de Buenos Aires 1033, Argentina

Read

3359

Times
was read the article

798

Total PDF

2561

Total HTML

Share statistics

 array:24 [
  "pii" => "S0325754115001194"
  "issn" => "03257541"
  "doi" => "10.1016/j.ram.2015.09.001"
  "estado" => "S300"
  "fechaPublicacion" => "2015-10-01"
  "aid" => "59"
  "copyright" => "Asociaci&#243;n Argentina de Microbiolog&#237;a"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Argent Microbiol. 2015;47:302-11"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1712
    "formatos" => array:3 [
      "EPUB" => 39
      "HTML" => 1275
      "PDF" => 398
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0325754115001212"
    "issn" => "03257541"
    "doi" => "10.1016/j.ram.2015.09.002"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "61"
    "copyright" => "Asociaci&#243;n Argentina de Microbiolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Argent Microbiol. 2015;47:312-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1875
      "formatos" => array:3 [
        "EPUB" => 29
        "HTML" => 1226
        "PDF" => 620
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>"
      "titulo" => "Evidencia serol&#243;gica de circulaci&#243;n del virus de la encefalitis de San Luis en aves de la Ciudad Aut&#243;noma de Buenos Aires&#44; Argentina"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "312"
          "paginaFinal" => "316"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Serological evidence of St&#46; Louis encephalitis virus circulation in birds from Buenos Aires City&#44; Argentina"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2730
              "Ancho" => 2705
              "Tamanyo" => 540081
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Distribuci&#243;n espacial de las aves seropositivas para SLEV&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Fernando J&#46; Beltr&#225;n, Luis A&#46; D&#237;az, Brenda Konigheim, Jos&#233; Molina, Juan B&#46; Beaudoin, Marta Contigiani, Lorena I&#46; Spinsanti"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Fernando J&#46;"
              "apellidos" => "Beltr&#225;n"
            ]
            1 => array:2 [
              "nombre" => "Luis A&#46;"
              "apellidos" => "D&#237;az"
            ]
            2 => array:2 [
              "nombre" => "Brenda"
              "apellidos" => "Konigheim"
            ]
            3 => array:2 [
              "nombre" => "Jos&#233;"
              "apellidos" => "Molina"
            ]
            4 => array:2 [
              "nombre" => "Juan B&#46;"
              "apellidos" => "Beaudoin"
            ]
            5 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Contigiani"
            ]
            6 => array:2 [
              "nombre" => "Lorena I&#46;"
              "apellidos" => "Spinsanti"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0325754115001212?idApp=UINPBA00004N"
    "url" => "/03257541/0000004700000004/v2_201602050024/S0325754115001212/v2_201602050024/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0325754115000929"
    "issn" => "03257541"
    "doi" => "10.1016/j.ram.2015.07.002"
    "estado" => "S300"
    "fechaPublicacion" => "2015-10-01"
    "aid" => "51"
    "copyright" => "Asociaci&#243;n Argentina de Microbiolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Argent Microbiol. 2015;47:295-301"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1678
      "formatos" => array:3 [
        "EPUB" => 51
        "HTML" => 1083
        "PDF" => 544
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Evaluation and comparison of serological methods for the detection of bovine neosporosis in Argentina"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "295"
          "paginaFinal" => "301"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Evaluaci&#243;n y comparaci&#243;n de pruebas serol&#243;gicas para la detecci&#243;n de la neosporosis bovina en Argentina"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1254
              "Ancho" => 1608
              "Tamanyo" => 103743
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Time course of antibody response in EI heifers &#40;mean&#41; determined by IFAT and p38-ELISA&#46; Each data point represents the mean value and error bars represent standard deviations of mean &#40;SEM&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Luc&#237;a M&#46; Campero, Lieselotte Minke, Gast&#243;n Mor&#233;, Magdalena Rambeaud, Diana Bacigalupe, Dadin P&#46; Moore, Yanina Hecker, Carlos M&#46; Campero, Gereon Schares, Mar&#237;a C&#46; Venturini"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "Luc&#237;a M&#46;"
              "apellidos" => "Campero"
            ]
            1 => array:2 [
              "nombre" => "Lieselotte"
              "apellidos" => "Minke"
            ]
            2 => array:2 [
              "nombre" => "Gast&#243;n"
              "apellidos" => "Mor&#233;"
            ]
            3 => array:2 [
              "nombre" => "Magdalena"
              "apellidos" => "Rambeaud"
            ]
            4 => array:2 [
              "nombre" => "Diana"
              "apellidos" => "Bacigalupe"
            ]
            5 => array:2 [
              "nombre" => "Dadin P&#46;"
              "apellidos" => "Moore"
            ]
            6 => array:2 [
              "nombre" => "Yanina"
              "apellidos" => "Hecker"
            ]
            7 => array:2 [
              "nombre" => "Carlos M&#46;"
              "apellidos" => "Campero"
            ]
            8 => array:2 [
              "nombre" => "Gereon"
              "apellidos" => "Schares"
            ]
            9 => array:2 [
              "nombre" => "Mar&#237;a C&#46;"
              "apellidos" => "Venturini"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0325754115000929?idApp=UINPBA00004N"
    "url" => "/03257541/0000004700000004/v2_201602050024/S0325754115000929/v2_201602050024/en/main.assets"
  ]
  "en" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "<span class="elsevierStyleItalic">Human papillomavirus</span> detection in Corrientes&#44; Argentina&#58; High prevalence of type 58 and its phylodynamics"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "302"
        "paginaFinal" => "311"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "H&#233;ctor M&#46; Mar&#237;n, Carolina Torres, Gerardo D&#46; Deluca, Viviana A&#46; Mbayed"
        "autores" => array:4 [
          0 => array:3 [
            "nombre" => "H&#233;ctor M&#46;"
            "apellidos" => "Mar&#237;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Carolina"
            "apellidos" => "Torres"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Gerardo D&#46;"
            "apellidos" => "Deluca"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:4 [
            "nombre" => "Viviana A&#46;"
            "apellidos" => "Mbayed"
            "email" => array:1 [
              0 => "vmbayed&#64;ffyb&#46;uba&#46;ar"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Instituto de Medicina Regional&#44; Universidad Nacional del Nordeste&#44; Av Las Heras 727&#44; Resistencia 3500&#44; Chaco&#44; Argentina"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "C&#225;tedra de Virolog&#237;a&#44; Facultad de Farmacia y Bioqu&#237;mica&#44; Universidad de Buenos Aires&#44; Jun&#237;n 956&#44; 4&#176; piso&#44; Ciudad Aut&#243;noma de Buenos Aires 1113&#44; Argentina"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "CONICET&#44; Av&#46; Rivadavia 1917&#44; Ciudad Aut&#243;noma de Buenos Aires 1033&#44; Argentina"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Detecci&#243;n del virus del papiloma humano en Corrientes&#44; Argentina&#58; alta prevalencia de genotipo 58 y su filodin&#225;mica"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 3967
            "Ancho" => 2800
            "Tamanyo" => 390639
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Maximum Clade Credibility Tree for the Alpha-9 species group &#40;a&#41; and for HPV type 58 &#40;b&#41; obtained with a substitution rate of 1<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;7</span><span class="elsevierStyleHsp" style=""></span>s&#47;s&#47;y&#46; The time to the most recent common ancestor &#40;median and HPD95<span class="elsevierStyleHsp" style=""></span>&#37;&#41; and posterior probability values for relevant groups are shown at nodes&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The surveillance of <span class="elsevierStyleItalic">Human papillomavirus</span> &#40;HPV&#41; infection is epidemiologically relevant considering the incorporation of HPV prophylactic vaccines in different countries&#46; In Argentina&#44; where its general prevalence in 2010 was estimated in 20&#46;1<span class="elsevierStyleHsp" style=""></span>&#37;<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">54</span></a>&#44; vaccination was introduced into the immunization schedule for females aged 11 years in 2011<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">37</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Among the over 150 HPV types described&#44; HPV-16 predominates&#44; whereas the prevalence of other HPV types varies according to the geographic region<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">5</span></a>&#46; It has been reported that about 70<span class="elsevierStyleHsp" style=""></span>&#37; of cervical cancers worldwide are due to HPV-16 and -18<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">20&#44;32</span></a>&#44; which are the goals of commercial vaccines&#46; However&#44; there are still other prevalent high-risk HPV types&#44; such as HPV-31&#44; -33&#44; -45 and -58<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">53</span></a>&#46; In some provinces of Argentina &#40;Chaco&#44; Corrientes&#44; C&#243;rdoba and Misiones&#41;&#44; an important detection of HPV-33 and HPV-58 has been reported<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">2&#44;17&#44;22&#44;23&#44;51</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Although there have been several studies on the genetic diversity and phylogenetics of HPV<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">4&#44;14&#44;19&#44;21&#44;42</span></a>&#44; most of them focused on the characterization of HPV-16 and HPV-18 variants and their associations with pathogenic potential and immunogenicity<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">18&#44;19</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Within HPV-58&#44; several authors have identified four distinct clusters &#40;A&#44; B&#44; C and D&#41;&#44; being lineage A the most prevalent worldwide<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">14&#44;19</span></a>&#46; Reports about the important detections of this high-risk type in regions of Argentina such as the Northeast<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">22&#44;23&#44;25</span></a>&#44; which has the highest mortality rates due to cervical cancer<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">1</span></a>&#44; require a deeper characterization of viruses of HPV-58&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The aim of this work was to study HPV sequences from the Province of Corrientes&#44; Argentina&#44; especially those belonging to HPV-58&#46; We attempted to characterize the viruses from samples taken from different cervical lesions&#44; their nucleotide changes&#44; phylogenetic relationships and the evolutionary dynamics of HPV-58 in the context of the alpha-9 papillomavirus species&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Materials and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Patients</span><p id="par0030" class="elsevierStylePara elsevierViewall">Samples belonged to sexually active women who attended the Services of Gynecology and Obstetrics at hospitals &#8220;Angela Iglesia Llano&#8221; and &#8220;Jos&#233; Ram&#243;n Vidal&#8221; in the city of Corrientes&#44; Province of Corrientes&#44; Argentina&#44; during 2005&#8211;2007 &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>255&#41;&#44; and who had colposcopic or cytohistologic findings suggestive of HPV infection &#40;according to the Bethesda System 2001&#41;&#46; Epidemiological data were collected through a standardized questionnaire&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">All patients included in this study signed a written informed consent and the study was approved by the Ethics Committee of the Instituto de Medicina Regional of the Universidad Nacional del Nordeste&#44; Corrientes&#44; Argentina &#40;Resolution No&#46;&#58; 435&#47;05&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Sample collection&#44; HPV detection and typing</span><p id="par0040" class="elsevierStylePara elsevierViewall">Ecto- and endocervical samples were obtained and DNA was extracted by the digestion method with cetyltrimethyl ammonium bromide &#40;CTAB&#41; and purification with isoamyl alcohol &#40;24&#58;1&#41;&#46; DNA quality was evaluated by PCR targeted to 268 base pairs &#40;bp&#41; of the human beta-globin gene using primers GH20 &#40;5&#8242;-GAAGAGCCAAGGACAGGTAC-3&#8242;&#41; and PG04 &#40;5&#8242;-CAACTTCATCCACGTTCACC-3&#8242;&#41; under conditions previously described<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">35</span></a>&#46; Negative samples for this test were discarded&#46; Viral DNA was detected by PCR using consensus primers MY09&#47;11<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">35</span></a>&#46; Positive samples were typed by RFLP analysis&#44; as previously described<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">3&#44;40</span></a>&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">E6&#47;E7 gene amplification and sequencing</span><p id="par0045" class="elsevierStylePara elsevierViewall">Seventeen samples typified as HPV-58 were amplified and sequenced in the E6 &#40;nt&#46; 110&#8211;559&#41; and E7 &#40;nt&#46; 574&#8211;870&#41; genes&#46; They were amplified by PCR using primers E6-P1&#47;E6-P2 and E7-P1&#47;E7-P2 as previously described<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">12</span></a>&#46; Amplicons were purified using the Wizard SV gel and PCR Clean-up System extraction kits &#40;Promega Corporation&#44; USA&#41; and sequenced in both directions &#40;3500xl Genetic Analyzer&#44; Applied Biosystems&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Statistical analysis</span><p id="par0050" class="elsevierStylePara elsevierViewall">Statistical associations were evaluated with the chi-square test using the Epi-Info v3&#46;5&#46;1 program<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">8</span></a>&#46; Logistic regression analyses were used to determine the odd ratios for HPV detection or high-risk HPV detection according to the cytological status of infections&#44; using the Infostat v2004 program<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">26</span></a>&#46; <span class="elsevierStyleItalic">p</span>-values<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#46;05 were considered significant&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Mutations and phylogenetic analysis of HPV-58</span><p id="par0055" class="elsevierStylePara elsevierViewall">Sequences from this work &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#41; were aligned with ClustalX v2&#46;1 and edited with Bioedit v7&#46;0&#46; Mutations in the E6 and E7 genes were determined by comparison with the prototype genome of HPV-58 &#40;GenBank accession number&#58; <a id="intr0010" class="elsevierStyleInterRef" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=nucleotide&doptcmdl=genbank&term=NC_001443">NC&#95;001443</a>&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">To classify sequences into HPV-58 lineages&#44; a Bayesian phylogenetic analysis was performed using E6 and E7 concatenated sequences&#46; Analysis was performed using an appropriate substitution model estimated with the jModeltest v2&#46;1 software&#44; the uncorrelated lognormal &#40;UCLN&#41; molecular clock model and a Bayesian Skyline Plot model implemented in BEAST v1&#46;8&#46; The Maximum Clade Credibility Tree &#40;MCCT&#41; was obtained using TreeAnnotator v1&#46;8 from the BEAST package&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Phylodynamic analyses</span><p id="par0065" class="elsevierStylePara elsevierViewall">The phylodynamic patterns of the HPV type 58 and the alpha-9 species group of the genus <span class="elsevierStyleItalic">Alphapapillomavirus</span> &#40;HPV types 16&#44; 31&#44; 33&#44; 35&#44; 52&#44; 58 and 67&#41; were studied using a Bayesian coalescent analysis&#46; Estimations included the demographic reconstruction and the time to the most recent common ancestors &#40;tMRCAs&#41; for the different groups&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Datasets included sequences from all groups of each type &#40;dataset HPV-58&#58; 154 sequences&#59; dataset HPV-Alpha-9&#58; 221 sequences&#41; &#40;available upon request&#41;&#46; Analyses were performed on the E6 and E7 genes&#44; using an appropriate substitution model and calibration for each gene&#46; Analyses were carried out using the UCLN molecular clock model and the Skygrid model implemented in BEAST v1&#46;8&#46; A substitution rate of 1&#46;0<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;7</span><span class="elsevierStyleHsp" style=""></span>substitutions per site per year &#40;s&#47;s&#47;y&#41;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">29</span></a> or previously proposed substitution rates for the E6 and E7 genes &#40;2&#46;39<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;8</span> and 1&#46;44<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;8</span><span class="elsevierStyleHsp" style=""></span>&#40;s&#47;s&#47;y&#41;&#44; respectively&#41; were used for calibration<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">41</span></a>&#46; The uncertainty in parameter estimates was evaluated in the 95<span class="elsevierStyleHsp" style=""></span>&#37; highest posterior density &#40;HPD95<span class="elsevierStyleHsp" style=""></span>&#37;&#41; interval&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">GenBank accession numbers</span><p id="par0075" class="elsevierStylePara elsevierViewall">Sequences reported in this work have been deposited in GenBank under accession numbers KP161621 and KP161654&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Results</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">HPV detection and typing</span><p id="par0080" class="elsevierStylePara elsevierViewall">A total of 255 samples belonging to women with a median age of 29 years &#40;range<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#8211;62&#41; and mode of 25 years &#40;confidence interval 95<span class="elsevierStyleHsp" style=""></span>&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#8211;34&#41; were collected for this study&#46; These samples were classified as having reactive cellular changes caused by inflammation &#40;RCC&#59; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>63&#44; 24&#46;7<span class="elsevierStyleHsp" style=""></span>&#37;&#41;&#44; atypical squamous cells of undetermined significance &#40;ASCUS&#59; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44; 4&#46;3<span class="elsevierStyleHsp" style=""></span>&#37;&#41;&#44; low-grade squamous intraepithelial lesions &#40;LSIL&#59; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>152&#44; 59&#46;6<span class="elsevierStyleHsp" style=""></span>&#37;&#41;&#44; high-grade squamous intraepithelial lesions &#40;HSIL&#59; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&#44; 7&#46;1<span class="elsevierStyleHsp" style=""></span>&#37;&#41; and cervical cancer &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44; 4&#46;3<span class="elsevierStyleHsp" style=""></span>&#37;&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">HPV DNA was detected in 56&#46;1<span class="elsevierStyleHsp" style=""></span>&#37; of the cervical lesions &#40;143&#47;255&#41;&#46; An increased severity of the cytological status was associated with a greater rate of HPV detection and especially&#44; with a greater rate of high-risk HPV types detection &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Twenty-two different HPV types were detected&#46; The decreasing order of the main types detected&#44; including their presence in multiple infections&#44; were HPV-16&#44; -58&#44; -53&#44; -31&#44; -6 and -18 &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; Multiple infections were detected in 8 samples &#40;3&#46;1<span class="elsevierStyleHsp" style=""></span>&#37;&#41;&#46; The frequency of the current vaccine viral types &#40;-16&#44; -18&#44; -6&#44; -11&#41; was 44&#46;8<span class="elsevierStyleHsp" style=""></span>&#37;&#44; while the high-risk and probable high-risk HPV types not included in the vaccine reached 33&#46;6<span class="elsevierStyleHsp" style=""></span>&#37;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">The most prevalent types -16 and -58 represented 21&#46;4 and 14&#46;3<span class="elsevierStyleHsp" style=""></span>&#37; of the LSIL cases in which HPV was detected&#44; respectively&#46; HPV-58 predominated among the HSIL cases with HPV detection&#44; reaching 37&#46;5<span class="elsevierStyleHsp" style=""></span>&#37;&#44; followed by HPV-16 in the 33&#46;3<span class="elsevierStyleHsp" style=""></span>&#37;&#46; In contrast&#44; HPV-58 was not detected among cervical cancers&#44; while HPV-16 was present in 80<span class="elsevierStyleHsp" style=""></span>&#37; of them&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">HPV DNA was not found in 43&#46;9<span class="elsevierStyleHsp" style=""></span>&#37; of samples&#44; possibly owing to low viral load or sample degradation&#44; while indeterminate cases &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#41; presented an electrophoretic RFLP pattern that did not match any of the patterns currently taken as reference&#44; according to Bernard <span class="elsevierStyleItalic">et al</span><a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">3</span></a>&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Analysis of mutations in HPV-58</span><p id="par0105" class="elsevierStylePara elsevierViewall">A deeper molecular characterization of the HPV-58&#44; the second most prevalent type in this study&#44; was performed to analyze changes with respect to the prototype virus and to look for mutations previously associated with cervical lesions&#46; Seventeen samples from women &#40;22&#8211;33 years&#41; with viruses typed as HPV-58 were sequenced along the E6 and E7 genes&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">The results showed substitutions in two nucleotide positions in the 450<span class="elsevierStyleHsp" style=""></span>bp of the E6 gene &#40;0&#46;4<span class="elsevierStyleHsp" style=""></span>&#37;&#41; and 11 in the 297<span class="elsevierStyleHsp" style=""></span>bp of the E7 gene &#40;3&#46;7<span class="elsevierStyleHsp" style=""></span>&#37;&#41;&#46; The genomes grouped into nine different variants named COR1 to COR9&#44; according to the substitution patterns&#44; compared with the prototype virus &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; Amino acid changes were observed only in the deduced E7 protein sequence&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">The most frequent mutations were C307T &#40;E6 gene&#44; in 90<span class="elsevierStyleHsp" style=""></span>&#37; of the samples&#41; and G694A &#40;G41R&#41;&#44; T744G&#44; and A761G &#40;G63D&#41;&#44; found in 100<span class="elsevierStyleHsp" style=""></span>&#37; of the E7 sequences&#46; Other seven mutations &#40;A542C in the E6 gene and G634C&#44; G686A&#44; G691A&#44; C767A&#44; G859A&#44; A866C in the E7 gene&#41; were also found&#59; however&#44; their oncogenic potential has not been described or evaluated yet&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Phylogenetic and phylodynamic analyses</span><p id="par0120" class="elsevierStylePara elsevierViewall">The phylogenetic analysis showed that samples from Corrientes city belonged to lineage A&#44; sublineage 2 &#40;A2&#41;&#44; according to the proposed intratypic taxonomy of HPV-58<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">14&#44;19</span></a>&#46; Moreover&#44; sequences from Corrientes were intermingled with sequences from all around the world&#58; China&#44; Japan&#44; Taiwan&#44; the USA&#44; Scotland and Costa Rica &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">Two substitution rates were used for calibrating the analyses of evolutionary dynamics of the alpha-9 species group and the HPV-58&#46; These alternative hypotheses estimated that the tMRCA for the alpha-9 group originated 20&#46;5 million years &#40;My&#41; ago &#40;HPD95<span class="elsevierStyleHsp" style=""></span>&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#46;3&#8211;25&#46;8<span class="elsevierStyleHsp" style=""></span>My&#41; or 3&#46;7<span class="elsevierStyleHsp" style=""></span>My &#40;HPD95<span class="elsevierStyleHsp" style=""></span>&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#46;0&#8211;4&#46;7<span class="elsevierStyleHsp" style=""></span>My&#41; for the slowest and the fastest substitution rates&#44; respectively&#44; whereas&#44; the split up of HPV-58 and its closest cluster&#44; type HPV-33&#44; was dated 8&#46;5<span class="elsevierStyleHsp" style=""></span>My ago &#40;HPD95<span class="elsevierStyleHsp" style=""></span>&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#46;4&#8211;11&#46;5<span class="elsevierStyleHsp" style=""></span>My&#41; or 1&#46;5<span class="elsevierStyleHsp" style=""></span>My ago &#40;HPD95<span class="elsevierStyleHsp" style=""></span>&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;0&#8211;2&#46;1<span class="elsevierStyleHsp" style=""></span>My&#41;&#46; Moreover&#44; type 16 resulted as the most ancient type &#40;&#8764;0&#46;8 or 0&#46;15<span class="elsevierStyleHsp" style=""></span>My&#41;&#44; followed by types 58&#44; 33 and 52 &#40;&#8764;0&#46;6 or &#8764;0&#46;11<span class="elsevierStyleHsp" style=""></span>My&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>a&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">A deeper analysis on type HPV-58 indicated that its diversification might have started &#8764;0&#46;54 or 0&#46;11<span class="elsevierStyleHsp" style=""></span>My years ago&#44; while the tMRCA for lineage A was estimated &#8764;300&#44;000 or &#8764;65&#44;800 years ago &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>b&#41;&#46; Finally&#44; diversification of main groups within the lineage A &#40;sublineages A1&#8211;A3&#41; might have started &#8764;70&#44;000&#8211;200&#44;000 or &#8764;23&#44;900&#8211;41&#44;000 years ago &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>b&#41;&#46;</p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0135" class="elsevierStylePara elsevierViewall">HPV is an important cofactor for cervical neoplasia&#44; and in Argentina it is the most frequent neoplasia &#40;20&#46;9&#47;100&#44;000 women&#41; after mammary cancer &#40;71&#46;2&#47;100&#44;000 women&#41;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">33</span></a>&#46; Provinces in the North and Northeastern regions of the country exhibit the highest rates for cervical cancer mortality<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">1</span></a>&#44; e&#46;g&#46; the Province of Corrientes shows a mortality rate due to cervical cancer of 14&#47;100&#44;000 women&#44; which is three-fold higher than the rate for Buenos Aires&#44; the Capital city of the country&#44; and even exceeds the value of the mortality rate due to mammary cancer estimated by screening studies in Corrientes<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">1&#44;36</span></a>&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">The population under study gathered women with a low socioeconomic status&#44; who are particularly vulnerable to this disease due to reduced access to prevention and control programs&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Despite the studies performed in this region&#44; the number of reported cases is still scarce to evaluate the role of high-risk types<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">2&#44;22&#8211;24&#44;47&#44;48</span></a>&#46; However&#44; it should be noted that we found a high diversity of oncogenic types&#44; with an increased proportion of high-risk and probable high-risk types not included in the current vaccines&#46; This is of concern since there are reports suggesting a limited cross-protection of the vaccines against non vaccine types<a class="elsevierStyleCrossRefs" href="#bib0485"><span class="elsevierStyleSup">43&#44;50&#44;53</span></a>&#46; Therefore&#44; it is necessary to strengthen the monitoring of regional circulation of these types in cases of intraepithelial lesions&#44; contributing to impact assessment of current vaccines against HPV<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">54</span></a>&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">The description of the molecular epidemiology of HPV before the vaccine introduction in 2011 will lead to a better description of the dynamics of the circulation of different genotypes and their variants and also to a better understanding of the relationship between HPV types and cancer in our country&#44; which is useful information for the evaluation of new vaccine formulations&#46; Further studies in post-vaccinal stages will allow to evaluate the dynamics of high-risk HPV types and cross protection among different types<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">10&#44;54</span></a>&#46; It is worth noting that HPV-58 is included in the nonavalent vaccine V503 formulation&#44; which is still under evaluation<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">The most frequently found type in Corrientes was HPV-16&#44; as also observed all around the world in populations both with normal cytology and cervical abnormalities<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">5&#44;9&#44;34&#44;46</span></a>&#46; However&#44; the secondary types vary depending on the geographic region under study&#46; In this work&#44; the most important secondary type was HPV-58&#44; as also observed in other studies in the cities of Corrientes and Resistencia<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">22&#44;23</span></a>&#46; This result differs from the reference meta-analysis conducted by Bruni <span class="elsevierStyleItalic">et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">5</span></a> on samples with normal cytology&#44; which showed that HPV-18 was the most important secondary type both globally and in Latin America and the Caribbean&#46; In different regions of the world&#44; and even in other regions of Argentina<a class="elsevierStyleCrossRefs" href="#bib0450"><span class="elsevierStyleSup">36&#44;39&#44;45</span></a>&#44; HPV-58 was found to have low frequency &#40;&#60;2<span class="elsevierStyleHsp" style=""></span>&#37;&#41; when samples with different grade of lesions were considered<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">9&#44;34&#44;46</span></a>&#46; However&#44; HPV-58 displays a high prevalence in specific regions of the world&#44; especially in Northeast Asia &#40;4&#8211;15<span class="elsevierStyleHsp" style=""></span>&#37;&#41;&#44; Mexico &#40;24&#8211;28<span class="elsevierStyleHsp" style=""></span>&#37;&#41;&#44; Costa Rica &#40;12<span class="elsevierStyleHsp" style=""></span>&#37;&#41; and Brazil &#40;12&#8211;14<span class="elsevierStyleHsp" style=""></span>&#37;&#41;<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">7&#44;11&#44;28&#44;30&#44;38&#44;52</span></a>&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Four different lineages &#40;A&#8211;D&#41; have been identified within HPV-58<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">14&#44;19</span></a>&#46; All the viruses reported in this work belonged to lineage A&#44; sublineage A2&#44; which is the most prevalent in the Americas<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">14</span></a>&#59; none of them belonged to lineage D&#44; which was previously reported in some samples from Argentina<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">14</span></a>&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">HPV-58 is considered a high-risk viral type&#46; However&#44; its disease impact shows geographic variation&#44; since cervical cancer and HSIL are more prevalent in Asian women with HPV-58 than in women from other regions<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">46</span></a>&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The association between pathogenicity and geographic location could be a consequence of specific genetic backgrounds of the host populations but it could also be related to a differential geographic distribution of distinct HPV variants&#46; For other types it has been proposed that different variant lineages might display different pathogenic potentials<a class="elsevierStyleCrossRefs" href="#bib0425"><span class="elsevierStyleSup">31&#44;44</span></a>&#46; In line with this fact&#44; subgroups within lineage A of HPV-58&#44; which display a differential distribution worldwide&#44; could be related to different clinical progression&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Chan <span class="elsevierStyleItalic">et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">14</span></a> proposed to further investigate the possible association of oncogenicity with sublineage A1 of HPV-58 in Asia&#46; Indeed&#44; some mutations in the E7 gene showed a trend of association with the severity of the neoplasia<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">12</span></a>&#46; In our work&#44; we found no association between high pathogenicity and HPV-58 infections&#44; neither with the mutations reported as involved in this phenotype&#59; however&#44; it should be noted that only sublineage A2 was detected and that the samples belonged to women under 35 years old&#44; and therefore not included in the age range &#40;35&#8211;64 years old&#41; strongly associated with progression to cervical cancer<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">32</span></a>&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The analysis of genome sequences showed that E7 mutations &#40;the only ones rendering amino acid changes&#41; were more frequent than E6 mutations&#46; Neither mutations previously associated with the severity of neoplasia<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">12&#44;15&#44;27</span></a>&#44; nor cervical cancer associated to HPV-58 were found&#46; However&#44; other mutations not reported previously &#40;such as C767A &#91;T65K&#93; and G859A &#91;A96T&#93;&#41; were found among the samples and deserve further attention given that they localize in a highly reactive epitope among patients with cervical cancer<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">13</span></a>&#46; Additional studies in the E6 protein assessing the presence of mutations in the protein binding motifs PDZ might help to study their impact on the low oncogenicity of HPV-58 in this population<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">49</span></a>&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">The evolutionary dynamics of the alpha-9 species group and particularly&#44; of type HPV-58 was analyzed&#46; The alpha-9 species separated into two highly supported groups&#44; one formed by types 16&#44; 31&#44; 35 and&#44; the other&#44; by types 33&#44; 52&#44; 58&#44; 67&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Different substitutions rates &#8211; needed for phylodynamic analysis calibration &#8211; have been proposed for papillomaviruses&#44; such as 1&#46;0<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;7</span><span class="elsevierStyleHsp" style=""></span>s&#47;s&#47;y &#40;originally proposed for the L1 gene of mucosal HPV&#41;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">29</span></a>&#44; 2&#46;4<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;8</span> and 1&#46;4<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;8</span><span class="elsevierStyleHsp" style=""></span>s&#47;s&#47;y &#40;from the <span class="elsevierStyleItalic">Feline papillomavirus</span> &#40;FPV&#41; for E6 and E7 genes&#44; respectively&#41;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">41</span></a>&#46; The use of these rates resulted in different diversification times of the viral types that belong to the alpha-9 species group&#44; including HPV-58&#46; For instance&#44; at type level&#44; the tMRCA of HPV-16&#44; -33&#44; -52 and -58 showed ancestral times within the last million years &#40;&#8764;0&#46;6 to &#8764;0&#46;8<span class="elsevierStyleHsp" style=""></span>My&#41; using the substitution rates proposed by Rector <span class="elsevierStyleItalic">et al&#46;</span> or about 0&#46;10&#8211;0&#46;15<span class="elsevierStyleHsp" style=""></span>My using those proposed by Halpern&#46; Particularly&#44; lineage A within HPV-58 would have diversified &#8764;65&#44;800 or &#8764;300&#44;000 years ago &#40;depending on the calibration used&#41;&#44; and the common ancestor of sublineages A1&#8211;A3 could have been dated &#8764;40&#44;000 or &#8764;200&#44;000 years ago&#44; suggesting that their dispersion &#8211; even using the fastest substitution rate &#8211; accompanied or preceded human migration across the globe<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">This hypothesis could explain the worldwide distribution of sublineage A2&#44; whereas other factors might be involved in the emergence and dispersion of the others groups&#44; as previously proposed<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">18</span></a>&#46; Is it worth noting that none of the substitutions rates used to calibrate are proposed for the E6 or E7 genes in HPV&#44; thus these estimations should be taken with caution&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">Summarizing&#44; this study describes the molecular epidemiology of HPV in a region of Argentina with a high rate for cervical cancer mortality&#46; The secondary type was HPV-58 &#40;after HPV-16&#41;&#44; sublineage A2&#46; Although we found no association between this type and high pathogenicity&#44; there are still some concerns about the extent of cross protection of the vaccines against the types not included in their design&#46; In addition&#44; we described genomic variants of HPV-58 and characterized the ancient origin of this type and its diversification&#44; in the context of the alpha-9 papillomavirus species phylodynamics&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Ethical disclosures</span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Protection of human and animal subjects</span><p id="par0205" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Confidentiality of data</span><p id="par0210" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Right to privacy and informed consent</span><p id="par0215" class="elsevierStylePara elsevierViewall">The authors must have obtained the informed consent of the patients and&#47;or subjects mentioned in the article&#46; The author for correspondence must be in possession of this document&#46;</p></span></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflict of interest</span><p id="par0220" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres602669"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec616720"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres602668"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec616719"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
          "secciones" => array:7 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Patients"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Sample collection&#44; HPV detection and typing"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "E6&#47;E7 gene amplification and sequencing"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Statistical analysis"
            ]
            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Mutations and phylogenetic analysis of HPV-58"
            ]
            5 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Phylodynamic analyses"
            ]
            6 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "GenBank accession numbers"
            ]
          ]
        ]
        6 => array:3 [
          "identificador" => "sec0050"
          "titulo" => "Results"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0055"
              "titulo" => "HPV detection and typing"
            ]
            1 => array:2 [
              "identificador" => "sec0060"
              "titulo" => "Analysis of mutations in HPV-58"
            ]
            2 => array:2 [
              "identificador" => "sec0065"
              "titulo" => "Phylogenetic and phylodynamic analyses"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Discussion"
        ]
        8 => array:3 [
          "identificador" => "sec0075"
          "titulo" => "Ethical disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0080"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0085"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0090"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        9 => array:2 [
          "identificador" => "sec0095"
          "titulo" => "Conflict of interest"
        ]
        10 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-05-21"
    "fechaAceptado" => "2015-09-09"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec616720"
          "palabras" => array:5 [
            0 => "HPV-58"
            1 => "Argentina"
            2 => "E6"
            3 => "E7"
            4 => "Phylodynamics"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec616719"
          "palabras" => array:5 [
            0 => "HPV-58"
            1 => "Argentina"
            2 => "E6"
            3 => "E7"
            4 => "Filodin&#225;mica"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Human papillomavirus</span> &#40;HPV&#41; has the highest mortality rate due to cervical cancer in Northeastern Argentina&#46; The aim of this work was to detect and characterize HPV in samples from the Province of Corrientes&#44; Argentina&#46; HPV detection and typing was performed using PCR-RFLP on samples with different cervical lesions &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>255&#41;&#46; Seventeen viruses typified as HPV-58 were sequenced &#40;E6 and E7 genes&#41; and mutations were analyzed&#46; HPV DNA was detected in 56&#46;1<span class="elsevierStyleHsp" style=""></span>&#37; of the cervical lesions &#40;143&#47;255&#41;&#46; Twenty-two different HPV types were detected&#46; The type most frequently found among the total number of samples and HPV-positive samples was HPV-16 &#40;14&#46;5<span class="elsevierStyleHsp" style=""></span>&#37; and 25&#46;9<span class="elsevierStyleHsp" style=""></span>&#37;&#44; respectively&#41;&#44; followed by HPV-58 &#40;8&#46;2<span class="elsevierStyleHsp" style=""></span>&#37;&#47;14&#46;7<span class="elsevierStyleHsp" style=""></span>&#37;&#44; respectively&#41;&#44; which is also considered a high-risk viral type&#46; Increased severity of the cytological status was associated with greater rates of HPV detection and&#44; especially&#44; with the detection of greater rates of high-risk types&#46; In addition&#44; the evolutionary dynamics of the alpha-9 species group and HPV-58 was studied&#46; All HPV-58 viruses reported in this work belonged to lineage A&#44; sublineage A2&#46; The phylodynamic analysis indicated that diversification of main groups within lineage A might have accompanied or preceded human migrations across the globe&#46; Given that the most prevalent viruses found belonged to high-risk HPV types&#44; some concerns might arise about the extent of cross protection of the vaccines against the types not included in their design&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El virus del papiloma humano &#40;<span class="elsevierStyleItalic">Human papillomavirus</span> &#91;HPV&#93;&#41; tiene la mayor tasa de mortalidad por c&#225;ncer de cuello uterino en el noreste de Argentina&#46; El objetivo de este trabajo fue detectar y caracterizar el HPV en muestras de la provincia de Corrientes&#44; Argentina&#46; La detecci&#243;n y la tipificaci&#243;n se realiz&#243; mediante PCR-RFLP en muestras con diferentes lesiones cervicales &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>255&#41;&#46; Se secuenciaron 17 virus tipificados como HPV-58 &#40;genes E6 y E7&#41; y se analizaron sus mutaciones&#46; Adem&#225;s&#44; se estudi&#243; la din&#225;mica evolutiva de los virus del grupo alfa-9 y&#44; en particular&#44; del HPV-58&#46; Se detect&#243; ADN viral en el 56&#44;1<span class="elsevierStyleHsp" style=""></span>&#37; de las lesiones cervicales &#40;143&#47;255&#41; y se detectaron 22 tipos del HPV&#46; El tipo encontrado con mayor frecuencia entre el total de muestras y entre las HPV-positivas fue el HPV-16 &#40;14&#44;5<span class="elsevierStyleHsp" style=""></span>&#37;&#47;25&#44;9<span class="elsevierStyleHsp" style=""></span>&#37;&#44; respectivamente&#41;&#44; seguido por el HPV-58 &#40;8&#44;2<span class="elsevierStyleHsp" style=""></span>&#37;&#47;14&#44;7<span class="elsevierStyleHsp" style=""></span>&#37;&#44; respectivamente&#41;&#44; tambi&#233;n considerado como de alto riesgo&#46; El aumento de la gravedad de las lesiones se asoci&#243; a mayores tasas de detecci&#243;n del HPV y&#44; en especial&#44; con mayores tasas de detecci&#243;n de tipos de alto riesgo&#46; Todos los HPV-58 encontrados pertenecieron al linaje A&#44; sublinaje A2&#46; El an&#225;lisis filodin&#225;mico indic&#243; que la diversificaci&#243;n de los grupos principales dentro del linaje A podr&#237;a haber acompa&#241;ado o precedido las migraciones humanas en todo el mundo&#46; Dado que los virus m&#225;s prevalentes pertenecieron a los tipos del HPV de alto riesgo&#44; podr&#237;an surgir interrogantes sobre el alcance de la protecci&#243;n cruzada de las vacunas contra los tipos no incluidos en su dise&#241;o&#46;</p></span>"
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 3588
            "Ancho" => 2986
            "Tamanyo" => 457510
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Bayesian phylogenetic tree of the E6 and E7 sequences of HPV-58&#46; Posterior probability values higher than 0&#46;5 are shown at nodes for relevant groups&#46; Isolates reported in this work are shown in bold&#46; Type HPV-33 was used as outgroup&#46; The country of origin is indicated when available &#40;abbreviated in uppercase&#41;&#46; BF&#44; Burkina Faso&#59; CHI&#44; China&#59; CR&#44; Costa Rica&#59; ITA&#44; Italy&#59; RW&#44; Rwanda&#59; TW&#44; Taiwan&#59; ZAM&#44; Zambia&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 3967
            "Ancho" => 2800
            "Tamanyo" => 390639
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Maximum Clade Credibility Tree for the Alpha-9 species group &#40;a&#41; and for HPV type 58 &#40;b&#41; obtained with a substitution rate of 1<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">&#8722;7</span><span class="elsevierStyleHsp" style=""></span>s&#47;s&#47;y&#46; The time to the most recent common ancestor &#40;median and HPD95<span class="elsevierStyleHsp" style=""></span>&#37;&#41; and posterior probability values for relevant groups are shown at nodes&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Cytology<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HPV positive &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Odd ratio &#40;IC95<span class="elsevierStyleHsp" style=""></span>&#37;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">High-risk HPV positive &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Odd ratio &#40;IC95<span class="elsevierStyleHsp" style=""></span>&#37;&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">RCC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63 &#40;24&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;19&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;7&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ASCUS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;4&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;63&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;4 &#40;1&#46;9&#8211;29&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;18&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;6 &#40;0&#46;4&#8211;15&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;298&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">L-SIL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">152 &#40;59&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">98 &#40;64&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;7 &#40;3&#46;8&#8211;15&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60 &#40;39&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;6 &#40;2&#46;9&#8211;20&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H-SIL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18 &#40;7&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;88&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&#46;0 &#40;6&#46;9&#8211;168&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;83&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">58&#46;0 &#40;12&#46;4&#8211;270&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;4&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;90&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#46;5 &#40;5&#46;0&#8211;364&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;90&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">116&#46;0 &#40;12&#46;2&#8211;1100&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">255&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">143 &#40;56&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">92 &#40;36&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab986748.png"
              ]
            ]
          ]
          "notaPie" => array:3 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">RCC&#44; reactive cellular changes&#59; L-SIL&#44; low-grade squamous intraepithelial lesion&#59; H-SIL&#44; high-grade squamous intraepithelial lesion&#59; CC&#44; cervical cancer&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">OR for the rates of HPV detection for each cytological status in reference to the RCC status&#44; obtained by a logistic regression analysis&#46;</p>"
            ]
            2 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "c"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">OR for the rates of high-risk HPV types detection for each cytological status with reference to the RCC status&#44; obtained by a logistic regression analysis&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Human papillomavirus</span> infections stratified by cytological status</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Type&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="6" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Number of cases</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">RCC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">ASCUS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">LSIL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">HSIL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">CC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36 &#40;14&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21 &#40;8&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;5&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;4&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;3&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;3&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;2&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;1&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;1&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;1&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;0&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;0&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;0&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;0&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;0&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;0&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&#43;33<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">31&#43;45<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">66&#43;45<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">66&#43;31<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">66&#43;84<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">16&#43;31<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">18&#43;55<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11&#43;61<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Indeterminate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;1&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Negative&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">112 &#40;43&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="7" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">152&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">255&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab986747.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0020"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Mixed infection&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Distribution of types by cytological classification of cases</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">E6</th><th class="td" title="table-head  " colspan="11" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">E7</th><th class="td" title="table-head  " align="left" valign="top" scope="col">AA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">LSIL &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">HSIL &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">307&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">542&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">634&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">686&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">691&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">694&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">744&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">756&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">761&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">767&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">801&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">859&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">866&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">A&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="middle">COR1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G41RG63D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="middle">COR2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G41RG63D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="middle">COR3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">C</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">D21HG41RG63D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="middle">COR4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">N40DG41RG63D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="middle">COR5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G41RG63D&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="middle">COR6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G41RG63DT65K&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="middle">COR7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G41RG63DA96T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="middle">COR8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G41RG63DD76E&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="middle">COR9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleUnderline">C</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">G38DN40DG41RG63DA96TQ98P&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="middle">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab986749.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0025"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Nucleotide sequence alignment showing the mutations in variants named COR1 to COR9&#46; AA&#44; amino acid changes&#46; A<span class="elsevierStyleSup">&#42;</span>&#44; HPV-58 reference genome &#40;accession number <a class="elsevierStyleInterRef" id="intr0005" href="ncbi-n:NC_001443">NC&#95;001443</a>&#41;&#46; Underlined letters indicate substitutions that result in an amino acid change&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">HPV-58 distribution of variants in LSIL and HSIL<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">a</span></a></p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:54 [
            0 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Proyecto para el mejoramiento del Programa Nacional de Prevenci&#243;n de C&#225;ncer de Cuello Uterino en Argentina&#58; informe final&#58; diagn&#243;stico de situaci&#243;n del Programa Nacional y Programas Provinciales"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Arrosi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2008"
                        "editorial" => "Organizacion Panamericana de la Salud"
                        "editorialLocalizacion" => "Buenos Aires"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Human papillomavirus</span> &#40;HPV&#41; detection and Papanicolaou cytology in low-resource women in Posadas city&#44; Misiones&#44; Argentina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "I&#46; Badano"
                            1 => "R&#46;W&#46; Pedrozo"
                            2 => "L&#46;S&#46; Ruiz Diaz"
                            3 => "J&#46;A&#46; Galuppo"
                            4 => "M&#46;A&#46; Picconi"
                            5 => "R&#46;H&#46; Campos"
                            6 => "D&#46;J&#46; Liotta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1590/S0325-75412011000400005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Argent Microbiol"
                        "fecha" => "2011"
                        "volumen" => "43"
                        "paginaInicial" => "263"
                        "paginaFinal" => "267"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22274823"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification and assessment of known and novel human papillomaviruses by polymerase chain reaction amplification&#44; restriction fragment length polymorphisms&#44; nucleotide sequence&#44; and phylogenetic algorithms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:9 [
                            0 => "H&#46;U&#46; Bernard"
                            1 => "S&#46;Y&#46; Chan"
                            2 => "M&#46;M&#46; Manos"
                            3 => "C&#46;K&#46; Ong"
                            4 => "L&#46;L&#46; Villa"
                            5 => "H&#46; Delius"
                            6 => "C&#46;L&#46; Peyton"
                            7 => "H&#46;M&#46; Bauer"
                            8 => "C&#46;M&#46; Wheeler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect Dis"
                        "fecha" => "1994"
                        "volumen" => "170"
                        "paginaInicial" => "1077"
                        "paginaFinal" => "1085"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7963696"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Classification of papillomaviruses &#40;PVs&#41; based on 189 PV types and proposal of taxonomic amendments"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46;U&#46; Bernard"
                            1 => "R&#46;D&#46; Burk"
                            2 => "Z&#46; Chen"
                            3 => "K&#46; van Doorslaer"
                            4 => "H&#46; zur Hausen"
                            5 => "E&#46;M&#46; de Villiers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.virol.2010.02.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Virology"
                        "fecha" => "2010"
                        "volumen" => "401"
                        "paginaInicial" => "70"
                        "paginaFinal" => "79"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20206957"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cervical human papillomavirus prevalence in 5 continents&#58; meta-analysis of 1 million women with normal cytological findings"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Bruni"
                            1 => "M&#46; Diaz"
                            2 => "X&#46; Castellsague"
                            3 => "E&#46; Ferrer"
                            4 => "F&#46;X&#46; Bosch"
                            5 => "S&#46; de Sanjose"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/657321"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect Dis"
                        "fecha" => "2010"
                        "volumen" => "202"
                        "paginaInicial" => "1789"
                        "paginaFinal" => "1799"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21067372"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "African genetic diversity&#58; implications for human demographic history&#44; modern human origins&#44; and complex disease mapping"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;C&#46; Campbell"
                            1 => "S&#46;A&#46; Tishkoff"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1146/annurev.genom.9.081307.164258"
                      "Revista" => array:6 [
                        "tituloSerie" => "Annu Rev Genomics Hum Genet"
                        "fecha" => "2008"
                        "volumen" => "9"
                        "paginaInicial" => "403"
                        "paginaFinal" => "433"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18593304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High prevalence and low E6 genetic variability of human papillomavirus 58 in women with cervical cancer and precursor lesions in Southeast Mexico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "J&#46;C&#46; Canche"
                            1 => "I&#46;R&#46; Lopez"
                            2 => "N&#46;G&#46; Suarez"
                            3 => "G&#46;C&#46; Acosta"
                            4 => "L&#46; Conde-Ferraez"
                            5 => "T&#46;C&#46; Cetina"
                            6 => "M&#46;R&#46; Losa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Mem Inst Oswaldo Cruz"
                        "fecha" => "2010"
                        "volumen" => "105"
                        "paginaInicial" => "144"
                        "paginaFinal" => "148"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20428672"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109712008741"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epi-Info v3&#46;5&#46;1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "CDC"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2008"
                        "editorial" => "Centers for Disease Control and Prevention"
                        "editorialLocalizacion" => "Atlanta&#44; GA"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus genotype distribution in low-grade cervical lesions&#58; comparison by geographic region and with cervical cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;M&#46; Clifford"
                            1 => "R&#46;K&#46; Rana"
                            2 => "S&#46; Franceschi"
                            3 => "J&#46;S&#46; Smith"
                            4 => "G&#46; Gough"
                            5 => "J&#46;M&#46; Pimenta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/1055-9965.EPI-04-0812"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Epidemiol Biomarkers Prev"
                        "fecha" => "2005"
                        "volumen" => "14"
                        "paginaInicial" => "1157"
                        "paginaFinal" => "1164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15894666"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global access to HPV vaccination&#58; what are we waiting for"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;M&#46; Clifford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(09)61789-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2009"
                        "volumen" => "374"
                        "paginaInicial" => "1948"
                        "paginaFinal" => "1949"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19962186"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;K&#46; Chan"
                            1 => "W&#46;H&#46; Li"
                            2 => "M&#46;Y&#46; Chan"
                            3 => "W&#46;L&#46; Ma"
                            4 => "J&#46;L&#46; Cheung"
                            5 => "A&#46;F&#46; Cheng"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Virol"
                        "fecha" => "1999"
                        "volumen" => "59"
                        "paginaInicial" => "232"
                        "paginaFinal" => "238"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10459162"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of human papillomavirus type 58 variant with the risk of cervical cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "P&#46;K&#46; Chan"
                            1 => "C&#46;W&#46; Lam"
                            2 => "T&#46;H&#46; Cheung"
                            3 => "W&#46;W&#46; Li"
                            4 => "K&#46;W&#46; Lo"
                            5 => "M&#46;Y&#46; Chan"
                            6 => "J&#46;L&#46; Cheung"
                            7 => "A&#46;F&#46; Cheng"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "2002"
                        "volumen" => "94"
                        "paginaInicial" => "1249"
                        "paginaFinal" => "1253"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12189229"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S073510970700633X"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "T-cell response to human papillomavirus type 58 L1&#44; E6&#44; And E7 peptides in women with cleared infection&#44; cervical intraepithelial neoplasia&#44; or invasive cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "P&#46;K&#46; Chan"
                            1 => "S&#46;J&#46; Liu"
                            2 => "T&#46;H&#46; Cheung"
                            3 => "W&#46; Yeo"
                            4 => "S&#46;M&#46; Ngai"
                            5 => "J&#46;L&#46; Cheung"
                            6 => "P&#46; Chong"
                            7 => "S&#46; Man"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1128/CVI.00105-10"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Vaccine Immunol"
                        "fecha" => "2010"
                        "volumen" => "17"
                        "paginaInicial" => "1315"
                        "paginaFinal" => "1321"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20668141"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of human papillomavirus type 58 lineages and the distribution worldwide"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:29 [
                            0 => "P&#46;K&#46; Chan"
                            1 => "A&#46;C&#46; Luk"
                            2 => "J&#46;S&#46; Park"
                            3 => "K&#46;K&#46; Smith-McCune"
                            4 => "J&#46;M&#46; Palefsky"
                            5 => "R&#46; Konno"
                            6 => "L&#46; Giovannelli"
                            7 => "F&#46; Coutlee"
                            8 => "S&#46; Hibbitts"
                            9 => "T&#46;Y&#46; Chu"
                            10 => "W&#46; Settheetham-Ishida"
                            11 => "M&#46;A&#46; Picconi"
                            12 => "A&#46; Ferrera"
                            13 => "F&#46; De Marco"
                            14 => "Y&#46;L&#46; Woo"
                            15 => "T&#46; Raiol"
                            16 => "P&#46; Pina-Sanchez"
                            17 => "J&#46;L&#46; Cheung"
                            18 => "J&#46;H&#46; Bae"
                            19 => "M&#46;Z&#46; Chirenje"
                            20 => "T&#46; Magure"
                            21 => "A&#46;B&#46; Moscicki"
                            22 => "A&#46;N&#46; Fiander"
                            23 => "R&#46; Di Stefano"
                            24 => "T&#46;H&#46; Cheung"
                            25 => "M&#46;M&#46; Yu"
                            26 => "S&#46;K&#46; Tsui"
                            27 => "D&#46; Pim"
                            28 => "L&#46; Banks"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/infdis/jir157"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect Dis"
                        "fecha" => "2011"
                        "volumen" => "203"
                        "paginaInicial" => "1565"
                        "paginaFinal" => "1573"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21592985"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:32 [
                            0 => "P&#46;K&#46; Chan"
                            1 => "C&#46; Zhang"
                            2 => "J&#46;S&#46; Park"
                            3 => "K&#46;K&#46; Smith-McCune"
                            4 => "J&#46;M&#46; Palefsky"
                            5 => "L&#46; Giovannelli"
                            6 => "F&#46; Coutlee"
                            7 => "S&#46; Hibbitts"
                            8 => "R&#46; Konno"
                            9 => "W&#46; Settheetham-Ishida"
                            10 => "T&#46;Y&#46; Chu"
                            11 => "A&#46; Ferrera"
                            12 => "M&#46; Alejandra Picconi"
                            13 => "F&#46; De Marco"
                            14 => "Y&#46;L&#46; Woo"
                            15 => "T&#46; Raiol"
                            16 => "P&#46; Pina-Sanchez"
                            17 => "J&#46;H&#46; Bae"
                            18 => "M&#46;C&#46; Wong"
                            19 => "M&#46;Z&#46; Chirenje"
                            20 => "T&#46; Magure"
                            21 => "A&#46;B&#46; Moscicki"
                            22 => "A&#46;N&#46; Fiander"
                            23 => "G&#46; Capra"
                            24 => "E&#46; Young Ki"
                            25 => "Y&#46; Tan"
                            26 => "Z&#46; Chen"
                            27 => "R&#46;D&#46; Burk"
                            28 => "M&#46;C&#46; Chan"
                            29 => "T&#46;H&#46; Cheung"
                            30 => "D&#46; Pim"
                            31 => "L&#46; Banks"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ijc.27932"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "2013"
                        "volumen" => "132"
                        "paginaInicial" => "2528"
                        "paginaFinal" => "2536"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23136059"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1933287414001603"
                          "estado" => "S300"
                          "issn" => "19332874"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The next generation of HPV vaccines&#58; nonavalent vaccine V503 on the horizon"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Chatterjee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1586/14760584.2014.963561"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Vaccines"
                        "fecha" => "2014"
                        "volumen" => "13"
                        "paginaInicial" => "1279"
                        "paginaFinal" => "1290"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25256262"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diversifying selection in human papillomavirus type 16 lineages based on complete genome analyses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Z&#46; Chen"
                            1 => "M&#46; Terai"
                            2 => "L&#46; Fu"
                            3 => "R&#46; Herrero"
                            4 => "R&#46; DeSalle"
                            5 => "R&#46;D&#46; Burk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1128/JVI.79.11.7014-7023.2005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Virol"
                        "fecha" => "2005"
                        "volumen" => "79"
                        "paginaInicial" => "7014"
                        "paginaFinal" => "7023"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15890941"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evolutionary dynamics of variant genomes of human papillomavirus types 18&#44; 45&#44; and 97"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Z&#46; Chen"
                            1 => "R&#46; DeSalle"
                            2 => "M&#46; Schiffman"
                            3 => "R&#46; Herrero"
                            4 => "R&#46;D&#46; Burk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1128/JVI.02068-08"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Virol"
                        "fecha" => "2009"
                        "volumen" => "83"
                        "paginaInicial" => "1443"
                        "paginaFinal" => "1455"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19036820"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evolution and taxonomic classification of alphapapillomavirus 7 complete genomes&#58; HPV18&#44; HPV39&#44; HPV45&#44; HPV59&#44; HPV68 and HPV70"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:10 [
                            0 => "Z&#46; Chen"
                            1 => "M&#46; Schiffman"
                            2 => "R&#46; Herrero"
                            3 => "R&#46; DeSalle"
                            4 => "K&#46; Anastos"
                            5 => "M&#46; Segondy"
                            6 => "V&#46;V&#46; Sahasrabuddhe"
                            7 => "P&#46;E&#46; Gravitt"
                            8 => "A&#46;W&#46; Hsing"
                            9 => "R&#46;D&#46; Burk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0072565"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2011"
                        "volumen" => "8"
                        "paginaInicial" => "e72565"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23977318"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus genotype attribution in invasive cervical cancer&#58; a retrospective cross-sectional worldwide study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:63 [
                            0 => "S&#46; de Sanjose"
                            1 => "W&#46;G&#46; Quint"
                            2 => "L&#46; Alemany"
                            3 => "D&#46;T&#46; Geraets"
                            4 => "J&#46;E&#46; Klaustermeier"
                            5 => "B&#46; Lloveras"
                            6 => "S&#46; Tous"
                            7 => "A&#46; Felix"
                            8 => "L&#46;E&#46; Bravo"
                            9 => "H&#46;R&#46; Shin"
                            10 => "C&#46;S&#46; Vallejos"
                            11 => "P&#46;A&#46; de Ruiz"
                            12 => "M&#46;A&#46; Lima"
                            13 => "N&#46; Guimera"
                            14 => "O&#46; Clavero"
                            15 => "M&#46; Alejo"
                            16 => "A&#46; Llombart-Bosch"
                            17 => "C&#46; Cheng-Yang"
                            18 => "S&#46;A&#46; Tatti"
                            19 => "E&#46; Kasamatsu"
                            20 => "E&#46; Iljazovic"
                            21 => "M&#46; Odida"
                            22 => "R&#46; Prado"
                            23 => "M&#46; Seoud"
                            24 => "M&#46; Grce"
                            25 => "A&#46; Usubutun"
                            26 => "A&#46; Jain"
                            27 => "G&#46;A&#46; Suarez"
                            28 => "L&#46;E&#46; Lombardi"
                            29 => "A&#46; Banjo"
                            30 => "C&#46; Menendez"
                            31 => "E&#46;J&#46; Domingo"
                            32 => "J&#46; Velasco"
                            33 => "A&#46; Nessa"
                            34 => "S&#46;C&#46; Chichareon"
                            35 => "Y&#46;L&#46; Qiao"
                            36 => "E&#46; Lerma"
                            37 => "S&#46;M&#46; Garland"
                            38 => "T&#46; Sasagawa"
                            39 => "A&#46; Ferrera"
                            40 => "D&#46; Hammouda"
                            41 => "L&#46; Mariani"
                            42 => "A&#46; Pelayo"
                            43 => "I&#46; Steiner"
                            44 => "E&#46; Oliva"
                            45 => "C&#46;J&#46; Meijer"
                            46 => "W&#46;F&#46; Al-Jassar"
                            47 => "E&#46; Cruz"
                            48 => "T&#46;C&#46; Wright"
                            49 => "A&#46; Puras"
                            50 => "C&#46;L&#46; Llave"
                            51 => "M&#46; Tzardi"
                            52 => "T&#46; Agorastos"
                            53 => "V&#46; Garcia-Barriola"
                            54 => "C&#46; Clavel"
                            55 => "J&#46; Ordi"
                            56 => "M&#46; Andujar"
                            57 => "X&#46; Castellsague"
                            58 => "G&#46;I&#46; Sanchez"
                            59 => "A&#46;M&#46; Nowakowski"
                            60 => "J&#46; Bornstein"
                            61 => "N&#46; Munoz"
                            62 => "F&#46;X&#46; Bosch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1470-2045(10)70230-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Oncol"
                        "fecha" => "2010"
                        "volumen" => "11"
                        "paginaInicial" => "1048"
                        "paginaFinal" => "1056"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20952254"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Classification of papillomaviruses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;M&#46; de Villiers"
                            1 => "C&#46; Fauquet"
                            2 => "T&#46;R&#46; Broker"
                            3 => "H&#46;U&#46; Bernard"
                            4 => "H&#46; zur Hausen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.virol.2004.03.033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Virology"
                        "fecha" => "2004"
                        "volumen" => "324"
                        "paginaInicial" => "17"
                        "paginaFinal" => "27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15183049"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus genotypes in women with cervical cytological abnormalities from an area with high incidence of cervical cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "G&#46;D&#46; Deluca"
                            1 => "R&#46;H&#46; Lucero"
                            2 => "M&#46;T&#46; Martin de Civetta"
                            3 => "L&#46; Vicente"
                            4 => "O&#46;L&#46; de Gorodner"
                            5 => "E&#46; Schelover"
                            6 => "J&#46;M&#46; Alonso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Inst Med Trop Sao Paulo"
                        "fecha" => "2004"
                        "volumen" => "46"
                        "paginaInicial" => "9"
                        "paginaFinal" => "12"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15057326"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Chlamydia trachomatis</span> and papillomavirus infection in women with cytohistological abnormalities in uterine cervix"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "G&#46;D&#46; Deluca"
                            1 => "H&#46;M&#46; Marin"
                            2 => "E&#46; Schelover"
                            3 => "E&#46;M&#46; Chamorro"
                            4 => "L&#46; Vicente"
                            5 => "M&#46; Albhom"
                            6 => "J&#46;M&#46; Alonso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Medicina"
                        "fecha" => "2006"
                        "volumen" => "66"
                        "paginaInicial" => "303"
                        "paginaFinal" => "306"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16977964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleItalic">Chlamydia trachomatis</span> as a probable cofactor in human papillomavirus infection in aboriginal women from northeastern Argentina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "G&#46;D&#46; Deluca"
                            1 => "J&#46; Basiletti"
                            2 => "E&#46; Schelover"
                            3 => "N&#46;D&#46; Vasquez"
                            4 => "J&#46;M&#46; Alonso"
                            5 => "H&#46;M&#46; Marin"
                            6 => "R&#46;H&#46; Lucero"
                            7 => "M&#46;A&#46; Picconi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Braz J Infect Dis"
                        "fecha" => "2011"
                        "volumen" => "15"
                        "paginaInicial" => "567"
                        "paginaFinal" => "572"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22218516"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papilloma virus risk factors for infection and genotype distribution in aboriginal women from Northern Argentina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46;D&#46; Deluca"
                            1 => "J&#46; Basiletti"
                            2 => "J&#46;V&#46; Gonzalez"
                            3 => "N&#46; Diaz Vasquez"
                            4 => "R&#46;H&#46; Lucero"
                            5 => "M&#46;A&#46; Picconi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Medicina"
                        "fecha" => "2012"
                        "volumen" => "72"
                        "paginaInicial" => "461"
                        "paginaFinal" => "466"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23241287"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "InfoStat versi&#243;n 2004"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; Di Rienzo"
                            1 => "F&#46; Casanoves"
                            2 => "M&#46;G&#46; Balzarini"
                            3 => "L&#46; Gonzalez"
                            4 => "M&#46; Tablada"
                            5 => "C&#46;W&#46; Robledo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2004"
                        "editorial" => "Grupo InfoStat&#44; FCA&#44; Universidad Nacional de C&#243;rdoba"
                        "editorialLocalizacion" => "Argentina"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Distribution of human papillomavirus 58 and 52 E6&#47;E7 variants in cervical neoplasia in Chinese women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "T&#46; Ding"
                            1 => "X&#46; Wang"
                            2 => "F&#46; Ye"
                            3 => "X&#46; Cheng"
                            4 => "D&#46; Ma"
                            5 => "W&#46; Lu"
                            6 => "X&#46; Xie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ygyno.2010.08.032"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gynecol Oncol"
                        "fecha" => "2010"
                        "volumen" => "119"
                        "paginaInicial" => "436"
                        "paginaFinal" => "443"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20870281"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High prevalence of human papillomavirus type 58 in Mexican colposcopy patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Gonzalez-Losa"
                            1 => "I&#46; Rosado-Lopez"
                            2 => "N&#46; Valdez-Gonzalez"
                            3 => "M&#46; Puerto-Solis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1386-6532(03)00138-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Virol"
                        "fecha" => "2004"
                        "volumen" => "29"
                        "paginaInicial" => "202"
                        "paginaFinal" => "205"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14962790"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of papillomavirus and immunodeficiency virus evolutionary patterns in the context of a papillomavirus vaccine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;L&#46; Halpern"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Clin Virol"
                        "fecha" => "2000"
                        "volumen" => "19"
                        "paginaInicial" => "43"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11091147"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002870314001653"
                          "estado" => "S300"
                          "issn" => "00028703"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Population-based study of human papillomavirus infection and cervical neoplasia in rural Costa Rica"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:13 [
                            0 => "R&#46; Herrero"
                            1 => "A&#46; Hildesheim"
                            2 => "C&#46; Bratti"
                            3 => "M&#46;E&#46; Sherman"
                            4 => "M&#46; Hutchinson"
                            5 => "J&#46; Morales"
                            6 => "I&#46; Balmaceda"
                            7 => "M&#46;D&#46; Greenberg"
                            8 => "M&#46; Alfaro"
                            9 => "R&#46;D&#46; Burk"
                            10 => "S&#46; Wacholder"
                            11 => "M&#46; Plummer"
                            12 => "M&#46; Schiffman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "2000"
                        "volumen" => "92"
                        "paginaInicial" => "464"
                        "paginaFinal" => "474"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10716964"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109714017288"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus type 16 variants and risk of cervical cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:15 [
                            0 => "A&#46; Hildesheim"
                            1 => "M&#46; Schiffman"
                            2 => "C&#46; Bromley"
                            3 => "S&#46; Wacholder"
                            4 => "R&#46; Herrero"
                            5 => "A&#46; Rodriguez"
                            6 => "M&#46;C&#46; Bratti"
                            7 => "M&#46;E&#46; Sherman"
                            8 => "U&#46; Scarpidis"
                            9 => "Q&#46;Q&#46; Lin"
                            10 => "M&#46; Terai"
                            11 => "R&#46;L&#46; Bromley"
                            12 => "K&#46; Buetow"
                            13 => "R&#46;J&#46; Apple"
                            14 => "R&#46;D&#46; Burk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "2001"
                        "volumen" => "93"
                        "paginaInicial" => "315"
                        "paginaFinal" => "318"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11181779"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109711027677"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IARC monographs on the evaluation of carcinogenic risks to humans&#46; Human papillomaviruses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "IARC"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "IARC Monogr"
                        "fecha" => "2007"
                        "volumen" => "90"
                        "paginaInicial" => "1"
                        "paginaFinal" => "678"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "GLOBOCAN 2012&#58; estimated cancer incidence&#44; mortality and prevalence worldwide in 2012"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "IARC"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:1 [
                        "fecha" => "2012"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus type distribution in 30&#44;848 invasive cervical cancers worldwide&#58; variation by geographical region&#44; histological type and year of publication"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; Li"
                            1 => "S&#46; Franceschi"
                            2 => "R&#46; Howell-Jones"
                            3 => "P&#46;J&#46; Snijders"
                            4 => "G&#46;M&#46; Clifford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ijc.25396"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "2010"
                        "volumen" => "128"
                        "paginaInicial" => "927"
                        "paginaFinal" => "935"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20473886"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of polymerase chain reaction amplification for the detection of genital human papillomaviruses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Manos"
                            1 => "Y&#46; Ting"
                            2 => "D&#46; Wright"
                            3 => "A&#46; Lewis"
                            4 => "T&#46; Brocker"
                            5 => "S&#46; Wolinsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer Cells"
                        "fecha" => "1989"
                        "volumen" => "7"
                        "paginaInicial" => "209"
                        "paginaFinal" => "214"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of human papillomavirus infection among women in Concordia&#44; Argentina&#58; a population-based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:11 [
                            0 => "E&#46; Matos"
                            1 => "D&#46; Loria"
                            2 => "G&#46;M&#46; Amestoy"
                            3 => "L&#46; Herrera"
                            4 => "M&#46;A&#46; Prince"
                            5 => "J&#46; Moreno"
                            6 => "C&#46; Krunfly"
                            7 => "A&#46;J&#46; van den Brule"
                            8 => "C&#46;J&#46; Meijer"
                            9 => "N&#46; Munoz"
                            10 => "R&#46; Herrero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.OLQ.0000085181.25063.6C"
                      "Revista" => array:6 [
                        "tituloSerie" => "Sex Transm Dis"
                        "fecha" => "2003"
                        "volumen" => "30"
                        "paginaInicial" => "593"
                        "paginaFinal" => "599"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12897679"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Vacuna contra el Virus del Papiloma Humano &#40;VPH&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "MSAL"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:1 [
                        "fecha" => "2014"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High prevalence of human papillomavirus type 58 in patients with cervical pre-malignant lesions in southern Brazil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Paesi"
                            1 => "E&#46;P&#46; Serafini"
                            2 => "F&#46; Barea"
                            3 => "S&#46;R&#46; Madi"
                            4 => "S&#46; Echeverrigaray"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jmv.21410"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Med Virol"
                        "fecha" => "2009"
                        "volumen" => "81"
                        "paginaInicial" => "1270"
                        "paginaFinal" => "1275"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19475616"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1933287414001585"
                          "estado" => "S300"
                          "issn" => "19332874"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Herpes simplex virus and human papillomavirus infection in cervical disease in Argentine women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46;O&#46; Perez"
                            1 => "G&#46; Barbisan"
                            2 => "M&#46;C&#46; Abba"
                            3 => "R&#46;M&#46; Laguens"
                            4 => "F&#46;N&#46; Dulout"
                            5 => "C&#46;D&#46; Golijow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Gynecol Pathol"
                        "fecha" => "2006"
                        "volumen" => "25"
                        "paginaInicial" => "42"
                        "paginaFinal" => "47"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16306783"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus type-16 variants in Quechua aboriginals from Argentina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "M&#46;A&#46; Picconi"
                            1 => "L&#46;V&#46; Alonio"
                            2 => "L&#46; Sichero"
                            3 => "V&#46; Mbayed"
                            4 => "L&#46;L&#46; Villa"
                            5 => "J&#46; Gronda"
                            6 => "R&#46; Campos"
                            7 => "A&#46; Teyssie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jmv.10343"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Virol"
                        "fecha" => "2003"
                        "volumen" => "69"
                        "paginaInicial" => "546"
                        "paginaFinal" => "552"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12601763"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0475"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ancient papillomavirus-host co-speciation in Felidae"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:15 [
                            0 => "A&#46; Rector"
                            1 => "P&#46; Lemey"
                            2 => "R&#46; Tachezy"
                            3 => "S&#46; Mostmans"
                            4 => "S&#46;J&#46; Ghim"
                            5 => "K&#46; Van Doorslaer"
                            6 => "M&#46; Roelke"
                            7 => "M&#46; Bush"
                            8 => "R&#46;J&#46; Montali"
                            9 => "J&#46; Joslin"
                            10 => "R&#46;D&#46; Burk"
                            11 => "A&#46;B&#46; Jenson"
                            12 => "J&#46;P&#46; Sundberg"
                            13 => "B&#46; Shapiro"
                            14 => "M&#46; Van Ranst"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/gb-2007-8-4-r57"
                      "Revista" => array:5 [
                        "tituloSerie" => "Genome Biol"
                        "fecha" => "2007"
                        "volumen" => "8"
                        "paginaInicial" => "R57"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17430578"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A population-based prospective study of carcinogenic human papillomavirus variant lineages&#44; viral persistence&#44; and cervical neoplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:18 [
                            0 => "M&#46; Schiffman"
                            1 => "A&#46;C&#46; Rodriguez"
                            2 => "Z&#46; Chen"
                            3 => "S&#46; Wacholder"
                            4 => "R&#46; Herrero"
                            5 => "A&#46; Hildesheim"
                            6 => "R&#46; Desalle"
                            7 => "B&#46; Befano"
                            8 => "K&#46; Yu"
                            9 => "M&#46; Safaeian"
                            10 => "M&#46;E&#46; Sherman"
                            11 => "J&#46; Morales"
                            12 => "D&#46; Guillen"
                            13 => "M&#46; Alfaro"
                            14 => "M&#46; Hutchinson"
                            15 => "D&#46; Solomon"
                            16 => "P&#46;E&#46; Castle"
                            17 => "R&#46;D&#46; Burk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1158/0008-5472.CAN-09-4179"
                      "Revista" => array:7 [
                        "tituloSerie" => "Cancer Res"
                        "fecha" => "2010"
                        "volumen" => "70"
                        "paginaInicial" => "3159"
                        "paginaFinal" => "3169"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20354192"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673612607715"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0485"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An update of prophylactic human papillomavirus L1 virus-like particle vaccine clinical trial results"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;T&#46; Schiller"
                            1 => "X&#46; Castellsague"
                            2 => "L&#46;L&#46; Villa"
                            3 => "A&#46; Hildesheim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.vaccine.2008.06.002"
                      "Revista" => array:7 [
                        "tituloSerie" => "Vaccine"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "paginaInicial" => "K53"
                        "paginaFinal" => "K61"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18847557"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1933287413000615"
                          "estado" => "S300"
                          "issn" => "19332874"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0490"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High grade cervical lesions are caused preferentially by non-European variants of HPVs 16 and 18"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "L&#46; Sichero"
                            1 => "S&#46; Ferreira"
                            2 => "H&#46; Trottier"
                            3 => "E&#46; Duarte-Franco"
                            4 => "A&#46; Ferenczy"
                            5 => "E&#46;L&#46; Franco"
                            6 => "L&#46;L&#46; Villa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ijc.22481"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "2007"
                        "volumen" => "120"
                        "paginaInicial" => "1763"
                        "paginaFinal" => "1768"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17230525"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0495"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cervical infection epidemiology of human papillomavirus in Ushuaia&#44; Argentina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "C&#46;C&#46; Sijvarger"
                            1 => "J&#46;V&#46; Gonzalez"
                            2 => "A&#46; Prieto"
                            3 => "A&#46;G&#46; Messmer"
                            4 => "M&#46;C&#46; Mallimaci"
                            5 => "V&#46;L&#46; Alonio"
                            6 => "A&#46;R&#46; Teyssie"
                            7 => "M&#46;A&#46; Picconi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Argent Microbiol"
                        "fecha" => "2006"
                        "volumen" => "38"
                        "paginaInicial" => "19"
                        "paginaFinal" => "24"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16784128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0500"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions&#58; a meta-analysis update"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "J&#46;S&#46; Smith"
                            1 => "L&#46; Lindsay"
                            2 => "B&#46; Hoots"
                            3 => "J&#46; Keys"
                            4 => "S&#46; Franceschi"
                            5 => "R&#46; Winer"
                            6 => "G&#46;M&#46; Clifford"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ijc.22527"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "2007"
                        "volumen" => "121"
                        "paginaInicial" => "621"
                        "paginaFinal" => "632"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17405118"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0505"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus cervical infection and associated risk factors in a region of Argentina with a high incidence of cervical carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:9 [
                            0 => "S&#46;A&#46; Tonon"
                            1 => "M&#46;A&#46; Picconi"
                            2 => "J&#46;B&#46; Zinovich"
                            3 => "D&#46;J&#46; Liotta"
                            4 => "P&#46;D&#46; Bos"
                            5 => "J&#46;A&#46; Galuppo"
                            6 => "L&#46;V&#46; Alonio"
                            7 => "J&#46;A&#46; Ferreras"
                            8 => "A&#46;R&#46; Teyssie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/(SICI)1098-0997(1999)7:5<237::AID-IDOG6>3.0.CO;2-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Infect Dis Obstet Gynecol"
                        "fecha" => "1999"
                        "volumen" => "7"
                        "paginaInicial" => "237"
                        "paginaFinal" => "243"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10524669"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0510"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones&#44; Argentina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:10 [
                            0 => "S&#46;A&#46; Tonon"
                            1 => "M&#46;A&#46; Picconi"
                            2 => "J&#46;B&#46; Zinovich"
                            3 => "W&#46; Nardari"
                            4 => "M&#46; Mampaey"
                            5 => "I&#46; Badano"
                            6 => "F&#46; Di Lello"
                            7 => "J&#46;A&#46; Galuppo"
                            8 => "L&#46;V&#46; Alonio"
                            9 => "A&#46;R&#46; Teyssie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Infect Dis"
                        "fecha" => "2004"
                        "volumen" => "8"
                        "paginaInicial" => "13"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14690776"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0167527314011164"
                          "estado" => "S300"
                          "issn" => "01675273"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0515"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Degradation of human PDZ-proteins by human alphapapillomaviruses represents an evolutionary adaptation to a novel cellular niche"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Van Doorslaer"
                            1 => "R&#46; DeSalle"
                            2 => "M&#46;H&#46; Einstein"
                            3 => "R&#46;D&#46; Burk"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.ppat.1004980"
                      "Revista" => array:6 [
                        "tituloSerie" => "PLoS Pathog"
                        "fecha" => "2015"
                        "volumen" => "11"
                        "paginaInicial" => "e1004980"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26086730"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109708007201"
                          "estado" => "S300"
                          "issn" => "07351097"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0520"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of vaccination on 14 high-risk HPV type infections&#58; a mathematical modelling approach"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:9 [
                            0 => "S&#46; Vanska"
                            1 => "K&#46; Auranen"
                            2 => "T&#46; Leino"
                            3 => "H&#46; Salo"
                            4 => "P&#46; Nieminen"
                            5 => "T&#46; Kilpi"
                            6 => "P&#46; Tiihonen"
                            7 => "D&#46; Apter"
                            8 => "M&#46; Lehtinen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0072088"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLOS ONE"
                        "fecha" => "2013"
                        "volumen" => "8"
                        "paginaInicial" => "e72088"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24009669"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0525"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Circulation of human papillomavirus &#40;HPV&#41; genotypes in women from Cordoba&#44; Argentina&#44; with squamous intraepithelial lesions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;F&#46; Venezuela"
                            1 => "A&#46;X&#46; Kiguen"
                            2 => "M&#46;C&#46; Frutos"
                            3 => "C&#46;G&#46; Cuffini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Inst Med Trop Sao Paulo"
                        "fecha" => "2012"
                        "volumen" => "54"
                        "paginaInicial" => "11"
                        "paginaFinal" => "16"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22370748"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673604168955"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0530"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The prevalence and role of human papillomavirus genotypes in primary cervical screening in the northeast of China"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:13 [
                            0 => "S&#46; Wang"
                            1 => "H&#46; Wei"
                            2 => "N&#46; Wang"
                            3 => "S&#46; Zhang"
                            4 => "Y&#46; Zhang"
                            5 => "Q&#46; Ruan"
                            6 => "W&#46; Jiang"
                            7 => "Q&#46; Xiao"
                            8 => "X&#46; Luan"
                            9 => "X&#46; Qian"
                            10 => "L&#46; Zhang"
                            11 => "X&#46; Gao"
                            12 => "X&#46; Sun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2407-12-160"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Cancer"
                        "fecha" => "2012"
                        "volumen" => "12"
                        "paginaInicial" => "160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22548873"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0535"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cross-protective efficacy of HPV-16&#47;18 AS04-adjuvanted vaccine against cervical infection and precancer caused by non-vaccine oncogenic HPV types&#58; 4-year end-of-study analysis of the randomised&#44; double-blind PATRICIA trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:27 [
                            0 => "C&#46;M&#46; Wheeler"
                            1 => "X&#46; Castellsague"
                            2 => "S&#46;M&#46; Garland"
                            3 => "A&#46; Szarewski"
                            4 => "J&#46; Paavonen"
                            5 => "P&#46; Naud"
                            6 => "J&#46; Salmeron"
                            7 => "S&#46;N&#46; Chow"
                            8 => "D&#46; Apter"
                            9 => "H&#46; Kitchener"
                            10 => "J&#46;C&#46; Teixeira"
                            11 => "S&#46;R&#46; Skinner"
                            12 => "U&#46; Jaisamrarn"
                            13 => "G&#46; Limson"
                            14 => "B&#46; Romanowski"
                            15 => "F&#46;Y&#46; Aoki"
                            16 => "T&#46;F&#46; Schwarz"
                            17 => "W&#46;A&#46; Poppe"
                            18 => "F&#46;X&#46; Bosch"
                            19 => "D&#46;M&#46; Harper"
                            20 => "W&#46; Huh"
                            21 => "K&#46; Hardt"
                            22 => "T&#46; Zahaf"
                            23 => "D&#46; Descamps"
                            24 => "F&#46; Struyf"
                            25 => "G&#46; Dubin"
                            26 => "M&#46; Lehtinen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1470-2045(11)70287-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Oncol"
                        "fecha" => "2012"
                        "volumen" => "13"
                        "paginaInicial" => "100"
                        "paginaFinal" => "110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22075170"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0540"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Information Centre on HPV and Cervical Cancer &#40;HPV Information Centre&#41;&#46; <span class="elsevierStyleItalic">Human papillomavirus</span> and related cancers in Argentina&#46; Fact Sheet 2013"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "WHO&#47;ICO"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:1 [
                        "fecha" => "2013"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03257541/0000004700000004/v2_201602050024/S0325754115001194/v2_201602050024/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "37861"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Microbiolog&#237;a cl&#237;nica y enfermedades infecciosas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03257541/0000004700000004/v2_201602050024/S0325754115001194/v2_201602050024/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0325754115001194?idApp=UINPBA00004N"
]

Article information

ISSN: 03257541
Original language: English

DOI:10.1016/j.ram.2015.09.001

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	3	0	3
2024 October	27	3	30
2024 September	61	4	65
2024 August	30	7	37
2024 July	21	4	25
2024 June	14	3	17
2024 May	17	5	22
2024 April	25	3	28
2024 March	22	5	27
2024 February	15	6	21
2024 January	18	6	24
2023 December	10	11	21
2023 November	12	11	23
2023 October	15	9	24
2023 September	19	5	24
2023 August	17	5	22
2023 July	11	3	14
2023 June	25	2	27
2023 May	45	5	50
2023 April	43	1	44
2023 March	35	1	36
2023 February	23	1	24
2023 January	27	8	35
2022 December	32	6	38
2022 November	18	2	20
2022 October	16	7	23
2022 September	17	11	28
2022 August	29	9	38
2022 July	18	6	24
2022 June	15	4	19
2022 May	27	5	32
2022 April	22	13	35
2022 March	18	13	31
2022 February	13	7	20
2022 January	10	5	15
2021 December	16	10	26
2021 November	17	8	25
2021 October	16	13	29
2021 September	25	7	32
2021 August	58	15	73
2021 July	24	7	31
2021 June	18	8	26
2021 May	18	10	28
2021 April	28	14	42
2021 March	31	14	45
2021 February	19	9	28
2021 January	16	11	27
2020 December	18	10	28
2020 November	10	3	13
2020 October	12	7	19
2020 September	26	8	34
2020 August	21	6	27
2020 July	32	5	37
2020 June	24	13	37
2020 May	17	5	22
2020 April	25	5	30
2020 March	27	3	30
2020 February	45	21	66
2020 January	58	11	69
2019 December	26	5	31
2019 November	10	8	18
2019 October	33	1	34
2019 September	40	11	51
2019 August	13	3	16
2019 July	25	7	32
2019 June	52	10	62
2019 May	115	9	124
2019 April	53	8	61
2019 March	14	5	19
2019 February	20	7	27
2019 January	15	4	19
2018 December	17	7	24
2018 November	16	4	20
2018 October	13	12	25
2018 September	8	5	13
2018 August	13	6	19
2018 July	11	2	13
2018 June	16	1	17
2018 May	8	6	14
2018 April	11	10	21
2018 March	7	0	7
2018 February	24	0	24
2018 January	13	1	14
2017 December	6	0	6
2017 November	12	5	17
2017 October	10	3	13
2017 September	6	4	10
2017 August	12	5	17
2017 July	12	4	16
2017 June	21	3	24
2017 May	7	4	11
2017 April	13	7	20
2017 March	11	34	45
2017 February	34	5	39
2017 January	13	7	20
2016 December	30	5	35
2016 November	34	4	38
2016 October	52	6	58
2016 September	41	4	45
2016 August	30	7	37
2016 July	24	2	26
2016 June	36	14	50
2016 May	31	20	51
2016 April	38	18	56
2016 March	59	26	85
2016 February	39	24	63
2016 January	37	31	68
2015 December	9	5	14

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter